With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterati...With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.展开更多
Alcohol abuse constitutes a significant health hazard,leading to various organ damage,notably the liver and brain.Shanxi aged vinegar(SAV)is one of the famous fermented and functional foods containing a variety of bio...Alcohol abuse constitutes a significant health hazard,leading to various organ damage,notably the liver and brain.Shanxi aged vinegar(SAV)is one of the famous fermented and functional foods containing a variety of bioactive ingredients with beneficial effects on the human body.This study aimed to explore the potential protective effect of SAV in alleviating acute alcohol intoxication(AAI)in mice.It was found that SAV at 2.5 mL/kg BW effectively ameliorated the decline in behavioral abilities following alcohol consumption,characterized by a shortened sobering period.SAV reduces alcohol-induced liver damage by inhibiting hepatic function enzymes and oxidative stress levels.Additionally,SAV mitigated the overactivation of microglia and the downregulation of neurotransmitter levels including acetylcholinesterase(AchE),5-hydroxytryptamine(5-HT)and dopamine(DA),thereby reducing ethanol-induced brain damage.Meanwhile,SAV significantly decreased concentrations of alcohol and acetaldehyde in the blood and increased alcohol dehydrogenase(ADH)and acetaldehyde dehydrogenase(ALDH)activities in the liver,indicating enhancement of ethanol metabolism.Moreover,we found that some gut microbiota including Verrucomicrobiota,Akkermansia,and Enterococcus were downregulated after SAV treatment in mice with AAI.These bacteria showed a negative correlation with anti-oxidative markers(glutathione(GSH)and catalase(CAT))and enzymes related to ethanol metabolism pathways(ADH and ALDH),and a positive correlation with hepatic function markers(alanine aminotransferase(ALT),aspartate aminotransferase(AST),and malondialdehyde(MDA)),alcohol metabolites(alcohol and acetaldehyde)and neurotransmitters(AchE,5-HT,and DA).However,Bacteroidota,norank_f_Muribaculaceae,and Alistipes exhibited the opposite direction.These findings suggest that SAV possesses protective effects against hepatic and neuro-toxicity,and could be a potential functional food for AAI prevention.展开更多
Bilingual lexicon induction focuses on learning word translation pairs,also known as bitexts,from monolingual corpora by establishing a mapping between the source and target embedding spaces.Despite recent advancement...Bilingual lexicon induction focuses on learning word translation pairs,also known as bitexts,from monolingual corpora by establishing a mapping between the source and target embedding spaces.Despite recent advancements,bilingual lexicon induction is limited to inducing bitexts consisting of individual words,lacking the ability to handle semantics-rich phrases.To bridge this gap and support downstream cross-lingual tasks,it is practical to develop a method for bilingual phrase induction that extracts bilingual phrase pairs from monolingual corpora without relying on cross-lingual knowledge.In this paper,the authors propose a novel phrase embedding training method based on the skip-gram structure.Specifically,a local hard negative sampling strategy that utilises negative samples of central tokens in sliding windows to enhance phrase embedding learning is introduced.The proposed method achieves competitive or superior performance compared to baseline approaches,with exceptional results recorded for distant languages.Additionally,we develop a phrase representation learning method that leverages multilingual pre-trained language models.These mPLMs-based representations can be combined with the above-mentioned static phrase embeddings to further improve the accuracy of the bilingual phrase induction task.We manually construct a dataset of bilingual phrase pairs and integrate it with MUSE to facilitate the bilingual phrase induction task.展开更多
Endemic fluorosis exists in almost all provinces of China.The long-term ingestion of groundwater containing high concentrations of fluoride is one of the main causes of fluoro-sis.We used artificial neural network to ...Endemic fluorosis exists in almost all provinces of China.The long-term ingestion of groundwater containing high concentrations of fluoride is one of the main causes of fluoro-sis.We used artificial neural network to model the relationship between groundwater fluo-ride concentrations from throughout China and environmental variables such as climatic,geological.and soil parameters as proxy predictors.The results show that the accuracy and area under the receiver operating characteristic curve of the model in the test dataset are 80.5%and 0.86%,respectively,and climatic variables are the most effective predictors.Based on the artificial neural network model,a nationwide prediction risk map of fluoride concen-trations exceeding 1.5 mg/L with a 0.5×0.5 arc minutes resolution was generated.The high risk areas are mainly located in western provinces of Xinjiang,Tibet,Qinghai,and Sichuan,and the northern provinces of Inner Mongolia,Hebei and Shandong.The total number of people estimated to be potentially at risk of fluorosis due to the use of untreated high flu-oride groundwater as drinking water is about 89 million,or 6%of the population.The high fluoride groundwater risk map helps the authorities to prioritize areas requiring mitigation measures and thus facilitates the implementation of water improvement and defluorida-tion projects.展开更多
Toll-like receptor 2 （TLR2） has recently been shown to be up-regulated in patients with non-valvular atrial fi-brillation （AF）. The present study was aimed to determine whether the pathogenesis and development of ...Toll-like receptor 2 （TLR2） has recently been shown to be up-regulated in patients with non-valvular atrial fi-brillation （AF）. The present study was aimed to determine whether the pathogenesis and development of AF is associated with the up-regulation of TLR2. Clinical data and right atrial appendage （RAA） specimens were col-lected from 20 patients with persisten AF （PeAF）, 15 patients with paroxysmal AF （PaAF） and 13 patients with no history of AF undergoing valvular replacement. The results showed that gene expression and protein content of TLR2 were increased in both the AF subgroups, compared with the sinus rhythm （SR） group. Between the two AF subgroups, PaAF had a higher TLR2 level than PeAF. However, no difference in interluekin （IL）-6 content was found among the three groups, and no correlation was found between TLR2 and IL-6 in PeAF patients （r = 0.090, P = 0.706）, PaAF patients （r = 0.408, P = 0.131） and AF patients （r = -0.301, P = 0.079）. Immunohistochemical analysis revealed that TLR2 was distributed in RAAs of AF patients and confirmed the immunoblotting results. In conclusion, we demonstrated that TLR2 was elevated in AF （especially PaAF） patients with valvular heart disease, further implicating inflammation involved in the pathogenesis and development of AF.展开更多
We report a case of myxoma with multiple recurrences in both the atrium and ventricle in a 26-year-old woman five years after the surgical removal of left atrial myxoma, Her 52-year-old mother had a similar medical hi...We report a case of myxoma with multiple recurrences in both the atrium and ventricle in a 26-year-old woman five years after the surgical removal of left atrial myxoma, Her 52-year-old mother had a similar medical history. To our knowledge, this was the first familial case who suffered multifocal cardiac myxoma recurrences without any sign of the myxoma complex. Based on our understanding of the mechanism of recurrence, the approaches to prevent the recurrence, and markers to predict recurrence, we propose that multifocal recurrences, as reported herein, may result from a combination of familial predisposition and multifocal onset. The hi-atrial surgical approach and transesophageal echocardiography are preferred for patients with recurrent cardiac myxomas, especially for those with multiple recurrences and familial myxoma. Immunological and genetic screenings may help to identify family members at risk for developing this disease.展开更多
Microstructure evolution of 2014 aluminum alloy was studied by hot compression deformation at 410?C to 470?C and strain rates of 0.07 s?1 to 0.53 s?1, to provide manufacturing references for aluminum plate. The deform...Microstructure evolution of 2014 aluminum alloy was studied by hot compression deformation at 410?C to 470?C and strain rates of 0.07 s?1 to 0.53 s?1, to provide manufacturing references for aluminum plate. The deformation temperature and especially strain rate ranges were chosen very close to the actual processing condition. The results show that the stress-strain curves display a stable flow at the given deformation conditions, corresponding a dominant microstructure evolution behavior of dynamic recovery (DRV) and few dynamic recrystallization (DRX). After solution treated at 502?C for 3 hours, quasi in-situ observation shows that static recrystallization (SRX) develop typical fine grains with several microns at grain boundaries, while static recovery (SRV) dominants the microstructure evolution during the soaking time, leading to a similar microstructure to that of the as-deformed. The average low angle grain boundaries (LAGBs) and high angle grain boundaries (HAGBs) display weak differences between as-deformed and solution treated specimens, which reveals a good thermal stability of microstructure for 2014 alloy. However, the deformation at the lower temperature has an obvious trend to induce SRX during solution soaking.展开更多
Group 3 innate lymphoid cells(ILC3s)control tissue homeostasis and orchestrate mucosal inflammation;however,the precise mechanisms governing ILC3 activity are fully understood.Here,we identified the transmembrane prot...Group 3 innate lymphoid cells(ILC3s)control tissue homeostasis and orchestrate mucosal inflammation;however,the precise mechanisms governing ILC3 activity are fully understood.Here,we identified the transmembrane protein neuropilin-1(NRP1)as a positive regulator of interleukin(IL)-17-producing ILC3s in the intestine.NRP1 was markedly upregulated in intestinal mucosal biopsies from patients with inflammatory bowel disease(IBD)compared with healthy controls.Genetic deficiency of NRP1 reduces the frequency of ILC3s in the gut and impairs their production of IL-17A in an NF-κB signaling-dependent and cell-intrinsic manner.The diminished IL-17A production in ILC3s altered the composition of the microbiota and improved the outcome of dextran sodium sulfate(DSS)-induced colitis.Furthermore,pharmacological inhibition of NRP1 with EG00229 alleviated the severity of colitis.These observations demonstrated the critical role of NRP1 in the control of intestinal ILC3s,suggesting that NRP1 is a potential therapeutic target for IBD.展开更多
基金supported by the Haihe Laboratory of Cell Ecosystem Innovation Foundation,No.22HHXBSS00047(to PL)Graduate Science and Technology Innovation Project of Tianjin,No.2022BKY173(to LZ)Tianjin Municipal Science and Technology Bureau Foundation,No.20201194(to PL).
文摘With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent worldwide.Aging is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of astrocytes.The microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive function.This article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative diseases.This article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial metabolites.Finally,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s diseases.Our findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.
基金financially supported by the Natural Science Foundation of Tianjin(24JCYBJC01220)the Open Project Program of State Key Laboratory of Food Nutrition and Safety,Tianjin University of Science&Technology(SKLFNS-NF-202318)the foundation of Shanxi Provincial Key Laboratory for Vinegar Fermentation Science and Engineering,China(20220401931002).
文摘Alcohol abuse constitutes a significant health hazard,leading to various organ damage,notably the liver and brain.Shanxi aged vinegar(SAV)is one of the famous fermented and functional foods containing a variety of bioactive ingredients with beneficial effects on the human body.This study aimed to explore the potential protective effect of SAV in alleviating acute alcohol intoxication(AAI)in mice.It was found that SAV at 2.5 mL/kg BW effectively ameliorated the decline in behavioral abilities following alcohol consumption,characterized by a shortened sobering period.SAV reduces alcohol-induced liver damage by inhibiting hepatic function enzymes and oxidative stress levels.Additionally,SAV mitigated the overactivation of microglia and the downregulation of neurotransmitter levels including acetylcholinesterase(AchE),5-hydroxytryptamine(5-HT)and dopamine(DA),thereby reducing ethanol-induced brain damage.Meanwhile,SAV significantly decreased concentrations of alcohol and acetaldehyde in the blood and increased alcohol dehydrogenase(ADH)and acetaldehyde dehydrogenase(ALDH)activities in the liver,indicating enhancement of ethanol metabolism.Moreover,we found that some gut microbiota including Verrucomicrobiota,Akkermansia,and Enterococcus were downregulated after SAV treatment in mice with AAI.These bacteria showed a negative correlation with anti-oxidative markers(glutathione(GSH)and catalase(CAT))and enzymes related to ethanol metabolism pathways(ADH and ALDH),and a positive correlation with hepatic function markers(alanine aminotransferase(ALT),aspartate aminotransferase(AST),and malondialdehyde(MDA)),alcohol metabolites(alcohol and acetaldehyde)and neurotransmitters(AchE,5-HT,and DA).However,Bacteroidota,norank_f_Muribaculaceae,and Alistipes exhibited the opposite direction.These findings suggest that SAV possesses protective effects against hepatic and neuro-toxicity,and could be a potential functional food for AAI prevention.
基金National Key Research and Development Program of China,Grant/Award Number:2023YFC3305003National Natural Science Foundation of China,Grant/Award Number:62376076。
文摘Bilingual lexicon induction focuses on learning word translation pairs,also known as bitexts,from monolingual corpora by establishing a mapping between the source and target embedding spaces.Despite recent advancements,bilingual lexicon induction is limited to inducing bitexts consisting of individual words,lacking the ability to handle semantics-rich phrases.To bridge this gap and support downstream cross-lingual tasks,it is practical to develop a method for bilingual phrase induction that extracts bilingual phrase pairs from monolingual corpora without relying on cross-lingual knowledge.In this paper,the authors propose a novel phrase embedding training method based on the skip-gram structure.Specifically,a local hard negative sampling strategy that utilises negative samples of central tokens in sliding windows to enhance phrase embedding learning is introduced.The proposed method achieves competitive or superior performance compared to baseline approaches,with exceptional results recorded for distant languages.Additionally,we develop a phrase representation learning method that leverages multilingual pre-trained language models.These mPLMs-based representations can be combined with the above-mentioned static phrase embeddings to further improve the accuracy of the bilingual phrase induction task.We manually construct a dataset of bilingual phrase pairs and integrate it with MUSE to facilitate the bilingual phrase induction task.
基金This work was supported by the National Natural Science Foundation of China(Nos:41772255,41521001).
文摘Endemic fluorosis exists in almost all provinces of China.The long-term ingestion of groundwater containing high concentrations of fluoride is one of the main causes of fluoro-sis.We used artificial neural network to model the relationship between groundwater fluo-ride concentrations from throughout China and environmental variables such as climatic,geological.and soil parameters as proxy predictors.The results show that the accuracy and area under the receiver operating characteristic curve of the model in the test dataset are 80.5%and 0.86%,respectively,and climatic variables are the most effective predictors.Based on the artificial neural network model,a nationwide prediction risk map of fluoride concen-trations exceeding 1.5 mg/L with a 0.5×0.5 arc minutes resolution was generated.The high risk areas are mainly located in western provinces of Xinjiang,Tibet,Qinghai,and Sichuan,and the northern provinces of Inner Mongolia,Hebei and Shandong.The total number of people estimated to be potentially at risk of fluorosis due to the use of untreated high flu-oride groundwater as drinking water is about 89 million,or 6%of the population.The high fluoride groundwater risk map helps the authorities to prioritize areas requiring mitigation measures and thus facilitates the implementation of water improvement and defluorida-tion projects.
基金supported by a grant for the PhD candidates of Jiangsu Province (No. JX22013082)
文摘Toll-like receptor 2 （TLR2） has recently been shown to be up-regulated in patients with non-valvular atrial fi-brillation （AF）. The present study was aimed to determine whether the pathogenesis and development of AF is associated with the up-regulation of TLR2. Clinical data and right atrial appendage （RAA） specimens were col-lected from 20 patients with persisten AF （PeAF）, 15 patients with paroxysmal AF （PaAF） and 13 patients with no history of AF undergoing valvular replacement. The results showed that gene expression and protein content of TLR2 were increased in both the AF subgroups, compared with the sinus rhythm （SR） group. Between the two AF subgroups, PaAF had a higher TLR2 level than PeAF. However, no difference in interluekin （IL）-6 content was found among the three groups, and no correlation was found between TLR2 and IL-6 in PeAF patients （r = 0.090, P = 0.706）, PaAF patients （r = 0.408, P = 0.131） and AF patients （r = -0.301, P = 0.079）. Immunohistochemical analysis revealed that TLR2 was distributed in RAAs of AF patients and confirmed the immunoblotting results. In conclusion, we demonstrated that TLR2 was elevated in AF （especially PaAF） patients with valvular heart disease, further implicating inflammation involved in the pathogenesis and development of AF.
文摘We report a case of myxoma with multiple recurrences in both the atrium and ventricle in a 26-year-old woman five years after the surgical removal of left atrial myxoma, Her 52-year-old mother had a similar medical history. To our knowledge, this was the first familial case who suffered multifocal cardiac myxoma recurrences without any sign of the myxoma complex. Based on our understanding of the mechanism of recurrence, the approaches to prevent the recurrence, and markers to predict recurrence, we propose that multifocal recurrences, as reported herein, may result from a combination of familial predisposition and multifocal onset. The hi-atrial surgical approach and transesophageal echocardiography are preferred for patients with recurrent cardiac myxomas, especially for those with multiple recurrences and familial myxoma. Immunological and genetic screenings may help to identify family members at risk for developing this disease.
文摘Microstructure evolution of 2014 aluminum alloy was studied by hot compression deformation at 410?C to 470?C and strain rates of 0.07 s?1 to 0.53 s?1, to provide manufacturing references for aluminum plate. The deformation temperature and especially strain rate ranges were chosen very close to the actual processing condition. The results show that the stress-strain curves display a stable flow at the given deformation conditions, corresponding a dominant microstructure evolution behavior of dynamic recovery (DRV) and few dynamic recrystallization (DRX). After solution treated at 502?C for 3 hours, quasi in-situ observation shows that static recrystallization (SRX) develop typical fine grains with several microns at grain boundaries, while static recovery (SRV) dominants the microstructure evolution during the soaking time, leading to a similar microstructure to that of the as-deformed. The average low angle grain boundaries (LAGBs) and high angle grain boundaries (HAGBs) display weak differences between as-deformed and solution treated specimens, which reveals a good thermal stability of microstructure for 2014 alloy. However, the deformation at the lower temperature has an obvious trend to induce SRX during solution soaking.
基金upported by the following grants:National Natural Science Foundation of China(No.81925018,82130049,82430055,to J.Z.82321001 to Y.Y.,and 82225015 to Q.L.)+1 种基金supported by the National Key Research and Development Project of China(2021ZD0202400,to Q.L.)the New Cornerstone Science Foundation through the XPLORER PRIZE(to Q.L.).
文摘Group 3 innate lymphoid cells(ILC3s)control tissue homeostasis and orchestrate mucosal inflammation;however,the precise mechanisms governing ILC3 activity are fully understood.Here,we identified the transmembrane protein neuropilin-1(NRP1)as a positive regulator of interleukin(IL)-17-producing ILC3s in the intestine.NRP1 was markedly upregulated in intestinal mucosal biopsies from patients with inflammatory bowel disease(IBD)compared with healthy controls.Genetic deficiency of NRP1 reduces the frequency of ILC3s in the gut and impairs their production of IL-17A in an NF-κB signaling-dependent and cell-intrinsic manner.The diminished IL-17A production in ILC3s altered the composition of the microbiota and improved the outcome of dextran sodium sulfate(DSS)-induced colitis.Furthermore,pharmacological inhibition of NRP1 with EG00229 alleviated the severity of colitis.These observations demonstrated the critical role of NRP1 in the control of intestinal ILC3s,suggesting that NRP1 is a potential therapeutic target for IBD.
