Polynyas and their adjacent seasonal ice zones(SIZs)represent the most productive regions in the Southern Ocean,supporting unique food webs that are highly sensitive to climate change.Understanding the dynamics of phy...Polynyas and their adjacent seasonal ice zones(SIZs)represent the most productive regions in the Southern Ocean,supporting unique food webs that are highly sensitive to climate change.Understanding the dynamics of phytoplankton and the carbon pool in these areas is crucial for assessing the role of the Southern Ocean in global carbon cycling.During the late stage of an algal bloom,seawater samples at 14 stations were collected in the Amundsen Sea Polynya(ASP)and adjacent SIZ.Using nutrients,phytoplankton pigments,organic carbon(OC),remote sensing data,and physicochemical measurements,as well as CHEMTAX model simulations,we investigated the response of the phytoplankton crops,taxonomic composition,and OC pool to environmental factors.Our analyses revealed that hydrodynamic regimes of the polynya,adjacent SIZs and open sea were regulated by the regionally varying intrusion of Circumpolar Deep Water,photosynthetically active radiation and sea ice melt water.The ASP exhibited the highest seasonal nutrient utilization rates[ΔN=(1059±386)mmol/m^(2),ΔP=(50±17)mmol/m^(2) andΔSi=(956±904)mmol/m^(2)],while the open sea had lower rates.The integrated chlorophyll a(Chl a)concentration at depths of 0–200 m ranged from 20.4 mg/m^(2) to 1420.0 mg/m^(2) and peaked in the polynya.In the study area,Haptophytes Phaeocystis antarctica was the dominant functional group(34%±27%),and diatoms acted as a secondary contributor(23%±14%).The major functional group and particulate OC(POC)contributor varied from diatoms(36%±12%)in the open sea to haptophytes(48%±31%)in the polynya waters.Strong light conditions and microelement limitations promoted the dominance of P.antarctica(low Fe forms)dominance in the ASP.The strong correlations between the POC and Chl a depth-integrated concentration suggest that the POC was primarily derived from phytoplankton,while dissolved OC(DOC)was influenced by consumer activity and water mass transport.In addition,the transport of OC in the upper 200 m of the water column within the ASP was quantified,revealing the predominantly westward fluxes for both DOC[9.0 mg/(m^(2)·s)]and POC[7.2 mg/(m^(2)·s)].The latitudinal transport exhibited the northward transport of DOC[8.1 mg/(m^(2)·s)]and southward transport of POC[4.3 mg/(m^(2)·s)]movement.These findings have significant implications for enhancing our understanding of how hydrodynamics influence OC cycling in polynya regions.展开更多
The melting of seasonal sea ice in Antarctica plays a pivotal role in the region’s carbon cycle,influencing global carbon storage and the exchange of carbon between the atmosphere and the ocean.However,the impact of ...The melting of seasonal sea ice in Antarctica plays a pivotal role in the region’s carbon cycle,influencing global carbon storage and the exchange of carbon between the atmosphere and the ocean.However,the impact of variability in the timing of seasonal sea ice retreat on the flux and composition of sinking particulate matter remains to be elucidated.In this study,we deployed sediment traps in Prydz Bay during the austral summers of 2019/2020 and 2020/2021,noting that sea ice melting occurred approximately one and a half months earlier in the former summer compared to the latter.We analyzed sediment trap data,which included total mass flux(TMF),particulate organic carbon(POC),biogenic silica(BSi),particulate inorganic carbon,and lithogenic particle(Litho)fluxes,as well as the stable isotopesδ^(13)C andδ^(15)N of particulate organic matter(POM).Additionally,we incorporated remote sensing data on sea ice concentration and chlorophyll a.This dramatic delay in sea ice melting timing could result in a significant increase in TMF,BSi and POC fluxes in the summer of 2020/2021 compared to 2019/2020.Elevated BSi fluxes and more ^(13)C-depleted POC in the austral summer of 2020/2021 suggest that the delayed melting of sea ice may have stimulated the productivity of centric diatoms.Furthermore,the higher BSi/POC ratio and more negativeδ^(15)N values of POM,along with a reduced presence of krill in the traps,indicate a diminished grazing pressure from zooplankton,which collectively enhanced the sedimentation efficiency of POC during the austral summer of 2020/2021.These findings highlight the critical role of sea ice melting timing in regulating productivity,flux and composition of sinking particulate matter in the Prydz Bay ecosystem,with significant implications for carbon cycling in polar oceans.展开更多
Refractory high-entropy alloys(RHEAs)stand as promising candidates for the development of a new generation of hightemperature materials due to their exceptional mechanical properties.However,the inherent low ductility...Refractory high-entropy alloys(RHEAs)stand as promising candidates for the development of a new generation of hightemperature materials due to their exceptional mechanical properties.However,the inherent low ductility and high density of RHEAs have hindered their widespread adoption in industrial applications.In this study,an Nb_(38)Ti_(35)Al_(15)V_(6)Cr_(4)(TaHfMoW)_(2) RHEA with a BCC/B2 dual-phase structure is successfully developed.The RHEA exhibits excellent specifc yield strength of 162.4 MPa·g^(−1)·cm^(3) and 84.3 MPa·g^(−1)·cm^(3) at room temperature(RT)and 800℃,respectively.It was found that the pinning efect of the B2 phase induces a gradual transition in dislocation slip mode from planar slip to cross slip,homogenizing the plastic fow and resulting in excellent compression plasticity(ε>50%).Additionally,the B2 phase endows the alloy with excellent yield strength at high temperatures by precipitation strengthening.Moreover,the dominated a/2<111>type dislocation contributes to the alloy's superior plasticity at high temperatures.展开更多
Nutrient uptake status dominates phytoplankton biomass and community structure in the Southern Ocean during austral summer,yet how nutrient utilization variability responds to phytoplankton community succession is sti...Nutrient uptake status dominates phytoplankton biomass and community structure in the Southern Ocean during austral summer,yet how nutrient utilization variability responds to phytoplankton community succession is still unclear,partly due to lack of data spanning the entire summer.In this study,nitrate,phosphate,and silicate combined with temperature,salinity,and apparent oxygen utilization(AOU)were analyzed along 45°E in the Cosmonaut Sea during December 2019,January 2021,and February 2022.The variations in nutrient utilization in the euphotic layer were studied using biogeochemical tracers,and seasonal nutrient depletion was also estimated.The results showed that nutrient distribution varied significantly from December to February.Significant positive correlations were observed for nitrate and silicate concentrations with salinity and AOU,indicating that nutrient distributions were mainly influenced by water mass and phytoplankton production.Increasing∆[N*]and decreasing∆[Si*]in the upper 50 m were observed south of 63.5°S from December to February,which possibly contributed to a progressive shift in dominant phytoplankton population from Phaeocystis antarctica to diatoms.The seasonal nutrient depletion generally increased from December to February.Moreover,the consumption of silicate substantially increased compared to nitrate,indicating that the abundance of diatoms was increasing with time during the austral summer.Our observations suggest that nutrient utilization status is closely related to phytoplankton community structure in the euphotic layer of the Cosmonaut Sea.展开更多
The progress from intelligent interactions requires electronic skin(E-skin)to shift from single-functional perception to multisensory capabilities.However,the intuitive and interference-free reading of multiple sensor...The progress from intelligent interactions requires electronic skin(E-skin)to shift from single-functional perception to multisensory capabilities.However,the intuitive and interference-free reading of multiple sensory signals without involving complex algorithms is a critical challenge.Herein,we propose a flexible multisensory E-skin by developing a highly homogeneous dispersion of BaTiO_(3)nanoparticles in polydimethylsiloxane dielectric layer.The E-skin is sensitive to externally applied pressure as well as temperature and can distinguish dual synergetic stimuli by the time decoupling effect.The pressure and temperature perception was achieved in an individual device,which greatly reduced the structural complexity compared with multifunctional integrated devices.The sensitivity of E-skin for pressure detection is as high as 0.0724 kPa^(−1)and the detection range reaches as wide as 15.625-10 MPa.The sensitivity to temperature detection is as high as−1.34℃^(−1)and the detection range reaches 20-200℃.More importantly,by equipping with a multilayer neural network,the evolution from tactile perception to advanced intelligent tactile cognition is demonstrated.展开更多
Dissolved organic carbon(DOC)constitutes the largest organic carbon reservoir in the ocean and plays a vital role in the oceanic carbon cycle.However,research on DOC in Antarctica has been limited,largely due to diffi...Dissolved organic carbon(DOC)constitutes the largest organic carbon reservoir in the ocean and plays a vital role in the oceanic carbon cycle.However,research on DOC in Antarctica has been limited,largely due to difficulties in sample collection.In this study,we investigate chromophoric dissolved organic matter(CDOM)in the Cosmonaut Sea and Cooperation Sea,Antarctica.The relative abundances of CDOM,as indicated by the absorption coefficient at 254 nm(a_(254)),exhibit significant variability,ranging from 1.29 m^(-1) to 8.37 m^(-1).The diatom species B is the primary contributor to CDOM in the region influenced by the Antarctic slope current.Using excitation-emission matrix fluorescence spectroscopy coupled with parallel factor analysis(EEM-PARAFAC),we identify three fluorescent components:one protein-like component(C1)and two humic-like components(C2 and C3).Our findings indicate that strong microbial activity in the euphotic zones of the Cosmonaut Sea and Cooperation Sea serves as a primary pathway for the removal of protein-like substances while also acting as a significant source of humic-like substances.Microbial degradation likely accounts for the decoupling of the vertical distribution of DOC and phytoplankton.Furthermore,the intrusion of modified circumpolar deep water(mCDW)into the euphotic zones of open ocean areas influences the distribution of CDOM at depths shallower than 200 m.These results have important implications for enhancing our understanding of the dynamics of CDOM and DOC in east Antarctica,as well as for improving assessments of the carbon cycle.展开更多
Synthetic phenolic antioxidants(SPAs)and parabens,particularly the high-molecularweight(HMW)SPAs and long alkyl chain(LAC)parabens with higher environmental persistence and toxicities,are widely produced and applied w...Synthetic phenolic antioxidants(SPAs)and parabens,particularly the high-molecularweight(HMW)SPAs and long alkyl chain(LAC)parabens with higher environmental persistence and toxicities,are widely produced and applied worldwide.However,their occurrence and potential risks in aquatic environments remain largely unknown.This work investigated 11 HMW SPAs and 3 LAC parabens in the river and treated industrial wastewater samples along the Yangtze River,the largest river and most important source water in China.For convenience of comparison,6 short alkyl chain(SAC)parabens were also included.In 15 industrial wastewater treatment plant effluents(effluent-IWTPs)and 34 surface water monitoring sections along the river,19 out of 20 target compounds were detected with total concentrations(TCs)from 152.5 to 1955.5 ng/L and 141.3 to 1364.9 ng/L in effluent-IWTPs and surface water,respectively.HMW SPAs 1,3,5-tris-[(3,5-di–tert–butyl–4-hydroxyphenyl)methyl]-1,3,5-triazinane-2,4,6-trione(AO3114)and octadecyl 3-(3,5-di–tert–butyl–4-hydroxyphenyl)propionate(AO1076)were the dominant ones.HMWSPAs bis(3–tert–butyl–4–hydroxy-5-methylphenyl)propionate(AO245)and 4,4'-sulfanediylbis(2–tert–butyl–5-methylphenol)(AO-TBM6)and SAC parabens propylparaben(PrP)and butylparaben(BuP)posed medium to high potential ecological risks in 27 surface water monitoring sections.Additionally,AO-TBM6 also exhibited potential health risks in 2 out of 11 drinking water sources.Though the ecotoxicity data are very limited,the ubiquitous presence of the LAC parabens including hexylparaben(HeP)and octylparaben(OcP)in surface water should be of concern since these compounds usually exhibit stronger estrogen potencies than the SAC ones.Finally,kernel density analysis revealed that regulation of industrial discharges is necessary to mitigate the HMW SPA and paraben contamination.展开更多
Electroplating sludge(ES),a byproduct of the electroplating industry,is a significant environmental concern due to its high content of soluble heavy metals(HMs).The significance of spinel formation from ES lies in its...Electroplating sludge(ES),a byproduct of the electroplating industry,is a significant environmental concern due to its high content of soluble heavy metals(HMs).The significance of spinel formation from ES lies in its potential for HMs enrichment and environmental remediation,offering a sustainable solution for hazardous waste management.The article delves into themultifaceted recycling of HMs-rich spinel fromES,encompassing its synthesis,metal enrichment,and thermodynamic stability.The pyro-metallurgical and hydrometallurgical processes for spinel synthesis were discussed,with a focus on the critical role of thermodynamic data in predicting the stability and formation of spinel structures.The crystallographic and magnetic properties of spinels,with their applications in environmental remediation and energy storage are highlighted.The article provides a comprehensive reviewon the recycling of HMs-rich spinel fromES,offering a means to recycle HMs,mitigate ecological harm,and contribute to a circular economy through the recovery and application of valuable materials.The selective leaching of metals from ES also faces challenges,which was limited by the separation,purification steps and high energy consumption.This high energy consumption is a significant operational cost and also contributes to environmental concerns related to carbon emissions.It is essential to address the challenges through continued research and development,improved technologies,and supportive regulatory frameworks.展开更多
Aiming at the problems of large fluctuation of output active power and poor control performance in the process of frequency support of an energy-storage-type static-var-generator(ESVG),the adaptive adjustment control ...Aiming at the problems of large fluctuation of output active power and poor control performance in the process of frequency support of an energy-storage-type static-var-generator(ESVG),the adaptive adjustment control method for its active-loop parameters is used to realize thewind-farmfrequency support,which has become the current research hotspot.Taking the ESVG with a supercapacitor on the DC side as the research object,the influence trend of the change of virtual rotation inertia and virtual damping coefficient on its virtual angular velocity and power angle is analyzed.Then,the constraint relationship between the equivalent virtual inertia time constant of the supercapacitor and the virtual rotation inertia of the ESVG is clarified.Then,combined with the second-order response characteristics of the ESVG power control loop,the selection principles of the frequency modulation coefficient,the virtual rotation inertia,and the virtual damping coefficient are determined.An ESVG adjustment control method,considering the adaptive adjustment of the active loop parameters of the supercapacitor equivalent inertia,is proposed.While ensuring the frequency support capability of the ESVG,the fluctuation degree of its output active power and the virtual angular velocity are suppressed,and the proposed adjustment method also improves the stability of the ESVG control system and the frequency support capability for the wind farm.Finally,the simulation verifies the correctness of the theoretical analysis and the effectiveness of the proposed strategy.展开更多
High-entropy alloys exhibit significant potential for application in the nuclear industry owing to their exceptional resistance to irradiation,excellent mechanical properties,and corrosion resistance.In this work,the ...High-entropy alloys exhibit significant potential for application in the nuclear industry owing to their exceptional resistance to irradiation,excellent mechanical properties,and corrosion resistance.In this work,the Mo_(0.5)V_(0.5)NbTiZr_(x)(x=0-2.0)high-entropy alloys containing alloying elements with low thermal neutron absorption cross section were designed and prepared.The crystal structure,microstructure,mechanical properties and corrosion resistance of the studied alloys were investigated.All the alloys possess a body-centered cubic crystal structure,which is consistent with the CALPHAD(acronym of CALculation of PHAse Diagram)modeling results.The addition of Zr does not alter the crystal structure of the Mo_(0.5)V_(0.5)NbTiZr_(x) alloys;however,it leads to an increase in the lattice constant as Zr content increases.The addition of Zr initially enhances the yield strength,but subsequently leads to a decline as the Zr content increases further.Specifically,the corrosion resistance of the Mo_(0.5)V_(0.5)NbTiZr_(x) alloys in superheated steam at 400℃ and 10.3 MPa decreases with the increase of Zr content.The effect of Zr content on the phase formation,mechanical properties and corrosion resistance of the Mo_(0.5)V_(0.5)NbTiZr_(x) high-entropy alloys are discussed.This study has successfully developed a novel Mo_(0.5)V_(0.5)NbTiZr_(0.25) high-entropy alloy,which demonstrates exceptional properties including high yield strength,excellent ductility,and superior anti-corrosion performance.The findings of this research have significant implications for the design of high-entropy alloys in nuclear applications.展开更多
Compared with cold rolling,warm rolling can significantly reduce or completely eliminate microstruc-ture damage to regulate the microstructure of the material,which is an effective method to improve the mechanical pro...Compared with cold rolling,warm rolling can significantly reduce or completely eliminate microstruc-ture damage to regulate the microstructure of the material,which is an effective method to improve the mechanical properties of the material.However,the effect of warm rolling on refractory complex concen-trated alloys(RCCAs)has rarely been reported.This research examines how warm rolling influences the microstructure,texture,and mechanical properties of the Zr_(45)Ti_(15)Nb_(30)Ta_(10)RCCA.The RCCA was warm-rolled to a 75%reduction in thickness at 650℃(two-phase zone)and then annealed at 1000°C for 1 h.To highlight the advantages of warm rolling,a comparison was conducted with similarly deformed and annealed cold-rolled RCCA.The warm-rolled RCCA exhibits a layered heterogeneous structure and induces the precipitation of the(Nb,Ta)-enriched bcc2 phase.The deformation texture of warm-rolled RCCA is weaker than that of cold-rolled RCCA,which is attributed to localized deformation inhomogene-ity.After annealing,warm rolling resulted in a remarkable increase in the yield strength of the RCCA,i.e.,from 861 MPa to 1071 MPa;meanwhile,moreover,the tensile plasticity was almost identical.Warm rolling leads to a change in plastic deformation of the RCCA from dislocation cross-slip to one dominated by the interaction of dislocations with subgrain boundaries as well as the bcc2 phase.The back tress gen-erated by the heterogeneous structure induced by warm rolling is also effective in increasing the yield strength of the RCCA.The remarkably layered heterogeneous structure,subgrain boundaries and textures result in warm-rolled RCCA with optimal strength-ductility combination.Our results provide an effective processing approach for tailoring the microstructure and mechanical properties of RCCAs.展开更多
The ecosystems in Southern Ocean(SO)are undergoing significant changes in the context of climate change.To identify environment-phytoplankton feedbacks in SO,seawater samples were collected in the Cosmonaut Sea(CS)dur...The ecosystems in Southern Ocean(SO)are undergoing significant changes in the context of climate change.To identify environment-phytoplankton feedbacks in SO,seawater samples were collected in the Cosmonaut Sea(CS)during the 37 th China Antarctic Research Expedition(Jan.2021)(CHINARE-37)and subjected to analysis of particulate organic carbon(POC)and phytoplankton pigments.The remote sensing data,CHEMTAX community compositional modeling analysis,and physicochemical measurements were combined to explore the spatial variation of phytoplankton crops,taxonomic composition,and their environmental drivers.Historical phytoplankton community data from the area were also compared against those of this study to investigate inter-annual community differences and their potential causes.The column-integrated POC and chlorophyll-a(Chl-a)concentrations were 12.0±4.9 g/m^(2) and 73.8±50.5 mg/m^(2),respectively.The two most dominant taxa were haptophyte that are adapted to high Fe availability(Hapt-HiFe,mainly Phaeocystis antarctica)and Diatoms-A(Phaeodactylum tricornutum)that contributed to 33%±25%and 24%±14%to the total phytoplankton crops,respectively.Through cluster analysis,the study area was divided into two regions dominated by Hapt-HiFe and Diatoms-A,respectively.Spatially,Hapt-HiFe was mainly concentrated in the southwest coastal area that featured low temperatures,low salinity,and shallow euphotic zones.The coastal region southwest of the southern boundary of the Antarctic circumpolar current was experiencing a bloom of Hapt-HiFe during the study period that significantly contributed to the POC pool and Chl-a concentrations(R=0.46,P<0.01;R=0.42,P<0.01).Besides,the dominance of Hapt-HiFe in the CS suggests a high biological availability of dissolved Fe that is primarily associated with inputs from sea ice melt and upwellings.展开更多
Rice false smut,caused by Ustilaginoidea virens,is a devastating disease that greatly reduces rice yield and quality.However,controlling rice false smut disease is challenging due to the unique infection mode of U.vir...Rice false smut,caused by Ustilaginoidea virens,is a devastating disease that greatly reduces rice yield and quality.However,controlling rice false smut disease is challenging due to the unique infection mode of U.virens.Therefore,there is a need for early diagnosis and monitoring techniques to prevent the spread of this disease.Lateral flow strip-based recombinase polymerase amplification(LF-RPA)overcomes the limitations of current U.virens detection technologies,which are time-consuming,require delicate equipment,and have a high false-positive rate.In this study,we used a comparative genomics approach to identify Uv_3611,a specific gene of U.virens,as the target for the LF-RPA assay.The designed primers and probe efffectively detected the genomic DNA(gDNA)of U.virens and demonstrated no cross-reactivity with related pathogens.Under optimal conditions,the LF-RPA assay demonstrated a sensitivity of 10 pg of U.virens gDNA.Additionally,by incorporating a simplified PEG-NaOH method for plant DNA extraction,the LF-RPA assay enabled the detection of U.virens in rice spikelets within 30 min,without the need for specialized equipment.Furthermore,the LF-RPA assay successfully detected U.virens in naturally infected rice and seed samples in the field.Therefore,the LF-RPA assay is sensitive,efficient,and convenient,and could be developed as a kit for monitoring rice false smut disease in the field.展开更多
In this work,a series of Co-based ternary Co-Er-B bulk metallic glasses(BMGs)with excellent soft magnetic properties and high strength were developed,and the local atomic structure of a typical Co_(71.5)Er_(3.5)B_(25)...In this work,a series of Co-based ternary Co-Er-B bulk metallic glasses(BMGs)with excellent soft magnetic properties and high strength were developed,and the local atomic structure of a typical Co_(71.5)Er_(3.5)B_(25) metallic glass was studied through in situ high-energy synchrotron X-ray diffraction and ab initio molecular dynamics simulations.The results reveal that the BMG samples can be obtained in a composition region of Co_(68.5-71.5)Er_(3.5-4)B_(25-27.5) by a conventional copper-mold casting method.The Co-Er-B metallic glasses possess stronger atomic bond strengths and denser local atomic packing structure composed of a higher fraction of icosahedral-like clusters but fewer deformed body-centered cubic and crystal-like polyhedrons,and they exhibit slower atomic diffusion behaviors during solidification,as compared to Co-Y-B counterparts.The enhancement in structural stability and the retardation of atomic-ordered diffusion lead to the better glass-forming ability of the Co-Er-B alloys.The smaller magnetic anisotropy energy in the Co-Er-B metallic glasses results in a lower coercivity of less than 1.3 A/m.The Co-Er-B BMGs exhibit high-yield strength of 3560-3969 MPa along with distinct plasticity of around 0.50%.展开更多
Erratum to:J Zhejiang Univ-Sci B(Biomed&Biotechnol)202122(9):718-732 https:/doi.org/10.1631/jzus.B2000544.The original version of this article(Liu et al.,2021)unfortunately contained a mistake:statement of equal c...Erratum to:J Zhejiang Univ-Sci B(Biomed&Biotechnol)202122(9):718-732 https:/doi.org/10.1631/jzus.B2000544.The original version of this article(Liu et al.,2021)unfortunately contained a mistake:statement of equal contribution is missing.This correction article shows that Chiyu LIU and Sixu CHEN contributed equally to this work.The original article has been corrected.展开更多
Cable-driven parallel robots(CDPRs)use cables instead of the rigid limbs of traditional parallel robots,thus processing a large potential workspace,easy to assemble and disassemble characteristics,and with application...Cable-driven parallel robots(CDPRs)use cables instead of the rigid limbs of traditional parallel robots,thus processing a large potential workspace,easy to assemble and disassemble characteristics,and with applications in numerous fields.However,owing to the influence of cable flexibility and nonlinear friction,model uncertainties are di cult to eliminate from the control design.Hence,in this study,the model uncertainties of CDPRs are first analyzed based on a brief introduction to related research.Control strategies for CDPRs with model uncertainties are then reviewed.The advantages and disadvantages of several control strategies for CDPRS are discussed through traditional control strategies with kinematic and dynamic uncertainties.Compared with these traditional control strategies,deep reinforcement learning and model predictive control have received widespread attention in recent years owing to their model independence and recursive feasibility with constraint limits.A comprehensive review and brief analysis of current advances in these two control strategies for CDPRs with model uncertainties are presented,concluding with discussions regarding development directions.展开更多
Background:Aortic dissection(AD)is a fatal cardiovascular disease for which the key involved genes are largely unknown.Here,we aimed to identify promising AD biomarkers from high-throughput RNA expressing data.Methods...Background:Aortic dissection(AD)is a fatal cardiovascular disease for which the key involved genes are largely unknown.Here,we aimed to identify promising AD biomarkers from high-throughput RNA expressing data.Methods:In the GSE98770 dataset,differentially expressed mRNAs(DE-mRNAs)and microRNAs(DE-microRNAs)were identified through differentially expressed gene analysis and gene set enrichment analysis.The regulatory network between DE-mRNAs and DE-microRNAs was established,and hub genes were identified with Cytoscape.Relationships between hub genes and AD were confirmed in the Comparative Toxicogenomics Database(CTD).Potential key transcription factors were discovered with Cytoscape.Hub gene verification was performed by qPCR and immunofluorescence analyses of human specimens.Results:DE-mRNAs and DE-microRNAs were identified.Four mRNAs and microRNA-1321(miR-1321)were found to have the most connections with other genes.CBL was connected to the most genes and interacted with miR-1321,which was also connected to the most genes among the DE-microRNAs.In addition,CBL was associated with AD in the CTD.Among the top five transcription factors potentially regulating CBL transcription,only HOXB13 was a DE-mRNA.The findings were further successfully verified in human specimens.Conclusion:CBL,which may be transcriptionally regulated by HOXB13 and post-transcriptionally regulated by miR-1321,was identified as the most promising potential biomarker for AD.展开更多
基金The National Polar Special Program under contract Nos IRASCC 01-01-02 and IRASCC 02-02the National Natural Science Foundation of China under contract Nos 41976228,42276255,41976227,42176227,and 42076243+1 种基金the International Cooperation Key Project of the Ministry of Science and Technology under contract No.2022YFE0136500the Scientific Research Fund of the Second Institute of Oceanography,Ministry of Natural Resources,under contract Nos JG2011,JG2211,JG2013,and JG1805.
文摘Polynyas and their adjacent seasonal ice zones(SIZs)represent the most productive regions in the Southern Ocean,supporting unique food webs that are highly sensitive to climate change.Understanding the dynamics of phytoplankton and the carbon pool in these areas is crucial for assessing the role of the Southern Ocean in global carbon cycling.During the late stage of an algal bloom,seawater samples at 14 stations were collected in the Amundsen Sea Polynya(ASP)and adjacent SIZ.Using nutrients,phytoplankton pigments,organic carbon(OC),remote sensing data,and physicochemical measurements,as well as CHEMTAX model simulations,we investigated the response of the phytoplankton crops,taxonomic composition,and OC pool to environmental factors.Our analyses revealed that hydrodynamic regimes of the polynya,adjacent SIZs and open sea were regulated by the regionally varying intrusion of Circumpolar Deep Water,photosynthetically active radiation and sea ice melt water.The ASP exhibited the highest seasonal nutrient utilization rates[ΔN=(1059±386)mmol/m^(2),ΔP=(50±17)mmol/m^(2) andΔSi=(956±904)mmol/m^(2)],while the open sea had lower rates.The integrated chlorophyll a(Chl a)concentration at depths of 0–200 m ranged from 20.4 mg/m^(2) to 1420.0 mg/m^(2) and peaked in the polynya.In the study area,Haptophytes Phaeocystis antarctica was the dominant functional group(34%±27%),and diatoms acted as a secondary contributor(23%±14%).The major functional group and particulate OC(POC)contributor varied from diatoms(36%±12%)in the open sea to haptophytes(48%±31%)in the polynya waters.Strong light conditions and microelement limitations promoted the dominance of P.antarctica(low Fe forms)dominance in the ASP.The strong correlations between the POC and Chl a depth-integrated concentration suggest that the POC was primarily derived from phytoplankton,while dissolved OC(DOC)was influenced by consumer activity and water mass transport.In addition,the transport of OC in the upper 200 m of the water column within the ASP was quantified,revealing the predominantly westward fluxes for both DOC[9.0 mg/(m^(2)·s)]and POC[7.2 mg/(m^(2)·s)].The latitudinal transport exhibited the northward transport of DOC[8.1 mg/(m^(2)·s)]and southward transport of POC[4.3 mg/(m^(2)·s)]movement.These findings have significant implications for enhancing our understanding of how hydrodynamics influence OC cycling in polynya regions.
基金The National Key Research and Development Program of China under contract No.2022YFE0136500the Scientific Research Fund of the Second Institute of Oceanography,Ministry of Natural Resources,under contract Nos JG2212 and JG2211+2 种基金the National Natural Science Foundation of China under contract Nos 42276255,41976228,and 42176227the National Polar Special Program“Impact and Response of Antarctic Seas to Climate Change”under contract Nos IRASCC 01-01-02 and IRASCC 02-02the China Scholarship Council under contract No.201704180017.
文摘The melting of seasonal sea ice in Antarctica plays a pivotal role in the region’s carbon cycle,influencing global carbon storage and the exchange of carbon between the atmosphere and the ocean.However,the impact of variability in the timing of seasonal sea ice retreat on the flux and composition of sinking particulate matter remains to be elucidated.In this study,we deployed sediment traps in Prydz Bay during the austral summers of 2019/2020 and 2020/2021,noting that sea ice melting occurred approximately one and a half months earlier in the former summer compared to the latter.We analyzed sediment trap data,which included total mass flux(TMF),particulate organic carbon(POC),biogenic silica(BSi),particulate inorganic carbon,and lithogenic particle(Litho)fluxes,as well as the stable isotopesδ^(13)C andδ^(15)N of particulate organic matter(POM).Additionally,we incorporated remote sensing data on sea ice concentration and chlorophyll a.This dramatic delay in sea ice melting timing could result in a significant increase in TMF,BSi and POC fluxes in the summer of 2020/2021 compared to 2019/2020.Elevated BSi fluxes and more ^(13)C-depleted POC in the austral summer of 2020/2021 suggest that the delayed melting of sea ice may have stimulated the productivity of centric diatoms.Furthermore,the higher BSi/POC ratio and more negativeδ^(15)N values of POM,along with a reduced presence of krill in the traps,indicate a diminished grazing pressure from zooplankton,which collectively enhanced the sedimentation efficiency of POC during the austral summer of 2020/2021.These findings highlight the critical role of sea ice melting timing in regulating productivity,flux and composition of sinking particulate matter in the Prydz Bay ecosystem,with significant implications for carbon cycling in polar oceans.
基金supported by the Chinese Academy of Sciences(ZDBS-LY-JSC023)the National Natural Science Foundation of China(No.52404370)+3 种基金the Natural Science Foundation of Liaoning Province(2023-BS-012)the Youth Innovation Promotion Association CAS(2021188)the IMR Innovation Fund(2023-PY16)the Guangdong Basic and Applied Basic Research Foundation(2023A1515111060).
文摘Refractory high-entropy alloys(RHEAs)stand as promising candidates for the development of a new generation of hightemperature materials due to their exceptional mechanical properties.However,the inherent low ductility and high density of RHEAs have hindered their widespread adoption in industrial applications.In this study,an Nb_(38)Ti_(35)Al_(15)V_(6)Cr_(4)(TaHfMoW)_(2) RHEA with a BCC/B2 dual-phase structure is successfully developed.The RHEA exhibits excellent specifc yield strength of 162.4 MPa·g^(−1)·cm^(3) and 84.3 MPa·g^(−1)·cm^(3) at room temperature(RT)and 800℃,respectively.It was found that the pinning efect of the B2 phase induces a gradual transition in dislocation slip mode from planar slip to cross slip,homogenizing the plastic fow and resulting in excellent compression plasticity(ε>50%).Additionally,the B2 phase endows the alloy with excellent yield strength at high temperatures by precipitation strengthening.Moreover,the dominated a/2<111>type dislocation contributes to the alloy's superior plasticity at high temperatures.
基金The National Polar Special Program“Impact and Response of Antarctic Seas to Climate Change”under contract Nos IRASCC 01-01-02 and IRASCC 02-02the National Key Research and Development Program of China under contract No.2022YFE0136500+1 种基金the National Natural Science Foundation of China(NSFC)under contract Nos 41976228,42276255 and 42176227the Scientific Research Fund of the Second Institute of Oceanography under contract Nos JG2011,JG2211 and JG2013.
文摘Nutrient uptake status dominates phytoplankton biomass and community structure in the Southern Ocean during austral summer,yet how nutrient utilization variability responds to phytoplankton community succession is still unclear,partly due to lack of data spanning the entire summer.In this study,nitrate,phosphate,and silicate combined with temperature,salinity,and apparent oxygen utilization(AOU)were analyzed along 45°E in the Cosmonaut Sea during December 2019,January 2021,and February 2022.The variations in nutrient utilization in the euphotic layer were studied using biogeochemical tracers,and seasonal nutrient depletion was also estimated.The results showed that nutrient distribution varied significantly from December to February.Significant positive correlations were observed for nitrate and silicate concentrations with salinity and AOU,indicating that nutrient distributions were mainly influenced by water mass and phytoplankton production.Increasing∆[N*]and decreasing∆[Si*]in the upper 50 m were observed south of 63.5°S from December to February,which possibly contributed to a progressive shift in dominant phytoplankton population from Phaeocystis antarctica to diatoms.The seasonal nutrient depletion generally increased from December to February.Moreover,the consumption of silicate substantially increased compared to nitrate,indicating that the abundance of diatoms was increasing with time during the austral summer.Our observations suggest that nutrient utilization status is closely related to phytoplankton community structure in the euphotic layer of the Cosmonaut Sea.
基金Ningbo Scientific and Technological Innovation 2025 Major Project,Grant/Award Number:2020Z022German Research Foundation(DFG)grants,Grant/Award Numbers:MA 5144/13-1,MA 5144/28-1+6 种基金the National Natural Science Foundation of China,Grant/Award Numbers:62204246,51931011,51971233,52127803,62174165the External Cooperation Program of Chinese Academy of Sciences,Grant/Award Numbers:174433KYSB20190038,174433KYSB20200013the Instrument Developing Project of the Chinese Academy of Sciences,Grant/Award Number:YJKYYQ20200030K.C.Wong Education Foundation,Grant/Award Number:GJTD-2020-11Chinese Academy of Sciences Youth Innovation Promotion Association,Grant/Award Number:2018334Zhejiang Provincial Key R&D Program,Grant/Award Numbers:2021C01183,2022C01032the National Natural Science Foundation of Zhejiang Province of China,Grant/Award Number:LQ23F040004.
文摘The progress from intelligent interactions requires electronic skin(E-skin)to shift from single-functional perception to multisensory capabilities.However,the intuitive and interference-free reading of multiple sensory signals without involving complex algorithms is a critical challenge.Herein,we propose a flexible multisensory E-skin by developing a highly homogeneous dispersion of BaTiO_(3)nanoparticles in polydimethylsiloxane dielectric layer.The E-skin is sensitive to externally applied pressure as well as temperature and can distinguish dual synergetic stimuli by the time decoupling effect.The pressure and temperature perception was achieved in an individual device,which greatly reduced the structural complexity compared with multifunctional integrated devices.The sensitivity of E-skin for pressure detection is as high as 0.0724 kPa^(−1)and the detection range reaches as wide as 15.625-10 MPa.The sensitivity to temperature detection is as high as−1.34℃^(−1)and the detection range reaches 20-200℃.More importantly,by equipping with a multilayer neural network,the evolution from tactile perception to advanced intelligent tactile cognition is demonstrated.
基金The National Natural Science Foundation of China under contract Nos 42276255,41976228,42176227 and 42306262the National Polar Special Program under contract Nos IRASCC 01-01-02,IRASCC 02-02-03,and IRASCC 02-02-05the Scientific Research Fund of the Second Institute of Oceanography under contract Nos JG2211 and JG2212.
文摘Dissolved organic carbon(DOC)constitutes the largest organic carbon reservoir in the ocean and plays a vital role in the oceanic carbon cycle.However,research on DOC in Antarctica has been limited,largely due to difficulties in sample collection.In this study,we investigate chromophoric dissolved organic matter(CDOM)in the Cosmonaut Sea and Cooperation Sea,Antarctica.The relative abundances of CDOM,as indicated by the absorption coefficient at 254 nm(a_(254)),exhibit significant variability,ranging from 1.29 m^(-1) to 8.37 m^(-1).The diatom species B is the primary contributor to CDOM in the region influenced by the Antarctic slope current.Using excitation-emission matrix fluorescence spectroscopy coupled with parallel factor analysis(EEM-PARAFAC),we identify three fluorescent components:one protein-like component(C1)and two humic-like components(C2 and C3).Our findings indicate that strong microbial activity in the euphotic zones of the Cosmonaut Sea and Cooperation Sea serves as a primary pathway for the removal of protein-like substances while also acting as a significant source of humic-like substances.Microbial degradation likely accounts for the decoupling of the vertical distribution of DOC and phytoplankton.Furthermore,the intrusion of modified circumpolar deep water(mCDW)into the euphotic zones of open ocean areas influences the distribution of CDOM at depths shallower than 200 m.These results have important implications for enhancing our understanding of the dynamics of CDOM and DOC in east Antarctica,as well as for improving assessments of the carbon cycle.
基金supported by the National Key Research and Development Program of China(Nos.2021YFC3200801 and 2021YFC3200804).
文摘Synthetic phenolic antioxidants(SPAs)and parabens,particularly the high-molecularweight(HMW)SPAs and long alkyl chain(LAC)parabens with higher environmental persistence and toxicities,are widely produced and applied worldwide.However,their occurrence and potential risks in aquatic environments remain largely unknown.This work investigated 11 HMW SPAs and 3 LAC parabens in the river and treated industrial wastewater samples along the Yangtze River,the largest river and most important source water in China.For convenience of comparison,6 short alkyl chain(SAC)parabens were also included.In 15 industrial wastewater treatment plant effluents(effluent-IWTPs)and 34 surface water monitoring sections along the river,19 out of 20 target compounds were detected with total concentrations(TCs)from 152.5 to 1955.5 ng/L and 141.3 to 1364.9 ng/L in effluent-IWTPs and surface water,respectively.HMW SPAs 1,3,5-tris-[(3,5-di–tert–butyl–4-hydroxyphenyl)methyl]-1,3,5-triazinane-2,4,6-trione(AO3114)and octadecyl 3-(3,5-di–tert–butyl–4-hydroxyphenyl)propionate(AO1076)were the dominant ones.HMWSPAs bis(3–tert–butyl–4–hydroxy-5-methylphenyl)propionate(AO245)and 4,4'-sulfanediylbis(2–tert–butyl–5-methylphenol)(AO-TBM6)and SAC parabens propylparaben(PrP)and butylparaben(BuP)posed medium to high potential ecological risks in 27 surface water monitoring sections.Additionally,AO-TBM6 also exhibited potential health risks in 2 out of 11 drinking water sources.Though the ecotoxicity data are very limited,the ubiquitous presence of the LAC parabens including hexylparaben(HeP)and octylparaben(OcP)in surface water should be of concern since these compounds usually exhibit stronger estrogen potencies than the SAC ones.Finally,kernel density analysis revealed that regulation of industrial discharges is necessary to mitigate the HMW SPA and paraben contamination.
基金supported by the National Natural Science Foundation of China(Nos.52370158 and 22006053)Guangzhou Science and Technology Plan Project(No.2024A04J0821)Guangdong Provincial Education Science Planning Project(Higher Education Special Project)(No.2023GXJK108).
文摘Electroplating sludge(ES),a byproduct of the electroplating industry,is a significant environmental concern due to its high content of soluble heavy metals(HMs).The significance of spinel formation from ES lies in its potential for HMs enrichment and environmental remediation,offering a sustainable solution for hazardous waste management.The article delves into themultifaceted recycling of HMs-rich spinel fromES,encompassing its synthesis,metal enrichment,and thermodynamic stability.The pyro-metallurgical and hydrometallurgical processes for spinel synthesis were discussed,with a focus on the critical role of thermodynamic data in predicting the stability and formation of spinel structures.The crystallographic and magnetic properties of spinels,with their applications in environmental remediation and energy storage are highlighted.The article provides a comprehensive reviewon the recycling of HMs-rich spinel fromES,offering a means to recycle HMs,mitigate ecological harm,and contribute to a circular economy through the recovery and application of valuable materials.The selective leaching of metals from ES also faces challenges,which was limited by the separation,purification steps and high energy consumption.This high energy consumption is a significant operational cost and also contributes to environmental concerns related to carbon emissions.It is essential to address the challenges through continued research and development,improved technologies,and supportive regulatory frameworks.
基金funded by the Science and Technology Project of State Grid Corporation,grant number 5500-202329500A-3-2-ZN,funding data 2023.10–2025.12.
文摘Aiming at the problems of large fluctuation of output active power and poor control performance in the process of frequency support of an energy-storage-type static-var-generator(ESVG),the adaptive adjustment control method for its active-loop parameters is used to realize thewind-farmfrequency support,which has become the current research hotspot.Taking the ESVG with a supercapacitor on the DC side as the research object,the influence trend of the change of virtual rotation inertia and virtual damping coefficient on its virtual angular velocity and power angle is analyzed.Then,the constraint relationship between the equivalent virtual inertia time constant of the supercapacitor and the virtual rotation inertia of the ESVG is clarified.Then,combined with the second-order response characteristics of the ESVG power control loop,the selection principles of the frequency modulation coefficient,the virtual rotation inertia,and the virtual damping coefficient are determined.An ESVG adjustment control method,considering the adaptive adjustment of the active loop parameters of the supercapacitor equivalent inertia,is proposed.While ensuring the frequency support capability of the ESVG,the fluctuation degree of its output active power and the virtual angular velocity are suppressed,and the proposed adjustment method also improves the stability of the ESVG control system and the frequency support capability for the wind farm.Finally,the simulation verifies the correctness of the theoretical analysis and the effectiveness of the proposed strategy.
基金supported by the Fundamental and Applied Fundamental Research Project of Guangzhou City(Grant No.:2023A04J1003)the LingChuang Research Project of China National Nuclear Corporation.
文摘High-entropy alloys exhibit significant potential for application in the nuclear industry owing to their exceptional resistance to irradiation,excellent mechanical properties,and corrosion resistance.In this work,the Mo_(0.5)V_(0.5)NbTiZr_(x)(x=0-2.0)high-entropy alloys containing alloying elements with low thermal neutron absorption cross section were designed and prepared.The crystal structure,microstructure,mechanical properties and corrosion resistance of the studied alloys were investigated.All the alloys possess a body-centered cubic crystal structure,which is consistent with the CALPHAD(acronym of CALculation of PHAse Diagram)modeling results.The addition of Zr does not alter the crystal structure of the Mo_(0.5)V_(0.5)NbTiZr_(x) alloys;however,it leads to an increase in the lattice constant as Zr content increases.The addition of Zr initially enhances the yield strength,but subsequently leads to a decline as the Zr content increases further.Specifically,the corrosion resistance of the Mo_(0.5)V_(0.5)NbTiZr_(x) alloys in superheated steam at 400℃ and 10.3 MPa decreases with the increase of Zr content.The effect of Zr content on the phase formation,mechanical properties and corrosion resistance of the Mo_(0.5)V_(0.5)NbTiZr_(x) high-entropy alloys are discussed.This study has successfully developed a novel Mo_(0.5)V_(0.5)NbTiZr_(0.25) high-entropy alloy,which demonstrates exceptional properties including high yield strength,excellent ductility,and superior anti-corrosion performance.The findings of this research have significant implications for the design of high-entropy alloys in nuclear applications.
基金This work was financially supported by the National Natu-ral Science Foundation of China(No.52074257)the Chinese Academy of Sciences(No.ZDBS-LY-JSC023).
文摘Compared with cold rolling,warm rolling can significantly reduce or completely eliminate microstruc-ture damage to regulate the microstructure of the material,which is an effective method to improve the mechanical properties of the material.However,the effect of warm rolling on refractory complex concen-trated alloys(RCCAs)has rarely been reported.This research examines how warm rolling influences the microstructure,texture,and mechanical properties of the Zr_(45)Ti_(15)Nb_(30)Ta_(10)RCCA.The RCCA was warm-rolled to a 75%reduction in thickness at 650℃(two-phase zone)and then annealed at 1000°C for 1 h.To highlight the advantages of warm rolling,a comparison was conducted with similarly deformed and annealed cold-rolled RCCA.The warm-rolled RCCA exhibits a layered heterogeneous structure and induces the precipitation of the(Nb,Ta)-enriched bcc2 phase.The deformation texture of warm-rolled RCCA is weaker than that of cold-rolled RCCA,which is attributed to localized deformation inhomogene-ity.After annealing,warm rolling resulted in a remarkable increase in the yield strength of the RCCA,i.e.,from 861 MPa to 1071 MPa;meanwhile,moreover,the tensile plasticity was almost identical.Warm rolling leads to a change in plastic deformation of the RCCA from dislocation cross-slip to one dominated by the interaction of dislocations with subgrain boundaries as well as the bcc2 phase.The back tress gen-erated by the heterogeneous structure induced by warm rolling is also effective in increasing the yield strength of the RCCA.The remarkably layered heterogeneous structure,subgrain boundaries and textures result in warm-rolled RCCA with optimal strength-ductility combination.Our results provide an effective processing approach for tailoring the microstructure and mechanical properties of RCCAs.
基金Supported by the China’s National Polar Special Program“Impact and Response of Antarctic Seas to Climate Change”(Nos.IRASCC 01-01-02,IRASCC 02-02)the Scientific Research Fund of the Second Institute of Oceanography(Nos.JG 2011,JG 2211,JG 2013,JG 1805)+1 种基金the National Natural Science Foundation of China(Nos.42276255,41976228,41976227)the International Cooperation Key Project of Ministry of Science and Technology(No.2022 YFE 0136500)。
文摘The ecosystems in Southern Ocean(SO)are undergoing significant changes in the context of climate change.To identify environment-phytoplankton feedbacks in SO,seawater samples were collected in the Cosmonaut Sea(CS)during the 37 th China Antarctic Research Expedition(Jan.2021)(CHINARE-37)and subjected to analysis of particulate organic carbon(POC)and phytoplankton pigments.The remote sensing data,CHEMTAX community compositional modeling analysis,and physicochemical measurements were combined to explore the spatial variation of phytoplankton crops,taxonomic composition,and their environmental drivers.Historical phytoplankton community data from the area were also compared against those of this study to investigate inter-annual community differences and their potential causes.The column-integrated POC and chlorophyll-a(Chl-a)concentrations were 12.0±4.9 g/m^(2) and 73.8±50.5 mg/m^(2),respectively.The two most dominant taxa were haptophyte that are adapted to high Fe availability(Hapt-HiFe,mainly Phaeocystis antarctica)and Diatoms-A(Phaeodactylum tricornutum)that contributed to 33%±25%and 24%±14%to the total phytoplankton crops,respectively.Through cluster analysis,the study area was divided into two regions dominated by Hapt-HiFe and Diatoms-A,respectively.Spatially,Hapt-HiFe was mainly concentrated in the southwest coastal area that featured low temperatures,low salinity,and shallow euphotic zones.The coastal region southwest of the southern boundary of the Antarctic circumpolar current was experiencing a bloom of Hapt-HiFe during the study period that significantly contributed to the POC pool and Chl-a concentrations(R=0.46,P<0.01;R=0.42,P<0.01).Besides,the dominance of Hapt-HiFe in the CS suggests a high biological availability of dissolved Fe that is primarily associated with inputs from sea ice melt and upwellings.
基金supported by grants from the Jiangsu Agricultural Science and Technology Innovation Fund,China(JASTIF)(CX(21)3012)to Haifeng Zhang。
文摘Rice false smut,caused by Ustilaginoidea virens,is a devastating disease that greatly reduces rice yield and quality.However,controlling rice false smut disease is challenging due to the unique infection mode of U.virens.Therefore,there is a need for early diagnosis and monitoring techniques to prevent the spread of this disease.Lateral flow strip-based recombinase polymerase amplification(LF-RPA)overcomes the limitations of current U.virens detection technologies,which are time-consuming,require delicate equipment,and have a high false-positive rate.In this study,we used a comparative genomics approach to identify Uv_3611,a specific gene of U.virens,as the target for the LF-RPA assay.The designed primers and probe efffectively detected the genomic DNA(gDNA)of U.virens and demonstrated no cross-reactivity with related pathogens.Under optimal conditions,the LF-RPA assay demonstrated a sensitivity of 10 pg of U.virens gDNA.Additionally,by incorporating a simplified PEG-NaOH method for plant DNA extraction,the LF-RPA assay enabled the detection of U.virens in rice spikelets within 30 min,without the need for specialized equipment.Furthermore,the LF-RPA assay successfully detected U.virens in naturally infected rice and seed samples in the field.Therefore,the LF-RPA assay is sensitive,efficient,and convenient,and could be developed as a kit for monitoring rice false smut disease in the field.
基金supported by the National Natural Science Foundation of China(Grant Nos.52171153 and 51871039)supported by the Department of Energy(DOE)Office of Science(DE-AC02-06CH11357)+1 种基金financial support from the Shanghai Science and Technology Committee,China(Grant No.22JC1410300)the Shanghai Key Laboratory of Material Frontiers Research in Extreme Environments(MFree),China(Grant No.22dz2260800).
文摘In this work,a series of Co-based ternary Co-Er-B bulk metallic glasses(BMGs)with excellent soft magnetic properties and high strength were developed,and the local atomic structure of a typical Co_(71.5)Er_(3.5)B_(25) metallic glass was studied through in situ high-energy synchrotron X-ray diffraction and ab initio molecular dynamics simulations.The results reveal that the BMG samples can be obtained in a composition region of Co_(68.5-71.5)Er_(3.5-4)B_(25-27.5) by a conventional copper-mold casting method.The Co-Er-B metallic glasses possess stronger atomic bond strengths and denser local atomic packing structure composed of a higher fraction of icosahedral-like clusters but fewer deformed body-centered cubic and crystal-like polyhedrons,and they exhibit slower atomic diffusion behaviors during solidification,as compared to Co-Y-B counterparts.The enhancement in structural stability and the retardation of atomic-ordered diffusion lead to the better glass-forming ability of the Co-Er-B alloys.The smaller magnetic anisotropy energy in the Co-Er-B metallic glasses results in a lower coercivity of less than 1.3 A/m.The Co-Er-B BMGs exhibit high-yield strength of 3560-3969 MPa along with distinct plasticity of around 0.50%.
文摘Erratum to:J Zhejiang Univ-Sci B(Biomed&Biotechnol)202122(9):718-732 https:/doi.org/10.1631/jzus.B2000544.The original version of this article(Liu et al.,2021)unfortunately contained a mistake:statement of equal contribution is missing.This correction article shows that Chiyu LIU and Sixu CHEN contributed equally to this work.The original article has been corrected.
基金Supported by National Natural Science Foundation of China(Grant No.51525504)。
文摘Cable-driven parallel robots(CDPRs)use cables instead of the rigid limbs of traditional parallel robots,thus processing a large potential workspace,easy to assemble and disassemble characteristics,and with applications in numerous fields.However,owing to the influence of cable flexibility and nonlinear friction,model uncertainties are di cult to eliminate from the control design.Hence,in this study,the model uncertainties of CDPRs are first analyzed based on a brief introduction to related research.Control strategies for CDPRs with model uncertainties are then reviewed.The advantages and disadvantages of several control strategies for CDPRS are discussed through traditional control strategies with kinematic and dynamic uncertainties.Compared with these traditional control strategies,deep reinforcement learning and model predictive control have received widespread attention in recent years owing to their model independence and recursive feasibility with constraint limits.A comprehensive review and brief analysis of current advances in these two control strategies for CDPRs with model uncertainties are presented,concluding with discussions regarding development directions.
基金supported by grants from the Guangzhou Basic and Applied Basic Research Foundation(202201010940)National Natural Science Foundation of China(82200306)Guangdong Basic and Applied Basic Research Foundation(2021A1515111092).
文摘Background:Aortic dissection(AD)is a fatal cardiovascular disease for which the key involved genes are largely unknown.Here,we aimed to identify promising AD biomarkers from high-throughput RNA expressing data.Methods:In the GSE98770 dataset,differentially expressed mRNAs(DE-mRNAs)and microRNAs(DE-microRNAs)were identified through differentially expressed gene analysis and gene set enrichment analysis.The regulatory network between DE-mRNAs and DE-microRNAs was established,and hub genes were identified with Cytoscape.Relationships between hub genes and AD were confirmed in the Comparative Toxicogenomics Database(CTD).Potential key transcription factors were discovered with Cytoscape.Hub gene verification was performed by qPCR and immunofluorescence analyses of human specimens.Results:DE-mRNAs and DE-microRNAs were identified.Four mRNAs and microRNA-1321(miR-1321)were found to have the most connections with other genes.CBL was connected to the most genes and interacted with miR-1321,which was also connected to the most genes among the DE-microRNAs.In addition,CBL was associated with AD in the CTD.Among the top five transcription factors potentially regulating CBL transcription,only HOXB13 was a DE-mRNA.The findings were further successfully verified in human specimens.Conclusion:CBL,which may be transcriptionally regulated by HOXB13 and post-transcriptionally regulated by miR-1321,was identified as the most promising potential biomarker for AD.
