BACKGROUND Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor.Apatinib has demonstrated encouraging antitumor activities.This study aimed to observe the efficacy and safety of apatinib for the treatm...BACKGROUND Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor.Apatinib has demonstrated encouraging antitumor activities.This study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain micrometastases.CASE SUMMARY We report two patients with multiple brain micrometastases after failure of second-line treatment.Both patients had extracerebral metastases.When the patients took 250 mg/d apatinib orally,the intracerebral lesions disappeared.The extracerebral lesions were partially alleviated.Both patients had a progressionfree survival of more than 12 mo and were still stable.The safety was good.The main adverse events(AEs)were mild hypertension and proteinuria,which could be controlled.CONCLUSION Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment.展开更多
The emission angle distribution of projectile fragments(PFs)and the temperature of PF emission sources for fragmentation of 56Fe on polyethylene,carbon,and aluminum targets at the highest energy of 497 A MeV are inves...The emission angle distribution of projectile fragments(PFs)and the temperature of PF emission sources for fragmentation of 56Fe on polyethylene,carbon,and aluminum targets at the highest energy of 497 A MeV are investigated on the basis of corrected data,using a CR-39 plastic nuclear track detector.It is found that the average emission angle of PFs increases with the decrease in PF charge for the same target,and no obvious dependence of angular distribution on the mass of the target nucleus is found for the same PF.The cumulative squared transverse momentum distribution of PFs can be well represented by a single Rayleigh distribution.The temperature of PF emission sources is extracted from the distribution,and it is about 1.0-8.0 MeV and does not depend on the mass of the target for PFs with charges of 9≤Z≤25.展开更多
The nuclear potential is a cornerstone in the study of nuclear structures and reactions. Research on the real part of nuclear potential has been well described using various models;however, that on the imaginary part ...The nuclear potential is a cornerstone in the study of nuclear structures and reactions. Research on the real part of nuclear potential has been well described using various models;however, that on the imaginary part of nuclear potential remains insufficient. This study proposes a novel method to extract the imaginary nuclear potential from the high-precision excitation function of backward quasi-elastic scattering. The typical systems^(16)O+^(152,154)Sm,^(184,186)W with deformed target nuclei were analyzed. Nuclear imaginary potentials were obtained successfully by fitting the excitation functions within the single-channel and coupled-channel frameworks, respectively. A good reproduction at the energy range between sub-and above-barrier energy regions was achieved. Results show long-range imaginary-part potential at a wide energy region covering the Coulomb barrier, consistent with the strong absorption for well-deformed systems. This work is a preliminary attempt to bridge the gap between fusion and scattering and extract the deformation parameters in the whole energy range. The subsequent systematic analysis needs to be further improved.展开更多
The reduced strong absorption distance d_(S) and Coulomb barrier height V_(B) are extracted from the quarter-point recipe from a series of experimental elastic scattering angle distributions.The nuclei with different ...The reduced strong absorption distance d_(S) and Coulomb barrier height V_(B) are extracted from the quarter-point recipe from a series of experimental elastic scattering angle distributions.The nuclei with different binding energies are systematically studied as the projectile,including the tightly bound,weakly bound,and halo nuclei.It is found that the mean d_(S) for halo nuclei is significantly larger than that of tightly and weakly bound nuclei.The complex behavior of d_(S) regarding the binding energy and properties of the target is observed for halo nuclei.The linear relationship of the reduced distance with system size may be used to estimate the Coulomb barrier radius R_(B),which is difficult to obtain from fusion reactions.The rule of V_(B) concerning the Coulomb parameter z is in agreement with other theoretical barrier laws extracted from the fusion reaction.Furthermore,the reason why the binding energy or deformation has little effect on the linear relationship of V_(B) as a function of z is clarified.展开更多
基金National Natural Science Foundation of China,No.81872032.
文摘BACKGROUND Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor.Apatinib has demonstrated encouraging antitumor activities.This study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain micrometastases.CASE SUMMARY We report two patients with multiple brain micrometastases after failure of second-line treatment.Both patients had extracerebral metastases.When the patients took 250 mg/d apatinib orally,the intracerebral lesions disappeared.The extracerebral lesions were partially alleviated.Both patients had a progressionfree survival of more than 12 mo and were still stable.The safety was good.The main adverse events(AEs)were mild hypertension and proteinuria,which could be controlled.CONCLUSION Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment.
基金supported by the National Natural Science Foundation of China(Nos.11075100 and 11565001)the Natural Foundation of Shanxi Province(No.2011011001-2)the Shanxi Provincial Foundation for Returned Overseas Chinese Scholars,China(No.2011-058)
文摘The emission angle distribution of projectile fragments(PFs)and the temperature of PF emission sources for fragmentation of 56Fe on polyethylene,carbon,and aluminum targets at the highest energy of 497 A MeV are investigated on the basis of corrected data,using a CR-39 plastic nuclear track detector.It is found that the average emission angle of PFs increases with the decrease in PF charge for the same target,and no obvious dependence of angular distribution on the mass of the target nucleus is found for the same PF.The cumulative squared transverse momentum distribution of PFs can be well represented by a single Rayleigh distribution.The temperature of PF emission sources is extracted from the distribution,and it is about 1.0-8.0 MeV and does not depend on the mass of the target for PFs with charges of 9≤Z≤25.
基金Supported by the National Key R&D Program of China (2022YFA1602302, 2023YFA1606402, 2024YFE0109804)the National Natural Science Foundation of China (U2167204, 12175313, 12175314, 12235020, 12275360, 12375130)the Continuous-Support Basic Scientific Research Project。
文摘The nuclear potential is a cornerstone in the study of nuclear structures and reactions. Research on the real part of nuclear potential has been well described using various models;however, that on the imaginary part of nuclear potential remains insufficient. This study proposes a novel method to extract the imaginary nuclear potential from the high-precision excitation function of backward quasi-elastic scattering. The typical systems^(16)O+^(152,154)Sm,^(184,186)W with deformed target nuclei were analyzed. Nuclear imaginary potentials were obtained successfully by fitting the excitation functions within the single-channel and coupled-channel frameworks, respectively. A good reproduction at the energy range between sub-and above-barrier energy regions was achieved. Results show long-range imaginary-part potential at a wide energy region covering the Coulomb barrier, consistent with the strong absorption for well-deformed systems. This work is a preliminary attempt to bridge the gap between fusion and scattering and extract the deformation parameters in the whole energy range. The subsequent systematic analysis needs to be further improved.
基金This study is supported by the National Key R&D Program of China(2022YFA1602302)the National Natural Science Foundation of China(12235020,12275360,12175314,12175313,U2167204)+3 种基金the Continuous Basic Scientific Research Project(WDJC-2019-13)the Leading Innovation Project(LC192209000701,LC202309000201)the project supported by the Director's Foundation of Department of Nuclear Physics,China Institute of Atomic Energy(12SZJJ-202305)the Young Talent Development Foundation(YC212212000101)。
文摘The reduced strong absorption distance d_(S) and Coulomb barrier height V_(B) are extracted from the quarter-point recipe from a series of experimental elastic scattering angle distributions.The nuclei with different binding energies are systematically studied as the projectile,including the tightly bound,weakly bound,and halo nuclei.It is found that the mean d_(S) for halo nuclei is significantly larger than that of tightly and weakly bound nuclei.The complex behavior of d_(S) regarding the binding energy and properties of the target is observed for halo nuclei.The linear relationship of the reduced distance with system size may be used to estimate the Coulomb barrier radius R_(B),which is difficult to obtain from fusion reactions.The rule of V_(B) concerning the Coulomb parameter z is in agreement with other theoretical barrier laws extracted from the fusion reaction.Furthermore,the reason why the binding energy or deformation has little effect on the linear relationship of V_(B) as a function of z is clarified.
