AIM： To study the effect of combined indwelling catheter, hemofiltration, respiration support and traditional Chinese medicine （e.g. Dahuang） in treating abdominal compartment syndrome of fulminant acute pancreatit...AIM： To study the effect of combined indwelling catheter, hemofiltration, respiration support and traditional Chinese medicine （e.g. Dahuang） in treating abdominal compartment syndrome of fulminant acute pancreatitis. METHODS： Patients with fulminant acute pancreatitis were divided randomly into 2 groups of combined indwelling catheter celiac drainage and intra-abdominal pressure monitoring and routine conservative measures group （group 1） and control group （group 2）. Routine non-operative conservative treatments including hemofiltration, respiration support, gastrointestinal TCM ablution were also applied in control group patients. Effectiveness of the two groups was observed, and APACHE Ⅱ scores were applied for analysis. RESULTS： On the second and fifth days after treatment, APACHE Ⅱ scores of group 1 and 2 patients were significantly different. Comparison of effectiveness （abdominalgia and burbulence relief time, hospitalization time） between groups 1 and 2 showed significant difference, as well as incidence rates of cysts formation. Mortality rates of groups 1 and 2 were 10.0% and 20.7%, respectively. For patients in group 1, celiac drainage quantity and intra-abdominal pressure, and hospitalization time were positively correlated （r = 0.552, 0.748, 0.923, P 〈 0.01） with APACHE Ⅱ scores. CONCLUSION： Combined indwelling catheter celiac drainage and intra-abdominal pressure monitoring, short veno-venous hemofiltration （SVVH）, gastrointestinal TCM ablution, respiration support have preventive and treatment effects on abdominal compartment syndrome of fulminant acute pancreatitis.展开更多
Objective:To investigate the inoculation status of Novel Coronavirus vaccine among college students in Hainan province and its related influencing factors,and to provide scientific basis for improving the inoculation ...Objective:To investigate the inoculation status of Novel Coronavirus vaccine among college students in Hainan province and its related influencing factors,and to provide scientific basis for improving the inoculation rate of this population.Methods:An electronic questionnaire survey was conducted among 7 colleges and universities in Hainan Province from April 16 to 19,2021.A total of 5896 valid questionnaires were collected with informed consent and voluntary filling.The questionnaire collected information including general demographic characteristics,knowledge attitude and behavioral problems related to COVID-19 vaccine.The difference in the vaccination rate of college students with different characteristics was compared.Multivariate Logistic regression analysis was used to screen the related factors affecting the vaccination rate of college students in Hainan.Results:There were 3,360(57%)female students,2,509(42.6%)medical students,2,380(40.4%)Hainan students,3,441(58.4%)undergraduates,3,281(57.3%)rural students,and 5,165(87.6%)Han students.The inoculation rate of COVID-19 vaccine among college students in Hainan province was 81.7%.The average score of knowledge about COVID-19 vaccine was 11.78±3.18,the total score was 17,and the relative attitude score was 47.77±6.10,the total score was 55.Univariate analysis found that difference gender,age,grade,stage of study,medical students,Hainanese origin,school organization vaccination,vaccine knowledge and attitude scores,the difference of inoculation rate was statistically significant(P<0.05).Multivariate analysis showed that women(OR=1.204),medical profession(OR=4.587),native place of Hainan(OR=1.541),rural area of origin(OR=1.311),school carrying out collective vaccine vaccination(OR=2.933),high scores of knowledge about COVID vaccine(OR=1.104)and attitude(OR=1.025)could increase the vaccination rate of college students(P<0.05).Conclusion:The vaccination rate of college students in Hainan Province still needs to be improved.It is necessary to strengthen the popularization of vaccine-related knowledge among male students and non-medical students,improve the mastery of the knowledge of the vaccine and enhance the confidence of the vaccine in China,which is conducive to the improvement of the vaccination rate of college students.展开更多
Objective:To understand the epidemic characters of COVID-19 epidemic in Hainan province of tropical China and provid evidences for the prevention and control of the epidemic.Methods:Data on the COVID-19 epidemic colle...Objective:To understand the epidemic characters of COVID-19 epidemic in Hainan province of tropical China and provid evidences for the prevention and control of the epidemic.Methods:Data on the COVID-19 epidemic collected from Health Commission of Hainan Province were analyzed by using the methods of retrospective descriptive epidemiology.Results:From January 22nd to February 21st,2020,COVID-19 was diagnosed in 168 confirmed cases(including 8 severe cases)in Hainan Province with the temporary fatality rate of 2.38%of 4 deaths,and 96 cases discharged from hospital,with the cure rate of 57.14%.The cases were distributed in altogether 15 cities and counties in Hainan Province,among which 121 cases were distributed in Sanya,Haikou,Danzhou and Wanning,accounting for 72.02%of the total number of cases.Cases in Sanya City were mainly found in Tianya district and Jiyang district,accounting for 69.81%of the total number of cases in Sanya.Cases in Haikou City were mainly found in Qiongshan district and Xiuying district,accounting for 72.5%of the total number of cases in Haikou.Among the patients,there were 81 males and 87 females,with a male-to-female ratio of 1.1;the youngest age was 3 months,the oldest was 79 years old,80%of the patients were in the age group of 30 to 69 years old,and the number of children and adolescents under 20 years old were relatively low.Conclusion:The daily number of new confirmed cases showed a gradual downward trend in Hainan province,and the epidemic situation was in transition from imported to local renewal,mainly in close contact between family members.With the increase of personnel mobility such as the resumption of work by enterprises and the return of migrant workers to the island,there is a risk of agglomeration epidemic.Prevention and control work in urban and rural areas should take a two-pronged approach.Amid preventing imported cases,more proactive measures should be taken to prevent and control the spread of local cases.展开更多
Objective:Pancreatic cancer is one of the highly malignant tumors of the digestive tract. The pathogenesis is still unclear. The clinical manifestations are mainly upper abdominal pain, jaundice, weight loss and fatig...Objective:Pancreatic cancer is one of the highly malignant tumors of the digestive tract. The pathogenesis is still unclear. The clinical manifestations are mainly upper abdominal pain, jaundice, weight loss and fatigue, and even mental and neurological disorders. However, these symptoms did not manifest in the early stage,leading to early detection, early diagnosis, early treatment, and poor prognosis. Therefore, research on clinical indicators of pancreatic cancer has become a hot topic, such as Tumor marker, albumin/globulin ratio and neutrophil/ lymphocyte ratio, collagen type VI α1 chain, constitutive photomorpho-genesis 9 signaloSome,Soluble UL16-binding protein 2 etc.These indic- ators are one of the commonly used diagnostic methods after pathology and imaging diagnosis.This article reviews and analyzes the indicators related to pancreatic cancer in recent years and reports the following.展开更多
We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein （rLrp） inhibits lipopolysaccharide （LPS）-induced tumor necrosis factor alpha （TNF-a）, interleukin-6, and interleuk...We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein （rLrp） inhibits lipopolysaccharide （LPS）-induced tumor necrosis factor alpha （TNF-a）, interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription factor NF-KB （Nuclear factor-kappa B）. Moreover, rLrp attenuated LPS-induced DNA binding and NF-κB transcriptional activity, which was accompanied by the degradation of inhibitory IκBα and a consequent decrease in the nuclear translocation of the NF-κB p65 subunit. RLrp interfered with the LPS-induced clustering of TNF receptor-associated factor 6 and with interleukin-1 receptor-associated kinase 1 binding to TAKI. Furthermore, rLrp did not attenuate proinflammatory cytokines or the expression of CD86 and major histocompatibility complex class-II induced by interferon-gamma in the macrophages of Toll-like receptor 2 deletion （TLR2-/-） mice and in protein kinase b （Akt）-depleted mouse cells, indicating that the inhibitory effects of rLrp were dependent on TLR2-mediated activation of the phosphatidylinositol 3-OH kinase （PI3K）/ Akt pathway. RLrp could also activate the PI3K/Akt pathway by stimulating the rapid phosphorylation of PI3K, Akt, and glycogen synthase kinase 3 beta in macrophages. In addition, 19 amino acid residues in the N-terminus of rLrp were determined to be important and required for the inhibitory effects mediated by TLR2. The inhibitory function of these 19 amino acids of rLrp raises the possibility that mimetic inhibitory peptides could be used to restrict innate immune responses in situations in which prolonged TLR signaling has deleterious effects. Our study offers new insight into the inhibitory mechanisms by which the TLR2-mediated PI3K/Akt pathway ensures the transient expression of potent inflammatory mediators.展开更多
文摘AIM： To study the effect of combined indwelling catheter, hemofiltration, respiration support and traditional Chinese medicine （e.g. Dahuang） in treating abdominal compartment syndrome of fulminant acute pancreatitis. METHODS： Patients with fulminant acute pancreatitis were divided randomly into 2 groups of combined indwelling catheter celiac drainage and intra-abdominal pressure monitoring and routine conservative measures group （group 1） and control group （group 2）. Routine non-operative conservative treatments including hemofiltration, respiration support, gastrointestinal TCM ablution were also applied in control group patients. Effectiveness of the two groups was observed, and APACHE Ⅱ scores were applied for analysis. RESULTS： On the second and fifth days after treatment, APACHE Ⅱ scores of group 1 and 2 patients were significantly different. Comparison of effectiveness （abdominalgia and burbulence relief time, hospitalization time） between groups 1 and 2 showed significant difference, as well as incidence rates of cysts formation. Mortality rates of groups 1 and 2 were 10.0% and 20.7%, respectively. For patients in group 1, celiac drainage quantity and intra-abdominal pressure, and hospitalization time were positively correlated （r = 0.552, 0.748, 0.923, P 〈 0.01） with APACHE Ⅱ scores. CONCLUSION： Combined indwelling catheter celiac drainage and intra-abdominal pressure monitoring, short veno-venous hemofiltration （SVVH）, gastrointestinal TCM ablution, respiration support have preventive and treatment effects on abdominal compartment syndrome of fulminant acute pancreatitis.
基金Hainan Province Key Research and Development Project(No.zdyf2020109)。
文摘Objective:To investigate the inoculation status of Novel Coronavirus vaccine among college students in Hainan province and its related influencing factors,and to provide scientific basis for improving the inoculation rate of this population.Methods:An electronic questionnaire survey was conducted among 7 colleges and universities in Hainan Province from April 16 to 19,2021.A total of 5896 valid questionnaires were collected with informed consent and voluntary filling.The questionnaire collected information including general demographic characteristics,knowledge attitude and behavioral problems related to COVID-19 vaccine.The difference in the vaccination rate of college students with different characteristics was compared.Multivariate Logistic regression analysis was used to screen the related factors affecting the vaccination rate of college students in Hainan.Results:There were 3,360(57%)female students,2,509(42.6%)medical students,2,380(40.4%)Hainan students,3,441(58.4%)undergraduates,3,281(57.3%)rural students,and 5,165(87.6%)Han students.The inoculation rate of COVID-19 vaccine among college students in Hainan province was 81.7%.The average score of knowledge about COVID-19 vaccine was 11.78±3.18,the total score was 17,and the relative attitude score was 47.77±6.10,the total score was 55.Univariate analysis found that difference gender,age,grade,stage of study,medical students,Hainanese origin,school organization vaccination,vaccine knowledge and attitude scores,the difference of inoculation rate was statistically significant(P<0.05).Multivariate analysis showed that women(OR=1.204),medical profession(OR=4.587),native place of Hainan(OR=1.541),rural area of origin(OR=1.311),school carrying out collective vaccine vaccination(OR=2.933),high scores of knowledge about COVID vaccine(OR=1.104)and attitude(OR=1.025)could increase the vaccination rate of college students(P<0.05).Conclusion:The vaccination rate of college students in Hainan Province still needs to be improved.It is necessary to strengthen the popularization of vaccine-related knowledge among male students and non-medical students,improve the mastery of the knowledge of the vaccine and enhance the confidence of the vaccine in China,which is conducive to the improvement of the vaccination rate of college students.
文摘Objective:To understand the epidemic characters of COVID-19 epidemic in Hainan province of tropical China and provid evidences for the prevention and control of the epidemic.Methods:Data on the COVID-19 epidemic collected from Health Commission of Hainan Province were analyzed by using the methods of retrospective descriptive epidemiology.Results:From January 22nd to February 21st,2020,COVID-19 was diagnosed in 168 confirmed cases(including 8 severe cases)in Hainan Province with the temporary fatality rate of 2.38%of 4 deaths,and 96 cases discharged from hospital,with the cure rate of 57.14%.The cases were distributed in altogether 15 cities and counties in Hainan Province,among which 121 cases were distributed in Sanya,Haikou,Danzhou and Wanning,accounting for 72.02%of the total number of cases.Cases in Sanya City were mainly found in Tianya district and Jiyang district,accounting for 69.81%of the total number of cases in Sanya.Cases in Haikou City were mainly found in Qiongshan district and Xiuying district,accounting for 72.5%of the total number of cases in Haikou.Among the patients,there were 81 males and 87 females,with a male-to-female ratio of 1.1;the youngest age was 3 months,the oldest was 79 years old,80%of the patients were in the age group of 30 to 69 years old,and the number of children and adolescents under 20 years old were relatively low.Conclusion:The daily number of new confirmed cases showed a gradual downward trend in Hainan province,and the epidemic situation was in transition from imported to local renewal,mainly in close contact between family members.With the increase of personnel mobility such as the resumption of work by enterprises and the return of migrant workers to the island,there is a risk of agglomeration epidemic.Prevention and control work in urban and rural areas should take a two-pronged approach.Amid preventing imported cases,more proactive measures should be taken to prevent and control the spread of local cases.
基金Hainan Provincial Key Research and Development Project(No.2016116).
文摘Objective:Pancreatic cancer is one of the highly malignant tumors of the digestive tract. The pathogenesis is still unclear. The clinical manifestations are mainly upper abdominal pain, jaundice, weight loss and fatigue, and even mental and neurological disorders. However, these symptoms did not manifest in the early stage,leading to early detection, early diagnosis, early treatment, and poor prognosis. Therefore, research on clinical indicators of pancreatic cancer has become a hot topic, such as Tumor marker, albumin/globulin ratio and neutrophil/ lymphocyte ratio, collagen type VI α1 chain, constitutive photomorpho-genesis 9 signaloSome,Soluble UL16-binding protein 2 etc.These indic- ators are one of the commonly used diagnostic methods after pathology and imaging diagnosis.This article reviews and analyzes the indicators related to pancreatic cancer in recent years and reports the following.
文摘We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein （rLrp） inhibits lipopolysaccharide （LPS）-induced tumor necrosis factor alpha （TNF-a）, interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription factor NF-KB （Nuclear factor-kappa B）. Moreover, rLrp attenuated LPS-induced DNA binding and NF-κB transcriptional activity, which was accompanied by the degradation of inhibitory IκBα and a consequent decrease in the nuclear translocation of the NF-κB p65 subunit. RLrp interfered with the LPS-induced clustering of TNF receptor-associated factor 6 and with interleukin-1 receptor-associated kinase 1 binding to TAKI. Furthermore, rLrp did not attenuate proinflammatory cytokines or the expression of CD86 and major histocompatibility complex class-II induced by interferon-gamma in the macrophages of Toll-like receptor 2 deletion （TLR2-/-） mice and in protein kinase b （Akt）-depleted mouse cells, indicating that the inhibitory effects of rLrp were dependent on TLR2-mediated activation of the phosphatidylinositol 3-OH kinase （PI3K）/ Akt pathway. RLrp could also activate the PI3K/Akt pathway by stimulating the rapid phosphorylation of PI3K, Akt, and glycogen synthase kinase 3 beta in macrophages. In addition, 19 amino acid residues in the N-terminus of rLrp were determined to be important and required for the inhibitory effects mediated by TLR2. The inhibitory function of these 19 amino acids of rLrp raises the possibility that mimetic inhibitory peptides could be used to restrict innate immune responses in situations in which prolonged TLR signaling has deleterious effects. Our study offers new insight into the inhibitory mechanisms by which the TLR2-mediated PI3K/Akt pathway ensures the transient expression of potent inflammatory mediators.
