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肾移植术后慢性活动性抗体介导的排斥反应预后相关危险因素分析
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作者 惠宇 蒋昊 +6 位作者 周政 胡林昆 王亮良 潘浩 魏雪栋 黄玉华 侯建全 《器官移植》 北大核心 2025年第4期565-573,共9页
目的探讨影响肾移植术后慢性活动性抗体介导排斥反应(caAMR)预后的独立危险因素。方法回顾性分析61例进行移植肾穿刺活组织检查(活检)并确诊为caAMR患者的资料,根据是否合并急性T细胞介导的排斥反应(TCMR)分为caAMR组(41例)和caAMR+TCMR... 目的探讨影响肾移植术后慢性活动性抗体介导排斥反应(caAMR)预后的独立危险因素。方法回顾性分析61例进行移植肾穿刺活组织检查(活检)并确诊为caAMR患者的资料,根据是否合并急性T细胞介导的排斥反应(TCMR)分为caAMR组(41例)和caAMR+TCMR组(20例),随访3年。采用受试者工作特征(ROC)曲线评估活检时24 h尿蛋白和估算肾小球滤过率(eGFR)在预测移植物丢失中的价值。应用LASSO-Cox回归模型分析影响caAMR预后的独立危险因素。应用Spearman等级相关矩阵分析比较分组、结局和Banff评分之间的相关性。采用Kaplan-Meier法分析各亚组移植肾存活率。结果caAMR组和caAMR+TCMR组3年移植肾存活率分别为83%和79%,活检时eGFR和24 h尿蛋白预测3年移植肾丢失ROC曲线下面积(AUC)分别为0.83[95%可信区间(CI)0.70~0.97]和0.78(95%CI 0.61~0.96)。LASSO-Cox回归分析及Kaplan-Meier法显示eGFR≤25.23 mL/(min·1.73 m^(2))及主要供者特异性抗体(DSA)为人类白细胞抗原(HLA)Ⅰ类可能是影响移植肾预后的独立危险因素,风险比分别为7.67(95%CI 2.18~27.02)和5.13(95%CI 1.33~19.80)。Banff慢性病变指标肾间质纤维化和肾小管萎缩之间存在强相关性(P<0.05)。结论活检时主要DSA为HLAⅠ类以及eGFR≤25.23mL/(min·1.73m^(2))可能是影响caAMR预后的独立危险因素。 展开更多
关键词 肾移植 慢性排斥反应 抗体介导的排斥反应 T细胞介导的排斥反应 供者特异性抗体 人类白细胞抗原 估算肾小球滤过率 移植肾丢失
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One new species in the subgenus Bactrocera(Diptera:Tephritidae)from Yunnan,China
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作者 Zhen HUANG hui yu +2 位作者 Yonghua BAI Youming HOU Qiongxia GUO 《Entomotaxonomia》 CSCD 2022年第1期56-61,共6页
One new species,Bactrocera(Bactrocera)latizona Huang,Yu&Bai sp.nov.,from Mengla,Yunnan Province,China is described.Illustrations of the new species and a key to common species of the subgenus of Bactrocera from Yu... One new species,Bactrocera(Bactrocera)latizona Huang,Yu&Bai sp.nov.,from Mengla,Yunnan Province,China is described.Illustrations of the new species and a key to common species of the subgenus of Bactrocera from Yunnan are given. 展开更多
关键词 fruit flies taxonomy key
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外周血CD4^(+)T淋巴细胞亚群与肾移植术后肾功能延迟恢复及近期预后的相关性
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作者 杨森林 惠宇 +3 位作者 包芯萍 周斌 魏雪栋 侯建全 《现代泌尿外科杂志》 2025年第6期470-475,537,共7页
目的探讨外周血CD4^(+)T淋巴细胞亚群与肾移植受者肾功能延迟恢复(DGF)及近期预后的相关性,以期帮助优化肾移植术前评估并为DGF免疫机制研究提供参考。方法回顾性分析2022年6月—2023年10月于苏州大学附属第一医院进行肾移植的103例受... 目的探讨外周血CD4^(+)T淋巴细胞亚群与肾移植受者肾功能延迟恢复(DGF)及近期预后的相关性,以期帮助优化肾移植术前评估并为DGF免疫机制研究提供参考。方法回顾性分析2022年6月—2023年10月于苏州大学附属第一医院进行肾移植的103例受者的临床资料。最终纳入61例受者,根据术后肾功能恢复情况分为DGF组(20例)和肾功能正常恢复(IGF)组(41例)。采用流式细胞术检测受者肾移植术后第7天外周血中两组CD4^(+)T淋巴细胞亚群的比例和绝对值,比较两组受者临床资料及外周血淋巴细胞亚群差异;针对存在差异的亚群,进一步分析在DGF组受者中,外周血Tfh及PD-1+Tfh细胞亚群比例和绝对值与术后第7天血肌酐(Scr)水平的相关性;绘制受试者工作特征(ROC)曲线并计算曲线下面积(AUC),评估与术后第7天Scr水平相关性最强的CD4^(+)T淋巴细胞亚群的比例及绝对值对近期肾功能的预测效能。结果DGF组和IGF组的Th1、Th2、Th17和调节性T细胞(Treg)等细胞的比例和绝对值比较差异无统计学意义(P>0.05);DGF组滤泡辅助性T细胞(Tfh)及PD-1+Tfh细胞的比例及绝对值均高于IGF组(P<0.0001)。DGF组较IGF组术后1个月及1年的Scr水平更高(P<0.01)、估算肾小球滤过率(eGFR)更低(P<0.01,P=0.02)。Spearman相关性分析显示:DGF组受者Tfh及PD-1+Tfh细胞亚群比例和绝对值与肾移植术后第7天Scr水平呈正相关(P<0.05)。ROC曲线显示,PD-1+Tfh细胞比例预测受者术后1个月Scr、eGFR的AUC分别为0.73(95%CI:0.61~0.86)、0.75(95%CI:0.62~0.88),预测受者术后1年Scr、eGFR的AUC分别为0.72(95%CI:0.59~0.86)、0.70(95%CI:0.58~0.83)。结论Tfh及PD-1+Tfh细胞比例及绝对值升高与肾移植受者术后DGF有关,PD-1+Tfh细胞比例可能有助于预测受者近期肾功能。 展开更多
关键词 肾移植 肾功能延迟恢复 淋巴细胞 滤泡辅助性T细胞 血肌酐
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板栗上虫瘿和成瘿枝的代谢组与转录组联合分析
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作者 陈婷婷 惠羽 +2 位作者 朱道弘 曾杨 杨筱慧 《生命科学研究》 2025年第1期86-94,共9页
虫瘿是由昆虫取食或产卵刺激引起植物组织细胞异常增殖和分化,从而形成的突起或瘤状结构。栗瘿蜂(Dryocosmus kuriphilus)虫瘿为其幼虫提供食物来源并保护其生长。营养假说认为,虫瘿为致瘿昆虫提供了丰富的营养物质,因此其虫瘿组织中的... 虫瘿是由昆虫取食或产卵刺激引起植物组织细胞异常增殖和分化,从而形成的突起或瘤状结构。栗瘿蜂(Dryocosmus kuriphilus)虫瘿为其幼虫提供食物来源并保护其生长。营养假说认为,虫瘿为致瘿昆虫提供了丰富的营养物质,因此其虫瘿组织中的营养物质含量应高于成瘿部位,而次生代谢产物的含量则相反。前期研究发现,栗瘿蜂虫瘿的糖类等营养物质高于其成瘿部位,而单宁等代谢物质的含量则相反,与营养假说一致。有研究分别利用代谢组和转录组分析发现,虫瘿的可溶性糖等营养物质含量高于成瘿部位,黄酮等次生代谢产物的含量则相反,同时与光合作用相关的基因表达下调。但是,目前尚无转录组和代谢组联合分析瘿蜂虫瘿与其成瘿部位差异的报道。本文首次联合代谢组和转录组,基于通路富集分析,更加全面地比较了板栗(Castanea mollissima)上栗瘿蜂虫瘿与成瘿部位之间的差异代谢物和差异表达基因。结果显示,栗瘿蜂虫瘿的氨基酸和多肽等含量上调,可能与其生长发育有关;而黄酮含量下调,可能是栗瘿蜂为了生存启动的防御机制,这二者均与营养假说相符。此外,通路富集分析显示,与光合作用相关的大部分基因在虫瘿中表达下调,抑制了寄主植物的光合作用。 展开更多
关键词 栗瘿蜂 虫瘿 成瘿枝 代谢组 转录组
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Revealing the intrinsic connection between residual strain distribution and dissolution mode in Mg-Sc-Y-Ag anode for Mg-air battery 被引量:2
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作者 Wei-li Cheng Xu-bang Hao +4 位作者 Jin-hui Wang hui yu Li-fei Wang Ze-qin Cui Cheng Chang 《Journal of Magnesium and Alloys》 2025年第3期1020-1033,共14页
The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconci... The dominated contradiction in optimizing the performance of magnesium-air battery anode lies in the difficulty of achieving a good balance between activation and passivation during discharge process.To further reconcile this contradiction,two Mg-0.1Sc-0.1Y-0.1Ag anodes with different residual strain distribution through extrusion with/without annealing are fabricated.The results indicate that annealing can significantly lessen the“pseudo-anode”regions,thereby changing the dissolution mode of the matrix and achieving an effective dissolution during discharge.Additionally,p-type semiconductor characteristic of discharge productfilm could suppress the self-corrosion reaction without reducing the polarization of anode.The magnesium-air battery utilizing annealed Mg-0.1Sc-0.1Y-0.1Ag as anode achieves a synergistic improvement in specific capacity(1388.89 mA h g^(-1))and energy density(1960.42 mW h g^(-1)).This anode modification method accelerates the advancement of high efficiency and long lifespan magnesium-air batteries,offering renewable and cost-effective energy solutions for electronics and emergency equipment. 展开更多
关键词 Mg-air batteries ANODE Residual strain distribution Dissolution mode Discharge mechanism
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Electrochemical behavior and discharge performance of as-rolled precipitate-free Mg-Sn alloy as anode for Mg-air batteries 被引量:2
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作者 Xu LI Wei-li CHENG +7 位作者 Jian LI Fei-er SHANGGUAN hui yu Li-fei WANG Hang LI Hong-xia WANG Jin-hui WANG Hua HOU 《Transactions of Nonferrous Metals Society of China》 2025年第3期832-848,共17页
A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anod... A novel precipitate-free Mg-0.1Sn anode with a homogeneous equal-axis grain structure was developed and rolled successfully at 573 K.Electrochemical test results indicate that the Mg-0.1Sn alloy exhibits enhanced anode dissolution kinetics.A Mg-air battery prepared using this anode exhibits a cell voltage of 1.626 V at 0.5 mA/cm^(2),reasonable anodic efficiency of 58.17%,and good specific energy of 1730.96 mW·h/g at 10 mA/cm^(2).This performance is attributed to the effective reactive anode surface,the suppressed chunk effect,and weak self-corrosion owing to the homogeneous basal texture. 展开更多
关键词 Mg-air battery Mg-Sn anode grain structure electrochemical behavior discharge performance
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Mechanical properties and corrosion behavior of hetero-structured lean Mg−1Bi−0.5Sn−0.5In alloy 被引量:1
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作者 Hong-wei XU Wen-ting XU +6 位作者 Wei-li CHENG Jian LI Li-fei WANG hui yu Jin-hui WANG Hua HOU Kwang Seon SHIN 《Transactions of Nonferrous Metals Society of China》 2025年第5期1440-1455,共16页
The microstructural characterization,corrosion behavior and tensile properties of the extruded lean Mg−1Bi−0.5Sn−0.5In(wt.%)alloy were investigated through scanning electron microscopy(SEM),electron backscatter diffra... The microstructural characterization,corrosion behavior and tensile properties of the extruded lean Mg−1Bi−0.5Sn−0.5In(wt.%)alloy were investigated through scanning electron microscopy(SEM),electron backscatter diffraction(EBSD),X-ray photoelectron spectroscopy(XPS),electrochemical measurements and tensile tests.The results reveal that a microstructure consisting of dynamically recrystallized and deformed grains is obtained.Notably,the investigated alloy exhibits excellent strength−ductility synergy,with tensile yield strength(TYS),ultimate tensile strength(UTS)and elongation(EL)of 254.8 MPa,315.4 MPa,and 25.3%,respectively.Furthermore,in 3.5 wt.%NaCl solution,with the increase of immersion time,the dominant corrosion mechanism of the studied alloy transforms from pitting corrosion to filiform corrosion.After the immersion for 24 h,a composite oxide film(SnO2−Bi2O3−In2O3)is formed,which delays the corrosion process,and the corrosion rate(PH=1.53 mm/a)is finally stabilized. 展开更多
关键词 Mg alloy EXTRUSION corrosion behavior tensile properties strengthening mechanism
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电力工程施工中的电力电缆敷设研究 被引量:1
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作者 惠裕 于金梅 +1 位作者 卜祥杰 宫资涵 《光源与照明》 2025年第3期191-193,共3页
电力电缆敷设是电力工程施工的重要组成部分,关系着区域供电的稳定性与可靠性。在电力电缆敷设环节,施工单位要分析电缆材质、敷设深度、安全标准等,做好地区调研与勘察工作,掌握区域实际情况,以便制订针对性的施工规划,提升电力电缆敷... 电力电缆敷设是电力工程施工的重要组成部分,关系着区域供电的稳定性与可靠性。在电力电缆敷设环节,施工单位要分析电缆材质、敷设深度、安全标准等,做好地区调研与勘察工作,掌握区域实际情况,以便制订针对性的施工规划,提升电力电缆敷设水平。文章从电力工程施工角度,概述了电力电缆敷设,分析了电力工程施工中的电力电缆敷设设计及施工要求,并探究了电力工程施工中的电力电缆敷设实践,以期提升电力电缆敷设技术应用水平。 展开更多
关键词 电力工程 电力电缆 电缆敷设
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有限时域内考虑延时效应的供应链广告协调
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作者 于浍 陈东彦 徐娜 《中国管理科学》 北大核心 2025年第4期275-284,共10页
广告投放与产生销售效果在时间上存在的偏差现象已引起管理者深入思考,其原因是广告的延时效应。本文在有限时域内探究当产品信誉受延时效应影响时的供应链广告决策与协调问题。首先,将产品信誉建立为品牌广告投入的延迟微分方程,并构... 广告投放与产生销售效果在时间上存在的偏差现象已引起管理者深入思考,其原因是广告的延时效应。本文在有限时域内探究当产品信誉受延时效应影响时的供应链广告决策与协调问题。首先,将产品信誉建立为品牌广告投入的延迟微分方程,并构建有限时域约束下的供应链广告决策模型,进而利用时滞系统有限时域最优控制理论求解得到分散式决策与集中式决策下的供应链最优广告策略、产品信誉以及利润。其次,对均衡结果进行综合比较分析,最终参照集中式决策供应链系统,设计一种需求依赖型混合契约使供应链实现完美协调。研究发现,不同于无限时域情形,有限时域内制造商的最优广告投入高度依赖于时间,且遵循“逐步减少-提前终止”原则;并且,随着广告投入周期的增长、延迟时间的缩短,制造商的最优广告投入水平则越高,这不仅提升了产品信誉度,同时可使供应链获得更多的利润。因此,即使广告发生延时效应,集中式决策也始终是供应链的最佳决策机制。本文的研究结果为供应链企业营销实践提供了重要的理论指导。 展开更多
关键词 有限时域 延时效应 广告策略 契约协调
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纳米8YSZ粉的热处理对等离子喷涂涂层热震性能的影响 被引量:12
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作者 陈涛 惠宇 +3 位作者 胥佳颖 邹兵林 曹学强 赵修建 《中国稀土学报》 CAS CSCD 北大核心 2016年第2期189-198,共10页
8YSZ纳米粉(晶粒度为20 nm)在800~1200℃范围内煅烧12 h(温度间隔100℃),然后用大气等离子喷涂方法制备相应的涂层。对涂层的相成分、结构、结合强度、弹性模量和热震性能进行了详细分析。分析结果表明:当粉末的煅烧温度高于1000℃时,8... 8YSZ纳米粉(晶粒度为20 nm)在800~1200℃范围内煅烧12 h(温度间隔100℃),然后用大气等离子喷涂方法制备相应的涂层。对涂层的相成分、结构、结合强度、弹性模量和热震性能进行了详细分析。分析结果表明:当粉末的煅烧温度高于1000℃时,8YSZ晶粒度明显增大;涂层为双模式结构即熔化区和未熔化区,涂层的密度和熔化程度随温度升高而增加,并导致硬度和弹性模量增大;1200℃煅烧粉末所制备的涂层由于微裂纹或微孔缺陷增加,导致涂层的弹性模量减小。涂层的失效原因主要归因于热膨胀系数不匹配,涂层的热震寿命与其弹性模量呈反比关系。 展开更多
关键词 纳米8YSZ 大气等离子喷涂 热障涂层 弹性模量 热震性能 稀土
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Symmetry Breaking Dynamics in Quantum Many-Body Systems
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作者 hui yu Zi-Xiang Li Shi-Xin Zhang 《Chinese Physics Letters》 2025年第11期150-173,共24页
Entanglement asymmetry(EA) has emerged as a powerful tool for characterizing symmetry breaking in quantum many-body systems. In this Letter, we explore how symmetry is dynamically broken through the lens of EA in two ... Entanglement asymmetry(EA) has emerged as a powerful tool for characterizing symmetry breaking in quantum many-body systems. In this Letter, we explore how symmetry is dynamically broken through the lens of EA in two distinct scenarios: a non-symmetric Hamiltonian quench and a non-symmetric random quantum circuit, with a particular focus on U(1) symmetry. In the former case, symmetry remains broken in the subsystem at late times, whereas in the latter case, the symmetry is initially broken and subsequently restored, consistent with the principles of quantum thermalization. Notably, the growth of EA exhibits unexpected overshooting behavior at early times in both contexts, contrasting with the behavior of charge variance. We also consider dynamics of non-symmetric initial states under the symmetry-breaking evolution. Due to the competition of symmetry-breaking in both the initial state and Hamiltonian, the early-time EA can increase and decrease, while quantum Mpemba effects remain evident despite the weak symmetry-breaking in both settings. 展开更多
关键词 entanglement asymmetry quantum circuit symmetry breaking quantum many body systems non symmetric Hamiltonian quench quantum thermalization non symmetric random quantum circuit entanglement asymmetry ea
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Topological Degeneracy Induced Flat Bands in Two-Dimensional Holed Systems
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作者 yuge Chen hui yu +2 位作者 yun-Peng Huang Zhen-yu Zheng Jiangping Hu 《Chinese Physics Letters》 2025年第9期305-310,共6页
Systems hosting flat bands offer a powerful platform for exploring strong correlation physics.Theoretically,topological degeneracy arising in systems with non-trivial topological orders on periodic manifolds of non-ze... Systems hosting flat bands offer a powerful platform for exploring strong correlation physics.Theoretically,topological degeneracy arising in systems with non-trivial topological orders on periodic manifolds of non-zero genus can generate ideal flat bands.However,experimental realization of such geometrically engineered systems is very difficult.In this work,we demonstrate that flat planes with strategically patterned hole defects can engineer ideal flat bands.We construct two families of models:singular flat band systems where degeneracy is stabilized by non-contractible loop excitations tied to hole defects and perfectly nested van Hove systems where degeneracy arises from line excitations in momentum space.These models circumvent the need for exotic manifolds while retaining the essential features of topological flat bands.By directly linking defect engineering to degeneracy mechanisms,our results establish a scalable framework for experimentally accessible flat band design. 展开更多
关键词 flat bandswe flat bands strategically patterned hole defects flat planes flat bandshoweverexperimental topological degeneracy geometrically engineered systems strong correlation physicstheoreticallytopological degeneracy
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Improved Simulation of Tropical Cyclone Soudelor(2015)Using a Modified Three-Dimensional Turbulence Parameterization
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作者 Gengjiao YE Xu ZHANG +3 位作者 Shanghong WANG hui yu Xuesong ZHU Mengjuan LIU 《Advances in Atmospheric Sciences》 2025年第7期1407-1422,共16页
A modified three-dimensional turbulence parameterization scheme,implemented by replacing the conventional eddydiffusivity formulation with the H-gradient model,has shown good performance in representing the subgrid-sc... A modified three-dimensional turbulence parameterization scheme,implemented by replacing the conventional eddydiffusivity formulation with the H-gradient model,has shown good performance in representing the subgrid-scale(SGS)turbulent fluxes associated with convective clouds in idealized tropical cyclone(TC)simulations.To evaluate the capability of the modified scheme in simulating real TCs,two sets of simulations of TC Soudelor(2015),one with the modified scheme and the other with the original scheme,are conducted.Comparisons with observations and coarse-grained results from large eddy simulation benchmarks demonstrate that the modified scheme improves the forecasting of the intensity and structure,as well as the SGS turbulent fluxes of Soudelor.Using the modified turbulence scheme,a TC with stronger intensity,smaller size,a shallower but stronger inflow layer,and a more intense but less inclined convective updraft is simulated.The rapid intensification process and secondary eyewall features can also be captured better by the modified scheme.By analyzing the mechanism by which turbulent transport impacts the intensity and structure of TCs,it is shown that accurately representing the turbulent transport associated with convective clouds above the planetary boundary layer helps to initiate the TC spin-up process. 展开更多
关键词 tropical cyclone turbulence parameterization numerical simulation tropical cyclone intensity tropical cyclone structure tropical cyclone spin-up process
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Microstructure and mechanical properties of high damping Zn-Al eutectoid alloy reinforced by in-situ formed Al_(2)O_(3)and Al_(3)Zr particles
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作者 Jian-jun ZHANG Dong-mei LU +4 位作者 Fu-xing YIN hui yu Pu-guang JI yu-fang LI Qing-zhou WANG 《Transactions of Nonferrous Metals Society of China》 2025年第6期1956-1974,共19页
Zn-Al eutectoid alloy(ZA22)has ultra-high damping property,but its mechanical properties are still relatively low.In order to simultaneously improve the tensile strength and plasticity,a novel Al matrix composite inoc... Zn-Al eutectoid alloy(ZA22)has ultra-high damping property,but its mechanical properties are still relatively low.In order to simultaneously improve the tensile strength and plasticity,a novel Al matrix composite inoculant containing in-situ formed Al_(2)O_(3) and Al3Zr particles was designed and used to reinforce the ZA22 alloy.The microstructure of the ZA22 alloy was significantly refined.Fine Al_(2)O_(3) particles were uniformly distributed in theαphase and the lamellar eutectoid structure,whereas Al3Zr particles were distributed in theαphase and at theα/ηinterface.Property tests showed that the tensile mechanical properties of the reinforced ZA22 alloys were significantly improved.The maximum tensile strength and elongation reached 355 MPa and 7.62%,which were 1.50 and 1.89 times those of the original ZA22 alloy,respectively.The increase in mechanical properties is attributed to the multiple strengthening and toughening factors constructed in the refined microstructure. 展开更多
关键词 ZA22 alloy Al_(2)O_(3) AL3ZR microstructure refinement tensile strength elongation
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Combined mesenchymal and neural stem cell therapy enhances neurological recovery in cerebral infarction
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作者 Ting Yang hui yu +1 位作者 Dong Han Zheng Xie 《World Journal of Stem Cells》 2025年第9期108-116,共9页
BACKGROUND Acute cerebral infarction(ACI),a leading cause of death and disability,causes brain ischemia due to vessel blockage.Current time-limited interventions,such as clot removal,often fail to restore full functio... BACKGROUND Acute cerebral infarction(ACI),a leading cause of death and disability,causes brain ischemia due to vessel blockage.Current time-limited interventions,such as clot removal,often fail to restore full function.Neurorestoration is vital,but complicated.Vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)promote angiogenesis and neuroprotection.Stem cell therapy has potential to promote neurorestoration.Specifically,neural stem cells(NSC)reconstruct neural tissue,while mesenchymal stem cells(MSCs)provide support and secrete beneficial factors.Combining NSCs and MSCs in stem cell therapy may synergistically enhance ACI recovery,potentially via the regulation of VEGF and bFGF.However,the mechanisms underlying this combined approach remain unclear.AIM To investigate the therapeutic effect of combined NSC and MSC transplantation on neurological recovery and bFGF/VEGF expression in ACI patients.METHODS This study enrolled 156 patients with ACI treated from June 2022 to June 2023.Patients were randomly assigned to two groups:The control group(n=78)received conventional drug therapy,while the observation group(n=78)received conventional therapy and combined NSC and MSC transplantation.The following outcomes were compared between groups:National Institutes of Health Stroke Scale(NIHSS)score,Barthel index,cerebral perfusion and diffusion on magnetic resonance imaging,serum bFGF and VEGF levels,clinical efficacy,and adverse events.RESULTS Serum VEGF and bFGF levels negatively correlated with NIHSS scores in patients with ACI(r=-0.388,r=-0.239;P<0.05).The observation group(NSC and MSC)showed a significantly higher clinical efficacy of treatment than the controls(85.9%vs 69.2%;P<0.05).Both groups showed improved cerebral perfusion,increased Barthel index,and decreased NIHSS scores post-treatment(P<0.05),with significantly greater improvements in the observation group.Serum VEGF and bFGF levels increased significantly in both groups(P<0.05),but were higher in the observation group.Adverse events in the observation group(transient fever:4 cases;agitation:1 case;headache:2 cases)were mild and resolved with symptomatic treatment.Six-month follow-up revealed no abnormalities in magnetic resonance imaging,electrocardiogram,or blood tests.CONCLUSION NSC-MSC combination therapy enhances neurological function and cerebral perfusion in patients with ACI by upregulating VEGF and bFGF expression,demonstrating favorable clinical efficacy and safety. 展开更多
关键词 Acute cerebral infarction Neural stem cells Mesenchymal stem cells Vascular endothelial growth factor Basic fibroblast growth factor Neurological function
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Preparation of porousα-Ga_(2)O_(3) nanowires by dealloying of Ga-based liquid metals to enhance cycling stability for lithium storage
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作者 Chang LUO Zi-gang WANG +5 位作者 Yi-chao WANG Shuai-ju MENG hui yu Wei-min ZHAO Chun-ling QIN Zhi-feng WANG 《Transactions of Nonferrous Metals Society of China》 2025年第9期3074-3092,共19页
Ga_(2)O_(3) is considered a potential anode material for next-generation lithium-ion batteries due to its high theoretical capacity and unique self-healing capability.To develop a novel preparation method and in-depth... Ga_(2)O_(3) is considered a potential anode material for next-generation lithium-ion batteries due to its high theoretical capacity and unique self-healing capability.To develop a novel preparation method and in-depth understanding of the electrochemical reaction mechanism of Ga_(2)O_(3),a brand-new liquid-liquid dealloying strategy was exploited to construct porous α-Ga_(2)O_(3) nanowire networks.Profiting from the well-designed porous structure,the material exhibits impressive cycling stability of a reversible capacity of 603.9 mA·h/g after 200 cycles at 1000 mA/g and a capacity retention of 125.2 mA·h/g after 100 cycles at 0.5C when assembling to Ga_(2)O_(3)//LiFePO_(4) full cells.The lithiation/delithiation reaction mechanism of the porous Ga_(2)O_(3) anodes is further revealed by ex-situ Raman,XRD,TEM measurements,and density functional theoretical(DFT)calculations,which establishes a correlation between the electrochemical performance and the phase transition fromα-Ga_(2)O_(3) to β-Ga_(2)O_(3) during cycling. 展开更多
关键词 liquid metal dealloying porous nanowires Ga_(2)O_(3) Li-ion battery anode
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A self-standing dual-electric field synergistic Janus nanofibre piezoelectric photocatalyst with degradation of antibiotics:Performances,DFT calculation and mechanism unveiling
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作者 Feng Sun Da Xu +7 位作者 Jingcheng Xu yunrui Xie Haina Qi Feng Liu Hong Shao hui yu Wensheng yu Xiangting Dong 《Journal of Materials Science & Technology》 2025年第5期278-291,共14页
A self-standing dual-electric field synergistic[TiO_(2)/polyvinylidene fluoride(PVDF)]//[g-C3 N4 tube/PVDF]Janus nanofibres(named as[TP]//[CTP]JNs)S-scheme heterostructure piezoelectric photocatalyst is designed and c... A self-standing dual-electric field synergistic[TiO_(2)/polyvinylidene fluoride(PVDF)]//[g-C3 N4 tube/PVDF]Janus nanofibres(named as[TP]//[CTP]JNs)S-scheme heterostructure piezoelectric photocatalyst is designed and constructed via conjugative electrospinning.Dual-fields of built-in electric fields supplied by S-scheme heterostructure and piezoelectric field formed by PVDF jointly boost separation and transfer of photo-induced charges.As a case study,piezoelectric photocatalytic efficiency of[TP]//[CTP]JNs for tetracycline hydrochloride(TCH)under ultrasonic united with simulated sunlight illumination is 93.35%(40 min),which is 1.39 times of the photocatalytic efficiency(light illumination only)and 5.32 times of piezoelectric catalytic efficiency(applying ultrasonic only),proving the advantages of the synergistic effect of piezoelectric catalysis and photocatalysis on contaminant degradation.The dynamic behaviors of photocatalysis and photo-generated charges are deeply revealed through fs-TA and TRPL decay spectra,and the degradation pathways of antibiotics are reasonably speculated by combining LCMS spectra with Fukui index.By the degradation ability,COMSOL simulation and DFT calculation,the structural advantage of Janus nanofibers is fully verified,and S-scheme charge transfer mechanism is confirmed by combining a series of sound ample experiments with theoretical calculations.Additionally,the construction mechanism of Janus nanofibers is proposed,and corresponding construction technique is established. 展开更多
关键词 Janus nanofibre piezoelectric photocatalyst Dual-electric field S-scheme heterostructure Self-standing Degradation of antibiotic
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Experimental and numerical studies on rock damage law in straight-hole cut blasting under biaxial confining pressure
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作者 Xiantang Zhang Zhaobin Li +4 位作者 hui yu Hongmin Zhou Hongli Wang Xiangtuan Jiao Fuzhi Wang 《International Journal of Mining Science and Technology》 2025年第9期1529-1541,共13页
To study the relationships between rock mass crack propagation and damage and confining pressure under blast impact loading during straight-hole cut blasting,tests were performed under different confining pressures.Th... To study the relationships between rock mass crack propagation and damage and confining pressure under blast impact loading during straight-hole cut blasting,tests were performed under different confining pressures.Then,the characteristics of rock mass crack development were analyzed,and the pressure resistance values of core samples before and after blasting were compared to study the trends of rock mass damage.Moreover,a three-dimensional numerical simulation model was established by LS-DYNA to analyze the stress wave propagation,cavity shape and crack propagation characteristics under different confining pressures.The propagation of rock blasting cracks is negatively correlated with the confining pressure.The greater the confining pressure,the shorter the crack development time.Additionally,the crack width is reduced from 0.4-1.7 to 0.04-1.4 mm,and the length is shortened from 280 to 120 mm.A comparison of the compressive strength revealed that blasting reduces the compressive strength of the rock mass.The greater the distance from the explosion source,the lower the degree of strength attenuation.An increase in the confining pressure can inhibit strength attenuation.Numerical simulations revealed that under the same confining pressure,the stress first peaks at the bottom of the blast hole.The greater the confining pressure,the longer the stress peak duration,the smaller the cavity volume,and the shorter the crack propagation length and depth.Under a confining pressure of 4 MPa,the longest crack was only 154.5 mm in length and 102 mm in depth.The research results provide a scientific basis for controlling rock damage and optimizing design in the excavation of deep rock roadways by blasting. 展开更多
关键词 Biaxial confining pressure Straight-hole cut blasting Exploded stress wave Crack growth Rock damage
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Correlation between musculoskeletal system function and predepressive states in elderly cancer patients: A single-center crosssectional study
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作者 yu-Qing Zhou Wen-Jing Xu +10 位作者 yu-Ling Yang hui Su hui Lu hui yu Jing Wang Ling Li Dan-Hua Liang Yong-Ping Xu Jing-Fang Xia Ying Chen Rui-Rong Wu 《World Journal of Psychiatry》 2025年第11期308-317,共10页
BACKGROUND Studies have shown that locomotive syndrome(LS)is significantly correlated with adverse outcomes,such as decreased self-care abilities,fractures,and increased mortality.Subthreshold depression(StD)is consid... BACKGROUND Studies have shown that locomotive syndrome(LS)is significantly correlated with adverse outcomes,such as decreased self-care abilities,fractures,and increased mortality.Subthreshold depression(StD)is considered an independent predictor of clinical depression,regarded as its prodromal stage,and even linked to increased mortality risk.Limited research has addressed the prevalence and relationship between LS and StD in elderly cancer patients.Understanding the prevalence of LS and StD among elderly cancer patients and elucidating their relationship will provide evidence to support the development of targeted interventions,thereby improving health outcomes in this population.AIM To investigate the relationship between musculoskeletal system function and predepressive states in elderly cancer patients.METHODS A convenience sampling method was employed to recruit 500 elderly cancer patients undergoing follow-up visits at the Department of Oncology,Affiliated Hospital of Jiangnan University,from April 2024 to December 2024.Participants completed the general information questionnaire, the 25-question Geriatric Locomotive Function Scale, and theGeriatric Depression Scale-Short Form-15. Influencing factors were analyzed, and correlation analyses wereperformed.RESULTSA total of 483 elderly cancer patients successfully completed the study. The prevalence of LS and StD amongparticipants was 56.5% and 38.7%, respectively. Logistic regression analysis identified age, tumor metastasis,exercise habits, and the presence of StD as significant risk factors for LS in elderly cancer patients. Additionally,having three or more chronic diseases and LS were significant predictors for developing StD. Spearman’s correlationanalysis revealed a significant positive correlation between LS and StD (r = 0.424, P < 0.001).CONCLUSIONElderly cancer patients exhibit a high prevalence of LS and StD, conditions which are positively correlated andmutually influential. Thus, it is critical to monitor and address pre-depressive states while evaluating and managingmotor function in this population. 展开更多
关键词 Elderly cancer patients Musculoskeletal function Locomotive syndrome Pre-depressive state CORRELATION
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Effects of dislocation loop on microstructure and mechanical properties of LN_(2)-quenched 2524 Al alloy
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作者 hui yu Li-ping TIAN +6 位作者 Li-wei QUAN Chao LIU Li-xin HUANG yu-ling XU Wei yu Bin-an JIANG Kwang-seon SHIN 《Transactions of Nonferrous Metals Society of China》 2025年第9期2822-2829,共8页
The microstructure and mechanical properties of 2524 Al alloy after quenching in liquid nitrogen(LN_(2))were investigated by TEM and compared with those of cold water quenching.The results show that the LN_(2) quenchi... The microstructure and mechanical properties of 2524 Al alloy after quenching in liquid nitrogen(LN_(2))were investigated by TEM and compared with those of cold water quenching.The results show that the LN_(2) quenching process effectively induces the formation of dislocation loops.These loops become large and unevenly distribute after aging for 15 min.Furthermore,such loops become rapidly immobilized by the precipitation of coarse S phases after 1 h aging.The alloy quenched in LN_(2) demonstrates superior peak hardness and displays a more rapid response to subsequent aging treatments compared with the cold water-quenched one.Despite the short aging time,LN_(2)-quenched sample achieves tensile strength of 488 MPa.This enhanced strength is attributed to the strengthening effect of numerous finely dispersed Guinier-Preston-Bagaryatsky(GPB)zones,in conjunction with the inhomogeneous formation of S phase on the dislocation loops. 展开更多
关键词 2524 Al alloy LN_(2)quenching dislocation loop GPB zone S phase
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