There exists a notion that there is an obesity paradox in the prognosis of community-acquired pneumonia.In other words,obese individuals with communityacquired pneumonia have a better prognosis.The study by Wang et al...There exists a notion that there is an obesity paradox in the prognosis of community-acquired pneumonia.In other words,obese individuals with communityacquired pneumonia have a better prognosis.The study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.展开更多
Lower Paleozoic black shales are important source rocks worldwide.The Upper Ordovician-Lower Silurian Renheqiao Formation of the Baoshan Block is a low-maturity equivalent of the Wufeng-Longmaxi(WF-LMX)Shale of the Si...Lower Paleozoic black shales are important source rocks worldwide.The Upper Ordovician-Lower Silurian Renheqiao Formation of the Baoshan Block is a low-maturity equivalent of the Wufeng-Longmaxi(WF-LMX)Shale of the Sichuan Basin.However,organic matter(OM)characteristics in these low-maturity Lower Paleozoic shales are not well understood.In this study,50 Renheqiao Formation shale samples collected from seven outcrop sections and one drill core were investigated with organic petrology,organic geochemistry,R_(o)ck-Eval pyrolysis,N_(2) and CO_(2) adsorption,and scanning electron microscope(SEM)analyses to study the OM content,type,thermal maturity,and the development of OM-hosted pores in these Lower Paleozoic shales.The total organic carbon(TOC)content of the Renheqiao Formation shales varies,with the maximum content of 10.07 wt%.R_(o)ck-Eval pyrolysis results show that present OM in the Renheqiao Formation shales is Type IV kerogen,a result of advanced thermal maturation.Graptolite reflectance(GR_(o))ranges from 1.26%to 1.85%,and equivalent vitrinite reflectance(EqR_(o))converted from GR_(o) ranges from 1.08%to 1.51%,indicating that the studied Renheqiao Formation shales are dominantly within the late-mature stage.EqR_(o) based on R_(o)ck-Eval T_(max) shows large variations,which indicates that R_(o)ck-Eval T_(max) is not a reliable thermal maturity indicator for the Lower Paleozoic Renheqiao Formation shales.Caution should be applied when assessing the thermal maturity of high-maturity black shales based on T_(max) when the S2 values are too low.Organic petrographic observations show that OM in these shales is dominated by solid bitumen(>70 vol%of total OM),with minor contributions by graptolites and chitinozoans.The specific surface area and pore volume of shales are controlled by TOC content.Organic pores are hosted by solid bitumen and were not observed in graptolites when examined under the SEM.Although the Renheqiao Formation has a lower thermal maturity than the over-mature WF-LMX Shale,it is mature enough that primary oil-prone macerals have been thermally transformed and could not be identified under the microscope.展开更多
The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind sol...The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind solar eruptions and coronal heating,and to directly measure the coronal magnetic field.The mission will perform in situ measurements of the current sheet between coronal mass ejections and their associated solar flares,and energetic particles produced by either reconnection or fast-mode shocks driven by coronal mass ejections.This will help to resolve the nature of reconnections in current sheets,and energetic particle acceleration regions.To investigate coronal heating,the mission will observe nano-flares on scales smaller than 70 km in the solar corona and regions smaller than 40 km in the photosphere,where magnetohydrodynamic waves originate.To study solar wind acceleration mechanisms,the mission will also track the process of ion charge-state freezing in the solar wind.A key achievement will be the observation of the coronal magnetic field at unprecedented proximity to the solar photosphere.The polar regions will also be observed at close range,and the inner edge of the solar system dust disk may be identified for the first time.This work presents the detailed background,science,and mission concept of SCOPE and discusses how we aim to address the questions mentioned above.展开更多
The Lower Cambrian shales in the Sichuan Basin are considered one of the most promising shale gas resources in China.However,large-scale commercial development has not been achieved due to the relatively low and signi...The Lower Cambrian shales in the Sichuan Basin are considered one of the most promising shale gas resources in China.However,large-scale commercial development has not been achieved due to the relatively low and significantly variable gas contents of the drilled shales.Excitingly,the first major breakthrough in deep and ultra-deep Lower Cambrian shale gas was made recently in the well Z201 in the southern Sichuan Basin,with a gas yield exceeding 73×10^(4)m^(3)/d.The success of well Z201 provides a favorable geological case to reveal the distinct enrichment mechanism of deep and ultra-deep Lower Cambrian shale gas.In this study,at drilling site of well Z201,fresh shale core samples with different gasin-place contents were collected,and their geochemical,pore development and water-bearing characteristics were analyzed systematically.The results showed that the Z201 organic-rich shales reached an overmature stage,with an average Raman maturity of 3.70%.The Z201 shales with high gas-in-place contents are mainly located in the Qiongzhusi 12section and the upper Qiongzhusi 11section,with an average gas-in-place content of 10.08 cm^(3)/g.Compared to the shales with low gas-in-place contents,the shales with high gas-in-place contents exhibit higher total organic carbon contents,greater porosities,and lower water saturations,providing more effective pore spaces for shale gas enrichment.The effective pore structures of the deep and ultra-deep Lower Cambrian shales are the primary factors affecting their gas-in-place contents.Similar to the shales with high gas-in-place contents of well Z201,the deep and ultra-deep Lower Cambrian shales in the Mianyang-Changning intracratonic sag,especially in the Ziyang area,generally developed in deep-water shelf facies with high total organic carbon contents and thick sedimentary thickness,providing favorable conditions for the development and preservation of effective pores.Therefore,they are the most promising targets for Lower Cambrian shale gas exploration.展开更多
Magnolia officinalis is a perennial deciduous tree that has medicinal properties.The AP2/ERF gene family has a number of roles in long-term growth and metabolism.The expression of this function varies with the growth ...Magnolia officinalis is a perennial deciduous tree that has medicinal properties.The AP2/ERF gene family has a number of roles in long-term growth and metabolism.The expression of this function varies with the growth period.In this work,based on the transcriptome data of Magnolia officinalis,the complete coding gene of Magnolia officinalis was obtained,and the corresponding protein sequence was retrieved from NCBI and compared with the model plant Arabidopsis thaliana.After screening,75 protein sequences from the AP2/ERF gene family were identified and called MoAP2/ERF1–MoAP2/ERF75,followed by bioinformatics analysis.75 AP2/ERF gene families were found and classified into four subfamilies.Their protein architectures had one or more conserved AP2 domains,which were typically unstable and hydrophilic.Subcellular research revealed that it was primarily located in the nucleus.Among them,the DREB subfamily showed stronger activity in the early growth period of Magnolia officinalis,suggesting that Magnolia officinalis had stronger resistance to adversity during this period.The 15 members of the MoAP2/ERF gene family showed significant differences during different growth periods,and they regulated the gene expression of Magnolia officinalis by binding to DNA.The 15 MoAP2/ERF gene families have a wide range of physiological activities in biological processes,cellular components,and molecular functions.Including MoAP2/ERF55 can catalyze imidazole glycerol phosphate synthase activity;MoAP2/ERF39 acts as a transcriptional activator of Pti6.展开更多
The structural phase transition of MnO_(2) nanorods was investigated using in situ high pressure synchrotron x-ray diffraction(XRD) and transmission electron microscopy(TEM). At pressures exceeding 10.9 GPa, a second-...The structural phase transition of MnO_(2) nanorods was investigated using in situ high pressure synchrotron x-ray diffraction(XRD) and transmission electron microscopy(TEM). At pressures exceeding 10.9 GPa, a second-order structural phase transition from tetragonal to orthogonal, which was accompanied by fine-scale crystal twinning phenomena, was observed in MnO_(2) nanorods. On account of the significant contribution of surface energy, the phase transition pressure exhibited appreciable hysteresis compared with the bulk counterparts, suggesting the enhanced structural stability of nanorod morphology. These findings reveal that the size and morphology exhibit a manifest correlation with the high pressure behavior of MnO_(2) nanomaterials, providing useful insights into the intricate interplay between structure and properties.展开更多
Innovating distillation technology to improve the efficiency of distillation equipment,reduce energy consumption,and increase product purity is an important challenge for the rapid development of the distillation indu...Innovating distillation technology to improve the efficiency of distillation equipment,reduce energy consumption,and increase product purity is an important challenge for the rapid development of the distillation industry.In this paper,steady-state simulations are developed for the separated isopropanol and water systems,and the sensitive temperature stage locations are determined using sensitivity and singular value decomposition(SVD).An open-loop steady-state gain analysis of the isopropanol/water system was performed,and a series of dynamic control schemes were designed and optimized to resist±10% feed flow disturbances and ±5% feed composition disturbances,comparing the performance of the control schemes one by one through IAE error analysis.The results show that the side-stream extractive distillation separation of isopropanol and water system using a single temperature fixed reflux ratio control loop suffers from a large product shift problem.One of the key control loops is to control the isopropanol purity by controlling the bottom of the column flow rate,and the scheme performs well under both single-temperature control and dual-temperature control,effectively resisting ±10% feed flow disturbances and ±5% feed composition disturbances.The improvement of product purity can be seen from the compone nt controllers play an important role,while the feed-fo rward effect under certain conditions can also enable the system to quickly restore stability and improve the system response speed.展开更多
Recent observations have demonstrated the capability of mapping the solar coronal magnetic field using the technique of coronal seismology based on the ubiquitous propagating Alfvénic/kink waves through imaging s...Recent observations have demonstrated the capability of mapping the solar coronal magnetic field using the technique of coronal seismology based on the ubiquitous propagating Alfvénic/kink waves through imaging spectroscopy.We established a magnetohydrodynamic model of a gravitationally stratified open magnetic flux tube,exciting kink waves propagating upwards along the tube.Forward modeling was performed to synthesize the Fe XIII 1074.7 and 1079.8 nm spectral line profiles,which were then used to determine the wave phase speed,plasma density,and magnetic field with seismology method.A comparison between the seismologically inferred results and the corresponding input values verifies the reliability of the seismology method.In addition,we also identified some factors that could lead to errors during magnetic field measurements.Our results may serve as a valuable reference for current and future coronal magnetic field measurements based on observations of propagating kink waves.展开更多
This paper explores the ideological and political education teaching practice in the new media marketing course based on Bandura’s triadic reciprocal determinism.It first analyzes the appropriateness of the triadic r...This paper explores the ideological and political education teaching practice in the new media marketing course based on Bandura’s triadic reciprocal determinism.It first analyzes the appropriateness of the triadic reciprocal determinism,then points out the issues in the ideological and political education of the new media marketing course in terms of“individual,”“behavior,”and“environment,”and finally proposes implementation paths for the ideological and political education teaching in the new media marketing course:curriculum ideological and political education content design based on individual cognition,curriculum ideological and political education participation based on behavioral patterns,and curriculum ideological and political education support based on environmental factors.展开更多
The Lower Paleozoic shale in south China has a very high maturity and experienced strong tectonic defor- mation. This character is quite different from the North America shale and has inhibited the shale gas evaluatio...The Lower Paleozoic shale in south China has a very high maturity and experienced strong tectonic defor- mation. This character is quite different from the North America shale and has inhibited the shale gas evaluation and exploration in this area. The present paper reports a com- prehensive investigation of maturity, reservoir properties, fluid pressure, gas content, preservation conditions, and other relevant aspects of the Lower Paleozoic shale from the Sichuan Basin and its surrounding areas. It is found that within the main maturity range （2.5 % 〈 EqRo 〈 3.5 %） of the shale, its porosity develops well, having a positive cor- relation with the TOC content, and its gas content is con- trolled mainly by the preservation conditions related to the tectonic deformation, but shale with a super high maturity （EqRo 〉 3.5 %） is considered a high risk for shale gas exploration. Taking the southern area of the Sichuan Basin and the southeastern area of Chongqing as examples of uplifted/folded and faulted/folded areas, respectively, geo- logical models of shale gas content and loss were proposed. For the uplifted/folded area with a simple tectonic defor- mation, the shale system （with a depth 〉 2000 m） has lar- gely retained overpressure during uplifting without a great loss of gas, and an industrial shale gas potential is generally possible. However, for the faulted/folded area with a strong tectonic deformation, the sealing condition of the shale system was usually destroyed to a certain degree with a great loss of free gas, which decreased the pressure coefficient and resulted in a low production capacity. It is predicted that the deeply buried shale （〉3000 m） has a greater gas potential and will become the focus for further exploration and development in most of the south China region （outside the Sichuan Basin）.展开更多
The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the...The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.展开更多
In this paper,an Uncertainty-based Multi-disciplinary Design Optimization (UMDO)method combining with fuzzy theory and Multi-Discipline Feasible (MDF) method is developed for the conceptual design of a Hybrid Rocket M...In this paper,an Uncertainty-based Multi-disciplinary Design Optimization (UMDO)method combining with fuzzy theory and Multi-Discipline Feasible (MDF) method is developed for the conceptual design of a Hybrid Rocket Motor (HRM) powered Launch Vehicle (LV).In the method proposed,membership functions are used to represent the uncertain factors,the fuzzy statistical experiment is introduced to analyze the propagation of uncertainties,and means,standard deviations and credibility measures are used to delineate uncertain responses.A geometric programming problem is solved to verify the feasibility of the Fuzzy-based Multi-Discipline Feasible(F-MDF) method.A multi-disciplinary analysis of a three-stage HRM powered LV involving the disciplines of propulsion,structure,aerodynamics and trajectory is implemented,and the mathematical models corresponding to the F-MDF method and the MDF method are established.A two-phase optimization method is proposed for multi-disciplinary design optimization of the LV,including the orbital capacity optimization phase based on the Ziolkowski formula,and the scheme trajectory verification phase based on the 3-degree-of-freedom point trajectory simulation.The correlation coefficients and the quadratic Response Surface Method (RSM) based on Latin Hypercube Sampling (LHS) are adopted for sensitive analysis of uncertain factors,and the Multi-Island Genetic Algorithm (MIGA) is adopted as the optimization algorithm.The results show that the F-MDF method is applicable in LV conceptual design,and the design with the F-MDF method is more reliable and robust than that with the MDF method.展开更多
Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PC...Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PCR and Western blot were conducted to detect the expression of DDP10-AS1 and DPP10 in lung cancer cell lines and tissues.The effects of DDP10-AS1 on DPP10 expression,cell growth,invasion,apoptosis,and in vivo tumor growth were investigated in lung cancer cells by Western blot,rescue experiments,colony formation,flow cytometry,and xenograft animal experiments.Results:The novel antisense lnc RNA DPP10-AS1 was found to be highly expressed in cancer tissues(P<0.0001),and its upregulation predicted poor prognosis in patients with lung cancer(P=0.0025).Notably,DPP10-AS1 promoted lung cancer cell growth,colony formation,and cell cycle progression,and repressed apoptosis in lung cancer cells by upregulating DPP10 expression.Additionally,DPP10-AS1 facilitated lung tumor growth via upregulation of DPP10 protein in a xenograft mouse model.Importantly,DPP10-AS1 positively regulated DPP10 gene expression,and both were coordinately upregulated in lung cancer tissues.Mechanically,DPP10-AS1 was found to associate with DPP10 m RNA but did not enhance DPP10 m RNA stability.Hypomethylation of DPP10-AS1 and DPP10 contributed to their coordinate upregulation in lung cancer.Conclusions:These findings indicated that the upregulation of the antisense lnc RNA DPP10-AS1 promotes lung cancer malignant processes and facilitates tumorigenesis by epigenetically regulating its cognate sense gene DPP10.DPP10-AS1 may serve as a candidate prognostic biomarker and a potential therapeutic target in lung cancer.展开更多
Since the efficiency of photovoltaic(PV) power is closely related to the weather,many PV enterprises install weather instruments to monitor the working state of the PV power system.With the development of the soft mea...Since the efficiency of photovoltaic(PV) power is closely related to the weather,many PV enterprises install weather instruments to monitor the working state of the PV power system.With the development of the soft measurement technology,the instrumental method seems obsolete and involves high cost.This paper proposes a novel method for predicting the types of weather based on the PV power data and partial meteorological data.By this method,the weather types are deduced by data analysis,instead of weather instrument A better fault detection is obtained by using the support vector machines(SVM) and comparing the predicted and the actual weather.The model of the weather prediction is established by a direct SVM for training multiclass predictors.Although SVM is suitable for classification,the classified results depend on the type of the kernel,the parameters of the kernel,and the soft margin coefficient,which are difficult to choose.In this paper,these parameters are optimized by particle swarm optimization(PSO) algorithm in anticipation of good prediction results can be achieved.Prediction results show that this method is feasible and effective.展开更多
文摘There exists a notion that there is an obesity paradox in the prognosis of community-acquired pneumonia.In other words,obese individuals with communityacquired pneumonia have a better prognosis.The study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.
基金supported by the project of“Shale Gas Resources Investigation and Evaluation in the Baoshan Block”from Sinopec Exploration Company and the National Natural Science Foundation of China(41925014 and 42172192)。
文摘Lower Paleozoic black shales are important source rocks worldwide.The Upper Ordovician-Lower Silurian Renheqiao Formation of the Baoshan Block is a low-maturity equivalent of the Wufeng-Longmaxi(WF-LMX)Shale of the Sichuan Basin.However,organic matter(OM)characteristics in these low-maturity Lower Paleozoic shales are not well understood.In this study,50 Renheqiao Formation shale samples collected from seven outcrop sections and one drill core were investigated with organic petrology,organic geochemistry,R_(o)ck-Eval pyrolysis,N_(2) and CO_(2) adsorption,and scanning electron microscope(SEM)analyses to study the OM content,type,thermal maturity,and the development of OM-hosted pores in these Lower Paleozoic shales.The total organic carbon(TOC)content of the Renheqiao Formation shales varies,with the maximum content of 10.07 wt%.R_(o)ck-Eval pyrolysis results show that present OM in the Renheqiao Formation shales is Type IV kerogen,a result of advanced thermal maturation.Graptolite reflectance(GR_(o))ranges from 1.26%to 1.85%,and equivalent vitrinite reflectance(EqR_(o))converted from GR_(o) ranges from 1.08%to 1.51%,indicating that the studied Renheqiao Formation shales are dominantly within the late-mature stage.EqR_(o) based on R_(o)ck-Eval T_(max) shows large variations,which indicates that R_(o)ck-Eval T_(max) is not a reliable thermal maturity indicator for the Lower Paleozoic Renheqiao Formation shales.Caution should be applied when assessing the thermal maturity of high-maturity black shales based on T_(max) when the S2 values are too low.Organic petrographic observations show that OM in these shales is dominated by solid bitumen(>70 vol%of total OM),with minor contributions by graptolites and chitinozoans.The specific surface area and pore volume of shales are controlled by TOC content.Organic pores are hosted by solid bitumen and were not observed in graptolites when examined under the SEM.Although the Renheqiao Formation has a lower thermal maturity than the over-mature WF-LMX Shale,it is mature enough that primary oil-prone macerals have been thermally transformed and could not be identified under the microscope.
基金supported by the National Key R&D Program of China (2022YFF0503800)National Natural Science Foundation of China grants (12073073, 11933009, 12273107 and U2031141)+6 种基金grants associated with the Yunnan Revitalization Talent Support Programthe Foundation of the Chinese Academy of Sciences (Light of West China Program)the Yunling Scholar Project of Yunnan Provincethe Yunnan Province Scientist Workshop of Solar Physicsthe Applied Basic Research of Yunnan Province grants (202101AT070018 and 2019FB005)supported by the National Natural Science Foundation of China grants (12273107 and U2031141)the Yunnan Key Laboratory of Solar Physics and Space Science (202205AG070009)
文摘The Solar Close Observations and Proximity Experiments(SCOPE)mission will send a spacecraft into the solar atmosphere at a low altitude of just 5 R☉from the solar center.It aims to elucidate the mechanisms behind solar eruptions and coronal heating,and to directly measure the coronal magnetic field.The mission will perform in situ measurements of the current sheet between coronal mass ejections and their associated solar flares,and energetic particles produced by either reconnection or fast-mode shocks driven by coronal mass ejections.This will help to resolve the nature of reconnections in current sheets,and energetic particle acceleration regions.To investigate coronal heating,the mission will observe nano-flares on scales smaller than 70 km in the solar corona and regions smaller than 40 km in the photosphere,where magnetohydrodynamic waves originate.To study solar wind acceleration mechanisms,the mission will also track the process of ion charge-state freezing in the solar wind.A key achievement will be the observation of the coronal magnetic field at unprecedented proximity to the solar photosphere.The polar regions will also be observed at close range,and the inner edge of the solar system dust disk may be identified for the first time.This work presents the detailed background,science,and mission concept of SCOPE and discusses how we aim to address the questions mentioned above.
基金supported by the National Natural Science Foundation of China(41925014).
文摘The Lower Cambrian shales in the Sichuan Basin are considered one of the most promising shale gas resources in China.However,large-scale commercial development has not been achieved due to the relatively low and significantly variable gas contents of the drilled shales.Excitingly,the first major breakthrough in deep and ultra-deep Lower Cambrian shale gas was made recently in the well Z201 in the southern Sichuan Basin,with a gas yield exceeding 73×10^(4)m^(3)/d.The success of well Z201 provides a favorable geological case to reveal the distinct enrichment mechanism of deep and ultra-deep Lower Cambrian shale gas.In this study,at drilling site of well Z201,fresh shale core samples with different gasin-place contents were collected,and their geochemical,pore development and water-bearing characteristics were analyzed systematically.The results showed that the Z201 organic-rich shales reached an overmature stage,with an average Raman maturity of 3.70%.The Z201 shales with high gas-in-place contents are mainly located in the Qiongzhusi 12section and the upper Qiongzhusi 11section,with an average gas-in-place content of 10.08 cm^(3)/g.Compared to the shales with low gas-in-place contents,the shales with high gas-in-place contents exhibit higher total organic carbon contents,greater porosities,and lower water saturations,providing more effective pore spaces for shale gas enrichment.The effective pore structures of the deep and ultra-deep Lower Cambrian shales are the primary factors affecting their gas-in-place contents.Similar to the shales with high gas-in-place contents of well Z201,the deep and ultra-deep Lower Cambrian shales in the Mianyang-Changning intracratonic sag,especially in the Ziyang area,generally developed in deep-water shelf facies with high total organic carbon contents and thick sedimentary thickness,providing favorable conditions for the development and preservation of effective pores.Therefore,they are the most promising targets for Lower Cambrian shale gas exploration.
基金supported by the National Natural Science Foundation of China(num-ber 81202933)the Natural Science Foundation of Sichuan Province(number 2025ZNSFSC0205 and number 2022NSFSC0592)the Science and Technology Plan Project of Mianyang City(number 2018YFZJ025).
文摘Magnolia officinalis is a perennial deciduous tree that has medicinal properties.The AP2/ERF gene family has a number of roles in long-term growth and metabolism.The expression of this function varies with the growth period.In this work,based on the transcriptome data of Magnolia officinalis,the complete coding gene of Magnolia officinalis was obtained,and the corresponding protein sequence was retrieved from NCBI and compared with the model plant Arabidopsis thaliana.After screening,75 protein sequences from the AP2/ERF gene family were identified and called MoAP2/ERF1–MoAP2/ERF75,followed by bioinformatics analysis.75 AP2/ERF gene families were found and classified into four subfamilies.Their protein architectures had one or more conserved AP2 domains,which were typically unstable and hydrophilic.Subcellular research revealed that it was primarily located in the nucleus.Among them,the DREB subfamily showed stronger activity in the early growth period of Magnolia officinalis,suggesting that Magnolia officinalis had stronger resistance to adversity during this period.The 15 members of the MoAP2/ERF gene family showed significant differences during different growth periods,and they regulated the gene expression of Magnolia officinalis by binding to DNA.The 15 MoAP2/ERF gene families have a wide range of physiological activities in biological processes,cellular components,and molecular functions.Including MoAP2/ERF55 can catalyze imidazole glycerol phosphate synthase activity;MoAP2/ERF39 acts as a transcriptional activator of Pti6.
基金Project supported by China Postdoctoral Science Foundation (Grant No. 2023M742049)Guangdong Basic and Applied Basic Research Foundation (Grant No. 2023A1515110844)the Innovative Training Program for College Students (Grant No. 20249076)。
文摘The structural phase transition of MnO_(2) nanorods was investigated using in situ high pressure synchrotron x-ray diffraction(XRD) and transmission electron microscopy(TEM). At pressures exceeding 10.9 GPa, a second-order structural phase transition from tetragonal to orthogonal, which was accompanied by fine-scale crystal twinning phenomena, was observed in MnO_(2) nanorods. On account of the significant contribution of surface energy, the phase transition pressure exhibited appreciable hysteresis compared with the bulk counterparts, suggesting the enhanced structural stability of nanorod morphology. These findings reveal that the size and morphology exhibit a manifest correlation with the high pressure behavior of MnO_(2) nanomaterials, providing useful insights into the intricate interplay between structure and properties.
基金the Key Research and Development Plan of Shandong Province (Major Scientific and Technological Innovation Project) (2021ZDSYS24)the Science Fund of Shandong Laboratory of Advanced Materials and Green Manufacturing (Yantai) (AMGM2023A09)the Open Project Program of Fujian Universities Engineering Research Center of Reactive Distillation Technology (RDRC202204), Fuzhou University。
文摘Innovating distillation technology to improve the efficiency of distillation equipment,reduce energy consumption,and increase product purity is an important challenge for the rapid development of the distillation industry.In this paper,steady-state simulations are developed for the separated isopropanol and water systems,and the sensitive temperature stage locations are determined using sensitivity and singular value decomposition(SVD).An open-loop steady-state gain analysis of the isopropanol/water system was performed,and a series of dynamic control schemes were designed and optimized to resist±10% feed flow disturbances and ±5% feed composition disturbances,comparing the performance of the control schemes one by one through IAE error analysis.The results show that the side-stream extractive distillation separation of isopropanol and water system using a single temperature fixed reflux ratio control loop suffers from a large product shift problem.One of the key control loops is to control the isopropanol purity by controlling the bottom of the column flow rate,and the scheme performs well under both single-temperature control and dual-temperature control,effectively resisting ±10% feed flow disturbances and ±5% feed composition disturbances.The improvement of product purity can be seen from the compone nt controllers play an important role,while the feed-fo rward effect under certain conditions can also enable the system to quickly restore stability and improve the system response speed.
基金supported by the National Natural Science Foundation of China (NSFC,grant No.12425301)the Strategic Priority Research Program of the Chinese Academy of Sciences (grant No.XDB0560000)+6 种基金the National Key R&D Program of China No.2022YFF0503800support from the National Natural Science Foundation of China (NSFC,grant No.12203030)supported by the C1 grant TRACEspace of Internal Funds KU Leuven and a Senior Research Project (G088021N) of the FWO Vlaanderensupport from the Flemish Government under the long-term structural Methusalem funding program,project SOUL:Stellar evolution in full glory,grant METH/24/012 at KU Leuvensubsidized by the Belgian Federal Science Policy Office through the contract B2/223/P1/CLOSE-UPfunding under the Horizon Europe program of the European Union under grant agreement (No.101131534)support by an FWO (Fonds voor Wetenschappelijk Onderzoek-Vlaanderen)postdoctoral fellowship (1273221N)
文摘Recent observations have demonstrated the capability of mapping the solar coronal magnetic field using the technique of coronal seismology based on the ubiquitous propagating Alfvénic/kink waves through imaging spectroscopy.We established a magnetohydrodynamic model of a gravitationally stratified open magnetic flux tube,exciting kink waves propagating upwards along the tube.Forward modeling was performed to synthesize the Fe XIII 1074.7 and 1079.8 nm spectral line profiles,which were then used to determine the wave phase speed,plasma density,and magnetic field with seismology method.A comparison between the seismologically inferred results and the corresponding input values verifies the reliability of the seismology method.In addition,we also identified some factors that could lead to errors during magnetic field measurements.Our results may serve as a valuable reference for current and future coronal magnetic field measurements based on observations of propagating kink waves.
基金Research on the Teaching Practice of Ideological and Political Education in the New Media Marketing Course from a Three-Way Interactive Perspective under the 2024 Special Project for Curriculum-Based Ideological and Political Education at Hebei Normal University of Science and Technology(PX-2424813)Research on the Teaching Incentive of Xi Jinping’s Important Thoughts on Youth Work in Addressing College Students’Sense of“Powerlessness”under the 2023 General Teaching Research Project at Hebei Normal University of Science and Technology(PX-1923438)。
文摘This paper explores the ideological and political education teaching practice in the new media marketing course based on Bandura’s triadic reciprocal determinism.It first analyzes the appropriateness of the triadic reciprocal determinism,then points out the issues in the ideological and political education of the new media marketing course in terms of“individual,”“behavior,”and“environment,”and finally proposes implementation paths for the ideological and political education teaching in the new media marketing course:curriculum ideological and political education content design based on individual cognition,curriculum ideological and political education participation based on behavioral patterns,and curriculum ideological and political education support based on environmental factors.
基金jointly supported by the National Key Basic Research Program of China (973 Program: 2012CB214700)the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB10040300)the National Natural Science Foundation of China (41321002)
文摘The Lower Paleozoic shale in south China has a very high maturity and experienced strong tectonic defor- mation. This character is quite different from the North America shale and has inhibited the shale gas evaluation and exploration in this area. The present paper reports a com- prehensive investigation of maturity, reservoir properties, fluid pressure, gas content, preservation conditions, and other relevant aspects of the Lower Paleozoic shale from the Sichuan Basin and its surrounding areas. It is found that within the main maturity range （2.5 % 〈 EqRo 〈 3.5 %） of the shale, its porosity develops well, having a positive cor- relation with the TOC content, and its gas content is con- trolled mainly by the preservation conditions related to the tectonic deformation, but shale with a super high maturity （EqRo 〉 3.5 %） is considered a high risk for shale gas exploration. Taking the southern area of the Sichuan Basin and the southeastern area of Chongqing as examples of uplifted/folded and faulted/folded areas, respectively, geo- logical models of shale gas content and loss were proposed. For the uplifted/folded area with a simple tectonic defor- mation, the shale system （with a depth 〉 2000 m） has lar- gely retained overpressure during uplifting without a great loss of gas, and an industrial shale gas potential is generally possible. However, for the faulted/folded area with a strong tectonic deformation, the sealing condition of the shale system was usually destroyed to a certain degree with a great loss of free gas, which decreased the pressure coefficient and resulted in a low production capacity. It is predicted that the deeply buried shale （〉3000 m） has a greater gas potential and will become the focus for further exploration and development in most of the south China region （outside the Sichuan Basin）.
基金supported by the National Natural Science Foundation of China(NSFC)under Grants 11825301,12003016,12073077the National Key R&D Program of China No.2021YFA0718600+1 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences with the Grant No.XDA15018400the Youth Innovation Promotion Association of CAS(2023061)。
文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections.
基金supported by National Natural Science Foundation of China (No. 51305014)
文摘In this paper,an Uncertainty-based Multi-disciplinary Design Optimization (UMDO)method combining with fuzzy theory and Multi-Discipline Feasible (MDF) method is developed for the conceptual design of a Hybrid Rocket Motor (HRM) powered Launch Vehicle (LV).In the method proposed,membership functions are used to represent the uncertain factors,the fuzzy statistical experiment is introduced to analyze the propagation of uncertainties,and means,standard deviations and credibility measures are used to delineate uncertain responses.A geometric programming problem is solved to verify the feasibility of the Fuzzy-based Multi-Discipline Feasible(F-MDF) method.A multi-disciplinary analysis of a three-stage HRM powered LV involving the disciplines of propulsion,structure,aerodynamics and trajectory is implemented,and the mathematical models corresponding to the F-MDF method and the MDF method are established.A two-phase optimization method is proposed for multi-disciplinary design optimization of the LV,including the orbital capacity optimization phase based on the Ziolkowski formula,and the scheme trajectory verification phase based on the 3-degree-of-freedom point trajectory simulation.The correlation coefficients and the quadratic Response Surface Method (RSM) based on Latin Hypercube Sampling (LHS) are adopted for sensitive analysis of uncertain factors,and the Multi-Island Genetic Algorithm (MIGA) is adopted as the optimization algorithm.The results show that the F-MDF method is applicable in LV conceptual design,and the design with the F-MDF method is more reliable and robust than that with the MDF method.
基金supported in part by research grants from the Non-profit Technology Research Program of Zhejiang(Grant No.LGF18H160006)the Natural Science Foundation of Zhejiang(Grant No.LQ18H200001)+3 种基金the Non-profit Technology Research Program of Ningbo(Grant No.2019C50040)the Natural Science Foundation of Ningbo(Grant No.2018A610204)the Major Project for Science and Technology Innovation 2025 of Ningbo(Grant No.2019B10037)the K.C.Wong Magna Fund at Ningbo University。
文摘Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PCR and Western blot were conducted to detect the expression of DDP10-AS1 and DPP10 in lung cancer cell lines and tissues.The effects of DDP10-AS1 on DPP10 expression,cell growth,invasion,apoptosis,and in vivo tumor growth were investigated in lung cancer cells by Western blot,rescue experiments,colony formation,flow cytometry,and xenograft animal experiments.Results:The novel antisense lnc RNA DPP10-AS1 was found to be highly expressed in cancer tissues(P<0.0001),and its upregulation predicted poor prognosis in patients with lung cancer(P=0.0025).Notably,DPP10-AS1 promoted lung cancer cell growth,colony formation,and cell cycle progression,and repressed apoptosis in lung cancer cells by upregulating DPP10 expression.Additionally,DPP10-AS1 facilitated lung tumor growth via upregulation of DPP10 protein in a xenograft mouse model.Importantly,DPP10-AS1 positively regulated DPP10 gene expression,and both were coordinately upregulated in lung cancer tissues.Mechanically,DPP10-AS1 was found to associate with DPP10 m RNA but did not enhance DPP10 m RNA stability.Hypomethylation of DPP10-AS1 and DPP10 contributed to their coordinate upregulation in lung cancer.Conclusions:These findings indicated that the upregulation of the antisense lnc RNA DPP10-AS1 promotes lung cancer malignant processes and facilitates tumorigenesis by epigenetically regulating its cognate sense gene DPP10.DPP10-AS1 may serve as a candidate prognostic biomarker and a potential therapeutic target in lung cancer.
基金supported by the National Natural Science Foundation of China(61433004,61473069)IAPI Fundamental Research Funds(2013ZCX14)+1 种基金supported by the Development Project of Key Laboratory of Liaoning Provincethe Enterprise Postdoctoral Fund Projects of Liaoning Province
文摘Since the efficiency of photovoltaic(PV) power is closely related to the weather,many PV enterprises install weather instruments to monitor the working state of the PV power system.With the development of the soft measurement technology,the instrumental method seems obsolete and involves high cost.This paper proposes a novel method for predicting the types of weather based on the PV power data and partial meteorological data.By this method,the weather types are deduced by data analysis,instead of weather instrument A better fault detection is obtained by using the support vector machines(SVM) and comparing the predicted and the actual weather.The model of the weather prediction is established by a direct SVM for training multiclass predictors.Although SVM is suitable for classification,the classified results depend on the type of the kernel,the parameters of the kernel,and the soft margin coefficient,which are difficult to choose.In this paper,these parameters are optimized by particle swarm optimization(PSO) algorithm in anticipation of good prediction results can be achieved.Prediction results show that this method is feasible and effective.
