The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular well-being.Given th...The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular well-being.Given the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other organs.Among these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral processes.Among the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of rapamycin.Branched-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared transporter.Beyond their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy metabolism.Notably,they impact GABAergic neurons and the excitation/inhibition balance.The rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock control.The mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully understood.Disturbed sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory dynamics.The mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these pathologies.In this context,the Drosophila model,though underutilized,holds promise in shedding new light on these mechanisms.Initial findings indicate its potential to introduce novel concepts,particularly in elucidating the intricate connections between the circadian clock,sleep/wake,and metabolism.Consequently,the use and transport of branched-chain amino acids emerge as critical components and orchestrators in the web of interactions across multiple organs throughout the sleep/wake cycle.They could represent one of the so far elusive mechanisms connecting sleep patterns to metabolic and cardiovascular health,paving the way for potential therapeutic interventions.展开更多
The lithospheric magnetic field is an important component of the geomagnetic field,and the oceanic lithosphere exhibits distinct characteristics.Because of its formation mechanisms,evolutionary history,and geomagnetic...The lithospheric magnetic field is an important component of the geomagnetic field,and the oceanic lithosphere exhibits distinct characteristics.Because of its formation mechanisms,evolutionary history,and geomagnetic field polarity reversals,the oceanic lithosphere has significant remanent magnetization,which causes magnetic anomaly stripes parallel to the mid-ocean ridges.However,it is difficult to construct a high-resolution lithospheric magnetic field model in oceanic regions with relatively sparse data or no data.Using forward calculated lithospheric magnetic field data based on an oceanic remanent magnetization(ORM) model with physical and geological foundations as a supplement is a feasible approach.We first collect the latest available oceanic crust age grid,plate motion model,geomagnetic polarity timescale,and oceanic lithosphere thermal structure.Combining the assumptions that the paleo geomagnetic field is a geocentric axial dipole field and that the normal oceanic crust moves only in the horizontal direction,we construct a vertically integrated ORM model of the normal oceanic crust with a known age,including the intensity,inclination,and declination.Both the ORM model and the global induced magnetization(GIM) model are then scaled from two aspects between their forward calculated results and the lithospheric magnetic field model LCS-1.One aspect is the difference in their spherical harmonic power spectra,and the other is the misfit between the grid data over the oceans.We last compare the forward calculated lithospheric magnetic anomaly from the scaled ORM and GIM models with the Macao Science Satellite-1(MSS-1) observed data.The comparison results show that the magnetic anomalies over the normal oceanic crust regions at satellite altitude are mainly contributed by the high-intensity remanent magnetization corresponding to the Cretaceous magnetic quiet period.In these regions,the predicted and observed anomalies show good consistency in spatial distribution,whereas their amplitude differences vary across regions.This result suggests that regional ORM construction should be attempted in future work to address these amplitude discrepancies.展开更多
Diatomic metasurfaces designed for interferometric mechanisms possess significant potential for the multidimensional manipulation of electromagnetic waves,including control over amplitude,phase,frequency,and polarizat...Diatomic metasurfaces designed for interferometric mechanisms possess significant potential for the multidimensional manipulation of electromagnetic waves,including control over amplitude,phase,frequency,and polarization.Geometric phase profiles with spin-selective properties are commonly associated with wavefront modulation,allowing the implementation of conjugate strategies within orthogonal circularly polarized channels.Simultaneous control of these characteristics in a single-layered diatomic metasurface will be an apparent technological extension.Here,spin-selective modulation of terahertz(THz)beams is realized by assembling a pair of meta-atoms with birefringent effects.The distinct modulation functions arise from geometric phase profiles characterized by multiple rotational properties,which introduce independent parametric factors that elucidate their physical significance.By arranging the key parameters,the proposed design strategy can be employed to realize independent amplitude and phase manipulation.A series of THz metasurface samples with specific modulation functions are characterized,experimentally demonstrating the accuracy of on-demand manipulation.This research paves the way for all-silicon meta-optics that may have great potential in imaging,sensing and detection.展开更多
BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths annually.Risk factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflamma...BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths annually.Risk factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflammatory bowel disease.Despite current treatments,survival rates for advanced CRC remain low,highlighting the need for better therapeutic strategies.AIM To evaluate both the clinical significance and the pathological implications of the Kinesin family member 14(KIF14)expression within CRC specimens.Additionally,this study aims to investigate the interaction between nitidine chloride(NC)and KIF14,considering their potential as therapeutic targets.METHODS The expression of the KIF14 protein in CRC was analyzed using immunohistochemical staining.The integration of multicenter high-throughput data facilitated the calculation of the standardized mean difference(SMD)for KIF14 mRNA levels.The assessment of clinical and pathological impact was enhanced by analyzing combined receiver operating characteristic curves,along with measures of sensitivity,specificity,and likelihood ratios.Additionally,clustered regularly interspaced short palindromic repeats knockout screening for cell growth and single-cell sequencing were employed to validate the significance of KIF14 expression in CRC.Survival analysis established the prognostic value of KIF14 in CRC.The molecular mechanism of NC against CRC was elucidated through whole-genome sequencing and enrichment analysis,and molecular docking was utilized to explore the targeting affinity between NC and KIF14.RESULTS KIF14 was highly expressed in 208 CRC patients.Data from 17 platforms involving 2436 CRC samples and 1320 noncancerous colorectal tissue controls indicated that KIF14 expression was significantly higher in CRC samples,with an SMD of 1.92(95%CI:1.49-2.35).The area under the curve was 0.94(95%CI:0.92-0.96),with a sensitivity of 0.85(95%CI:0.78-0.90)and a specificity of 0.90(95%CI:0.85-0.93).The positive and negative likelihood ratios were 8.38(95%CI:5.39-13.02)and 0.17(95%CI:0.11-0.26),respectively.At the single-cell level,significant overexpression of KIF14 was observed in CRC cells(P<0.001),with 35 CRC cell lines dependent on KIF14 for growth.The K-M plots demonstrated that KIF14 possesses prognostic value in CRC patients within the GSE71187 and GSE103679 datasets(P<0.05).Binding energy calculations indicated that KIF14 is a potential target for NC(binding energy:10.3 kcal/mol).CONCLUSION KIF14 promotes the growth of CRC cells and acts as an oncogenic factor,potentially serving as a therapeutic target for NC in the treatment of CRC.展开更多
The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatia...The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatial resolution than expected.In this paper,we developed the SDI point-spread function(PSF)and Image Bivariate Optimization Algorithm(SPIBOA)to improve the quality of SDI images.The bivariate optimization method smartly combines deep learning with optical system modeling.Despite the lack of information about the real image taken by SDI and the optical system function,this algorithm effectively estimates the PSF of the SDI imaging system directly from a large sample of observational data.We use the estimated PSF to conduct deconvolution correction to observed SDI images,and the resulting images show that the spatial resolution after correction has increased by a factor of more than three with respect to the observed ones.Meanwhile,our method also significantly reduces the inherent noise in the observed SDI images.The SPIBOA has now been successfully integrated into the routine SDI data processing,providing important support for the scientific studies based on the data.The development and application of SPIBOA also paves new ways to identify astronomical telescope systems and enhance observational image quality.Some essential factors and precautions in applying the SPIBOA method are also discussed.展开更多
Small signaling peptides,generally comprising fewer than 100 amino acids,act as crucial signaling molecules in cell-to-cell communications.Upon perception by their membrane-localized corresponding receptors or co-rece...Small signaling peptides,generally comprising fewer than 100 amino acids,act as crucial signaling molecules in cell-to-cell communications.Upon perception by their membrane-localized corresponding receptors or co-receptors,these peptide-receptor modules then(de)activate either long-distance or local signaling pathways,thereby orchestrating developmental and adaptive responses via(post)transcriptional,(post)translational,and epigenetic regulations.The physiological functions of small signaling peptides are implicated in a multitude of developmental processes and adaptive responses,including but not limited to,shoot and root morphogenesis,organ abscission,nodulation,Casparian strip formation,pollen development,taproot growth,and various abiotic stress responses such as aluminum,cadmium,drought,cold,and salinity.Additionally,they play a critical role in response to pathogenic invasions.These small signaling peptides also modulate significant agronomic and horticultural traits,such as fruit size,maize kernel development,fiber elongation,and rice awn formation.Here,we underscore the roles of several small signaling peptide families such as CLE,RALF,EPFL,mi PEP,CEP,IDA/IDL,and PSK in regulating these biological processes.These novel insights will deepen our current understanding of small signaling peptides,and offer innovative strategies for genetic breeding stress-tolerant crops and horticultural plants,contributing to establish sustainable agricultural systems.展开更多
Ovarian cancer remains a leading cause of gynecological cancer mortality1,and patients with advanced stage ovarian cancer frequently develop malignant ascites that foster immunosuppressive microenvironments and therap...Ovarian cancer remains a leading cause of gynecological cancer mortality1,and patients with advanced stage ovarian cancer frequently develop malignant ascites that foster immunosuppressive microenvironments and therapeutic resistance2,3.Although ascites have traditionally been considered detrimental,we report a paradoxical role in which they enhance the cytotoxicity ofγδT cells—a unique T cell subset that can be allogenically transferred for cancer treatment4,5—toward ovarian cancer.展开更多
Additive manufacturing(AM)has revolutionized the production of metal bone implants,enabling unprecedented levels of customization and functionality.Recent advancements in surface-modification technologies have been cr...Additive manufacturing(AM)has revolutionized the production of metal bone implants,enabling unprecedented levels of customization and functionality.Recent advancements in surface-modification technologies have been crucial in enhancing the performance and biocompatibility of implants.Through leveraging the versatility of AM techniques,particularly powder bed fusion,a range of metallic biomaterials,including stainless steel,titanium,and biodegradable alloys,can be utilized to fabricate implants tailored for craniofacial,trunk,and limb bone reconstructions.However,the potential of AM is contingent on addressing intrinsic defects that may hinder implant performance.Techniques such as sandblasting,chemical treatment,electropolishing,heat treatment,and laser technology effectively remove residual powder and improve the surface roughness of these implants.The development of functional coatings,applied via both dry and wet methods,represents a significant advancement in surface modification research.These coatings not only improve mechanical and biological interactions at the implant-bone interface but also facilitate controlled drug release and enhance antimicrobial properties.Addition-ally,micro-and nanoscale surface modifications using chemical and laser techniques can precisely sculpt implant surfaces to promote the desired cellular responses.This detailed exploration of surface engineering offers a wealth of opportunities for creating next-generation implants that are not only biocompatible but also bioactive,laying the foundation for more effective solutions in bone reconstruction.展开更多
It is urgent to develop high-performance polyimide(PI)films that simultaneously exhibit high transparency,exceptional thermal stability,mechanical robustness,and low dielectric to fulfil the requirements of flexible d...It is urgent to develop high-performance polyimide(PI)films that simultaneously exhibit high transparency,exceptional thermal stability,mechanical robustness,and low dielectric to fulfil the requirements of flexible display technologies.Herein,a series of fluorinated polyimide films(FPIs)were fabricated by the condensation of 5,5′-(perfluoropropane-2,2-diyl)bis(isobenzofuran-1,3-dione)(6FDA)and the fluorinated triphenylmethane diamine monomer(EDA,MEDA and DMEDA)with heat-crosslinkable tetrafluorostyrene side groups,which was incorporated by different numbers of methyl groups pendant in the ortho position of amino groups.Subsequently,the FPI films underwent heating to produce crosslinking FPIs(C-FPIs)through the self-crosslinking of double bonds in the tetrafluorostyrene.The transparency,solvent resistance,thermal stability,mechanical robustness and dielectric properties of FPI and C-FPI films can be tuned by the number of methyl groups and crosslinking,which were deeply investigated by virtue of molecular dynamics(MD)simulations and density functional theory(DFT).As a result,all the films exhibited exceptional optically colorless and transparent,with transmittance in the visible region of 450-700 nm exceeding 79.9%,and the cut-off wavelengths(λ_(off))were nearly 350 nm.The thermal decomposition temperatures at 5% weight loss(T_(d5%))for all samples exceeded 504℃.These films exhibited a wide range of tunable tensile strength(46.5-75.1 MPa).Significantly,they showed exceptional dielectric properties with the dielectric constant of 2.3-2.5 at full frequency(10^(7)-20 Hz).This study not only highlights the relationship between the polymer molecular structure and properties,but offer insights for balancing optical transparency,heat resistance and low dielectric constant in PI films.展开更多
This study provides a thorough investigation into the vibration behavior and impulse response characteristics of composite honeycomb cylindrical shells filled with damping gel(DG-FHCSs).To address the limitations of e...This study provides a thorough investigation into the vibration behavior and impulse response characteristics of composite honeycomb cylindrical shells filled with damping gel(DG-FHCSs).To address the limitations of existing methods,a dynamic model is developed for both free and forced vibration scenarios.These models incorporate the virtual spring technology to accurately simulate a wide range of boundary conditions.Using the first-order shear deformation theory in conjunction with the Jacobi orthogonal polynomials,an energy expression is formulated,and the natural frequencies and mode shapes are determined via the Ritz method.Based on the Newmark-βmethod,the pulse response amplitudes and attenuation characteristics under various transient excitation loads are analyzed and evaluated.The accuracy of the theoretical model and the vibration suppression capability of the damping gel are experimentally validated.Furthermore,the effects of key structural parameters on the natural frequency and vibration response are systematically examined.展开更多
Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory...Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory bulb(OB),an early target in neurodegenerative diseases,acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles.This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC).Olfactory function was assessed through olfactory discrimination tests,while iron levels in OB tissues,cerebrospinal fluid(CSF),and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS),immunohistochemical staining,and iron assays.Transcriptomic changes and immune responses were assessed using RNA sequencing and immune cell infiltration analysis.Results showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB,as well as damage to olfactory sensory neurons.Notably,these effects occurred without elevations in CSF or serum iron levels.OB iron accumulation activated multiple immune cells,including microglia and astrocytes,but did not trigger ferroptosis.Spatial transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity,with an abundance of neuroglia and neurons.Among neurons,GABAergic neurons were the most prevalent,followed by glutamatergic and dopaminergic neurons,while cholinergic and serotonergic neurons were sparsely distributed.Under iron-stressed conditions,oligodendrocytes,dopaminergic neurons,and glutamatergic neurons exhibited significant damage,while GABAergic neurons remained unaffected.These findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron dysregulation.展开更多
In order to enhance the wear resistance of 45 steel,a WC/Stellite 6 composite layer with 30%WC which with different morphologies(spherical and irregular)was prepared on the surface of 45 steel by laser cladding techno...In order to enhance the wear resistance of 45 steel,a WC/Stellite 6 composite layer with 30%WC which with different morphologies(spherical and irregular)was prepared on the surface of 45 steel by laser cladding technology.The effects of WC morphology on the phase composition,microstructure,microhardness,and wear resistance of the cladding layer were compared and analyzed.The res-ults show that the surface of the cladding layer was well formed.M_(23)C_(6),M_(7)C_(3),WC,and W_(2)C exist in both cladding layers.With the ad-dition of spherical WC,the diffraction peaks of γ-Co appear on the left side of the main peak of Co6W6C.The area of intergranular carbides accounts for a large proportion in the surface layer which with the fine grains.During the process of laser cladding the spherical WC particles with loose structure are prone to melting,including their interior.However,the melting amount of irregular WC particles is finite,which only occurs on the periphery of the particles,and the particle interior is relatively intact.The microhard-ness of two cladding layers gradient increases from the substrate to the surface layer.The surface layer added spherical WC has high-er microhardness,which reaches 790.6 HV1.Nevertheless,the wear resistance of the cladding layer added irregular WC is better than that of the cladding layer added spherical WC.The reason is because that the incompletely melted irregular WC particles are uni-formly distributed in the cladding layer which provided the support points for the cladding layer matrix during the wear process,the wear of the cladding layer by the grinding pair is reduced consequently.展开更多
Traditional pyrometallurgy and hydrometallurgy processes primarily focus on the recovery of valuable metals(Co,Ni,etc.)from spent lithium-ion batteries.However,these methods are not economical for recycling cheap LiFe...Traditional pyrometallurgy and hydrometallurgy processes primarily focus on the recovery of valuable metals(Co,Ni,etc.)from spent lithium-ion batteries.However,these methods are not economical for recycling cheap LiFePO_(4).Herein,a synergistic thermal-decomposition and electric-drive strategy is proposed to recover the whole spent LiFePO_(4)electrode by in-situ recovering the inactive lithium(dead lithium and trapped interlayer lithium).Firstly,the organic components in the dense solid electrolyte interface(SEI)are effectively decomposed through thermal-decomposition processing,exposing the dead lithium encapsulated within the SEI and recovering the electron channels between the dead lithium and graphite.Leveraging the difference between the Gibbs free energy of the dead lithium and graphite as the driving force facilitates the dead lithium inserting into the anode.Then,fully utilizing the remaining discharge capacity of the spent LiFePO_(4)cell,the inactive lithium is reinserted into LiFePO_(4)lattice during the electric-drive process.Consequently,the reactivated lithium content increases by more than 16%,reaching a capacity of 134.2 mA h g^(-1)compared to 115.2 mA h g^(-1)from degraded LiFePO_(4),allowing for effective participation in the subsequent cycling.This work provides new perspectives on highly profitable cycles with low energy and material consumption and a low carbon footprint.展开更多
Rechargeable aqueous Zn-MoO_(x)batteries are promising energy storage devices with high theoretical specific capacity and low cost.However,MoO_(3)cathodes suffer drastic capacity decay during the initial discharging/c...Rechargeable aqueous Zn-MoO_(x)batteries are promising energy storage devices with high theoretical specific capacity and low cost.However,MoO_(3)cathodes suffer drastic capacity decay during the initial discharging/charging process in conventional electrolytes,resulting in a short cycle life and challenging the development of Zn-MoO_(x)batteries.Here we comprehensively investigate the dissolution mechanism of MoO_(3)cathodes and innovatively introduce a polymer to inhibit the irreversible processes.Our findings reveal that this capacity decay originates from the irreversible Zn^(2+)/H^(+)co-intercalation/extraction process in aqueous electrolytes.Even worse,during Zn^(2+)intercalation,the formed Zn_(x)MoO_(3-x)intermediate phase with lower valence states(Mo^(5+)/Mo^(4+))experiences severe dissolution in aqueous environments.To address these challenges,we developed a first instance of coating a polyaniline(PANI)shell around the MoO_(3)nanorod effectively inhibiting these irreversible processes and protecting structural integrity during long-term cycling.Detailed structural analysis and theoretical calculations indicate that=N-groups in PANI@MoO_(3-x)simultaneously weaken H+adsorption and enhance Zn^(2+)adsorption,which endowed the PANI@MoO_(3-x)cathode with reversible Zn^(2+)/H^(+)intercalation/extraction.Consequently,the obtained PANI@MoO_(3-x)cathode delivers an excellent discharge capacity of 316.86 mA h g^(-1)at 0.1 A g^(-1)and prolonged cycling stability of 75.49%capacity retention after 1000 cycles at 5 A g^(-1).This work addresses the critical issues associated with MoO_(3)cathodes and significantly advances the understanding of competitive multi-ion energy storage mechanisms in aqueous Zn-MoO_(3)batteries.展开更多
Polyanionic materials are considered one of the most promising cathode materials for sodium-ion batteries because of the stable structure framework and high working voltage.However,most polyanionic materials possess l...Polyanionic materials are considered one of the most promising cathode materials for sodium-ion batteries because of the stable structure framework and high working voltage.However,most polyanionic materials possess limited sodium storage sites and have to undergo complex local structure evolution during charge/discharge.Herein,we conducted a systematic investigation into the impact of structural forms of NaVOPO_(4)on the electrochemical properties.Amorphous and crystalline NaVOPO_(4)are synthesized through a controlled reflux reduction method,and the amorphous NaVOPO_(4)(a-NVOP)demonstrates much better electrochemical performance compared to the crystalline counterpart.Specifically,the a-NVOP electrode delivers high reversible capacity(142 mAh g^(-1)at 14.5 mA g^(-1),close to the theoretical capacity of 145 mAh g^(-1)),high energy density(497 Wh kg^(-1)based on cathode material)and remarkable cyclability with capacity retention of 80%after 500 cycles.In situ and ex situ experimental analyses and theoretical calculations reveal that the superior performance is primarily due to the maintaining of the amorphous state during the charge/discharge process to endow high stability and accelerated intercalation/deintercalation of large-sized Na^(+)without lattice constraints.Furthermore,the amorphous cathode materials show promising electrochemical properties in lithium-,potassium-and zinc-ion batteries,highlighting their broad adaptability and potential across various battery systems.展开更多
The urgent demand for clean energy solutions has intensified the search for advanced storage materials,with rechargeable alkali-ion batteries(AIBs)playing a pivotal role in electrochemical energy storage.Enhancing ele...The urgent demand for clean energy solutions has intensified the search for advanced storage materials,with rechargeable alkali-ion batteries(AIBs)playing a pivotal role in electrochemical energy storage.Enhancing electrode performance is critical to addressing the increasing need for high-energy and high-power AIBs.Next-generation anode materials face significant challenges,including limited energy storage capacities and complex reaction mechanisms that complicate structural modeling.Sn-based materials have emerged as promising candidates for AIBs due to their inherent advantages.Recent research has increasingly focused on the development of heterojunctions as a strategy to enhance the performance of Sn-based anode materials.Despite significant advances in this field,comprehensive reviews summarizing the latest developments are still sparse.This review provides a detailed overview of recent progress in Sn-based heterojunction-type anode materials.It begins with an explanation of the concept of heterojunctions,including their fabrication,characterization,and classification.Cutting-edge research on Sn-based heterojunction-type anodes for AIBs is highlighted.Finally,the review summarizes the latest advancements in heterojunction technology and discusses future directions for research and development in this area.展开更多
As a green sustainable alternative technology,synthesizing nitrate by electrocatalytic nitrogen oxidation reaction(NOR)can replace the traditional energyintensive Ostwald process.But low nitrogen fixation yields and p...As a green sustainable alternative technology,synthesizing nitrate by electrocatalytic nitrogen oxidation reaction(NOR)can replace the traditional energyintensive Ostwald process.But low nitrogen fixation yields and poor selectivity due to the high bond energy of the N≡N bond and competition from the oxygen evolution reaction in the electrolyte restrict its application.On the other hand,two-dimensional(2D)PdS_(2)as a member in the family of group-10 novel transition metal dichalcogenides(NTMDs)presents the interesting optical and electronic properties due to its novel folded pentagonal structure,but few researches involve to its fabrication and application.Herein,unique imitating growth feature for PdS_(2)on different 2D substrates has been firstly discovered for constructing 2D/2D heterostructures by interface engineering.Due to the different exposed chemical groups on the substrates,PdS_(2)grows as the imitation to the morphologies of the substrates and presents different thickness,size,shape and the degree of oxidation,resulting in the significant difference in the NOR activity and stability of the obtained composite catalysts.Especially,the thin and small PdS_(2)nanoplates with more defects can be obtained by decorating poly(1-vinyl-3-ethylimidazolium bromide)on the 2D substrate,easily oxidized during the preparation process,resulting in the in situ generation of SO_(4)^(2−),which plays a crucial role in reducing the activation energy of the NOR process,leading to improved efficiency for nitrate production,verified by theoretical calculation.This research provides valuable insights for the development of novel electrocatalysts based on NTMDs for NOR and highlights the importance of interface engineering in enhancing catalytic performance.展开更多
BACKGROUND Gastric neuroendocrine carcinomas(NECs)exhibit aggressive features,such as rapid growth,higher rate of metastasis,and a generally unfavorable prognosis compared to gastric adenocarcinoma.As a result,therape...BACKGROUND Gastric neuroendocrine carcinomas(NECs)exhibit aggressive features,such as rapid growth,higher rate of metastasis,and a generally unfavorable prognosis compared to gastric adenocarcinoma.As a result,therapeutic options for NECs remain limited,contributing to the poor prognosis of patients.Immunotherapy has emerged as a promising treatment strategy and demonstrated the potential to partially improve the survival and prognosis of patients with NECs.Nevertheless,the unique clinical response termed pseudoprogression(PsP)has garnered considerable attention in the context of immunotherapy.CASE SUMMARY Presented here is a case of NEC recurrence five and a half months after radical gastric surgery.The 45-year-old male patient underwent combination treatment involving a PD-1 blocker and tyrosine kinase inhibitors and encountered two instances of PsP during treatment.The patient ultimately achieved a durable treatment response without altering his treatment regimens,resulting in a substantial therapeutic benefit.CONCLUSION This case report aimed to provide the authors’experience with the diagnosis of PsP and treatment strategies for PsP in ongoing immunotherapy.展开更多
Traditional quantum circuit scheduling approaches underutilize the inherent parallelism of quantum computation in the Noisy Intermediate-Scale Quantum(NISQ)era,overlook the inter-layer operations can be further parall...Traditional quantum circuit scheduling approaches underutilize the inherent parallelism of quantum computation in the Noisy Intermediate-Scale Quantum(NISQ)era,overlook the inter-layer operations can be further parallelized.Based on this,two quantum circuit scheduling optimization approaches are designed and integrated into the quantum circuit compilation process.Firstly,we introduce the Layered Topology Scheduling Approach(LTSA),which employs a greedy algorithm and leverages the principles of topological sorting in graph theory.LTSA allocates quantum gates to a layered structure,maximizing the concurrent execution of quantum gate operations.Secondly,the Layerwise Conflict Resolution Approach(LCRA)is proposed.LCRA focuses on utilizing directly executable quantum gates within layers.Through the insertion of SWAP gates and conflict resolution checks,it minimizes conflicts and enhances parallelism,thereby optimizing the overall computational efficiency.Experimental findings indicate that LTSA and LCRA individually achieve a noteworthy reduction of 51.1%and 53.2%,respectively,in the number of inserted SWAP gates.Additionally,they contribute to a decrease in hardware gate overhead by 14.7%and 15%,respectively.Considering the intricate nature of quantum circuits and the temporal dependencies among different layers,the amalgamation of both approaches leads to a remarkable 51.6%reduction in inserted SWAP gates and a 14.8%decrease in hardware gate overhead.These results underscore the efficacy of the combined LTSA and LCRA in optimizing quantum circuit compilation.展开更多
Semantic segmentation of concrete bridge defect images frequently encounters challenges due to insufficient precision and the limited computational capabilities ofmobile devices,thereby considerably affecting the reli...Semantic segmentation of concrete bridge defect images frequently encounters challenges due to insufficient precision and the limited computational capabilities ofmobile devices,thereby considerably affecting the reliability of bridge defect monitoring and health assessment.To tackle these issues,a concrete defects dataset(including spalling,crack,and exposed steel rebar)was curated and multiple semantic segmentation models were developed.In these models,a deep convolutional network or a lightweight convolutional network were employed as the backbone feature extraction networks,with different loss functions configured and various attention mechanism modules introduced for conducting multi-angle comparative research.The comparison of results indicates that utilizing VGG16 as the backbone network of U-Net for semantic segmentation of multi-class concrete defects images resulted in the highest recognition accuracy,achieving a Mean Intersection over Union(MIoU)of 80.37%and a Mean Pixel Accuracy(MPA)of 90.03%.The optimal combination of loss functions was found to be Focal loss and Dice loss.The lightweight convolutional network Mobile NetV2-DeeplabV3 slightly reduced recognition accuracy but significantly decreased the number of parameters,resulting in a faster detection speed of 71.87 frames/s,making it suitable for real-time defect detection.After integrating the SE(Squeeze-and-Excitation),CBAM(Convolutional Block Attention Module),and Coordinate Attention(CA)modules,both VGG16-U-Net and MobileNetV2-DeeplabV3 achieved improved recognition accuracy.Among them,the CAmodule(Coordinate Attention)effectively guides the model to accurately identify subtle concrete defects.The improved VGG16-U-Net can identify previously the new untrained concrete defect images in the concrete structural health monitoring(SHM)system,and the recognition accuracy can meet the demand for intelligent defect image recognition for structural health monitoring of concrete structures.展开更多
基金supported by a grant from the French Society of Sleep Research and Medicine(to LS)The China Scholarship Council(to HL)The CNRS,INSERM,Claude Bernard University Lyon1(to LS)。
文摘The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular well-being.Given the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other organs.Among these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral processes.Among the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of rapamycin.Branched-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared transporter.Beyond their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy metabolism.Notably,they impact GABAergic neurons and the excitation/inhibition balance.The rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock control.The mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully understood.Disturbed sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory dynamics.The mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these pathologies.In this context,the Drosophila model,though underutilized,holds promise in shedding new light on these mechanisms.Initial findings indicate its potential to introduce novel concepts,particularly in elucidating the intricate connections between the circadian clock,sleep/wake,and metabolism.Consequently,the use and transport of branched-chain amino acids emerge as critical components and orchestrators in the web of interactions across multiple organs throughout the sleep/wake cycle.They could represent one of the so far elusive mechanisms connecting sleep patterns to metabolic and cardiovascular health,paving the way for potential therapeutic interventions.
基金supported by the National Natural Science Foundation of China (41804067, 42174090, 42250101, and 42250103)the Science Research Project of the Hebei Education Department (BJK2024107)+3 种基金the Hebei Natural Science Foundation (D2022403044)the Opening Fund of the Key Laboratory of Geological Survey and Evaluation of the Ministry of Education (GLAB2023ZR02)the MOST Special Fund from the State Key Laboratory of Geological Processes and Mineral Resources (MSFGPMR2022-4)the Excellent Young Scientist Fund of Hebei GEO University (YQ202403)。
文摘The lithospheric magnetic field is an important component of the geomagnetic field,and the oceanic lithosphere exhibits distinct characteristics.Because of its formation mechanisms,evolutionary history,and geomagnetic field polarity reversals,the oceanic lithosphere has significant remanent magnetization,which causes magnetic anomaly stripes parallel to the mid-ocean ridges.However,it is difficult to construct a high-resolution lithospheric magnetic field model in oceanic regions with relatively sparse data or no data.Using forward calculated lithospheric magnetic field data based on an oceanic remanent magnetization(ORM) model with physical and geological foundations as a supplement is a feasible approach.We first collect the latest available oceanic crust age grid,plate motion model,geomagnetic polarity timescale,and oceanic lithosphere thermal structure.Combining the assumptions that the paleo geomagnetic field is a geocentric axial dipole field and that the normal oceanic crust moves only in the horizontal direction,we construct a vertically integrated ORM model of the normal oceanic crust with a known age,including the intensity,inclination,and declination.Both the ORM model and the global induced magnetization(GIM) model are then scaled from two aspects between their forward calculated results and the lithospheric magnetic field model LCS-1.One aspect is the difference in their spherical harmonic power spectra,and the other is the misfit between the grid data over the oceans.We last compare the forward calculated lithospheric magnetic anomaly from the scaled ORM and GIM models with the Macao Science Satellite-1(MSS-1) observed data.The comparison results show that the magnetic anomalies over the normal oceanic crust regions at satellite altitude are mainly contributed by the high-intensity remanent magnetization corresponding to the Cretaceous magnetic quiet period.In these regions,the predicted and observed anomalies show good consistency in spatial distribution,whereas their amplitude differences vary across regions.This result suggests that regional ORM construction should be attempted in future work to address these amplitude discrepancies.
基金supports from National Key Research and Development Program of China(2021YFB2800703)Sichuan Province Science and Technology Support Program(25QNJJ2419)+1 种基金National Natural Science Foundation of China(U22A2008,12404484)Laoshan Laboratory Science and Technology Innovation Project(LSKJ202200801).
文摘Diatomic metasurfaces designed for interferometric mechanisms possess significant potential for the multidimensional manipulation of electromagnetic waves,including control over amplitude,phase,frequency,and polarization.Geometric phase profiles with spin-selective properties are commonly associated with wavefront modulation,allowing the implementation of conjugate strategies within orthogonal circularly polarized channels.Simultaneous control of these characteristics in a single-layered diatomic metasurface will be an apparent technological extension.Here,spin-selective modulation of terahertz(THz)beams is realized by assembling a pair of meta-atoms with birefringent effects.The distinct modulation functions arise from geometric phase profiles characterized by multiple rotational properties,which introduce independent parametric factors that elucidate their physical significance.By arranging the key parameters,the proposed design strategy can be employed to realize independent amplitude and phase manipulation.A series of THz metasurface samples with specific modulation functions are characterized,experimentally demonstrating the accuracy of on-demand manipulation.This research paves the way for all-silicon meta-optics that may have great potential in imaging,sensing and detection.
基金Natural Science Foundation of Shandong Province,No.ZR2020QH185Scientific Research Nurturing Fund of The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan Hospital,No.QYPY2020NSFC0803+2 种基金Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project,No.Z-A20220415Guangxi Medical University Teacher Teaching Ability Development Project,No.2022JFA02Guangxi Medical University Undergraduate Education and Teaching Reform Project,No.2023Y05.
文摘BACKGROUND Colorectal cancer(CRC)is the third most common cancer globally,causing over 900000 deaths annually.Risk factors include aging,diet,obesity,sedentary lifestyle,tobacco use,genetic predisposition,and inflammatory bowel disease.Despite current treatments,survival rates for advanced CRC remain low,highlighting the need for better therapeutic strategies.AIM To evaluate both the clinical significance and the pathological implications of the Kinesin family member 14(KIF14)expression within CRC specimens.Additionally,this study aims to investigate the interaction between nitidine chloride(NC)and KIF14,considering their potential as therapeutic targets.METHODS The expression of the KIF14 protein in CRC was analyzed using immunohistochemical staining.The integration of multicenter high-throughput data facilitated the calculation of the standardized mean difference(SMD)for KIF14 mRNA levels.The assessment of clinical and pathological impact was enhanced by analyzing combined receiver operating characteristic curves,along with measures of sensitivity,specificity,and likelihood ratios.Additionally,clustered regularly interspaced short palindromic repeats knockout screening for cell growth and single-cell sequencing were employed to validate the significance of KIF14 expression in CRC.Survival analysis established the prognostic value of KIF14 in CRC.The molecular mechanism of NC against CRC was elucidated through whole-genome sequencing and enrichment analysis,and molecular docking was utilized to explore the targeting affinity between NC and KIF14.RESULTS KIF14 was highly expressed in 208 CRC patients.Data from 17 platforms involving 2436 CRC samples and 1320 noncancerous colorectal tissue controls indicated that KIF14 expression was significantly higher in CRC samples,with an SMD of 1.92(95%CI:1.49-2.35).The area under the curve was 0.94(95%CI:0.92-0.96),with a sensitivity of 0.85(95%CI:0.78-0.90)and a specificity of 0.90(95%CI:0.85-0.93).The positive and negative likelihood ratios were 8.38(95%CI:5.39-13.02)and 0.17(95%CI:0.11-0.26),respectively.At the single-cell level,significant overexpression of KIF14 was observed in CRC cells(P<0.001),with 35 CRC cell lines dependent on KIF14 for growth.The K-M plots demonstrated that KIF14 possesses prognostic value in CRC patients within the GSE71187 and GSE103679 datasets(P<0.05).Binding energy calculations indicated that KIF14 is a potential target for NC(binding energy:10.3 kcal/mol).CONCLUSION KIF14 promotes the growth of CRC cells and acts as an oncogenic factor,potentially serving as a therapeutic target for NC in the treatment of CRC.
基金supported by the National Natural Science Foundation of China(NSFC)under grant No.12233012,the Strategic Priority Research Program of the Chinese Academy of Sciences,grant No.XDB0560102the National Key R&D Program of China 2022YFF0503003(2022YFF0503000)。
文摘The in-flight calibration and performance of the Solar Disk Imager(SDI),which is a pivotal instrument of the LyαSolar Telescope onboard the Advanced Space-based Solar Observatory mission,suggested a much lower spatial resolution than expected.In this paper,we developed the SDI point-spread function(PSF)and Image Bivariate Optimization Algorithm(SPIBOA)to improve the quality of SDI images.The bivariate optimization method smartly combines deep learning with optical system modeling.Despite the lack of information about the real image taken by SDI and the optical system function,this algorithm effectively estimates the PSF of the SDI imaging system directly from a large sample of observational data.We use the estimated PSF to conduct deconvolution correction to observed SDI images,and the resulting images show that the spatial resolution after correction has increased by a factor of more than three with respect to the observed ones.Meanwhile,our method also significantly reduces the inherent noise in the observed SDI images.The SPIBOA has now been successfully integrated into the routine SDI data processing,providing important support for the scientific studies based on the data.The development and application of SPIBOA also paves new ways to identify astronomical telescope systems and enhance observational image quality.Some essential factors and precautions in applying the SPIBOA method are also discussed.
基金supported by funding from Jiangxi Agricultural University(9232308314 to Huibin Han)Science and Technology Department of Jiangxi Province(20223BCJ25037 to Huibin Han and 20202ACB215002 to Shuaiying Peng)+1 种基金the Outstanding Youth Fund Project of the Natural Science Foundation of Jiangxi Province,China(20242BAB23066 to Yong Zhou)National Natural Science Foundation of China(32060047 to Jianping Liu,32160739 to Youxin Yang,32460797 to Yong Zhou and 32460081 to Huibin Han)。
文摘Small signaling peptides,generally comprising fewer than 100 amino acids,act as crucial signaling molecules in cell-to-cell communications.Upon perception by their membrane-localized corresponding receptors or co-receptors,these peptide-receptor modules then(de)activate either long-distance or local signaling pathways,thereby orchestrating developmental and adaptive responses via(post)transcriptional,(post)translational,and epigenetic regulations.The physiological functions of small signaling peptides are implicated in a multitude of developmental processes and adaptive responses,including but not limited to,shoot and root morphogenesis,organ abscission,nodulation,Casparian strip formation,pollen development,taproot growth,and various abiotic stress responses such as aluminum,cadmium,drought,cold,and salinity.Additionally,they play a critical role in response to pathogenic invasions.These small signaling peptides also modulate significant agronomic and horticultural traits,such as fruit size,maize kernel development,fiber elongation,and rice awn formation.Here,we underscore the roles of several small signaling peptide families such as CLE,RALF,EPFL,mi PEP,CEP,IDA/IDL,and PSK in regulating these biological processes.These novel insights will deepen our current understanding of small signaling peptides,and offer innovative strategies for genetic breeding stress-tolerant crops and horticultural plants,contributing to establish sustainable agricultural systems.
基金supported by the National Natural Science Foundation of China(Grant No.82274034)the Peking University Medicine plus X Pilot Program-Platform Construction Project(Grant No.2024YXXLHPT004).
文摘Ovarian cancer remains a leading cause of gynecological cancer mortality1,and patients with advanced stage ovarian cancer frequently develop malignant ascites that foster immunosuppressive microenvironments and therapeutic resistance2,3.Although ascites have traditionally been considered detrimental,we report a paradoxical role in which they enhance the cytotoxicity ofγδT cells—a unique T cell subset that can be allogenically transferred for cancer treatment4,5—toward ovarian cancer.
基金supported by National Natural Science Foundation of China(Grant No.52275343)Natural Science Foundation of Zhejiang Province(Grant No.LY23E050003)Ningbo Youth Science and Technology Innovation Leading Talent Project(Grant No.2023QL021).
文摘Additive manufacturing(AM)has revolutionized the production of metal bone implants,enabling unprecedented levels of customization and functionality.Recent advancements in surface-modification technologies have been crucial in enhancing the performance and biocompatibility of implants.Through leveraging the versatility of AM techniques,particularly powder bed fusion,a range of metallic biomaterials,including stainless steel,titanium,and biodegradable alloys,can be utilized to fabricate implants tailored for craniofacial,trunk,and limb bone reconstructions.However,the potential of AM is contingent on addressing intrinsic defects that may hinder implant performance.Techniques such as sandblasting,chemical treatment,electropolishing,heat treatment,and laser technology effectively remove residual powder and improve the surface roughness of these implants.The development of functional coatings,applied via both dry and wet methods,represents a significant advancement in surface modification research.These coatings not only improve mechanical and biological interactions at the implant-bone interface but also facilitate controlled drug release and enhance antimicrobial properties.Addition-ally,micro-and nanoscale surface modifications using chemical and laser techniques can precisely sculpt implant surfaces to promote the desired cellular responses.This detailed exploration of surface engineering offers a wealth of opportunities for creating next-generation implants that are not only biocompatible but also bioactive,laying the foundation for more effective solutions in bone reconstruction.
基金financially supported by the Natural Science Foundation of Shandong Province(Nos.ZR2021ME055,ZR2022QB170 and ZR2022MB034)the Foundation(No.GZKF202128)of State Key Laboratory of Biobased Material and Green Papermaking,Qilu University of Technology,Shandong Academy of Sciencesthe Development Program Project of Young Innovation Team of Institutions of Higher Learning in Shandong Province.
文摘It is urgent to develop high-performance polyimide(PI)films that simultaneously exhibit high transparency,exceptional thermal stability,mechanical robustness,and low dielectric to fulfil the requirements of flexible display technologies.Herein,a series of fluorinated polyimide films(FPIs)were fabricated by the condensation of 5,5′-(perfluoropropane-2,2-diyl)bis(isobenzofuran-1,3-dione)(6FDA)and the fluorinated triphenylmethane diamine monomer(EDA,MEDA and DMEDA)with heat-crosslinkable tetrafluorostyrene side groups,which was incorporated by different numbers of methyl groups pendant in the ortho position of amino groups.Subsequently,the FPI films underwent heating to produce crosslinking FPIs(C-FPIs)through the self-crosslinking of double bonds in the tetrafluorostyrene.The transparency,solvent resistance,thermal stability,mechanical robustness and dielectric properties of FPI and C-FPI films can be tuned by the number of methyl groups and crosslinking,which were deeply investigated by virtue of molecular dynamics(MD)simulations and density functional theory(DFT).As a result,all the films exhibited exceptional optically colorless and transparent,with transmittance in the visible region of 450-700 nm exceeding 79.9%,and the cut-off wavelengths(λ_(off))were nearly 350 nm.The thermal decomposition temperatures at 5% weight loss(T_(d5%))for all samples exceeded 504℃.These films exhibited a wide range of tunable tensile strength(46.5-75.1 MPa).Significantly,they showed exceptional dielectric properties with the dielectric constant of 2.3-2.5 at full frequency(10^(7)-20 Hz).This study not only highlights the relationship between the polymer molecular structure and properties,but offer insights for balancing optical transparency,heat resistance and low dielectric constant in PI films.
基金supported by the National Natural Science Foundation of China(Nos.12472005 and 52175079)the Aerospace Science Foundation of China(No.2022Z009050002)+2 种基金the Key Laboratory of Vibration and Control of Aero-Propulsion SystemMinistry of Education of China(No.VCAME201603)the Tai-Hang Laboratory Program(No.AK023)。
文摘This study provides a thorough investigation into the vibration behavior and impulse response characteristics of composite honeycomb cylindrical shells filled with damping gel(DG-FHCSs).To address the limitations of existing methods,a dynamic model is developed for both free and forced vibration scenarios.These models incorporate the virtual spring technology to accurately simulate a wide range of boundary conditions.Using the first-order shear deformation theory in conjunction with the Jacobi orthogonal polynomials,an energy expression is formulated,and the natural frequencies and mode shapes are determined via the Ritz method.Based on the Newmark-βmethod,the pulse response amplitudes and attenuation characteristics under various transient excitation loads are analyzed and evaluated.The accuracy of the theoretical model and the vibration suppression capability of the damping gel are experimentally validated.Furthermore,the effects of key structural parameters on the natural frequency and vibration response are systematically examined.
基金supported by the National Natural Science Foundation of China (32471188,32170984,82301787)。
文摘Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function;however,its abnormal accumulation is also implicated in various neurological disorders.The olfactory bulb(OB),an early target in neurodegenerative diseases,acts as a gateway for environmental toxins and contains diverse neuronal populations with distinct roles.This study explored the cell-specific vulnerability to iron in the OB using a mouse model of intranasal administration of ferric ammonium citrate(FAC).Olfactory function was assessed through olfactory discrimination tests,while iron levels in OB tissues,cerebrospinal fluid(CSF),and serum were quantified using inductively coupled plasma mass spectrometry(ICP-MS),immunohistochemical staining,and iron assays.Transcriptomic changes and immune responses were assessed using RNA sequencing and immune cell infiltration analysis.Results showed that intranasal FAC administration impaired olfactory function,accompanied by iron deposition in the olfactory mucosa and OB,as well as damage to olfactory sensory neurons.Notably,these effects occurred without elevations in CSF or serum iron levels.OB iron accumulation activated multiple immune cells,including microglia and astrocytes,but did not trigger ferroptosis.Spatial transcriptomic sequencing of healthy adult mouse OBs revealed significant cellular heterogeneity,with an abundance of neuroglia and neurons.Among neurons,GABAergic neurons were the most prevalent,followed by glutamatergic and dopaminergic neurons,while cholinergic and serotonergic neurons were sparsely distributed.Under iron-stressed conditions,oligodendrocytes,dopaminergic neurons,and glutamatergic neurons exhibited significant damage,while GABAergic neurons remained unaffected.These findings highlight the selective vulnerability of neuronal and glial populations to iron-induced stress,offering novel insights into the loss of specific cell types in the OB during iron dysregulation.
基金supported by the National Natural Science Foundation of China(52161007)Science and Technology Planning Project of Guangdong Province of China(20170902,20180902)+1 种基金Science and Technology Planning Project of Yangjiang City of Guangdong Province(SDZX2020009)Research project of Shenzhen city(JSGG20210420091802007).
文摘In order to enhance the wear resistance of 45 steel,a WC/Stellite 6 composite layer with 30%WC which with different morphologies(spherical and irregular)was prepared on the surface of 45 steel by laser cladding technology.The effects of WC morphology on the phase composition,microstructure,microhardness,and wear resistance of the cladding layer were compared and analyzed.The res-ults show that the surface of the cladding layer was well formed.M_(23)C_(6),M_(7)C_(3),WC,and W_(2)C exist in both cladding layers.With the ad-dition of spherical WC,the diffraction peaks of γ-Co appear on the left side of the main peak of Co6W6C.The area of intergranular carbides accounts for a large proportion in the surface layer which with the fine grains.During the process of laser cladding the spherical WC particles with loose structure are prone to melting,including their interior.However,the melting amount of irregular WC particles is finite,which only occurs on the periphery of the particles,and the particle interior is relatively intact.The microhard-ness of two cladding layers gradient increases from the substrate to the surface layer.The surface layer added spherical WC has high-er microhardness,which reaches 790.6 HV1.Nevertheless,the wear resistance of the cladding layer added irregular WC is better than that of the cladding layer added spherical WC.The reason is because that the incompletely melted irregular WC particles are uni-formly distributed in the cladding layer which provided the support points for the cladding layer matrix during the wear process,the wear of the cladding layer by the grinding pair is reduced consequently.
基金supported by the Key Technologies R&D Program of Xiamen(No.3502Z20231057)the Natural Science Foundation of Fujian Province,China(No.2024J011210,No.2021J011214,No.2021J01685)+5 种基金the High-Level Talent Start-Up Foundation of Xiamen Institute of Technology for financial support(No.YKJ23017R)the Industry Leading Key Projects of Fujian Province(No.2022H0057)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2020R01002)the Fujian Young and Middle-aged Teachers Teacher Education Research Project(Science and Technology)(No.JAT200461)2023 Xiamen Overseas Students Scientific Research Project(Start-up)the National Natural Science Foundation of China(No.21975212,No.22101242,No.52002352,No.52071295)。
文摘Traditional pyrometallurgy and hydrometallurgy processes primarily focus on the recovery of valuable metals(Co,Ni,etc.)from spent lithium-ion batteries.However,these methods are not economical for recycling cheap LiFePO_(4).Herein,a synergistic thermal-decomposition and electric-drive strategy is proposed to recover the whole spent LiFePO_(4)electrode by in-situ recovering the inactive lithium(dead lithium and trapped interlayer lithium).Firstly,the organic components in the dense solid electrolyte interface(SEI)are effectively decomposed through thermal-decomposition processing,exposing the dead lithium encapsulated within the SEI and recovering the electron channels between the dead lithium and graphite.Leveraging the difference between the Gibbs free energy of the dead lithium and graphite as the driving force facilitates the dead lithium inserting into the anode.Then,fully utilizing the remaining discharge capacity of the spent LiFePO_(4)cell,the inactive lithium is reinserted into LiFePO_(4)lattice during the electric-drive process.Consequently,the reactivated lithium content increases by more than 16%,reaching a capacity of 134.2 mA h g^(-1)compared to 115.2 mA h g^(-1)from degraded LiFePO_(4),allowing for effective participation in the subsequent cycling.This work provides new perspectives on highly profitable cycles with low energy and material consumption and a low carbon footprint.
基金supported by National Natural Science Foundation of China(22209064,52071171,and 52202248)the Fundamental Research Funds for Public Universities in Liaoning(LJKLJ202434)+6 种基金the Australian Research Council(ARC)through Future Fellowship(FT210100298)Discovery Project(DP220100603)Linkage Project(LP210200504,LP220100088,LP230200897)Industrial Transformation Research Hub(IH240100009)schemesthe Australian Government through the Cooperative Research Centres Projects(CRCPXIII000077)the Australian Renewable Energy Agency(ARENA)as part of ARENA’s Transformative Research Accelerating Commercialisation Program(TM021)European Commission’s Australia-Spain Network for Innovation and Research Excellence(AuSpire)。
文摘Rechargeable aqueous Zn-MoO_(x)batteries are promising energy storage devices with high theoretical specific capacity and low cost.However,MoO_(3)cathodes suffer drastic capacity decay during the initial discharging/charging process in conventional electrolytes,resulting in a short cycle life and challenging the development of Zn-MoO_(x)batteries.Here we comprehensively investigate the dissolution mechanism of MoO_(3)cathodes and innovatively introduce a polymer to inhibit the irreversible processes.Our findings reveal that this capacity decay originates from the irreversible Zn^(2+)/H^(+)co-intercalation/extraction process in aqueous electrolytes.Even worse,during Zn^(2+)intercalation,the formed Zn_(x)MoO_(3-x)intermediate phase with lower valence states(Mo^(5+)/Mo^(4+))experiences severe dissolution in aqueous environments.To address these challenges,we developed a first instance of coating a polyaniline(PANI)shell around the MoO_(3)nanorod effectively inhibiting these irreversible processes and protecting structural integrity during long-term cycling.Detailed structural analysis and theoretical calculations indicate that=N-groups in PANI@MoO_(3-x)simultaneously weaken H+adsorption and enhance Zn^(2+)adsorption,which endowed the PANI@MoO_(3-x)cathode with reversible Zn^(2+)/H^(+)intercalation/extraction.Consequently,the obtained PANI@MoO_(3-x)cathode delivers an excellent discharge capacity of 316.86 mA h g^(-1)at 0.1 A g^(-1)and prolonged cycling stability of 75.49%capacity retention after 1000 cycles at 5 A g^(-1).This work addresses the critical issues associated with MoO_(3)cathodes and significantly advances the understanding of competitive multi-ion energy storage mechanisms in aqueous Zn-MoO_(3)batteries.
基金financially supported by the National Nature Science Foundation of China(Nos.22209125,22479118,and 22479117)the National Key Research and Development Program of China(No.2021YFB3800300)
文摘Polyanionic materials are considered one of the most promising cathode materials for sodium-ion batteries because of the stable structure framework and high working voltage.However,most polyanionic materials possess limited sodium storage sites and have to undergo complex local structure evolution during charge/discharge.Herein,we conducted a systematic investigation into the impact of structural forms of NaVOPO_(4)on the electrochemical properties.Amorphous and crystalline NaVOPO_(4)are synthesized through a controlled reflux reduction method,and the amorphous NaVOPO_(4)(a-NVOP)demonstrates much better electrochemical performance compared to the crystalline counterpart.Specifically,the a-NVOP electrode delivers high reversible capacity(142 mAh g^(-1)at 14.5 mA g^(-1),close to the theoretical capacity of 145 mAh g^(-1)),high energy density(497 Wh kg^(-1)based on cathode material)and remarkable cyclability with capacity retention of 80%after 500 cycles.In situ and ex situ experimental analyses and theoretical calculations reveal that the superior performance is primarily due to the maintaining of the amorphous state during the charge/discharge process to endow high stability and accelerated intercalation/deintercalation of large-sized Na^(+)without lattice constraints.Furthermore,the amorphous cathode materials show promising electrochemical properties in lithium-,potassium-and zinc-ion batteries,highlighting their broad adaptability and potential across various battery systems.
文摘The urgent demand for clean energy solutions has intensified the search for advanced storage materials,with rechargeable alkali-ion batteries(AIBs)playing a pivotal role in electrochemical energy storage.Enhancing electrode performance is critical to addressing the increasing need for high-energy and high-power AIBs.Next-generation anode materials face significant challenges,including limited energy storage capacities and complex reaction mechanisms that complicate structural modeling.Sn-based materials have emerged as promising candidates for AIBs due to their inherent advantages.Recent research has increasingly focused on the development of heterojunctions as a strategy to enhance the performance of Sn-based anode materials.Despite significant advances in this field,comprehensive reviews summarizing the latest developments are still sparse.This review provides a detailed overview of recent progress in Sn-based heterojunction-type anode materials.It begins with an explanation of the concept of heterojunctions,including their fabrication,characterization,and classification.Cutting-edge research on Sn-based heterojunction-type anodes for AIBs is highlighted.Finally,the review summarizes the latest advancements in heterojunction technology and discusses future directions for research and development in this area.
基金the Australian Research Council (ARC) through Future Fellowship (FT210100298)Discovery Project (DP220100603)+8 种基金Linkage Project (LP210200504,LP220100088, LP230200897)Industrial Transformation Research Hub (IH240100009) schemesthe Australian Government through the Cooperative Research Centres Projects (CRCPXIII000077)the Australian Renewable Energy Agency (ARENA) as part of ARENA’s Transformative Research Accelerating Commercialisation Program (TM021)European Commission’s Australia-Spain Network for Innovation and Research Excellence (Au Spire)the Foundation of Liaoning Province Education Administration (2020LQN03)the Foundation of Liaoning Province Education Administration in 2024 (Independent topic selection-Natural science category-Strategic industrialization project LJ212410163023)the Scientific Research Fund of Liaoning Provincial Education Department (JYTMS20230767)the Liaoning Revitalization Talents Program (XLYC2007132)
文摘As a green sustainable alternative technology,synthesizing nitrate by electrocatalytic nitrogen oxidation reaction(NOR)can replace the traditional energyintensive Ostwald process.But low nitrogen fixation yields and poor selectivity due to the high bond energy of the N≡N bond and competition from the oxygen evolution reaction in the electrolyte restrict its application.On the other hand,two-dimensional(2D)PdS_(2)as a member in the family of group-10 novel transition metal dichalcogenides(NTMDs)presents the interesting optical and electronic properties due to its novel folded pentagonal structure,but few researches involve to its fabrication and application.Herein,unique imitating growth feature for PdS_(2)on different 2D substrates has been firstly discovered for constructing 2D/2D heterostructures by interface engineering.Due to the different exposed chemical groups on the substrates,PdS_(2)grows as the imitation to the morphologies of the substrates and presents different thickness,size,shape and the degree of oxidation,resulting in the significant difference in the NOR activity and stability of the obtained composite catalysts.Especially,the thin and small PdS_(2)nanoplates with more defects can be obtained by decorating poly(1-vinyl-3-ethylimidazolium bromide)on the 2D substrate,easily oxidized during the preparation process,resulting in the in situ generation of SO_(4)^(2−),which plays a crucial role in reducing the activation energy of the NOR process,leading to improved efficiency for nitrate production,verified by theoretical calculation.This research provides valuable insights for the development of novel electrocatalysts based on NTMDs for NOR and highlights the importance of interface engineering in enhancing catalytic performance.
基金Wu Jieping Medical Foundation,No.320.6750.2021-02-113.
文摘BACKGROUND Gastric neuroendocrine carcinomas(NECs)exhibit aggressive features,such as rapid growth,higher rate of metastasis,and a generally unfavorable prognosis compared to gastric adenocarcinoma.As a result,therapeutic options for NECs remain limited,contributing to the poor prognosis of patients.Immunotherapy has emerged as a promising treatment strategy and demonstrated the potential to partially improve the survival and prognosis of patients with NECs.Nevertheless,the unique clinical response termed pseudoprogression(PsP)has garnered considerable attention in the context of immunotherapy.CASE SUMMARY Presented here is a case of NEC recurrence five and a half months after radical gastric surgery.The 45-year-old male patient underwent combination treatment involving a PD-1 blocker and tyrosine kinase inhibitors and encountered two instances of PsP during treatment.The patient ultimately achieved a durable treatment response without altering his treatment regimens,resulting in a substantial therapeutic benefit.CONCLUSION This case report aimed to provide the authors’experience with the diagnosis of PsP and treatment strategies for PsP in ongoing immunotherapy.
基金funded by the Natural Science Foundation of Heilongjiang Province(Grant No.LH2022F035)the Cultivation Programme for Young Innovative Talents in Ordinary Higher Education Institutions of Heilongjiang Province(Grant No.UNPYSCT-2020212)the Cultivation Programme for Young Innovative Talents in Scientific Research of Harbin University of Commerce(Grant No.2023-KYYWF-0983).
文摘Traditional quantum circuit scheduling approaches underutilize the inherent parallelism of quantum computation in the Noisy Intermediate-Scale Quantum(NISQ)era,overlook the inter-layer operations can be further parallelized.Based on this,two quantum circuit scheduling optimization approaches are designed and integrated into the quantum circuit compilation process.Firstly,we introduce the Layered Topology Scheduling Approach(LTSA),which employs a greedy algorithm and leverages the principles of topological sorting in graph theory.LTSA allocates quantum gates to a layered structure,maximizing the concurrent execution of quantum gate operations.Secondly,the Layerwise Conflict Resolution Approach(LCRA)is proposed.LCRA focuses on utilizing directly executable quantum gates within layers.Through the insertion of SWAP gates and conflict resolution checks,it minimizes conflicts and enhances parallelism,thereby optimizing the overall computational efficiency.Experimental findings indicate that LTSA and LCRA individually achieve a noteworthy reduction of 51.1%and 53.2%,respectively,in the number of inserted SWAP gates.Additionally,they contribute to a decrease in hardware gate overhead by 14.7%and 15%,respectively.Considering the intricate nature of quantum circuits and the temporal dependencies among different layers,the amalgamation of both approaches leads to a remarkable 51.6%reduction in inserted SWAP gates and a 14.8%decrease in hardware gate overhead.These results underscore the efficacy of the combined LTSA and LCRA in optimizing quantum circuit compilation.
基金supported by the National Natural Science Foundation of China(51708188).
文摘Semantic segmentation of concrete bridge defect images frequently encounters challenges due to insufficient precision and the limited computational capabilities ofmobile devices,thereby considerably affecting the reliability of bridge defect monitoring and health assessment.To tackle these issues,a concrete defects dataset(including spalling,crack,and exposed steel rebar)was curated and multiple semantic segmentation models were developed.In these models,a deep convolutional network or a lightweight convolutional network were employed as the backbone feature extraction networks,with different loss functions configured and various attention mechanism modules introduced for conducting multi-angle comparative research.The comparison of results indicates that utilizing VGG16 as the backbone network of U-Net for semantic segmentation of multi-class concrete defects images resulted in the highest recognition accuracy,achieving a Mean Intersection over Union(MIoU)of 80.37%and a Mean Pixel Accuracy(MPA)of 90.03%.The optimal combination of loss functions was found to be Focal loss and Dice loss.The lightweight convolutional network Mobile NetV2-DeeplabV3 slightly reduced recognition accuracy but significantly decreased the number of parameters,resulting in a faster detection speed of 71.87 frames/s,making it suitable for real-time defect detection.After integrating the SE(Squeeze-and-Excitation),CBAM(Convolutional Block Attention Module),and Coordinate Attention(CA)modules,both VGG16-U-Net and MobileNetV2-DeeplabV3 achieved improved recognition accuracy.Among them,the CAmodule(Coordinate Attention)effectively guides the model to accurately identify subtle concrete defects.The improved VGG16-U-Net can identify previously the new untrained concrete defect images in the concrete structural health monitoring(SHM)system,and the recognition accuracy can meet the demand for intelligent defect image recognition for structural health monitoring of concrete structures.
