Background:The role of lipid metabolism in the development and prognosis of bone metastasis in breast cancer(BRCA)patients remains an area of uncertainty.Methods:In this research,mRNA sequencing data,lncRNA sequencing...Background:The role of lipid metabolism in the development and prognosis of bone metastasis in breast cancer(BRCA)patients remains an area of uncertainty.Methods:In this research,mRNA sequencing data,lncRNA sequencing data,and miRNA sequencing data of BRCA samples were sourced from the UCSC Xena database.Initially,differentially expressed genes(DEGs),designated as DEGs1,were screened out between the BRCA group and the control group.Subsequently,another set of DEGs,referred to as DEGs2,were identified between the group with bone metastasis and the group without bone metastasis.To identify lipid metabolism-related genes(LMSRGs),Weighted Gene Co-expression Network Analysis(WGCNA)was employed.Results:The intersection of DEGs1,DEGs2,and LMSRGs led to the identification of differentially expressed LMSRGs.Biomarkers were then obtained through the application of univariate logistic regression analysis,Support Vector Machine-Recursive Feature Elimination,and multivariate logistic regression analysis.Conclusion:In conclusion,this study has identified two potential biomarkers,RGS9BP and SOCS3,for the prognostic assessment of BRCA patients with bone metastasis.These findings provide a scientific foundation for further investigations into bone metastasis in BRCA patients.展开更多
A high-performance and broadband heterojunction photodetector has been successfully fabricated.The heterostructure device is based on a uniform and pinhole-free perovskite film constructed on top of a single-crystal g...A high-performance and broadband heterojunction photodetector has been successfully fabricated.The heterostructure device is based on a uniform and pinhole-free perovskite film constructed on top of a single-crystal germanium layer.The perovskite/germanium photodetector shows enhanced performance and a broad spectrum compared with the single-material-based device.The photon response properties are characterized in detail from the visible to near-infrared spectrum.At an optical fibre communication wavelength of 1550 nm,the heterojunction device exhibits the highest responsivity of 1.4 A/W.The performance is promoted because of an antireflection perovskite coating,the thickness of which is optimized to 150 nm at the telecommunication band.At a visible light wavelength of 680 nm,the device shows outstanding responsivity and detectivity of 228 A/W and 1.6×10^(10) Jones,respectively.These excellent properties arise from the photoconductive gain boost in the heterostructure device.The presented heterojunction photodetector provides a competitive approach for wide-spectrum photodetection from visible to optical communication areas.Based on the distinguished capacity of light detection and harvesting from the visible to near-infrared spectrum,the designed germanium/perovskite heterostructure configuration is believed to provide new building blocks for novel optoelectronic devices.展开更多
Quantum key distribution （QKD） is a technology with the potential capability to achieve information-theoretic security. Phase- coding is an important approach to develop practical QKD systems in fiber channel. In or...Quantum key distribution （QKD） is a technology with the potential capability to achieve information-theoretic security. Phase- coding is an important approach to develop practical QKD systems in fiber channel. In order to improve the phase-coding modulation rate, we proposed a new digital-modulation method in this paper and constructed a compact and robust prototype of QKD system using currently available components in our lab to demonstrate the effectiveness of the method. The system was deployed in laboratory environment over a 50 km fiber and continuously operated during 87 h without manual interaction. The quantum bit error rate （QBER） of the system was stable with an average value of 3.22% and the secure key generation rate is 8.91 kbps. Although the modulation rate of the photon in the derno system was only 200 MHz, which was limited by the Faraday- Michelson interferometer （FMI） structure, the proposed method and the field programmable gate array （FPGA） based electronics scheme have a great potential for high speed QKD systems with Giga-bits/second modulation rate.展开更多
基金supported by Shanghai 2021“Science and Technology Innovation Action Plan”Medical Innovation Research Special Project(21Y11923000)Sailing Program,Scientific and Innovative Action Plan of Shanghai(20YF1449800)2021 Outstanding Young Medical Talents Training Project in Pudong Health System(PWRq2021-07).
文摘Background:The role of lipid metabolism in the development and prognosis of bone metastasis in breast cancer(BRCA)patients remains an area of uncertainty.Methods:In this research,mRNA sequencing data,lncRNA sequencing data,and miRNA sequencing data of BRCA samples were sourced from the UCSC Xena database.Initially,differentially expressed genes(DEGs),designated as DEGs1,were screened out between the BRCA group and the control group.Subsequently,another set of DEGs,referred to as DEGs2,were identified between the group with bone metastasis and the group without bone metastasis.To identify lipid metabolism-related genes(LMSRGs),Weighted Gene Co-expression Network Analysis(WGCNA)was employed.Results:The intersection of DEGs1,DEGs2,and LMSRGs led to the identification of differentially expressed LMSRGs.Biomarkers were then obtained through the application of univariate logistic regression analysis,Support Vector Machine-Recursive Feature Elimination,and multivariate logistic regression analysis.Conclusion:In conclusion,this study has identified two potential biomarkers,RGS9BP and SOCS3,for the prognostic assessment of BRCA patients with bone metastasis.These findings provide a scientific foundation for further investigations into bone metastasis in BRCA patients.
基金the National Natural Science Foundation of China(Nos.61874109,51525202,61674140,61574054,51672076,61804177)the Foundation for Innovative Research Groups of NSFC(Grant 21521063).
文摘A high-performance and broadband heterojunction photodetector has been successfully fabricated.The heterostructure device is based on a uniform and pinhole-free perovskite film constructed on top of a single-crystal germanium layer.The perovskite/germanium photodetector shows enhanced performance and a broad spectrum compared with the single-material-based device.The photon response properties are characterized in detail from the visible to near-infrared spectrum.At an optical fibre communication wavelength of 1550 nm,the heterojunction device exhibits the highest responsivity of 1.4 A/W.The performance is promoted because of an antireflection perovskite coating,the thickness of which is optimized to 150 nm at the telecommunication band.At a visible light wavelength of 680 nm,the device shows outstanding responsivity and detectivity of 228 A/W and 1.6×10^(10) Jones,respectively.These excellent properties arise from the photoconductive gain boost in the heterostructure device.The presented heterojunction photodetector provides a competitive approach for wide-spectrum photodetection from visible to optical communication areas.Based on the distinguished capacity of light detection and harvesting from the visible to near-infrared spectrum,the designed germanium/perovskite heterostructure configuration is believed to provide new building blocks for novel optoelectronic devices.
基金supported by the National Key Basic Research Program of China(Grant Nos.2011CBA00200 and 2011CB921200)the National Natural Science Foundation of China(Grant Nos.61201239,6120511811304397 and 61475148)the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant Nos.XDB01030100 and XDB01030300)
文摘Quantum key distribution （QKD） is a technology with the potential capability to achieve information-theoretic security. Phase- coding is an important approach to develop practical QKD systems in fiber channel. In order to improve the phase-coding modulation rate, we proposed a new digital-modulation method in this paper and constructed a compact and robust prototype of QKD system using currently available components in our lab to demonstrate the effectiveness of the method. The system was deployed in laboratory environment over a 50 km fiber and continuously operated during 87 h without manual interaction. The quantum bit error rate （QBER） of the system was stable with an average value of 3.22% and the secure key generation rate is 8.91 kbps. Although the modulation rate of the photon in the derno system was only 200 MHz, which was limited by the Faraday- Michelson interferometer （FMI） structure, the proposed method and the field programmable gate array （FPGA） based electronics scheme have a great potential for high speed QKD systems with Giga-bits/second modulation rate.
