Pulmonary hypertension(PH)is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure,which may eventually develop to right heart failure...Pulmonary hypertension(PH)is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure,which may eventually develop to right heart failure and death.Although newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH,limited types of effective and economical drugs for PH still makes it as a life-threatening disease.Some drugs from Chinese materia medica(CMM)have been traditionally applied in the treatment of lung diseases.Accumulating evidence suggests active pharmaceutical ingredients(APIs)derived from those medicines brings promising future for the prevention and treatment of PH.In this review,we summarized the pharmacological effects of APIs derived from CMM which are potent in treating PH,so as to provide new thoughts for initial drug discovery and identification of potential therapeutic strategies in alternative medicine for PH.展开更多
目的分析免疫吸附(IA)治疗儿童神经系统自身免疫疾病的疗效和安全性。方法收集2020-3-1-2025-3-1广州医科大学附属妇女儿童医疗中心神经内科收治的神经系统自身免疫性疾病并接受IA治疗的13例儿童,其中男4例,女9例,年龄(9.2±2.3)岁...目的分析免疫吸附(IA)治疗儿童神经系统自身免疫疾病的疗效和安全性。方法收集2020-3-1-2025-3-1广州医科大学附属妇女儿童医疗中心神经内科收治的神经系统自身免疫性疾病并接受IA治疗的13例儿童,其中男4例,女9例,年龄(9.2±2.3)岁。根据改良Rankin评分(mRS)分为重症组(mRS=5分)和非重症组(mRS≤4分)。13例中抗N-甲基-D-天冬氨酸受体脑炎5例,水通道蛋白4抗体阳性视神经脊髓炎谱系疾病2例,髓鞘少突胶质细胞糖蛋白抗体相关疾病1例,重症肌无力3例,吉兰-巴雷综合征1例,慢性炎症性脱髓鞘性多发性神经根神经病1例。分析患者的临床资料、辅助检查结果、治疗及预后的资料。结果重症组1例患者(16.7%)IA治疗后7 d mRS改善,5例患者(83.3%)IA治疗后联用二线免疫治疗,末次随访mRS降低但无统计学差异(P=0.068)。非重症组IA治疗后和末次随访mRS评分均明显低于治疗前(P<0.05)。10例患儿IA治疗后超声检查发现置管静脉血栓,予药物溶栓治疗后缓解。结论IA治疗儿童神经系统自身免疫疾病有效且安全,联用二线免疫治疗可更好地改善疾病预后。IA治疗后应常规行置管处血管超声检查。展开更多
文摘Pulmonary hypertension(PH)is a severe pathophysiological condition characterized by pulmonary artery remodeling and continuous increases in pulmonary artery pressure,which may eventually develop to right heart failure and death.Although newly discovered and incredible treatment strategies in recent years have improved the prognosis of PH,limited types of effective and economical drugs for PH still makes it as a life-threatening disease.Some drugs from Chinese materia medica(CMM)have been traditionally applied in the treatment of lung diseases.Accumulating evidence suggests active pharmaceutical ingredients(APIs)derived from those medicines brings promising future for the prevention and treatment of PH.In this review,we summarized the pharmacological effects of APIs derived from CMM which are potent in treating PH,so as to provide new thoughts for initial drug discovery and identification of potential therapeutic strategies in alternative medicine for PH.
文摘目的分析免疫吸附(IA)治疗儿童神经系统自身免疫疾病的疗效和安全性。方法收集2020-3-1-2025-3-1广州医科大学附属妇女儿童医疗中心神经内科收治的神经系统自身免疫性疾病并接受IA治疗的13例儿童,其中男4例,女9例,年龄(9.2±2.3)岁。根据改良Rankin评分(mRS)分为重症组(mRS=5分)和非重症组(mRS≤4分)。13例中抗N-甲基-D-天冬氨酸受体脑炎5例,水通道蛋白4抗体阳性视神经脊髓炎谱系疾病2例,髓鞘少突胶质细胞糖蛋白抗体相关疾病1例,重症肌无力3例,吉兰-巴雷综合征1例,慢性炎症性脱髓鞘性多发性神经根神经病1例。分析患者的临床资料、辅助检查结果、治疗及预后的资料。结果重症组1例患者(16.7%)IA治疗后7 d mRS改善,5例患者(83.3%)IA治疗后联用二线免疫治疗,末次随访mRS降低但无统计学差异(P=0.068)。非重症组IA治疗后和末次随访mRS评分均明显低于治疗前(P<0.05)。10例患儿IA治疗后超声检查发现置管静脉血栓,予药物溶栓治疗后缓解。结论IA治疗儿童神经系统自身免疫疾病有效且安全,联用二线免疫治疗可更好地改善疾病预后。IA治疗后应常规行置管处血管超声检查。
