Five pairs of optically pure meroterpenoid enantiomers(1 a/1 b-5 a/5 b)and two known compounds(6 and 7)were isolated from Rhododendron fastigiatum.Compounds 1 a/1 b-5 a/5 b were resolved from naturally scalemic mixtur...Five pairs of optically pure meroterpenoid enantiomers(1 a/1 b-5 a/5 b)and two known compounds(6 and 7)were isolated from Rhododendron fastigiatum.Compounds 1 a/1 b-5 a/5 b were resolved from naturally scalemic mixtures by chiral HPLC.Their structures were elucidated by spectroscopic methods,X-ray crystallographic experiments,and ECD analyses.Compounds 1 a/1 b,2 a/2 b,3 b,4 a/4 b,and 5 a/5 b were new meroterpenoids with different polycyclic systems.Two enantiomeric pairs(2 a/2 b and 3 a/3 b),6,and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1 B(PTP1 B)in vitro.展开更多
基金supported by the National Natural Science Foundation of China(No.81222045)the Fudan-SIMM Joint Research Fund(No.FU-SIMM20181011)
文摘Five pairs of optically pure meroterpenoid enantiomers(1 a/1 b-5 a/5 b)and two known compounds(6 and 7)were isolated from Rhododendron fastigiatum.Compounds 1 a/1 b-5 a/5 b were resolved from naturally scalemic mixtures by chiral HPLC.Their structures were elucidated by spectroscopic methods,X-ray crystallographic experiments,and ECD analyses.Compounds 1 a/1 b,2 a/2 b,3 b,4 a/4 b,and 5 a/5 b were new meroterpenoids with different polycyclic systems.Two enantiomeric pairs(2 a/2 b and 3 a/3 b),6,and 7 exhibited inhibitory effects on protein tyrosine phosphatase 1 B(PTP1 B)in vitro.
