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调节巨噬细胞极化:一种新兴的炎症性肠病治疗策略
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作者 韩泽旭 史海涛 +4 位作者 王富洲 邢云颖 郝紫泞 郭学玲 王英泽 《中国生物工程杂志》 北大核心 2025年第7期86-98,共13页
炎症性肠病(inflammatory bowel disease,IBD)的全球发病率不断上升,给患者带来沉重的治疗负担。氨基水杨酸制剂和糖皮质激素等传统药物疗法在IBD治疗中占据主导地位,但其耐药性和副作用等问题日益凸显,限制了其临床应用效果。近年来,... 炎症性肠病(inflammatory bowel disease,IBD)的全球发病率不断上升,给患者带来沉重的治疗负担。氨基水杨酸制剂和糖皮质激素等传统药物疗法在IBD治疗中占据主导地位,但其耐药性和副作用等问题日益凸显,限制了其临床应用效果。近年来,巨噬细胞在IBD治疗中的潜在作用逐渐受到关注。随着对巨噬细胞极化机制的深入研究以及新型药物递送系统的不断涌现,靶向巨噬细胞极化以恢复免疫平衡成为一种极具潜力的治疗策略。系统分析巨噬细胞极化的类型及其在肠道稳态中的关键作用,深入探讨治疗IBD过程中巨噬细胞极化调控的信号通路以及调控巨噬细胞极化的多种方式,包括中药调节、新型复合材料的应用,以及通过菌群代谢物质改变巨噬细胞极化方向缓解炎症。这些研究成果不仅为IBD治疗提供了新的靶点,也为IBD治疗策略的优化和创新提供了重要的理论参考。 展开更多
关键词 巨噬细胞极化 纳米药物 中药成分 菌群代谢物 炎症性肠病
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Numerical simulation of solitary and random wave propagation through vegetation based on VOF method 被引量:6
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作者 ZHANG Mingliang hao zining +1 位作者 ZHANG Yunpeng WU Weiming 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2013年第7期38-46,共9页
A vertical two-dimensional numerical model has been applied to solving the Reynolds Averaged Navier- Stokes (RANS} equations in the simulation of current and wave propagation through vegetated and non- vegetated wate... A vertical two-dimensional numerical model has been applied to solving the Reynolds Averaged Navier- Stokes (RANS} equations in the simulation of current and wave propagation through vegetated and non- vegetated waters. The k-e model is used for turbulence closure of RANS equations. The effect of vegeta- tion is simulated by adding the drag force of vegetation in the flow momentum equations and turbulence model. To solve the modified N-S equations, the finite difference method is used with the staggered grid system to solver equations. The Youngs' fractional volume of fluid (VOF) is applied tracking the free sur- face with second-order accuracy. The model has been tested by simulating dam break wave, pure current with vegetation, solitary wave runup on vegetated and non-vegetated channel, regular and random waves over a vegetated field. The model reasonably well reproduces these experimental observations, the model- ing approach presented herein should be useful in simulating nearshore processes in coastal domains with vegetation effects. 展开更多
关键词 VOF method VEGETATION SOLITARY regular and random waves wave height attenuation k-emodel
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Integrating 1D and 2D hydrodynamic,sediment transport model for dam-break flow using finite volume method 被引量:3
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作者 ZHANG MingLiang XU YuanYuan +1 位作者 hao zining QIAO Yang 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2014年第4期774-783,共10页
The purpose of this study is to set up a dynamically linked 1D and 2D hydrodynamic and sediment transport models for dam break flow.The 1D-2D coupling model solves the generalized shallow water equations,the non-equil... The purpose of this study is to set up a dynamically linked 1D and 2D hydrodynamic and sediment transport models for dam break flow.The 1D-2D coupling model solves the generalized shallow water equations,the non-equilibrium sediment transport and bed change equations in a coupled fashion using an explicit finite volume method.It considers interactions among transient flow,strong sediment transport and rapid bed change by including bed change and variable flow density in the flow continuity and momentum equations.An unstructured Quadtree rectangular grid with local refinement is used in the 2D model.The intercell flux is computed by the HLL approximate Riemann solver with shock captured capability for computing the dry-to-wet interface for all models.The effects of pressure and gravity are included in source term in this coupling model which can simplify the computation and eliminate numerical imbalance between source and flux terms.The developed model has been tested against experimental and real-life case of dam-break flow over fix bed and movable bed.The results are compared with analytical solution and measured data with good agreement.The simulation results demonstrate that the coupling model is capable of calculating the flow,erosion and deposition for dam break flows in complicated natural domains. 展开更多
关键词 1D/2D coupling model finite volume method HLL approximate Riemann solver non-equilibrium sediment transport
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