Extracorporeal liver surgery(ELS), also known as liver autotransplantation, is a hybrid(cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently b...Extracorporeal liver surgery(ELS), also known as liver autotransplantation, is a hybrid(cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, ex-situ liver resection and autotransplantation(ELRA), ante-situm liver resection and autotransplantation(ALRA) and auxiliary partial liver autotransplantation(APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous effort s done by Chinese surgeons and researchers. Especially, the precision liver surgery paradigm has allowed to transform ELS into a modularized, more simplified, and standardized surgery, to upgrade surgical skills, to improve peri-operative outcome and long-term survival, to increase the capability of surgeons to select more complex diseases and to expand the level of medical service to the population. This review highlights the Chinese contributions to the field of ELS, focusing thereby on features of different surgical types, technical innovations, disease selection and surgical indication, patient prognosis and future perspectives.展开更多
针对目前已有的手工设计描述符对局部曲面几何特征描述不够全面的问题,本文提出了一种高鉴别强鲁棒的多视图几何分布特征描述符(Multi-View Geometric Distribution Signatures,MGDS)。首先,基于关键点及其邻域点构建局部参考框架(Local...针对目前已有的手工设计描述符对局部曲面几何特征描述不够全面的问题,本文提出了一种高鉴别强鲁棒的多视图几何分布特征描述符(Multi-View Geometric Distribution Signatures,MGDS)。首先,基于关键点及其邻域点构建局部参考框架(Local Reference Frame,LRF),对局部曲面进行体素化,计算三维体素的质心点分布、二维扇区轮廓特征、二维网格点密度分布以及局面曲面深度波动,生成几何特征描述符。接着,基于LRF多次旋转局部曲面,产生新的形状表示,利用质心、轮廓点、密度以及z值波动信息对旋转后的曲面进行编码。通过多个视角获取这些几何特征描述符,将它们串联成一个特征向量,得到最终的多视图几何分布特征描述符MGDS。本文在RandomView,SpaceTime,Kinect以及B3R四个数据集中不同的高斯噪声以及网格分辨率下进行实验,并与目前已有的10种描述符进行比较。与其他描述符相比,MGDS描述符的性能优于已有的局部特征描述符。实验结果表明,本文所提出的MGDS具有较好的描述性与鲁棒性,可用于三维点云的准确配准。展开更多
Amino acids are widely present as intermediates in marine nitrogen cycle.However,amino acid distributions in deep-sea seawater,especially in abyssal and hadal zones,are very limited.This study investigated the occurre...Amino acids are widely present as intermediates in marine nitrogen cycle.However,amino acid distributions in deep-sea seawater,especially in abyssal and hadal zones,are very limited.This study investigated the occurrence,vertical variations,and degradation behavior of dissolved free amino acids(DFAA),dissolved combined amino acids(DCAA),and total hydrolyzable amino acids(THAA)in seawater from the sea surface to the hadal zone of the northern Yap Trench.The results showed that concentrations ofΣDFAA,ΣDCAA andΣTHAA ranged from 0.09 to 1.78,0.99 to 17.69 and 1.18 to 18.01μmol/L in the study area,respectively.In the seawater from the trench,glycine was the predominant DFAA,while the DCAA and THAA was dominated by threonine.Mean concentrations of DFAA,DCAA and THAA in different water layers were in the order of:mesopelagic>euphotic>abyssal>bathyal.The concentrations of DCAA and THAA in the sediment-seawater interface were higher than those from the euphotic to abyssal layer.The organic matter(OM)in the seawater of the stations near the Yap Islands were older,while the OM in the stations near the Yap Trench axis was relatively fresh above 1000-m depth.The OM in the sediment-seawater interface is older,especially on the west side of the trench.This is the first systematic survey of DCAA and THAA in the Yap Trench,providing insights into the vertical variations and degradation behaviors of amino acids from the sea surface to the hadal environment.展开更多
Quasi-zero stiffness(QZS)isolators have received considerable attention over the past years due to their outstanding vibration isolation performance in low-frequency bands.However,traditional mechanisms for achieving ...Quasi-zero stiffness(QZS)isolators have received considerable attention over the past years due to their outstanding vibration isolation performance in low-frequency bands.However,traditional mechanisms for achieving QZS suffer from low stiffness regions and significant nonlinear restoring forces with hardening characteristics,often struggling to withstand excitations with high amplitude.This paper presents a novel QZS vibration isolator that utilizes a more compact spring-rod mechanism(SRM)to provide primary negative stiffness.The nonlinearity of SRM is adjustable via altering the raceway of its spring-rod end,along with the compensatory force provided by the cam-roller mechanism so as to avoid complex nonlinear behaviors.The absolute zero stiffness can be achieved by a well-designed raceway curve with a concise mathematical expression.The nonlinear stiffness with softening properties can also be achieved by parameter adjustment.The study begins with the forcedisplacement relationship of the integrated mechanism first,followed by the design theory of the cam profile.The dynamic response and absolute displacement transmissibility of the isolation system are obtained based on the harmonic balance method.The experimental results show that the proposed vibration isolator maintains relatively low-dynamic stiffness even under non-ideal conditions,and exhibits enhanced vibration isolation performance compared to the corresponding linear isolator.展开更多
Relic gravitational waves(RGWs)from the early Universe carry crucial and fundamental cosmological information.Therefore,it is of extraordinary importance to investigate potential RGW signals in the data from observato...Relic gravitational waves(RGWs)from the early Universe carry crucial and fundamental cosmological information.Therefore,it is of extraordinary importance to investigate potential RGW signals in the data from observatories such as the LIGO-Virgo-KAGRA network.Here,focusing on typical RGWs from the inflation and the first-order phase transition(by sound waves and bubble collisions),effective and targeted deep learning neural networks are established to search for these RGW signals within the real LIGO data(O2,O3a and O3b).Through adjustment and adaptation processes,we develop suitable Convolutional Neural Networks(CNNs)to estimate the likelihood(characterized by quantitative values and distributions)that the focused RGW signals are present in the LIGO data.We find that if the constructed CNN properly estimates the parameters of the RGWs,it can determine with high accuracy(approximately 94%to 99%)whether the samples contain such RGW signals;otherwise,the likelihood provided by the CNN cannot be considered reliable.After testing a large amount of LIGO data,the findings show no evidence of RGWs from:1)inflation,2)sound waves,or 3)bubble collisions,as predicted by the focused theories.The results also provide upper limits of their GW spectral energy densities of h^(2)Ω_(gw)~10^(-5),respectively for parameter boundaries within 1)[β∈(-1.87,-1.85)×α∈(0.005,0.007)],2)[β/H_(pt)∈(0.02,0.16)×α∈(1,10)×T_(pt)∈(5*10^(9),10^(10))Gev],and 3)[β/H_(pt)∈(0.08,0.2)×α∈(1,10)×T_(pt)∈(5*10^(9),8*10^(10))Gev].In short,null results and upper limits are obtained,and the analysis suggests that our developed methods and neural networks to search for typical RGWs in the LIGO data are effective and reliable,providing a viable scheme for exploring possible RGWs from the early Universe and placing constraints on relevant cosmological theories.展开更多
目的探索集训期新兵乐观与主观幸福感(包括情感幸福感和认知幸福感)的关系及认知情绪调节策略在其中的作用。方法采用修订版生活定向测试(life orientation test-revised,LOT-R)、正负性情绪量表(positive and negative affect scale,PA...目的探索集训期新兵乐观与主观幸福感(包括情感幸福感和认知幸福感)的关系及认知情绪调节策略在其中的作用。方法采用修订版生活定向测试(life orientation test-revised,LOT-R)、正负性情绪量表(positive and negative affect scale,PANAS)、生活满意度量表(satisfaction with life scale,SWLS)和认知情绪调节问卷(cognitive emotion regulation questionnaire,CERQ)对同一批次入伍的2247名新兵实施问卷调查。结果新兵的乐观与情感幸福感、认知幸福感、适应性认知情绪调节策略均呈正相关关系(r值分别为0.536,0.425,0.220,P均<0.01),与非适应性认知情绪调节策略呈负相关关系(r=-0.325,P<0.01)。回归分析结果显示,在控制年龄、性别、文化程度、是否独生子女等人口学变量后,适应性与非适应性认知情绪调节策略同时进入回归方程预测情感幸福感、认知幸福感时,乐观和适应性认知情绪调节策略均可正向预测情感幸福感(β=1.146、0.358,P均<0.001)、认知幸福感(β=0.432、0.132,P均<0.001),非适应性认知情绪调节策略可负向预测情感幸福感(β=-0.543,P<0.001)、认知幸福感(β=-0.182,P<0.001)。中介分析结果显示,乐观对情感幸福感的直接效应显著,效应值为1.146[95%置信区间(confidence interval,CI):1.031~1.262],直接效应占比为60.57%;适应性与非适应性认知情绪调节策略在其中的中介效应均显著,效应值分别为0.244(95%CI:0.191~0.299)、0.502(95%CI:0.429~0.579),中介效应占比分别为32.71%、67.29%,非适应性认知情绪调节策略的中介效应大于适应性认知情绪调节策略的中介效应。乐观对认知幸福感的直接效应显著,效应值为0.432(95%CI:0.368~0.495),直接效应占比为62.61%;适应性与非适应性认知情绪调节策略在其中的中介效应均显著,效应值分别为0.090(95%CI:0.068~0.114)、0.168(95%CI:0.139~0.202),中介效应占比分别为34.88%、65.12%,非适应性认知情绪调节策略的中介效应大于适应性认知情绪调节策略的中介效应。结论新兵的乐观不仅可直接正向影响其主观幸福感,还可分别通过适应性与非适应性认知情绪调节策略间接影响主观幸福感,且非适应性认知情绪调节策略的中介效应大于适应性认知情绪调节策略。因此,未来可在集训期间开展针对提升乐观的心理训练,并通过培养合理使用情绪调节策略,来提升新兵的主观幸福感,为新兵心理健康维护工作提供新的思路。展开更多
基金supported by grants from the Beijing Hospitals Authority Youth Program (12022B4010)BTCH Young Talent En-lightenment Program (2024QMRC24)CAMS Innovation Fund for Medical Sciences (2019-I2M-5–056)。
文摘Extracorporeal liver surgery(ELS), also known as liver autotransplantation, is a hybrid(cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, ex-situ liver resection and autotransplantation(ELRA), ante-situm liver resection and autotransplantation(ALRA) and auxiliary partial liver autotransplantation(APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous effort s done by Chinese surgeons and researchers. Especially, the precision liver surgery paradigm has allowed to transform ELS into a modularized, more simplified, and standardized surgery, to upgrade surgical skills, to improve peri-operative outcome and long-term survival, to increase the capability of surgeons to select more complex diseases and to expand the level of medical service to the population. This review highlights the Chinese contributions to the field of ELS, focusing thereby on features of different surgical types, technical innovations, disease selection and surgical indication, patient prognosis and future perspectives.
基金the National Key Research and Development Program of China(No.2022YFC2803803)the National Natural Science Foundation of China(No.42076040)the 111 Project(No.B13030)。
文摘Amino acids are widely present as intermediates in marine nitrogen cycle.However,amino acid distributions in deep-sea seawater,especially in abyssal and hadal zones,are very limited.This study investigated the occurrence,vertical variations,and degradation behavior of dissolved free amino acids(DFAA),dissolved combined amino acids(DCAA),and total hydrolyzable amino acids(THAA)in seawater from the sea surface to the hadal zone of the northern Yap Trench.The results showed that concentrations ofΣDFAA,ΣDCAA andΣTHAA ranged from 0.09 to 1.78,0.99 to 17.69 and 1.18 to 18.01μmol/L in the study area,respectively.In the seawater from the trench,glycine was the predominant DFAA,while the DCAA and THAA was dominated by threonine.Mean concentrations of DFAA,DCAA and THAA in different water layers were in the order of:mesopelagic>euphotic>abyssal>bathyal.The concentrations of DCAA and THAA in the sediment-seawater interface were higher than those from the euphotic to abyssal layer.The organic matter(OM)in the seawater of the stations near the Yap Islands were older,while the OM in the stations near the Yap Trench axis was relatively fresh above 1000-m depth.The OM in the sediment-seawater interface is older,especially on the west side of the trench.This is the first systematic survey of DCAA and THAA in the Yap Trench,providing insights into the vertical variations and degradation behaviors of amino acids from the sea surface to the hadal environment.
基金supported by the National Natural Science Foundation of China(Grant No.11732006)the“Qinglan Project”of Jiangsu Higher Education Institutions.
文摘Quasi-zero stiffness(QZS)isolators have received considerable attention over the past years due to their outstanding vibration isolation performance in low-frequency bands.However,traditional mechanisms for achieving QZS suffer from low stiffness regions and significant nonlinear restoring forces with hardening characteristics,often struggling to withstand excitations with high amplitude.This paper presents a novel QZS vibration isolator that utilizes a more compact spring-rod mechanism(SRM)to provide primary negative stiffness.The nonlinearity of SRM is adjustable via altering the raceway of its spring-rod end,along with the compensatory force provided by the cam-roller mechanism so as to avoid complex nonlinear behaviors.The absolute zero stiffness can be achieved by a well-designed raceway curve with a concise mathematical expression.The nonlinear stiffness with softening properties can also be achieved by parameter adjustment.The study begins with the forcedisplacement relationship of the integrated mechanism first,followed by the design theory of the cam profile.The dynamic response and absolute displacement transmissibility of the isolation system are obtained based on the harmonic balance method.The experimental results show that the proposed vibration isolator maintains relatively low-dynamic stiffness even under non-ideal conditions,and exhibits enhanced vibration isolation performance compared to the corresponding linear isolator.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.11605015,12347101 and 12147102the Natural Scienceof Chongqing under Grant No.cstc2020jcyjmsxm X0944the Research Funds for the Central Universities under Grant No.2022CDJXY-002。
文摘Relic gravitational waves(RGWs)from the early Universe carry crucial and fundamental cosmological information.Therefore,it is of extraordinary importance to investigate potential RGW signals in the data from observatories such as the LIGO-Virgo-KAGRA network.Here,focusing on typical RGWs from the inflation and the first-order phase transition(by sound waves and bubble collisions),effective and targeted deep learning neural networks are established to search for these RGW signals within the real LIGO data(O2,O3a and O3b).Through adjustment and adaptation processes,we develop suitable Convolutional Neural Networks(CNNs)to estimate the likelihood(characterized by quantitative values and distributions)that the focused RGW signals are present in the LIGO data.We find that if the constructed CNN properly estimates the parameters of the RGWs,it can determine with high accuracy(approximately 94%to 99%)whether the samples contain such RGW signals;otherwise,the likelihood provided by the CNN cannot be considered reliable.After testing a large amount of LIGO data,the findings show no evidence of RGWs from:1)inflation,2)sound waves,or 3)bubble collisions,as predicted by the focused theories.The results also provide upper limits of their GW spectral energy densities of h^(2)Ω_(gw)~10^(-5),respectively for parameter boundaries within 1)[β∈(-1.87,-1.85)×α∈(0.005,0.007)],2)[β/H_(pt)∈(0.02,0.16)×α∈(1,10)×T_(pt)∈(5*10^(9),10^(10))Gev],and 3)[β/H_(pt)∈(0.08,0.2)×α∈(1,10)×T_(pt)∈(5*10^(9),8*10^(10))Gev].In short,null results and upper limits are obtained,and the analysis suggests that our developed methods and neural networks to search for typical RGWs in the LIGO data are effective and reliable,providing a viable scheme for exploring possible RGWs from the early Universe and placing constraints on relevant cosmological theories.
文摘目的探索集训期新兵乐观与主观幸福感(包括情感幸福感和认知幸福感)的关系及认知情绪调节策略在其中的作用。方法采用修订版生活定向测试(life orientation test-revised,LOT-R)、正负性情绪量表(positive and negative affect scale,PANAS)、生活满意度量表(satisfaction with life scale,SWLS)和认知情绪调节问卷(cognitive emotion regulation questionnaire,CERQ)对同一批次入伍的2247名新兵实施问卷调查。结果新兵的乐观与情感幸福感、认知幸福感、适应性认知情绪调节策略均呈正相关关系(r值分别为0.536,0.425,0.220,P均<0.01),与非适应性认知情绪调节策略呈负相关关系(r=-0.325,P<0.01)。回归分析结果显示,在控制年龄、性别、文化程度、是否独生子女等人口学变量后,适应性与非适应性认知情绪调节策略同时进入回归方程预测情感幸福感、认知幸福感时,乐观和适应性认知情绪调节策略均可正向预测情感幸福感(β=1.146、0.358,P均<0.001)、认知幸福感(β=0.432、0.132,P均<0.001),非适应性认知情绪调节策略可负向预测情感幸福感(β=-0.543,P<0.001)、认知幸福感(β=-0.182,P<0.001)。中介分析结果显示,乐观对情感幸福感的直接效应显著,效应值为1.146[95%置信区间(confidence interval,CI):1.031~1.262],直接效应占比为60.57%;适应性与非适应性认知情绪调节策略在其中的中介效应均显著,效应值分别为0.244(95%CI:0.191~0.299)、0.502(95%CI:0.429~0.579),中介效应占比分别为32.71%、67.29%,非适应性认知情绪调节策略的中介效应大于适应性认知情绪调节策略的中介效应。乐观对认知幸福感的直接效应显著,效应值为0.432(95%CI:0.368~0.495),直接效应占比为62.61%;适应性与非适应性认知情绪调节策略在其中的中介效应均显著,效应值分别为0.090(95%CI:0.068~0.114)、0.168(95%CI:0.139~0.202),中介效应占比分别为34.88%、65.12%,非适应性认知情绪调节策略的中介效应大于适应性认知情绪调节策略的中介效应。结论新兵的乐观不仅可直接正向影响其主观幸福感,还可分别通过适应性与非适应性认知情绪调节策略间接影响主观幸福感,且非适应性认知情绪调节策略的中介效应大于适应性认知情绪调节策略。因此,未来可在集训期间开展针对提升乐观的心理训练,并通过培养合理使用情绪调节策略,来提升新兵的主观幸福感,为新兵心理健康维护工作提供新的思路。
