Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectra...Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectral similarity between buildings and backgrounds,sensor variations,and insufficient computational efficiency.To address these challenges,this paper proposes a novel Multi-scale Efficient Wavelet-based Change Detection Network(MewCDNet),which integrates the advantages of Convolutional Neural Networks and Transformers,balances computational costs,and achieves high-performance building change detection.The network employs EfficientNet-B4 as the backbone for hierarchical feature extraction,integrates multi-level feature maps through a multi-scale fusion strategy,and incorporates two key modules:Cross-temporal Difference Detection(CTDD)and Cross-scale Wavelet Refinement(CSWR).CTDD adopts a dual-branch architecture that combines pixel-wise differencing with semanticaware Euclidean distance weighting to enhance the distinction between true changes and background noise.CSWR integrates Haar-based Discrete Wavelet Transform with multi-head cross-attention mechanisms,enabling cross-scale feature fusion while significantly improving edge localization and suppressing spurious changes.Extensive experiments on four benchmark datasets demonstrate MewCDNet’s superiority over comparison methods:achieving F1 scores of 91.54%on LEVIR,93.70%on WHUCD,and 64.96%on S2Looking for building change detection.Furthermore,MewCDNet exhibits optimal performance on the multi-class⋅SYSU dataset(F1:82.71%),highlighting its exceptional generalization capability.展开更多
In recent years,optoelectronic synapses have garnered significant attention in the field of neuromorphic computing due to their integration of optical sensing and synaptic functions.In this work,we propose an optoelec...In recent years,optoelectronic synapses have garnered significant attention in the field of neuromorphic computing due to their integration of optical sensing and synaptic functions.In this work,we propose an optoelectronic synapse based on IGZO/Bi_(3.25)La_(0.75)Ti_3O_(12)heterojunction.Under UV light stimulation,this device can simulate a range of synaptic behaviors,including paired-pulse facilitation,spike-intensity-dependent plasticity,spike-number-dependent plasticity,spike-width-dependent plasticity,and the transition from short-term memory to long-term memory.The majority of perceptible information for humans is acquired through the visual system.The 3×3 retinal morphology synapse arrays constructed based on plasticity behaviors not only integrates light perception and storage functions but also exhibits adaptive adjustment capabilities to address image blurring caused by object movement.At the same time,in CNN recognition training,the device successfully simulates the learning-relearning mechanism of the human brain.These findings highlight the device's immense potential for applications in artificial vision systems.展开更多
The utilization and storage of CO_(2) emissions from oil production and consumption in the upstream oil industry will contribute to sustainable development.CO_(2) flooding is the key technology for the upstream oil in...The utilization and storage of CO_(2) emissions from oil production and consumption in the upstream oil industry will contribute to sustainable development.CO_(2) flooding is the key technology for the upstream oil industry to transition to sustainable development.However,there is a significant challenge in achieving high recovery and storage efficiency in unconventional reservoirs,particularly in underde-veloped countries.Numerous studies have indicated that the limited sweep range caused by premature gas channeling of CO_(2) is a crucial bottleneck that hinders the enhancement of recovery,storage efficiency and safety.This review provides a comprehensive summary of the research and technical advancements regarding the front sweep characteristics of CO_(2) during migration.It particularly focuses on the char-acteristics,applicable stages,and research progress of different technologies used for regulating CO_(2) flooding sweep.Finally,based on the current application status and development trends,the review offers insights into the future research direction for these technologies.It is concluded that the front migration characteristics of CO_(2) play a crucial role in determining the macroscopic sweep range.The focus of future research lies in achieving cross-scale correlation and information coupling of CO_(2) migration processes.Currently,the influence weight of permeability,injection speed,pressure and other parameters on the characteristics of‘fingering-gas channeling’is still not well clear.There is an urgent need to establish prediction model and early warning mechanism that considers multi-parameters and cross-scale gas channeling degrees,in order to create effective strategies for prevention and control.There are currently three technologies available for sweep regulation:flow field intervention,mobility reduction,and gas channeling plugging.To expand the sweep effectively,it is important to systematically integrate these technologies based on their regulation characteristics and applicable stages.This can be achieved by constructing an intelligent synergistic hierarchical segmented regulation technology known as‘flow field intervention+mobility regulation+channel plugging chemically’.This work is expected to provide valuable insights for achieving conformance control of CO_(2)-EOR and safe storage of CO_(2).展开更多
Although Al or Ti addition is promising to improve the performance of IN718,traditional metallurgical processing methods encounter difficulties in manufacturing superalloys with higher Al and Ti content.Laser powder b...Although Al or Ti addition is promising to improve the performance of IN718,traditional metallurgical processing methods encounter difficulties in manufacturing superalloys with higher Al and Ti content.Laser powder bed fusion(LPBF)exhibits great potential to address these challenges,but the effects of Al or Ti content on additively manufactured IN718 stay unclear.In this work,we fabricated crack-free modified IN718 alloys with elevated Al or Ti content through in-situ alloying using laser powder bed fusion.The results revealed that the alloy 1 wt.%Ti addition outperformed IN718 in strength at both ambient and elevated temperatures by about 120 and 70 MPa,respectively,while the addition of 1 wt.%Al decreases the yield strength due to the significant decrease of γʹ ʹphase fraction.However,the addition of 3 wt.%Al leads to precipitation ofσ-phase,while 3 wt.%Ti addition leads to growth of coarseη-phase of micrometers at grain boundaries.After aging treatment at 720℃ for 50 h,it is also found that the thermal stability of γʹʹ phase is substantially improved by Ti alloying due to the formation of γʹʹ/γʹ/γʹʹ sandwich structure.These findings highlight the advantages of Ti alloying in enhancing thermal stability and mechanical performance.展开更多
The activation of the sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing ...The activation of the sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing reactive oxygen species(ROS)levels.Clinical trials have demonstrated that Zhongfeng Xingnao Liquid(ZFXN)ameliorates post-stroke cognitive impairment(PSCI).However,the underlying mechanism,particularly whether it involves protecting mitochondria and inhibiting apoptosis through the SIRT1/Nrf2/HO-1 pathway,remains unclear.This study employed an oxygen-glucose deprivation(OGD)cell model using SHSY5Y cells and induced PSCI in rats through modified bilateral carotid artery ligation(2VO).The effects of ZFXN on learning and memory,neuroprotective activity,mitochondrial function,oxidative stress,and the SIRT1/Nrf2/HO-1 pathway were evaluated both in vivo and in vitro.Results indicated that ZFXN significantly increased the B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)ratio,reduced terminal deoxynucleotidyl transferase-mediated d UTP nickend-labeling(TUNEL)+cells,and markedly improved cognition,synaptic plasticity,and neuronal function in the hippocampus and cortex.Furthermore,ZFXN exhibited potent antioxidant activity,evidenced by decreased ROS and malondialdehyde(MDA)content and increased superoxide dismutase(SOD),catalase(CAT),and glutathione(GSH)levels.ZFXN also demonstrated considerable enhancement of mitochondrial membrane potential(MMP),Tom 20 fluorescence intensity,adenosine triphosphate(ATP)and energy charge(EC)levels,and mitochondrial complexⅠandⅢactivity,thereby inhibiting mitochondrial damage.Additionally,ZFXN significantly increased SIRT1 activity and elevated SIRT1,nuclear Nrf2,and HO-1 levels.Notably,these effects were substantially counteracted when SIRT1 was suppressed by the inhibitor EX-527 in vitro.In conclusion,ZFXN alleviates PSCI by activating the SIRT1/Nrf2/HO-1 pathway and preventing mitochondrial damage.展开更多
In this work,fow behavior and dynamic recrystallization(DRX)mechanism of a low carbon martensitic stainless bearing steel,CSS-42L,were investigated using a thermomechanical simulator under the temperature and strain r...In this work,fow behavior and dynamic recrystallization(DRX)mechanism of a low carbon martensitic stainless bearing steel,CSS-42L,were investigated using a thermomechanical simulator under the temperature and strain rate ranges of 900 to 1100℃ and 0.1 to 20 s^(−1),respectively.The Arrhenius-type constitutive equation was established based on the fow stress curves.Moreover,the peak stress decreased with the increase in deformation temperature and the decrease in strain rate.There were two DRX mechanisms during hot deformation of the current studied steel,the main one being discontinuous dynamic recrystallization mechanism,acting through grain boundary bulging and migration,and the auxiliary one being continuous dynamic recrystallization mechanism,working through the rotation of sub-grains.On the basis of microstructural characterizations,power dissipation maps and fow instability maps,the optimized hot deformation parameters for CSS-42L bearing steel were determined as 1050℃/0.1 s^(−1) and 1100℃/1 s^(−1).展开更多
Adaptive optics(AO)has significantly advanced high-resolution solar observations by mitigating atmospheric turbulence.However,traditional post-focal AO systems suffer from external configurations that introduce excess...Adaptive optics(AO)has significantly advanced high-resolution solar observations by mitigating atmospheric turbulence.However,traditional post-focal AO systems suffer from external configurations that introduce excessive optical surfaces,reduced light throughput,and instrumental polarization.To address these limitations,we propose an embedded solar adaptive optics telescope(ESAOT)that intrinsically incorporates the solar AO(SAO)subsystem within the telescope's optical train,featuring a co-designed correction chain with a single Hartmann-Shack full-wavefront sensor(HS f-WFS)and a deformable secondary mirror(DSM).The HS f-WFS uses temporal-spatial hybrid sampling technique to simultane-ously resolve tip-tilt and high-order aberrations,while the DSM performs real-time compensation through adaptive modal optimization.This unified architecture achieves symmetrical polarization suppression and high system throughput by min-imizing optical surfaces.A 600 mm ESAOT prototype incorporating a 12×12 micro-lens array HS f-WFS and 61-actuator piezoelectric DSM has been developed and successfully conducted on-sky photospheric observations.Validations in-cluding turbulence simulations,optical bench testing,and practical observations at the Lijiang observatory collectively confirm the system's capability to maintain aboutλ/10 wavefront error during active region tracking.This architectural breakthrough of the ESAOT addresses long-standing SAO integration challenges in solar astronomy and provides scala-bility analyses confirming direct applicability to the existing and future large solar observation facilities.展开更多
The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits ...The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.展开更多
BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and heal.AIM T...BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and heal.AIM To explore the effects of betaine ointment(BO)in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic mice.METHODS By detecting the minimum inhibitory concentrations(MICs)of betaine and plant monomer components such as psoralen,we prepared BO with betaine as the main ingredient,blended it with traditional Chinese medicines such as gromwell root and psoralen,and evaluated its antibacterial effects and safety in vitro and in vivo.The skin infection wound models of ordinary mice and diabetic mice were constructed,and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects in vivo and the anti-inflammatory and anti-apoptotic effects of BO.RESULTS The MICs of betaine against microorganisms such as Staphylococcus aureus(S.aureus),Candida albicans and Cryptococcus neoformans ranged from 4 to 32μg/mL.Gromwell root and psoralea,both of which contain antimicrobial components,mixed to prepare BO with MICs ranging from 16 to 64μg/mL,which is 32-256 times lower than those of Zicao ointment,although the MIC is greater than that of betaine.After 15 days of treatment with BO for USA300-infected ordinary mice,the wound scab removal rates were 83.3%,while those of mupirocin ointment and Zicao ointment were 66.7%and 0%,respectively,and the differences were statistically significant.In diabetic mice,the wound scab removal rate of BO and mupirolacin ointment was 80.0%,but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound healing.CONCLUSION The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensitive or drug-resistant S.aureus-infected ordinary mice and diabetic mice.展开更多
基金supported by the Henan Province Key R&D Project under Grant 241111210400the Henan Provincial Science and Technology Research Project under Grants 252102211047,252102211062,252102211055 and 232102210069+2 种基金the Jiangsu Provincial Scheme Double Initiative Plan JSS-CBS20230474,the XJTLU RDF-21-02-008the Science and Technology Innovation Project of Zhengzhou University of Light Industry under Grant 23XNKJTD0205the Higher Education Teaching Reform Research and Practice Project of Henan Province under Grant 2024SJGLX0126。
文摘Accurate and efficient detection of building changes in remote sensing imagery is crucial for urban planning,disaster emergency response,and resource management.However,existing methods face challenges such as spectral similarity between buildings and backgrounds,sensor variations,and insufficient computational efficiency.To address these challenges,this paper proposes a novel Multi-scale Efficient Wavelet-based Change Detection Network(MewCDNet),which integrates the advantages of Convolutional Neural Networks and Transformers,balances computational costs,and achieves high-performance building change detection.The network employs EfficientNet-B4 as the backbone for hierarchical feature extraction,integrates multi-level feature maps through a multi-scale fusion strategy,and incorporates two key modules:Cross-temporal Difference Detection(CTDD)and Cross-scale Wavelet Refinement(CSWR).CTDD adopts a dual-branch architecture that combines pixel-wise differencing with semanticaware Euclidean distance weighting to enhance the distinction between true changes and background noise.CSWR integrates Haar-based Discrete Wavelet Transform with multi-head cross-attention mechanisms,enabling cross-scale feature fusion while significantly improving edge localization and suppressing spurious changes.Extensive experiments on four benchmark datasets demonstrate MewCDNet’s superiority over comparison methods:achieving F1 scores of 91.54%on LEVIR,93.70%on WHUCD,and 64.96%on S2Looking for building change detection.Furthermore,MewCDNet exhibits optimal performance on the multi-class⋅SYSU dataset(F1:82.71%),highlighting its exceptional generalization capability.
基金financially supported by the National Natural Science Foundation of China(Grant Nos.11574057 and12172093)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2021A1515012607)。
文摘In recent years,optoelectronic synapses have garnered significant attention in the field of neuromorphic computing due to their integration of optical sensing and synaptic functions.In this work,we propose an optoelectronic synapse based on IGZO/Bi_(3.25)La_(0.75)Ti_3O_(12)heterojunction.Under UV light stimulation,this device can simulate a range of synaptic behaviors,including paired-pulse facilitation,spike-intensity-dependent plasticity,spike-number-dependent plasticity,spike-width-dependent plasticity,and the transition from short-term memory to long-term memory.The majority of perceptible information for humans is acquired through the visual system.The 3×3 retinal morphology synapse arrays constructed based on plasticity behaviors not only integrates light perception and storage functions but also exhibits adaptive adjustment capabilities to address image blurring caused by object movement.At the same time,in CNN recognition training,the device successfully simulates the learning-relearning mechanism of the human brain.These findings highlight the device's immense potential for applications in artificial vision systems.
基金National Key Research and Development Program of China(No.2023YFB4104204)National Natural Science Foundation of China(No.U23B2090).
文摘The utilization and storage of CO_(2) emissions from oil production and consumption in the upstream oil industry will contribute to sustainable development.CO_(2) flooding is the key technology for the upstream oil industry to transition to sustainable development.However,there is a significant challenge in achieving high recovery and storage efficiency in unconventional reservoirs,particularly in underde-veloped countries.Numerous studies have indicated that the limited sweep range caused by premature gas channeling of CO_(2) is a crucial bottleneck that hinders the enhancement of recovery,storage efficiency and safety.This review provides a comprehensive summary of the research and technical advancements regarding the front sweep characteristics of CO_(2) during migration.It particularly focuses on the char-acteristics,applicable stages,and research progress of different technologies used for regulating CO_(2) flooding sweep.Finally,based on the current application status and development trends,the review offers insights into the future research direction for these technologies.It is concluded that the front migration characteristics of CO_(2) play a crucial role in determining the macroscopic sweep range.The focus of future research lies in achieving cross-scale correlation and information coupling of CO_(2) migration processes.Currently,the influence weight of permeability,injection speed,pressure and other parameters on the characteristics of‘fingering-gas channeling’is still not well clear.There is an urgent need to establish prediction model and early warning mechanism that considers multi-parameters and cross-scale gas channeling degrees,in order to create effective strategies for prevention and control.There are currently three technologies available for sweep regulation:flow field intervention,mobility reduction,and gas channeling plugging.To expand the sweep effectively,it is important to systematically integrate these technologies based on their regulation characteristics and applicable stages.This can be achieved by constructing an intelligent synergistic hierarchical segmented regulation technology known as‘flow field intervention+mobility regulation+channel plugging chemically’.This work is expected to provide valuable insights for achieving conformance control of CO_(2)-EOR and safe storage of CO_(2).
基金financial support from the National Key R&D Program of China(No.2021YFB3702301)the National Natural Science Foundation of China(No.52171008)+4 种基金financial support from the National Key R&D Program of China(No.2019YFE03130003)the National Natural Science Foundation of China(No.51922054)the Tsinghua University Initiative Scientific Research Program(No.20233080002)the Mobility Programme from the Sino-German Center(No.M-0319)financial support from the National Natural Science Foundation of China(No.52374390).
文摘Although Al or Ti addition is promising to improve the performance of IN718,traditional metallurgical processing methods encounter difficulties in manufacturing superalloys with higher Al and Ti content.Laser powder bed fusion(LPBF)exhibits great potential to address these challenges,but the effects of Al or Ti content on additively manufactured IN718 stay unclear.In this work,we fabricated crack-free modified IN718 alloys with elevated Al or Ti content through in-situ alloying using laser powder bed fusion.The results revealed that the alloy 1 wt.%Ti addition outperformed IN718 in strength at both ambient and elevated temperatures by about 120 and 70 MPa,respectively,while the addition of 1 wt.%Al decreases the yield strength due to the significant decrease of γʹ ʹphase fraction.However,the addition of 3 wt.%Al leads to precipitation ofσ-phase,while 3 wt.%Ti addition leads to growth of coarseη-phase of micrometers at grain boundaries.After aging treatment at 720℃ for 50 h,it is also found that the thermal stability of γʹʹ phase is substantially improved by Ti alloying due to the formation of γʹʹ/γʹ/γʹʹ sandwich structure.These findings highlight the advantages of Ti alloying in enhancing thermal stability and mechanical performance.
基金supported by the Science&Technology Department of Sichuan Province(No.2019YFS0040)the Improvement Plan of“Xinglin Scholar”Scientific Research Talent,Chengdu University of Traditional Chinese Medicine(No.XKTD2022002)。
文摘The activation of the sirtuin1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase 1(HO-1)pathway has been shown to mitigate oxidative stress-induced apoptosis and mitochondrial damage by reducing reactive oxygen species(ROS)levels.Clinical trials have demonstrated that Zhongfeng Xingnao Liquid(ZFXN)ameliorates post-stroke cognitive impairment(PSCI).However,the underlying mechanism,particularly whether it involves protecting mitochondria and inhibiting apoptosis through the SIRT1/Nrf2/HO-1 pathway,remains unclear.This study employed an oxygen-glucose deprivation(OGD)cell model using SHSY5Y cells and induced PSCI in rats through modified bilateral carotid artery ligation(2VO).The effects of ZFXN on learning and memory,neuroprotective activity,mitochondrial function,oxidative stress,and the SIRT1/Nrf2/HO-1 pathway were evaluated both in vivo and in vitro.Results indicated that ZFXN significantly increased the B-cell lymphoma 2(Bcl2)/Bcl2-associated X(Bax)ratio,reduced terminal deoxynucleotidyl transferase-mediated d UTP nickend-labeling(TUNEL)+cells,and markedly improved cognition,synaptic plasticity,and neuronal function in the hippocampus and cortex.Furthermore,ZFXN exhibited potent antioxidant activity,evidenced by decreased ROS and malondialdehyde(MDA)content and increased superoxide dismutase(SOD),catalase(CAT),and glutathione(GSH)levels.ZFXN also demonstrated considerable enhancement of mitochondrial membrane potential(MMP),Tom 20 fluorescence intensity,adenosine triphosphate(ATP)and energy charge(EC)levels,and mitochondrial complexⅠandⅢactivity,thereby inhibiting mitochondrial damage.Additionally,ZFXN significantly increased SIRT1 activity and elevated SIRT1,nuclear Nrf2,and HO-1 levels.Notably,these effects were substantially counteracted when SIRT1 was suppressed by the inhibitor EX-527 in vitro.In conclusion,ZFXN alleviates PSCI by activating the SIRT1/Nrf2/HO-1 pathway and preventing mitochondrial damage.
基金fnancially supported by the Scientifc Research Project of the Department of Education in Hunan Prov ince,China(Grant No.23B0533).
文摘In this work,fow behavior and dynamic recrystallization(DRX)mechanism of a low carbon martensitic stainless bearing steel,CSS-42L,were investigated using a thermomechanical simulator under the temperature and strain rate ranges of 900 to 1100℃ and 0.1 to 20 s^(−1),respectively.The Arrhenius-type constitutive equation was established based on the fow stress curves.Moreover,the peak stress decreased with the increase in deformation temperature and the decrease in strain rate.There were two DRX mechanisms during hot deformation of the current studied steel,the main one being discontinuous dynamic recrystallization mechanism,acting through grain boundary bulging and migration,and the auxiliary one being continuous dynamic recrystallization mechanism,working through the rotation of sub-grains.On the basis of microstructural characterizations,power dissipation maps and fow instability maps,the optimized hot deformation parameters for CSS-42L bearing steel were determined as 1050℃/0.1 s^(−1) and 1100℃/1 s^(−1).
基金support from the National Science Foundation of China(NSFC)(Grants No.12293031 and No.61905252)the National Science Foundation for Distinguished Young Scholars(Grant No.12022308)the National Key R&D Program of China(Grants No.2021YFC2202200 and No.2021YFC2202204).
文摘Adaptive optics(AO)has significantly advanced high-resolution solar observations by mitigating atmospheric turbulence.However,traditional post-focal AO systems suffer from external configurations that introduce excessive optical surfaces,reduced light throughput,and instrumental polarization.To address these limitations,we propose an embedded solar adaptive optics telescope(ESAOT)that intrinsically incorporates the solar AO(SAO)subsystem within the telescope's optical train,featuring a co-designed correction chain with a single Hartmann-Shack full-wavefront sensor(HS f-WFS)and a deformable secondary mirror(DSM).The HS f-WFS uses temporal-spatial hybrid sampling technique to simultane-ously resolve tip-tilt and high-order aberrations,while the DSM performs real-time compensation through adaptive modal optimization.This unified architecture achieves symmetrical polarization suppression and high system throughput by min-imizing optical surfaces.A 600 mm ESAOT prototype incorporating a 12×12 micro-lens array HS f-WFS and 61-actuator piezoelectric DSM has been developed and successfully conducted on-sky photospheric observations.Validations in-cluding turbulence simulations,optical bench testing,and practical observations at the Lijiang observatory collectively confirm the system's capability to maintain aboutλ/10 wavefront error during active region tracking.This architectural breakthrough of the ESAOT addresses long-standing SAO integration challenges in solar astronomy and provides scala-bility analyses confirming direct applicability to the existing and future large solar observation facilities.
基金supported bythe National Natural Science Foundation of China(Nos.U23A20523,82272504,and 82072456)the Department of Science and Technology of Jilin Province,China(Nos.20210101439JC,20210101321JC,20220204119YY,202201ZYTS131,202201ZYTS129,20230204114YY,YDZJ202201ZYTS505,and YDZJ202301ZYTS076)+4 种基金the Special Program for Science and Technology Personnel of Changchun(No.ZKICKJJ2023015)the Key Training Plan for Outstanding Youth of Jilin University(No.419070623036)the Research Fund of the First Hospital of Jilin University(No.2021-zl-01)the Graduate Innovation Fund of Jilin University(No.2024CX125)the Foun-dation of National Center for Translational Medicine(Shanghai)SHU Branch,China(No.SUITM-202405).
文摘The pore structure of porous scaffolds plays a crucial role in bone repair.The prevalent bone implant structure in clinical practice is the traditional cubic structure.However,the traditional cubic structure exhibits sharp edges and junctions that are not conducive to cell adhesion or growth.In this study,a double gyroid(DG)Ti6Al4V scaffold based on a triply periodic minimal surface(TPMS)structure was devised,and the osseointegration performance of DG structural scaffolds with varying porosities was investigated.Compression tests revealed that the elastic modulus and compressive strength of DG structural scaffolds were sufficient for orthopedic implants.In vitro cellular experiments demonstrated that the DG structure significantly enhanced cell proliferation,vascularization,and osteogenic differentiation compared to the cubic structure.The DG structure with 55%porosity exhibited the most favorable outcomes.In vivo experiments in rabbits further demonstrated that DG scaffolds could promote neovascularization and bone regeneration and maturation;those with 55%porosity performed best.Comparing the surface area,specific surface area per unit volume,and internal flow distribution characteristics of gyroid and DG structure scaffolds,the latter are more conducive to cell adhesion and growth within scaffolds.This study underscored the potential of DG scaffolds based on the TPMS structure in optimizing the pore structure design of titanium scaffolds,inducing angiogenesis,and advancing the clinical application of titanium scaffolds for repairing bone defects.
基金Supported by Guangxi Science and Technology Major Projects,No.2023AA20009National Natural Science Foundation of China,No.32360035 and No.32060018.
文摘BACKGROUND Skin wounds are highly common in diabetic patients,and with increasing types of pathogenic bacteria and antibiotic resistance,wounds and infections in diabetic patients are difficult to treat and heal.AIM To explore the effects of betaine ointment(BO)in promoting the healing of skin wounds and reducing the inflammation and apoptosis of skin cells in microbially infected diabetic mice.METHODS By detecting the minimum inhibitory concentrations(MICs)of betaine and plant monomer components such as psoralen,we prepared BO with betaine as the main ingredient,blended it with traditional Chinese medicines such as gromwell root and psoralen,and evaluated its antibacterial effects and safety in vitro and in vivo.The skin infection wound models of ordinary mice and diabetic mice were constructed,and the OTC drugs mupirocin ointment and Zicao ointment were used as controls to evaluate the antibacterial effects in vivo and the anti-inflammatory and anti-apoptotic effects of BO.RESULTS The MICs of betaine against microorganisms such as Staphylococcus aureus(S.aureus),Candida albicans and Cryptococcus neoformans ranged from 4 to 32μg/mL.Gromwell root and psoralea,both of which contain antimicrobial components,mixed to prepare BO with MICs ranging from 16 to 64μg/mL,which is 32-256 times lower than those of Zicao ointment,although the MIC is greater than that of betaine.After 15 days of treatment with BO for USA300-infected ordinary mice,the wound scab removal rates were 83.3%,while those of mupirocin ointment and Zicao ointment were 66.7%and 0%,respectively,and the differences were statistically significant.In diabetic mice,the wound scab removal rate of BO and mupirolacin ointment was 80.0%,but BO reduced wound inflammation and the apoptosis of skin cells and facilitated wound healing.CONCLUSION The ointment prepared by mixing betaine and traditional Chinese medicine can effectively inhibit common skin microorganisms and has a strong effect on the skin wounds of sensitive or drug-resistant S.aureus-infected ordinary mice and diabetic mice.
