The specific absorption rate (SAR) characterises the energy intake from outside energy sources. Dominantly, the dosing of electromagnetic radiation uses the SAR, defining the absorbed power in unit mass, measured in W...The specific absorption rate (SAR) characterises the energy intake from outside energy sources. Dominantly, the dosing of electromagnetic radiation uses the SAR, defining the absorbed power in unit mass, measured in W/kg. Ionisation radiation creates a certain distortion in the DNA, which is the goal of radiation in oncology. The dose in this case counts the time duration of the actual SAR, and uses the absorbed energy instead of the absorbed power, measured by Gy (=J/kg). The ionising rate is the desired result, and the developed temperature is only an unwanted side effect. In the case of non-ionising radiation, the same characterisation is used for completely opposite goals. There, the direct interest is the temperature increase, and the excitation processes other than temperature increasing energy consumptions are neglected. Our objective in this work is to clarify the connections of SAR and developed temperature, and discussing the actual debates about non-ther-mal energy absorption.展开更多
Hyperthermia in oncology is an emerging complementary therapy. The clinical results depend on multiple conditional factors, like the type of cancer, the stage, the applied treatment device, and the complementary conve...Hyperthermia in oncology is an emerging complementary therapy. The clinical results depend on multiple conditional factors, like the type of cancer, the stage, the applied treatment device, and the complementary conventional therapy. The molecular effect could also be different depending on the temperature, heating dose, kind of energy transfer, and timing sequences compared to the concomitant treatment. This article examines the molecular impacts of a specific technique used in oncological hyperthermia called modulated electro-hyperthermia (mEHT). What sets mEHT apart is its emphasis on harnessing the combined effects of thermal and nonthermal factors. Nonthermal energy absorption occurs through the excitation of molecules, while the thermal component ensures the ideal conditions for this process. The applied radiofrequency current selects the malignant cells, and the modulation drives the nonthermal effects to immunogenic cell death, helping to develop tumor-specific antitumoral immune reactions. The synergy of the thermal and nonthermal components excites the lipid-assembled clusters of transmembrane proteins (membrane rafts) as the channels of transient receptor potentials (TRPs), the heat-shock proteins (HSPs), the voltage-gated channels, and the voltage-sensitive phosphatases (VSPs). All these transmembrane compartments channeling various ionic species (like calcium and proton) interact with the cytoskeleton and are involved in the apoptotic signal pathways.展开更多
文摘The specific absorption rate (SAR) characterises the energy intake from outside energy sources. Dominantly, the dosing of electromagnetic radiation uses the SAR, defining the absorbed power in unit mass, measured in W/kg. Ionisation radiation creates a certain distortion in the DNA, which is the goal of radiation in oncology. The dose in this case counts the time duration of the actual SAR, and uses the absorbed energy instead of the absorbed power, measured by Gy (=J/kg). The ionising rate is the desired result, and the developed temperature is only an unwanted side effect. In the case of non-ionising radiation, the same characterisation is used for completely opposite goals. There, the direct interest is the temperature increase, and the excitation processes other than temperature increasing energy consumptions are neglected. Our objective in this work is to clarify the connections of SAR and developed temperature, and discussing the actual debates about non-ther-mal energy absorption.
文摘Hyperthermia in oncology is an emerging complementary therapy. The clinical results depend on multiple conditional factors, like the type of cancer, the stage, the applied treatment device, and the complementary conventional therapy. The molecular effect could also be different depending on the temperature, heating dose, kind of energy transfer, and timing sequences compared to the concomitant treatment. This article examines the molecular impacts of a specific technique used in oncological hyperthermia called modulated electro-hyperthermia (mEHT). What sets mEHT apart is its emphasis on harnessing the combined effects of thermal and nonthermal factors. Nonthermal energy absorption occurs through the excitation of molecules, while the thermal component ensures the ideal conditions for this process. The applied radiofrequency current selects the malignant cells, and the modulation drives the nonthermal effects to immunogenic cell death, helping to develop tumor-specific antitumoral immune reactions. The synergy of the thermal and nonthermal components excites the lipid-assembled clusters of transmembrane proteins (membrane rafts) as the channels of transient receptor potentials (TRPs), the heat-shock proteins (HSPs), the voltage-gated channels, and the voltage-sensitive phosphatases (VSPs). All these transmembrane compartments channeling various ionic species (like calcium and proton) interact with the cytoskeleton and are involved in the apoptotic signal pathways.
