A large amount of free radicals can be generated in human body during metabolic process.These free radicals can result in oxidative stress and homeostasis imbalance,even some chronic diseases and cancers if they are n...A large amount of free radicals can be generated in human body during metabolic process.These free radicals can result in oxidative stress and homeostasis imbalance,even some chronic diseases and cancers if they are not promptly removed.Currently,many studies devote to exploring and utilizing natural antioxidants to remove excessive free radicals in human body,thus realizing the prevention and treatment of diseases.In the present study,the major species of natural antioxidants in foods that are benefit for the prevention and treatments of diseases have been summarized.Meanwhile,the research progress and future development have also been proposed.All of these studies,on the one hand,can provide a theoretical basis for the development of drugs and healthy foods;on the other hand,can offer novel development ideas for food industry,especially for food additive industry.展开更多
Triplet-triplet annihilation(TTA) upconversion-based materials have potential application in the broad range of research areas, including photocatalysis and life sciences. However, near-infrared(NIR)-to-blue upconvert...Triplet-triplet annihilation(TTA) upconversion-based materials have potential application in the broad range of research areas, including photocatalysis and life sciences. However, near-infrared(NIR)-to-blue upconverted emission is preferred for most of the practical applications, but developing a NIR-to-blue TTA upconversion system is a challenging task in photochemistry. In this work, a thermally activated delayed fluorescence(TADF) material with intense visible-to-NIR absorption is demonstrated that shows a longer triplet state lifetime(32 μs) and high triplet state energy(E_(T)= 1.55 e V). For the first time, a heavy atomfree NIR(λ_(ex)> 650 nm) to blue(λ_(em)< 460 nm) TTA upconversion system was devised, employing the dimeric borondifluoride curcuminoid TADF material as triplet photosensitizer(PS) and a large anti-Stokes shift(0.88 e V) along with moderate upconversion yield was achieved. Our work provides the solution and guidance for the future development of purely organic heavy atom-free NIR activating TTA upconversion system for a wide array of applications.展开更多
We are only beginning to understand the influence of agricultural practices,together with soil properties and geographic factors,affect bacterial communities and their influence on the soil processes.Here,we quantify ...We are only beginning to understand the influence of agricultural practices,together with soil properties and geographic factors,affect bacterial communities and their influence on the soil processes.Here,we quantify how typical agro-practices,i.e.,no-tillage,ridge tillage,continuous corn cropping,and crop rotation with corn and bean,and the corresponding soil physicochemical characteristics affect bacterial diversity and community compositions of the rhizosphere and root zone soils.Results show that species richness in the rhizosphere was significantly higher than that in the root zone soils(p<0.05),typically with more abundant Crenarchaeota and Firmicutes populations that are active members for C and N cycling.Specifically,crop rotation compared to other agro-practices was able to mediate soil pH value and the available P and thereby control the bacterial diversity pattern in the rhizosphere(p<0.05),while tillage practices regulated the relative abundance of bacterial populations in root zone soils by varying the soil available N(p<0.05).Analysis of biomarker patterns suggests that the observed differences in bacterial functional capabilities(e.g.,nutrient cycling)are strongly related to the physicochemical properties of surrounding soils.Our results highlight the importance of soil-plant interaction in shaping soil bacterial community structure typically in the rhizosphere and root zone soils and also illustrates the challenges in linking soil ecosystem function to microbial processes.展开更多
Soil microorganisms play a key role in the function of soil ecosystem,yet our knowledge about how microbial communities respond to the typically sandy soil environmental properties along the soil profile is still insu...Soil microorganisms play a key role in the function of soil ecosystem,yet our knowledge about how microbial communities respond to the typically sandy soil environmental properties along the soil profile is still insufficient.We investigated the soil microbial community patterns from top(0–20 cm)to clay-layer(>80 cm)of the typical sandy soils in three regions in China with different levels of precipitation,including Lishu County in Jilin Province(LS),Langfang City in Hebei Province(LF)and Zhengzhou City in Henan Province(ZZ).Our findings showed that small-size aggregates(<0.5 mm)rather than large ones(³0.5 mm)dominated the soil profile.The relative abundances of Actinobacteria,Crenarchaeota and Firmicutes were highly related to aggregate proportions of the deep clay-layer soil.The network analysis revealed the distinct community patterns among modules,evidencing niche differentiation along the soil profile.The keystone species OTU_11292 was observed having migrated clearly into the other module of the clay-layer soil.Different roles of the OTU_30(belonging to Gemmatimonadetes)in soil processes might partly explain the different microbial distribution between top-and clay-layer soils.These findings provided new insights into the candidate mechanisms of microbial diversity maintenance and community patterning of sandy soils,which were necessary for better understanding of ecological rules guiding long-term agricultural practice.展开更多
In order to improve the morphology of microchannels fabricated by femtosecond laser ablation, the thermal process was introduced into the post-treatment processing. It was found that the thermal process cannot only de...In order to improve the morphology of microchannels fabricated by femtosecond laser ablation, the thermal process was introduced into the post-treatment processing. It was found that the thermal process cannot only decrease the roughness but also the width and depth of the microchannel. The change rates of width, depth, and roughness of the microchannel increase with processing temperature. When we prolong the time of constant temperature, the change rate of the width decreases at the beginning, and then it tends to be stable. However,the change rates of depth and roughness increase, and then they tend to be stable. In this Letter, we discuss the reasons of the above phenomena.展开更多
Background:The tumor microenvironment(TME)plays an important role in regulating gastric cancer(GC)progression.The infiltration of M0 macrophages into the TME negatively affects the prognosis of patients with various t...Background:The tumor microenvironment(TME)plays an important role in regulating gastric cancer(GC)progression.The infiltration of M0 macrophages into the TME negatively affects the prognosis of patients with various tumors.Methods:The data were obtained from the TCGA and GEO databases and our hospital(107 patients).The expression of IQGAP3 was knocked down in AGS and NCI-N87 GC cells.Cell proliferation,migration,and invasion assays were performed.RNA sequencing was performed on GC cells with different IQGAP3 expression.AGS and THP-1 cells were mixed to create a co-cultured subcutaneous tumor model in nude mice.Tumor growth in the mice was observed by using luciferin fluorescence and the tumor tissues were subjected to immunohistochemistry.Results:The expression of IQGAP3 was increased in GC tissues(P<0.001)and was associated with infiltration of M0 macrophages and a poor prognosis for GC patients(P<0.01).Knockdown of IQGAP3 resulted in decreased expression of CXCL13(P<0.001)and less phosphorylation of pSTAT3 and pERK1/2(P<0.001).The expression of CXCL13 was decreased after the pSTAT3 and pERK1/2 phosphorylation inhibitors were added.In the co-culture experiment,the M0/THP-1 ratio decreased significantly in the low-IQGAP3-expression group(P<0.001).However,adding recombinant human CXCL13 proteins to the low IQGAP3 expression group increased the M0/THP-1 ratio.In vivo,tumor growth and M0 macrophage infiltration were both suppressed in the group with low IQGAP3 expression.Conclusion:IQGAP3 is a potential pro-carcinogenic factor in GC.IQGAP3 promotes the expression and secretion of CXCL13 via the ERK1/2 and STAT3 pathways,thereby causing M0 macrophages to infiltrate the TME.展开更多
文摘A large amount of free radicals can be generated in human body during metabolic process.These free radicals can result in oxidative stress and homeostasis imbalance,even some chronic diseases and cancers if they are not promptly removed.Currently,many studies devote to exploring and utilizing natural antioxidants to remove excessive free radicals in human body,thus realizing the prevention and treatment of diseases.In the present study,the major species of natural antioxidants in foods that are benefit for the prevention and treatments of diseases have been summarized.Meanwhile,the research progress and future development have also been proposed.All of these studies,on the one hand,can provide a theoretical basis for the development of drugs and healthy foods;on the other hand,can offer novel development ideas for food industry,especially for food additive industry.
基金the National Natural Science Foundation of China (Nos. 21975053, 21975055, U2001222)Guangdong Basic and Applied Basic Research Foundation (Nos. 2019B1515120023, 2022B1515020041)Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2019) for financial support。
文摘Triplet-triplet annihilation(TTA) upconversion-based materials have potential application in the broad range of research areas, including photocatalysis and life sciences. However, near-infrared(NIR)-to-blue upconverted emission is preferred for most of the practical applications, but developing a NIR-to-blue TTA upconversion system is a challenging task in photochemistry. In this work, a thermally activated delayed fluorescence(TADF) material with intense visible-to-NIR absorption is demonstrated that shows a longer triplet state lifetime(32 μs) and high triplet state energy(E_(T)= 1.55 e V). For the first time, a heavy atomfree NIR(λ_(ex)> 650 nm) to blue(λ_(em)< 460 nm) TTA upconversion system was devised, employing the dimeric borondifluoride curcuminoid TADF material as triplet photosensitizer(PS) and a large anti-Stokes shift(0.88 e V) along with moderate upconversion yield was achieved. Our work provides the solution and guidance for the future development of purely organic heavy atom-free NIR activating TTA upconversion system for a wide array of applications.
基金We acknowledge the financial support by the National Key Research and Development Program of China(2016YFD-0200306)the National Natural Science Foundation of China(41877412).
文摘We are only beginning to understand the influence of agricultural practices,together with soil properties and geographic factors,affect bacterial communities and their influence on the soil processes.Here,we quantify how typical agro-practices,i.e.,no-tillage,ridge tillage,continuous corn cropping,and crop rotation with corn and bean,and the corresponding soil physicochemical characteristics affect bacterial diversity and community compositions of the rhizosphere and root zone soils.Results show that species richness in the rhizosphere was significantly higher than that in the root zone soils(p<0.05),typically with more abundant Crenarchaeota and Firmicutes populations that are active members for C and N cycling.Specifically,crop rotation compared to other agro-practices was able to mediate soil pH value and the available P and thereby control the bacterial diversity pattern in the rhizosphere(p<0.05),while tillage practices regulated the relative abundance of bacterial populations in root zone soils by varying the soil available N(p<0.05).Analysis of biomarker patterns suggests that the observed differences in bacterial functional capabilities(e.g.,nutrient cycling)are strongly related to the physicochemical properties of surrounding soils.Our results highlight the importance of soil-plant interaction in shaping soil bacterial community structure typically in the rhizosphere and root zone soils and also illustrates the challenges in linking soil ecosystem function to microbial processes.
基金the financial supports of the National Basic Research Program of China(Grant no.2016YFD0200306)the National Natural Science Foundation of China(Grant no.41877412)the Scholarship of the‘National 1000(Young)Talents Program’of China.
文摘Soil microorganisms play a key role in the function of soil ecosystem,yet our knowledge about how microbial communities respond to the typically sandy soil environmental properties along the soil profile is still insufficient.We investigated the soil microbial community patterns from top(0–20 cm)to clay-layer(>80 cm)of the typical sandy soils in three regions in China with different levels of precipitation,including Lishu County in Jilin Province(LS),Langfang City in Hebei Province(LF)and Zhengzhou City in Henan Province(ZZ).Our findings showed that small-size aggregates(<0.5 mm)rather than large ones(³0.5 mm)dominated the soil profile.The relative abundances of Actinobacteria,Crenarchaeota and Firmicutes were highly related to aggregate proportions of the deep clay-layer soil.The network analysis revealed the distinct community patterns among modules,evidencing niche differentiation along the soil profile.The keystone species OTU_11292 was observed having migrated clearly into the other module of the clay-layer soil.Different roles of the OTU_30(belonging to Gemmatimonadetes)in soil processes might partly explain the different microbial distribution between top-and clay-layer soils.These findings provided new insights into the candidate mechanisms of microbial diversity maintenance and community patterning of sandy soils,which were necessary for better understanding of ecological rules guiding long-term agricultural practice.
基金supported by the National Natural Science Foundation of China(Nos.51475482,51475482,51475481,and 51875585)the National Key R&D Program of China(Nos.2018YFB1107803 and 2017YFB1104800)
文摘In order to improve the morphology of microchannels fabricated by femtosecond laser ablation, the thermal process was introduced into the post-treatment processing. It was found that the thermal process cannot only decrease the roughness but also the width and depth of the microchannel. The change rates of width, depth, and roughness of the microchannel increase with processing temperature. When we prolong the time of constant temperature, the change rate of the width decreases at the beginning, and then it tends to be stable. However,the change rates of depth and roughness increase, and then they tend to be stable. In this Letter, we discuss the reasons of the above phenomena.
基金National Natural Science Foundation of China(no.82372860,no.81641098)Peking University First Hospital Youth Clinical Research Project(no.2021CR03)+3 种基金Peking University First Hospital Multidisciplinary Research Project(no.2022CR13)the Youth Cultivated Research Fund of Peking University Health Center(grant no.BMU2020PYB026)National Project for Clinical Key Specialty DevelopmentTianjin Key Medical Discipline Construction Project(grant no.TJYXZDXK-3-003A).
文摘Background:The tumor microenvironment(TME)plays an important role in regulating gastric cancer(GC)progression.The infiltration of M0 macrophages into the TME negatively affects the prognosis of patients with various tumors.Methods:The data were obtained from the TCGA and GEO databases and our hospital(107 patients).The expression of IQGAP3 was knocked down in AGS and NCI-N87 GC cells.Cell proliferation,migration,and invasion assays were performed.RNA sequencing was performed on GC cells with different IQGAP3 expression.AGS and THP-1 cells were mixed to create a co-cultured subcutaneous tumor model in nude mice.Tumor growth in the mice was observed by using luciferin fluorescence and the tumor tissues were subjected to immunohistochemistry.Results:The expression of IQGAP3 was increased in GC tissues(P<0.001)and was associated with infiltration of M0 macrophages and a poor prognosis for GC patients(P<0.01).Knockdown of IQGAP3 resulted in decreased expression of CXCL13(P<0.001)and less phosphorylation of pSTAT3 and pERK1/2(P<0.001).The expression of CXCL13 was decreased after the pSTAT3 and pERK1/2 phosphorylation inhibitors were added.In the co-culture experiment,the M0/THP-1 ratio decreased significantly in the low-IQGAP3-expression group(P<0.001).However,adding recombinant human CXCL13 proteins to the low IQGAP3 expression group increased the M0/THP-1 ratio.In vivo,tumor growth and M0 macrophage infiltration were both suppressed in the group with low IQGAP3 expression.Conclusion:IQGAP3 is a potential pro-carcinogenic factor in GC.IQGAP3 promotes the expression and secretion of CXCL13 via the ERK1/2 and STAT3 pathways,thereby causing M0 macrophages to infiltrate the TME.
