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A Transformer Based on Feedback Attention Mechanism for Diagnosis of Coronary Heart Disease Using Echocardiographic Images
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作者 Chunlai du Xin Gu +4 位作者 Yanhui Guo Siqi Guo Ziwei Pang Yi du guoqing du 《Computers, Materials & Continua》 2025年第5期3435-3450,共16页
Coronary artery disease is a highly lethal cardiovascular condition,making early diagnosis crucial for patients.Echocardiograph is employed to identify coronary heart disease(CHD).However,due to issues such as fuzzy o... Coronary artery disease is a highly lethal cardiovascular condition,making early diagnosis crucial for patients.Echocardiograph is employed to identify coronary heart disease(CHD).However,due to issues such as fuzzy object boundaries,complex tissue structures,and motion artifacts in ultrasound images,it is challenging to detect CHD accurately.This paper proposes an improved Transformer model based on the Feedback Self-Attention Mechanism(FSAM)for classification of ultrasound images.The model enhances attention weights,making it easier to capture complex features.Experimental results show that the proposed method achieves high levels of accuracy,recall,precision,F1 score,and area under the receiver operating characteristic curve(72.3%,79.5%,82.0%,81.0%,and 0.73%,respectively).The proposed model was compared with widely used models,including convolutional neural network and visual Transformer model,and the results show that our model outperforms others in the above evaluation metrics.In conclusion,the proposed model provides a promising approach for diagnosing CHD using echocardiogram. 展开更多
关键词 Computer-aided diagnosis(CAD) TRANSFORMER coronary heart disease feedback self-attention mechanism
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ANGPT1和TEK影响人类肿瘤进展的泛癌分析
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作者 杜国庆 刘志琴 +1 位作者 李姚 史永华 《昆明医科大学学报》 CAS 2024年第6期57-68,共12页
目的探讨血管生成素1(angiopoietins-1,ANGPT1)及其受体TEK(tyrosine kinase)在泛癌中的表达、预后及免疫浸润的情况。方法应用TIMER2.0、Kaplan-Meier plotter、UALCAN等数据库分析ANGPT1及TEK在泛癌中的表达、预后;利用SangerBox3.0及... 目的探讨血管生成素1(angiopoietins-1,ANGPT1)及其受体TEK(tyrosine kinase)在泛癌中的表达、预后及免疫浸润的情况。方法应用TIMER2.0、Kaplan-Meier plotter、UALCAN等数据库分析ANGPT1及TEK在泛癌中的表达、预后;利用SangerBox3.0及R软件分析ANGPT1、TEK与肿瘤突变负荷(tumor mutation burden,TMB)、微卫星不稳定(microsatellite instability,MSI)、免疫检查点(immune checkpoint,ICP)、免疫浸润的相关性;使用String数据库、GO与KEGG分析鉴定与ANGPT1和TEK相关的蛋白及调节通路。结果ANGPT1和TEK在多数肿瘤中低表达(P<0.05)。ANGPT1、TEK低表达患者预后不良(P<0.05)。ANGPT1和TEK的表达水平与肾透明细胞癌、膀胱尿路上皮癌、乳腺浸润性癌等临床分期相关(P<0.05)。ANGPT1、TEK表达与肿瘤的TMB、MSI、ICP相关(P<0.05),与免疫浸润正相关(P<0.05)。与ANGPT1和TEK关系密切的基因有GRB2、PIK3R1、EGFR等,主要参与Grb2-EGFR、ERBB3:ERBB2、Shc-EGFR等复合物相关的生物学过程和功能,主要涉及ErbB信号通路。结论ANGPT1和TEK可能通过ErbB信号通路在肿瘤发生发展中起重要作用,有望成为多种癌症的潜在临床预后标志物。 展开更多
关键词 ANGPT1 TEK 泛癌分析 R语言
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