Underwater launch is a transient vibration process under the impact load.The hydrodynamic calculation is an important part of equipment research.In this paper,firstly,combining the theory of the Euler-Bernoulli beam a...Underwater launch is a transient vibration process under the impact load.The hydrodynamic calculation is an important part of equipment research.In this paper,firstly,combining the theory of the Euler-Bernoulli beam and the potential flow,the transfer equation of the Euler-Bernoulli beam considering the hydroelastic effect is derived,which expands the application scope of the transfer matrix.The correctness of the transfer matrix for the beam with hydroelastic behaviors is verified by comparison with the results of the finite element analysis.Then the dynamics model of the underwater launch system is established based on the multibody system transfer matrix method,and the beam with hydroelastic behaviors is employed as the external vehicle.Subsequently,the overall transfer and dynamic equation are derived,resulting in the solution of the wet natural frequency and the dynamic response under the impact load.The comparison with experimental data validates the dynamics model and simulation results and ensures its reliability in practical applications.The dynamic of the system demonstrates that the launching interval and adjacent tube effect will exert an influence on the subsequent emission.This research provides a fast and efficient method for the dynamic calculation of the underwater launch system.展开更多
As the performance of the box-type multiple launch rocket system(BMLRS)improves,its mechanical structures,particularly the plane clearance design between the slider on the rocket and the guide inside the launch canist...As the performance of the box-type multiple launch rocket system(BMLRS)improves,its mechanical structures,particularly the plane clearance design between the slider on the rocket and the guide inside the launch canister,have grown increasingly complex.However,deficiencies still exist in the current launch modeling theory for BMLRS.In this study,a multi-rigid-flexible-body launch dynamics model coupling the launch platform and rocket was established using the multibody system transfer matrix method and the Newton-Euler formulation.Furthermore,considering the bending of the launch canister,a detection algorithm for slider-guide plane clearance contact was proposed.To quantify the contact force and friction effect between the slider and guide,the contact force model and modified Coulomb model were introduced.Both the modal and launch tests were conducted.Additionally,the modal convergence was verified.By comparing the modal experiments and simulation results,the maximum relative error of the eigenfrequency is 3.29%.thereby verifying the accuracy of the developed BMLRS dynamics model.Furthermore,the launch test validated the proposed plane clearance contact model.Moreover,the study investigated the influence of various model parameters on the dynamic characteristics of BMLRS,including launch canister bending stiffness,slider and guide material,slider-guide clearance,slider length and layout.This analysis of influencing factors provides a foundation for future optimization in BMLRS design.展开更多
Introduction: Anti-Müllerian hormone (AMH) is shown to be a possible indicator of ovarian function. Severe systemic lupus erythematosus (SLE) patients exposed to high-dose cyclophosphamide (CTX) have a much highe...Introduction: Anti-Müllerian hormone (AMH) is shown to be a possible indicator of ovarian function. Severe systemic lupus erythematosus (SLE) patients exposed to high-dose cyclophosphamide (CTX) have a much higher risk of developing infertility and premature ovarian failure. Therefore, we performed a prospective case-control study to evaluate the impact of SLE on women’s ovarian reserve using AMH before CTX therapy. Methods: SLE patients before receiving CTX therapy were enrolled in our hospital. Age-matched healthy women were served as controls. Serum AMH level was measured using an enzyme-linked immunosorbent assay. Basal hormone levels were measured including follicle-stimulating hormone, luteinizing hormone, and estradiol on the third day of their menstrual periods. All participants underwent transvaginal ultrasonographic examination for the determination of total antral follicle count on the third day. Results: AMH value in SLE patients was significantly lower compared to healthy control with normal ovarian reserve. No significant difference in AMH levels was found between SLE and healthy control with low ovarian reserve. Conclusions: SLE patients not receiving CTX therapy even with normal menstruation, still had an impaired ovarian reserve. Therefore, early monitoring of AMH levels could better reflect the ovarian function and reproductive outcomes of SLE patients and relative protective strategy needed to reserve fertility.展开更多
How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS consi...How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.展开更多
Field experiments were conducted in 2011 on an experimental farm at the Cotton Research Insti-tute, Chinese Academy of Agricultural Sciences, Anyang, China. We conducted experiments with a “SPAD-502” meter to quickl...Field experiments were conducted in 2011 on an experimental farm at the Cotton Research Insti-tute, Chinese Academy of Agricultural Sciences, Anyang, China. We conducted experiments with a “SPAD-502” meter to quickly measure the relative value of chlorophyll content in the leaf blades of field cotton. Our goal was to seek a suitable leaf on a cotton plant to diagnose senescence status of crop plants at later stages of growth. We began by studying the dynamic change rule of the dis-tal-most four leaves of the cotton plant during the entire growth period with two early-maturing cultivars (CCRI 36, CCRI 50) and two mid-maturing cultivars (CCRI 41, SCRC 28). We also examined the effect of different nitrogen and potassium fertilizer rates on SPAD values of the leaves of SCRC 28. Our results suggest that SPAD values of the 1st distal stem leaves from two early cultivars can act as good indicators of senescence status in the plants, if they are measured between 10 d before the boll-opening stage and 10 d after boll opening stage. Differences of SPAD values of the 3rd distal stem leaves of two mid-maturing cultivars measured between about 15 d before the boll opening stage and 15 d after the boll opening stage can also be used to measure senescence status in these cotton cultivars. The conclusion can be used for cotton producer to manage N fertilizer better at later growth stage.展开更多
Notwithstanding the exceptional photodetection capabilities of the laterally-structured perovskite single-crystal sheet(SCS),attributed to its notably lengthy carrier diffusion length and reduced defect density,operat...Notwithstanding the exceptional photodetection capabilities of the laterally-structured perovskite single-crystal sheet(SCS),attributed to its notably lengthy carrier diffusion length and reduced defect density,operating the device within free space and exposing the SCS to the environment present obstacles in attaining on-chip integration and long-term stability.To overcome these challenges,this study proposes the introduction of a waveguide(WG)structure methodology,and selects the silicon WG(SWG)core and the polymer polymethyl methacrylate(PMMA)WG(PWG)fiber as materials.Furthermore,it integrates these two WG structures with the laterally-structured SCS photodetector into WG-SCS devices,enabling photodetection under near-field excitation of the WG.Significantly,the WG-SCS device encapsulated with silicone sealant demonstrates exceedingly high stability,with no degradation in performance after being exposed to light and water stimuli for 1000 h.This study demonstrates the viability of on-chip integration of lateral-structured SCS photodetectors by means of introducing WG structures and investigates the technical facets of the device’s long-term environmental stability.The results are expected to exert a crucial role in device integration in future applications such as optical communication,quantum photonics,and biochemical sensing.展开更多
Non-Gaussian random vibrations have gained more attention in the dynamics-research community due to the frequently encountered non-Gaussian dynamic environments in engineering practice.This work proposes a novel non-G...Non-Gaussian random vibrations have gained more attention in the dynamics-research community due to the frequently encountered non-Gaussian dynamic environments in engineering practice.This work proposes a novel non-Gaussian random vibration test method by simultaneous control of multiple correlation coefficients,skewness,and kurtoses.The multi-channel time-domain coupling model is first constructed which is mainly composed of the designed parameters and independent signal sources.The designed parameters are related to the defined correlation coefficients and root mean square values.The synthesized multiple non-Gaussian random signals are unitized to provide independent signal sources for coupling.The first four statistical characteristics of the synthesized non-Gaussian random signals are theoretically derived so that the relationships among the generated signals,independent signal sources,and correlation coefficients are achieved.Subsequently,a multi-channel closed-loop equalization procedure for non-Gaussian random vibration control is presented to produce a multi-channel correlated non-Gaussian random vibration environment.Finally,a simulation example and an experimental verification are provided.Results from the simulation and experiment indicate that the multi-channel response spectral densities,correlation coefficients,skewnesses,and kurtoses can be stably and effectively controlled within the corresponding tolerances by the proposed method.展开更多
Ruddlesden-Popper(RP)layered perovskite single crystals(SCs)have been widely utilized in high-performance and weather-resistant photodetectors(PDs)due to their unique properties,including highly anisotropic carrier tr...Ruddlesden-Popper(RP)layered perovskite single crystals(SCs)have been widely utilized in high-performance and weather-resistant photodetectors(PDs)due to their unique properties,including highly anisotropic carrier transport,superior dark current suppression,and exceptional chemical stability.While the large-scale fabrication of RP layered perovskite SCs has been successfully achieved,the absence of systematic investigations into their mechanical strain properties poses a significant barrier to their application in flexible optoelectronic devices.This study introduces a polymer-SC-electrode-polymer lateral architecture PD,which employs a damage-free transfer technique to transfer centimeter-scale(C_6H_(5)C_(2)H_(4)NH_(3)_(2)PbI_(4)SC sheets(SC-sheets)with a thickness of~1μm from rigid substrates to flexible electrode substrates.This transfer process is facilitated by an organic polymer solution solidification-based method.The lateral device configuration effectively exploits the in-plane high electrical conductivity of RP layered perovskites,achieving responsivity of 728 mA/W,on/off ratio of 1.6×10^(4),specific detectivity of 2.14×10^(13)Jones,and external quantum efficiency of 222%.The self-sealing bilayer polymer sandwich structure imparts superior mechanical strain tolerance to the SCs,as demonstrated by mechanical bending tests that reveal an ultimate failure curvature radius of the SC-sheet in the range of 2.5-2.7 mm.Notably,even after superthreshold bendinginduced fragmentation,the crystal segments maintain robust adhesion to electrodes through polymer chain interactions,thereby preserving efficient PD functionality.This work represents a significant advancement in the development of flexible optoelectronics based on RP layered SCs and expands their applicability in next-generation wearable devices.展开更多
To bridge the gap between artists and non-specialists,we present a unified framework,Neural-Polyptych,to facilitate the creation of expansive,high-resolution paintings by seamlessly incorporating interactive hand-draw...To bridge the gap between artists and non-specialists,we present a unified framework,Neural-Polyptych,to facilitate the creation of expansive,high-resolution paintings by seamlessly incorporating interactive hand-drawn sketches with fragments from original paintings.We have designed a multi-scale GAN-based architecture to decompose the generation process into two parts,each responsible for identifying global and local features.To enhance the fidelity of semantic details generated from users'sketched outlines,we introduce a Correspondence Attention module utilizing our Reference Bank strategy.This ensures the creation of high-quality,intricately detailed elements within the artwork.The final result is achieved by carefully blending these local elements while preserving coherent global consistency.Consequently,this methodology enables the production of digital paintings at megapixel scale,accommodating diverse artistic expressions and enabling users to recreate content in a controlled manner.We validate our approach to diverse genres of both Eastern and Western paintings.Applications such as large painting extension,texture shuffling,genre switching,mural art restoration,and recomposition can be successfully based on our framework.展开更多
Single-crystal(SC) structures have long been regarded as the optimal configuration for metal halide perovskite photodetectors(PDs);however, their applications in large-area imaging and wearable electronics face limita...Single-crystal(SC) structures have long been regarded as the optimal configuration for metal halide perovskite photodetectors(PDs);however, their applications in large-area imaging and wearable electronics face limitations due to size constraints and mechanical inflexibility. To address these challenges, this study develops a hybrid composite structure— polycrystalline powder(PCP) matrix(PCPM)—by strategically homogenizing 20 μm PCPs within a poly(methyl methacrylate) matrix. Such a configuration enables the formation of densely packed PCP microstructures while maintaining electric conductivity and mechanical flexibility. In the single-photon regime, responsivity(R) and external quantum efficiency(EQE) decline by 50%, with concurrent 3–4-fold enhancements in the On/Off ratio and 12–16-fold improvements in specific detectivity(D), compared with those of SC counterparts. Notably, in the two-photon regime, R and EQE exhibit a 2–3-fold increase, and the On/Off ratio and D exhibit 12–16-fold improvements. The PCPM configuration enables the high-repetitionrate wafer-scale fabrication of active layers for imaging PDs and provides exceptional mechanical flexibility and self-recovery. These findings establish PCPMs as a scalable platform for next-generation perovskite wearable electronics.展开更多
background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic stroke.Gasdermin D(GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death,which...background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic stroke.Gasdermin D(GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death,which can exacerbate neuroinflammatory responses and brain damage.Stimulator of interferon genes(STING)was recently described as a vital innate immune adaptor protein associated with neuroinflammation.Nevertheless,the regulatory effects of STING on microglial pyroptosis post-stroke have not been well elaborated.Methods STING-knockout and wild-type(WT)mice were subjected to middle cerebral artery occlusion(MCAO).STING small interfering RNA(siRNA)was transfected into BV2 cells before oxygen-glucose deprivation/reoxygenation(OGD/R).STING-overexpressing adeno-associated virus(AAV)and NOD-like receptor family pyrin domain containing 3(NLRP3)siRNA were administered by stereotaxic injection.2,3,5-Triphenyl tetrazolium chloride(TTC)staining,TdT-mediated dUTP nick end labeling(TUNEL)staining,Fluoro-Jade C(FJC)staining,neurobehavioural tests,immunohistochemistry,cytokine antibody array assay,transmission electron microscopy,immunoblot,Enzyme-linked immunosorbent assay(ELISA)and quantitative real-time polymerase chain reaction(qRT-PCR)were carried out.Co-immunoprecipitation assays were used to investigate the interplay between STING and NLRP3.Results STING expression was increased after MCAO and mainly detected on microglia.STING deletion alleviated brain infarction,neuronal damage and neurobehavioural impairment in mice subjected to MCAO.STING knockout suppressed microglial activation and the secretion of inflammatory chemokines,accompanied by mitigation of microglial pyroptosis.Specific upregulation of microglial STING by AAV-F4/80-STING aggravated brain injury and microglial pyroptosis.Mechanistically,co-immunoprecipitation showed that STING bound to NLRP3 in microglia.Supplementation of NLRP3 siRNA reversed AAV-F4/80-STING-induced deterioration of microglial pyroptosis.Conclusions The current findings indicate that STING modulates NLRP3-mediated microglial pyroptosis following MCAO.STING may serve as a therapeutic target in neuroinflammation induced by cerebral ischaemic/reperfusion(I/R)injury.展开更多
Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium.It is characterized by acute onset,rapid progress and high risk of death.Its pathogenesis involves excessive immune activation of the innate...Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium.It is characterized by acute onset,rapid progress and high risk of death.Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm.According to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term prognosis.Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.展开更多
The excellent Upland cotton(Gossypium hirsutum)cultivars developed since 1949 have made a huge contribution to cotton production in China,the world's largest producer and consumer of cotton.However,the genetic and...The excellent Upland cotton(Gossypium hirsutum)cultivars developed since 1949 have made a huge contribution to cotton production in China,the world's largest producer and consumer of cotton.However,the genetic and genomic basis for the improvements of these cotton cultivars remains largely unclear.In this study,we selected 16 Upland cotton cultivars with important historical status in Chinese cotton breeding and constructed a multiparent,advanced generation,intercross(MAGiC)population comprising 920 recombinant inbred lines.A genome-wide association study using the MAGIC population identified 54 genomic loci associated with lint yield and fiber quality.Of them,25(46.30%)pleiotropic genomic loci cause simultaneous changes of lint yield and/or fiber quality traits,revealing complex trade-offs and linkage drags in Upland cotton agronomic traits.Deep sequencing data of 11 introduced ancestor cultivars and publicly available resequencing datasets of 839 cultivars developed in China during the past 70 years were integrated to explore the historical distribution and origin of the elite or selected alleles.Interestingly,85%oftheseelitealleles were selectedandfixed fromdifferent Americanancestors,consistentwithcotton breeding practices in China.However,seven elite alleles of native origin that are responsible for Fusarium wilt resistance,early maturing,good-quality fiber,and other characteristics were not found in American an-cestors but have greatly contributed to Chinese cotton breeding and wide cultivation.Taken together,these results provide a genetic basis for further improving cotton cultivars and reveal that the genetic composition of Chinese cotton cultivars is narrow and mainly derived from early introduced American varieties.展开更多
We show that a metasurface composed of a subwavelength metallic slit array embedded in an asymmetric dielectric environment can exhibit either diffraction （EOD）. The cascaded refractive extraordinary optical transmi...We show that a metasurface composed of a subwavelength metallic slit array embedded in an asymmetric dielectric environment can exhibit either diffraction （EOD）. The cascaded refractive extraordinary optical transmission （EOT） or extraordinary optical indices of the dielectrics can leverage multiple decaying passages into variant subsections with different diffraction order combinations according to the diffraction order chart in the k-vector space, providing a flexible by changing the wavevector of the efficiencies can be enhanced to near or EOD in a single tional metasurface onstrated. Our findings incident light. As a result, either the unity by the excitation of the localized provide a convenient way components on a single planar device.展开更多
Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models.Here,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical re...Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models.Here,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy responses.The proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging methods.The subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy samples.The signatures of the S-II subtype in particular suggested potential benefits from immunotherapy.Differentially overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical trials.Finally,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line immunotherapy.Collectively,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.展开更多
Circular single-stranded DNA(ssDNA)viruses have been rarely found in fungi,and the evolutionary and ecological relationships among ssDNA viruses infecting fungi and other organisms remain unclear.In this study,a novel...Circular single-stranded DNA(ssDNA)viruses have been rarely found in fungi,and the evolutionary and ecological relationships among ssDNA viruses infecting fungi and other organisms remain unclear.In this study,a novel circular ssDNA virus,tentatively named Diaporthe sojae circular DNA virus 1(DsCDV1),was identified in the phytopathogenic fungus Diaporthe sojae isolated from pear trees.DsCDV1 has a monopartite genome(3185 nt in size)encapsidated in isometric virions(21-26 nm in diameter).The genome comprises seven putative open reading frames encoding a discrete replicase(Rep)split by an intergenic region,a putative capsid protein(CP),several proteins of unknown function(P1-P4),and a long intergenic region.Notably,the two split parts of DsCDV1 Rep share high identities with the Reps of Geminiviridae and Genomoviridae,respectively,indicating an evolutionary linkage with both families.Phylogenetic analysis based on Rep or CP sequences placed DsCDV1 in a unique cluster,supporting the establishment of a new family,tentatively named Gegemycoviridae,intermediate to both families.DsCDV1 significantly attenuates fungal growth and nearly erases fungal virulence when transfected into the host fungus.Remarkably,DsCDV1 can systematically infect tobacco and pear seedlings,providing broad-spectrum resistance to fungal diseases.Subcellular localization analysis revealed that DsCDV1 P3 is systematically localized in the plasmodesmata,while its expression in trans-complementation experiments could restore systematic infection of a movement-deficient plant virus,suggesting that P3 is a movement protein.DsCDV1 exhibits unique molecular and biological traits not observed in other ssDNA viruses,serving as a link between fungal and plant ssDNA viruses and presenting an evolutionary connection between ssDNA viruses and fungi.These findings contribute to expanding our understanding of ssDNA virus diversity and evolution,offering potential biocontrol applications for managing crucial plant diseases.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.92266201).
文摘Underwater launch is a transient vibration process under the impact load.The hydrodynamic calculation is an important part of equipment research.In this paper,firstly,combining the theory of the Euler-Bernoulli beam and the potential flow,the transfer equation of the Euler-Bernoulli beam considering the hydroelastic effect is derived,which expands the application scope of the transfer matrix.The correctness of the transfer matrix for the beam with hydroelastic behaviors is verified by comparison with the results of the finite element analysis.Then the dynamics model of the underwater launch system is established based on the multibody system transfer matrix method,and the beam with hydroelastic behaviors is employed as the external vehicle.Subsequently,the overall transfer and dynamic equation are derived,resulting in the solution of the wet natural frequency and the dynamic response under the impact load.The comparison with experimental data validates the dynamics model and simulation results and ensures its reliability in practical applications.The dynamic of the system demonstrates that the launching interval and adjacent tube effect will exert an influence on the subsequent emission.This research provides a fast and efficient method for the dynamic calculation of the underwater launch system.
基金supported by National Natural Science Foundation of China(Grant No.92266201).
文摘As the performance of the box-type multiple launch rocket system(BMLRS)improves,its mechanical structures,particularly the plane clearance design between the slider on the rocket and the guide inside the launch canister,have grown increasingly complex.However,deficiencies still exist in the current launch modeling theory for BMLRS.In this study,a multi-rigid-flexible-body launch dynamics model coupling the launch platform and rocket was established using the multibody system transfer matrix method and the Newton-Euler formulation.Furthermore,considering the bending of the launch canister,a detection algorithm for slider-guide plane clearance contact was proposed.To quantify the contact force and friction effect between the slider and guide,the contact force model and modified Coulomb model were introduced.Both the modal and launch tests were conducted.Additionally,the modal convergence was verified.By comparing the modal experiments and simulation results,the maximum relative error of the eigenfrequency is 3.29%.thereby verifying the accuracy of the developed BMLRS dynamics model.Furthermore,the launch test validated the proposed plane clearance contact model.Moreover,the study investigated the influence of various model parameters on the dynamic characteristics of BMLRS,including launch canister bending stiffness,slider and guide material,slider-guide clearance,slider length and layout.This analysis of influencing factors provides a foundation for future optimization in BMLRS design.
文摘Introduction: Anti-Müllerian hormone (AMH) is shown to be a possible indicator of ovarian function. Severe systemic lupus erythematosus (SLE) patients exposed to high-dose cyclophosphamide (CTX) have a much higher risk of developing infertility and premature ovarian failure. Therefore, we performed a prospective case-control study to evaluate the impact of SLE on women’s ovarian reserve using AMH before CTX therapy. Methods: SLE patients before receiving CTX therapy were enrolled in our hospital. Age-matched healthy women were served as controls. Serum AMH level was measured using an enzyme-linked immunosorbent assay. Basal hormone levels were measured including follicle-stimulating hormone, luteinizing hormone, and estradiol on the third day of their menstrual periods. All participants underwent transvaginal ultrasonographic examination for the determination of total antral follicle count on the third day. Results: AMH value in SLE patients was significantly lower compared to healthy control with normal ovarian reserve. No significant difference in AMH levels was found between SLE and healthy control with low ovarian reserve. Conclusions: SLE patients not receiving CTX therapy even with normal menstruation, still had an impaired ovarian reserve. Therefore, early monitoring of AMH levels could better reflect the ovarian function and reproductive outcomes of SLE patients and relative protective strategy needed to reserve fertility.
基金This work was supported by the National Natural Science Foundation of China(Grant Nos.92266201,52305112,and 11972193)We also gratefully acknowledge Jiangsu Funding Program for Excellent Postdoctoral Talent(Grant No.2022ZB244)Project funded by China Postdoctoral Science Foundation(Grant Nos.2022TQ0159,and 2022M721624).
基金National Natural Science Foundation of China(Grant Nos.11972193 and 92266201)。
文摘How to effectively evaluate the firing precision of weapon equipment at low cost is one of the core contents of improving the test level of weapon system.A new method to evaluate the firing precision of the MLRS considering the credibility of simulation system based on Bayesian theory is proposed in this paper.First of all,a comprehensive index system for the credibility of the simulation system of the firing precision of the MLRS is constructed combined with the group analytic hierarchy process.A modified method for determining the comprehensive weight of the index is established to improve the rationality of the index weight coefficients.The Bayesian posterior estimation formula of firing precision considering prior information is derived in the form of mixed prior distribution,and the rationality of prior information used in estimation model is discussed quantitatively.With the simulation tests,the different evaluation methods are compared to validate the effectiveness of the proposed method.Finally,the experimental results show that the effectiveness of estimation method for firing precision is improved by more than 25%.
文摘Field experiments were conducted in 2011 on an experimental farm at the Cotton Research Insti-tute, Chinese Academy of Agricultural Sciences, Anyang, China. We conducted experiments with a “SPAD-502” meter to quickly measure the relative value of chlorophyll content in the leaf blades of field cotton. Our goal was to seek a suitable leaf on a cotton plant to diagnose senescence status of crop plants at later stages of growth. We began by studying the dynamic change rule of the dis-tal-most four leaves of the cotton plant during the entire growth period with two early-maturing cultivars (CCRI 36, CCRI 50) and two mid-maturing cultivars (CCRI 41, SCRC 28). We also examined the effect of different nitrogen and potassium fertilizer rates on SPAD values of the leaves of SCRC 28. Our results suggest that SPAD values of the 1st distal stem leaves from two early cultivars can act as good indicators of senescence status in the plants, if they are measured between 10 d before the boll-opening stage and 10 d after boll opening stage. Differences of SPAD values of the 3rd distal stem leaves of two mid-maturing cultivars measured between about 15 d before the boll opening stage and 15 d after the boll opening stage can also be used to measure senescence status in these cotton cultivars. The conclusion can be used for cotton producer to manage N fertilizer better at later growth stage.
基金supported by the National Natural Science Foundation of China(Grant No.62005183)the Key Project of the National Key R&D Program of China(Grant No.2022YFA1404500).
文摘Notwithstanding the exceptional photodetection capabilities of the laterally-structured perovskite single-crystal sheet(SCS),attributed to its notably lengthy carrier diffusion length and reduced defect density,operating the device within free space and exposing the SCS to the environment present obstacles in attaining on-chip integration and long-term stability.To overcome these challenges,this study proposes the introduction of a waveguide(WG)structure methodology,and selects the silicon WG(SWG)core and the polymer polymethyl methacrylate(PMMA)WG(PWG)fiber as materials.Furthermore,it integrates these two WG structures with the laterally-structured SCS photodetector into WG-SCS devices,enabling photodetection under near-field excitation of the WG.Significantly,the WG-SCS device encapsulated with silicone sealant demonstrates exceedingly high stability,with no degradation in performance after being exposed to light and water stimuli for 1000 h.This study demonstrates the viability of on-chip integration of lateral-structured SCS photodetectors by means of introducing WG structures and investigates the technical facets of the device’s long-term environmental stability.The results are expected to exert a crucial role in device integration in future applications such as optical communication,quantum photonics,and biochemical sensing.
基金supported by the National Natural Science Foundation of China(Grant Nos.12202187,92266201 and 92266301)the Fundamental Research Funds for the Central Universities(Grant No.30924010819).
文摘Non-Gaussian random vibrations have gained more attention in the dynamics-research community due to the frequently encountered non-Gaussian dynamic environments in engineering practice.This work proposes a novel non-Gaussian random vibration test method by simultaneous control of multiple correlation coefficients,skewness,and kurtoses.The multi-channel time-domain coupling model is first constructed which is mainly composed of the designed parameters and independent signal sources.The designed parameters are related to the defined correlation coefficients and root mean square values.The synthesized multiple non-Gaussian random signals are unitized to provide independent signal sources for coupling.The first four statistical characteristics of the synthesized non-Gaussian random signals are theoretically derived so that the relationships among the generated signals,independent signal sources,and correlation coefficients are achieved.Subsequently,a multi-channel closed-loop equalization procedure for non-Gaussian random vibration control is presented to produce a multi-channel correlated non-Gaussian random vibration environment.Finally,a simulation example and an experimental verification are provided.Results from the simulation and experiment indicate that the multi-channel response spectral densities,correlation coefficients,skewnesses,and kurtoses can be stably and effectively controlled within the corresponding tolerances by the proposed method.
基金supported by the Key Project of the National Key R&D Program of China(Grant No.2022YFA1404500)the National Natural Science Foundation of China(Grant Nos.12434017,62005183)the Guangdong Basic and Applied Basic Research Foundation(Grant No.2025A1515010329)。
文摘Ruddlesden-Popper(RP)layered perovskite single crystals(SCs)have been widely utilized in high-performance and weather-resistant photodetectors(PDs)due to their unique properties,including highly anisotropic carrier transport,superior dark current suppression,and exceptional chemical stability.While the large-scale fabrication of RP layered perovskite SCs has been successfully achieved,the absence of systematic investigations into their mechanical strain properties poses a significant barrier to their application in flexible optoelectronic devices.This study introduces a polymer-SC-electrode-polymer lateral architecture PD,which employs a damage-free transfer technique to transfer centimeter-scale(C_6H_(5)C_(2)H_(4)NH_(3)_(2)PbI_(4)SC sheets(SC-sheets)with a thickness of~1μm from rigid substrates to flexible electrode substrates.This transfer process is facilitated by an organic polymer solution solidification-based method.The lateral device configuration effectively exploits the in-plane high electrical conductivity of RP layered perovskites,achieving responsivity of 728 mA/W,on/off ratio of 1.6×10^(4),specific detectivity of 2.14×10^(13)Jones,and external quantum efficiency of 222%.The self-sealing bilayer polymer sandwich structure imparts superior mechanical strain tolerance to the SCs,as demonstrated by mechanical bending tests that reveal an ultimate failure curvature radius of the SC-sheet in the range of 2.5-2.7 mm.Notably,even after superthreshold bendinginduced fragmentation,the crystal segments maintain robust adhesion to electrodes through polymer chain interactions,thereby preserving efficient PD functionality.This work represents a significant advancement in the development of flexible optoelectronics based on RP layered SCs and expands their applicability in next-generation wearable devices.
基金supported by the National Key R&D Program of China(No.2023YFF0905103)National Natural Science Foundation of China(No.62172013).
文摘To bridge the gap between artists and non-specialists,we present a unified framework,Neural-Polyptych,to facilitate the creation of expansive,high-resolution paintings by seamlessly incorporating interactive hand-drawn sketches with fragments from original paintings.We have designed a multi-scale GAN-based architecture to decompose the generation process into two parts,each responsible for identifying global and local features.To enhance the fidelity of semantic details generated from users'sketched outlines,we introduce a Correspondence Attention module utilizing our Reference Bank strategy.This ensures the creation of high-quality,intricately detailed elements within the artwork.The final result is achieved by carefully blending these local elements while preserving coherent global consistency.Consequently,this methodology enables the production of digital paintings at megapixel scale,accommodating diverse artistic expressions and enabling users to recreate content in a controlled manner.We validate our approach to diverse genres of both Eastern and Western paintings.Applications such as large painting extension,texture shuffling,genre switching,mural art restoration,and recomposition can be successfully based on our framework.
基金supported by the Key Project of the National Key R&D Program of China (Grant No.2022YFA1404500)the National Natural Science Foundation of China (Grant Nos.12434017,62005183)the Guangdong Basic and Applied Basic Research Foundation (Grant No.2025A1515010329)。
文摘Single-crystal(SC) structures have long been regarded as the optimal configuration for metal halide perovskite photodetectors(PDs);however, their applications in large-area imaging and wearable electronics face limitations due to size constraints and mechanical inflexibility. To address these challenges, this study develops a hybrid composite structure— polycrystalline powder(PCP) matrix(PCPM)—by strategically homogenizing 20 μm PCPs within a poly(methyl methacrylate) matrix. Such a configuration enables the formation of densely packed PCP microstructures while maintaining electric conductivity and mechanical flexibility. In the single-photon regime, responsivity(R) and external quantum efficiency(EQE) decline by 50%, with concurrent 3–4-fold enhancements in the On/Off ratio and 12–16-fold improvements in specific detectivity(D), compared with those of SC counterparts. Notably, in the two-photon regime, R and EQE exhibit a 2–3-fold increase, and the On/Off ratio and D exhibit 12–16-fold improvements. The PCPM configuration enables the high-repetitionrate wafer-scale fabrication of active layers for imaging PDs and provides exceptional mechanical flexibility and self-recovery. These findings establish PCPMs as a scalable platform for next-generation perovskite wearable electronics.
基金supported by the National Natural Science Foundation of China(No.82101368)the Anhui Provincial Natural Science Foundation(Nos.2008085QH368 and 2108085MH272).
文摘background Ischaemia-evoked neuroinflammation is a critical pathogenic event following ischaemic stroke.Gasdermin D(GSDMD)-associated pyroptosis represents a type of inflammation-associated programmed cell death,which can exacerbate neuroinflammatory responses and brain damage.Stimulator of interferon genes(STING)was recently described as a vital innate immune adaptor protein associated with neuroinflammation.Nevertheless,the regulatory effects of STING on microglial pyroptosis post-stroke have not been well elaborated.Methods STING-knockout and wild-type(WT)mice were subjected to middle cerebral artery occlusion(MCAO).STING small interfering RNA(siRNA)was transfected into BV2 cells before oxygen-glucose deprivation/reoxygenation(OGD/R).STING-overexpressing adeno-associated virus(AAV)and NOD-like receptor family pyrin domain containing 3(NLRP3)siRNA were administered by stereotaxic injection.2,3,5-Triphenyl tetrazolium chloride(TTC)staining,TdT-mediated dUTP nick end labeling(TUNEL)staining,Fluoro-Jade C(FJC)staining,neurobehavioural tests,immunohistochemistry,cytokine antibody array assay,transmission electron microscopy,immunoblot,Enzyme-linked immunosorbent assay(ELISA)and quantitative real-time polymerase chain reaction(qRT-PCR)were carried out.Co-immunoprecipitation assays were used to investigate the interplay between STING and NLRP3.Results STING expression was increased after MCAO and mainly detected on microglia.STING deletion alleviated brain infarction,neuronal damage and neurobehavioural impairment in mice subjected to MCAO.STING knockout suppressed microglial activation and the secretion of inflammatory chemokines,accompanied by mitigation of microglial pyroptosis.Specific upregulation of microglial STING by AAV-F4/80-STING aggravated brain injury and microglial pyroptosis.Mechanistically,co-immunoprecipitation showed that STING bound to NLRP3 in microglia.Supplementation of NLRP3 siRNA reversed AAV-F4/80-STING-induced deterioration of microglial pyroptosis.Conclusions The current findings indicate that STING modulates NLRP3-mediated microglial pyroptosis following MCAO.STING may serve as a therapeutic target in neuroinflammation induced by cerebral ischaemic/reperfusion(I/R)injury.
基金supported in part by the National Natural Science Foundation of China(81790624,81630010)Top-Notch Talent Program of Hubei Province and Tongji Hospital(2021YBJRC005)。
文摘Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium.It is characterized by acute onset,rapid progress and high risk of death.Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm.According to China’s practical experience,the adoption of the“life support-based comprehensive treatment regimen”(with mechanical circulation support and immunomodulation therapy as the core)can significantly improve the survival rate and long-term prognosis.Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment.
基金supported by grants from the NSFC(32172008)the Xinjiang Production and Construction Corps(2019AB021,2021AB008,and 2020CB003)+2 种基金project of Hainan Yazhou Bay Seed Lab(B21HJ0223)the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01002)the Fundamental Research Funds for the Central Universities(226-2022-00100,2020XZZX004-03,and 226-2022-00153).
文摘The excellent Upland cotton(Gossypium hirsutum)cultivars developed since 1949 have made a huge contribution to cotton production in China,the world's largest producer and consumer of cotton.However,the genetic and genomic basis for the improvements of these cotton cultivars remains largely unclear.In this study,we selected 16 Upland cotton cultivars with important historical status in Chinese cotton breeding and constructed a multiparent,advanced generation,intercross(MAGiC)population comprising 920 recombinant inbred lines.A genome-wide association study using the MAGIC population identified 54 genomic loci associated with lint yield and fiber quality.Of them,25(46.30%)pleiotropic genomic loci cause simultaneous changes of lint yield and/or fiber quality traits,revealing complex trade-offs and linkage drags in Upland cotton agronomic traits.Deep sequencing data of 11 introduced ancestor cultivars and publicly available resequencing datasets of 839 cultivars developed in China during the past 70 years were integrated to explore the historical distribution and origin of the elite or selected alleles.Interestingly,85%oftheseelitealleles were selectedandfixed fromdifferent Americanancestors,consistentwithcotton breeding practices in China.However,seven elite alleles of native origin that are responsible for Fusarium wilt resistance,early maturing,good-quality fiber,and other characteristics were not found in American an-cestors but have greatly contributed to Chinese cotton breeding and wide cultivation.Taken together,these results provide a genetic basis for further improving cotton cultivars and reveal that the genetic composition of Chinese cotton cultivars is narrow and mainly derived from early introduced American varieties.
基金National Natural Science Foundation of China(NSFC)(11604217,11574218,11734012,61420106014,61522504)Fundamental Research Funds for the Central Universities(21617410)Guangdong Provincial Innovation and Entrepreneurship Project(2016ZT06D081)
文摘We show that a metasurface composed of a subwavelength metallic slit array embedded in an asymmetric dielectric environment can exhibit either diffraction （EOD）. The cascaded refractive extraordinary optical transmission （EOT） or extraordinary optical indices of the dielectrics can leverage multiple decaying passages into variant subsections with different diffraction order combinations according to the diffraction order chart in the k-vector space, providing a flexible by changing the wavevector of the efficiencies can be enhanced to near or EOD in a single tional metasurface onstrated. Our findings incident light. As a result, either the unity by the excitation of the localized provide a convenient way components on a single planar device.
基金supported by the National Key R&D Program of China(Grant Nos.2018YFA0507503,2017YFA0505102,2017YFA0505103,and 2017YFA0505104)the National Natural Science Foundation of China(Grant Nos.82072597,62131009,31770892,31970725,31870828,81874237,and 81974016)+2 种基金the Beijing Municipal Natural Science Foundation(Grant No.7192199)the State Key Laboratory of Proteomics(Grant No.SKLP-K202002)the Kaifeng Science and Technology Development Plan Project(Grant No.1806005),China.
文摘Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models.Here,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy responses.The proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging methods.The subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy samples.The signatures of the S-II subtype in particular suggested potential benefits from immunotherapy.Differentially overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical trials.Finally,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line immunotherapy.Collectively,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.
基金supported by Earmarked Fund for China Agricultural Research System(grant number CARS-28)to G.W.and W.X.the National Natural Science Foundation of China(grant number 32172475)to W.X.
文摘Circular single-stranded DNA(ssDNA)viruses have been rarely found in fungi,and the evolutionary and ecological relationships among ssDNA viruses infecting fungi and other organisms remain unclear.In this study,a novel circular ssDNA virus,tentatively named Diaporthe sojae circular DNA virus 1(DsCDV1),was identified in the phytopathogenic fungus Diaporthe sojae isolated from pear trees.DsCDV1 has a monopartite genome(3185 nt in size)encapsidated in isometric virions(21-26 nm in diameter).The genome comprises seven putative open reading frames encoding a discrete replicase(Rep)split by an intergenic region,a putative capsid protein(CP),several proteins of unknown function(P1-P4),and a long intergenic region.Notably,the two split parts of DsCDV1 Rep share high identities with the Reps of Geminiviridae and Genomoviridae,respectively,indicating an evolutionary linkage with both families.Phylogenetic analysis based on Rep or CP sequences placed DsCDV1 in a unique cluster,supporting the establishment of a new family,tentatively named Gegemycoviridae,intermediate to both families.DsCDV1 significantly attenuates fungal growth and nearly erases fungal virulence when transfected into the host fungus.Remarkably,DsCDV1 can systematically infect tobacco and pear seedlings,providing broad-spectrum resistance to fungal diseases.Subcellular localization analysis revealed that DsCDV1 P3 is systematically localized in the plasmodesmata,while its expression in trans-complementation experiments could restore systematic infection of a movement-deficient plant virus,suggesting that P3 is a movement protein.DsCDV1 exhibits unique molecular and biological traits not observed in other ssDNA viruses,serving as a link between fungal and plant ssDNA viruses and presenting an evolutionary connection between ssDNA viruses and fungi.These findings contribute to expanding our understanding of ssDNA virus diversity and evolution,offering potential biocontrol applications for managing crucial plant diseases.
