In response to the challenges of sand production and high water cut during the exploitation of oil reservoirs in unconsolidated sandstones,a novel sand-water dual-control functional polymer,PDSM,was synthesized using ...In response to the challenges of sand production and high water cut during the exploitation of oil reservoirs in unconsolidated sandstones,a novel sand-water dual-control functional polymer,PDSM,was synthesized using acrylamide(AM),methacryloxyethyltrimethyl ammonium chloride(DMC),and styrene monomer(SM)as raw materials.The chemical structure and thermal stability of PDSM were verified by1H-NMR,FT-IR,and TGA analyses.To evaluate its performance,functional polymers PDM and PSM,containing only DMC or SM,respectively,were used as control groups.The study systematically investigated the static adsorption,sand production,sand leakage time,standard water-oil resistance ratio,and water cut reduction performance of PDSM.The results demonstrated that,due to the synergistic effect of functional monomers DMC and SM,PDSM exhibited superior dual-control over sand and water compared to PDM and PSM.PDSM enhanced wettability properties reduce the contact angle of the water phase on oil-wet rock surfaces to 64.0°,facilitating better adsorption of polymer molecules on the rock surface and achieving a static adsorption capacity of 14.6 mg/g.PDSM effectively bridges/bundles sand grains through SM and DMC,increasing resistance to fluid erosion.At a flow rate of 100 mL/min,sand production was only 0.026 g/L,surpassing the"Q/SH 10202377-2020"standard for sand inhibitors,which defines"excellent"performance as having a sand production rate of≤0.05 g/L.PDSM forms an adsorption layer(polymer concentrated layer)on the rock surface,expanding when in contact with water and shrinking when in contact with oil,thereby significantly reducing the permeability of the water layer without affecting the permeability of the oil layer.The standard water-oil resistance ratio was measured at 5.41,and the watercut of produced fluid was reduced by 18.6%.These findings provide new theoretical insights and technical guidance for developing dual-function sand-water control agents.展开更多
Inadequate strength and stability of active crude oil emulsions stabilized by conventional surfactants always lead to a limited plugging rate of plugging agents.Thus,to address this issue,the synthesis of amphiphilic ...Inadequate strength and stability of active crude oil emulsions stabilized by conventional surfactants always lead to a limited plugging rate of plugging agents.Thus,to address this issue,the synthesis of amphiphilic Janus nanosheets was effectively carried out for enhancing the system performances and subsequently characterized.Based on the outcomes of orthogonal tests,an assessment was conducted on the nanosheet and surfactant formulations to optimize the enhancement of emulsion properties.The experimental demonstration of the complex system has revealed its remarkable emulsifying capability,ability to decrease interfacial tension and improve rheological behavior at high temperature(80℃)and high salinity(35,000 ppm)conditions.Involving probable mechanism of the system performance enhancement is elucidated by considering the synergistic effect between surfactants and nanosheets.Furthermore,variables including water-to-oil ratio,salinity,temperature and stirring intensity during operation,which affect the properties of prepared emulsions,were investigated in detail.The efficacy and stability of the complex system in obstructing medium and high permeability cores were demonstrated.Notably,the core with a high permeability of 913.58 mD exhibited a plugging rate of 98.55%.This study establishes the foundations of medium and high permeability reservoirs plugging with novel active crude oil plugging agents in severe environments.展开更多
Background:Buyang Huanwu decoction(BHD)is a traditional Chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral hemorrha...Background:Buyang Huanwu decoction(BHD)is a traditional Chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral hemorrhage.This study aims to investigate the treatment mechanism of BHD to provide a basis for its clinical application in hypertension treatment.Methods:Network pharmacology analysis and cell culture experiments were performed to explore the potential proteins and mechanisms of action of BHD against hypertension.Bioactive compounds related to BHD were screened,and relevant targets associated with hypertension and BHD were retrieved.Molecular docking technology was used to identify the effective signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network cores.Lastly,the effects and mechanisms of BHD on salt-sensitive hypertensive endothelial cells were investigated.Results:Ninety-three potential therapeutic targets for BHD and salt-sensitive hypertension were found to be closely associated with the PI3K/Akt/eNOS signaling pathway and oxidative stress.Cell experiments further indicated the pivotal role of endothelial cells in hypertension,and validation analysis showed that BHD significantly preserved cell morphology,suppressed oxidative stress reactions,activated the PI3K/Akt/eNOS signaling pathways,preserved normal endothelial cell function,and reduced cell apoptosis.Conclusion:BHD effectively activates the PI3K/Akt/VEGF signaling pathway,attenuates oxidative stress-induced injury in endothelial cells exposed to high salt levels,and mitigates apoptosis,supporting the use of traditional Chinese medicine BHD in the treatment of salt-sensitive hypertension.展开更多
基金supported by the National Natural Science Foundation of China(General Program)(Grant No.52474071)the financial support from the China Scholarship Council(TM.Lei,No.202406450004)。
文摘In response to the challenges of sand production and high water cut during the exploitation of oil reservoirs in unconsolidated sandstones,a novel sand-water dual-control functional polymer,PDSM,was synthesized using acrylamide(AM),methacryloxyethyltrimethyl ammonium chloride(DMC),and styrene monomer(SM)as raw materials.The chemical structure and thermal stability of PDSM were verified by1H-NMR,FT-IR,and TGA analyses.To evaluate its performance,functional polymers PDM and PSM,containing only DMC or SM,respectively,were used as control groups.The study systematically investigated the static adsorption,sand production,sand leakage time,standard water-oil resistance ratio,and water cut reduction performance of PDSM.The results demonstrated that,due to the synergistic effect of functional monomers DMC and SM,PDSM exhibited superior dual-control over sand and water compared to PDM and PSM.PDSM enhanced wettability properties reduce the contact angle of the water phase on oil-wet rock surfaces to 64.0°,facilitating better adsorption of polymer molecules on the rock surface and achieving a static adsorption capacity of 14.6 mg/g.PDSM effectively bridges/bundles sand grains through SM and DMC,increasing resistance to fluid erosion.At a flow rate of 100 mL/min,sand production was only 0.026 g/L,surpassing the"Q/SH 10202377-2020"standard for sand inhibitors,which defines"excellent"performance as having a sand production rate of≤0.05 g/L.PDSM forms an adsorption layer(polymer concentrated layer)on the rock surface,expanding when in contact with water and shrinking when in contact with oil,thereby significantly reducing the permeability of the water layer without affecting the permeability of the oil layer.The standard water-oil resistance ratio was measured at 5.41,and the watercut of produced fluid was reduced by 18.6%.These findings provide new theoretical insights and technical guidance for developing dual-function sand-water control agents.
基金financially supported by National Natural Science Foundation of China(52374053)Beijing Natural Science Foundation(2204092)Beijing Municipal Excellent Talent Training Funds Youth Advanced Individual Project(2018000020124G163)。
文摘Inadequate strength and stability of active crude oil emulsions stabilized by conventional surfactants always lead to a limited plugging rate of plugging agents.Thus,to address this issue,the synthesis of amphiphilic Janus nanosheets was effectively carried out for enhancing the system performances and subsequently characterized.Based on the outcomes of orthogonal tests,an assessment was conducted on the nanosheet and surfactant formulations to optimize the enhancement of emulsion properties.The experimental demonstration of the complex system has revealed its remarkable emulsifying capability,ability to decrease interfacial tension and improve rheological behavior at high temperature(80℃)and high salinity(35,000 ppm)conditions.Involving probable mechanism of the system performance enhancement is elucidated by considering the synergistic effect between surfactants and nanosheets.Furthermore,variables including water-to-oil ratio,salinity,temperature and stirring intensity during operation,which affect the properties of prepared emulsions,were investigated in detail.The efficacy and stability of the complex system in obstructing medium and high permeability cores were demonstrated.Notably,the core with a high permeability of 913.58 mD exhibited a plugging rate of 98.55%.This study establishes the foundations of medium and high permeability reservoirs plugging with novel active crude oil plugging agents in severe environments.
基金the Liaoning Provincial Science and Technology Plan Project(2023-MSLH-178)the Project Fund of Liaoning Provincial Department of Education(LJKMZ20221315,L202025)+1 种基金the Special Fund of Liaoning Provincial Department of Science and Technology for Central Guidance of Local Science and Technology Development(2018416016)the Project Fund of Liaoning Provincial Department of Human Resources and Social Security"Millions of Talents Program"(2020921097).
文摘Background:Buyang Huanwu decoction(BHD)is a traditional Chinese medicine herbal formula used for treating hypertension,particularly in the later stages of hypertension when it is associated with intracerebral hemorrhage.This study aims to investigate the treatment mechanism of BHD to provide a basis for its clinical application in hypertension treatment.Methods:Network pharmacology analysis and cell culture experiments were performed to explore the potential proteins and mechanisms of action of BHD against hypertension.Bioactive compounds related to BHD were screened,and relevant targets associated with hypertension and BHD were retrieved.Molecular docking technology was used to identify the effective signaling pathway based on the Kyoto Encyclopedia of Genes and Genomes and protein-protein interaction network cores.Lastly,the effects and mechanisms of BHD on salt-sensitive hypertensive endothelial cells were investigated.Results:Ninety-three potential therapeutic targets for BHD and salt-sensitive hypertension were found to be closely associated with the PI3K/Akt/eNOS signaling pathway and oxidative stress.Cell experiments further indicated the pivotal role of endothelial cells in hypertension,and validation analysis showed that BHD significantly preserved cell morphology,suppressed oxidative stress reactions,activated the PI3K/Akt/eNOS signaling pathways,preserved normal endothelial cell function,and reduced cell apoptosis.Conclusion:BHD effectively activates the PI3K/Akt/VEGF signaling pathway,attenuates oxidative stress-induced injury in endothelial cells exposed to high salt levels,and mitigates apoptosis,supporting the use of traditional Chinese medicine BHD in the treatment of salt-sensitive hypertension.
