Micro-droplets of soft matter solutions have different morphologies upon drying,and can become wrinkled,buckled or cavitated particles.We investigate the morphology evolution of a drying soft matter droplet in this wo...Micro-droplets of soft matter solutions have different morphologies upon drying,and can become wrinkled,buckled or cavitated particles.We investigate the morphology evolution of a drying soft matter droplet in this work:at the early stage of drying,wrinkling or cavitation instability can occur in the droplet,depending on the comparison between the critical wrinkling and cavitation pressure;at a later stage of drying,no wrinkles will appear if cavitation happens first,while cavitation can still occur if wrinkling happens first.A three-dimensional phase diagram in the space of elastic length,gel layer thickness and weight loss is provided to illustrate the drying pathways of a soft matter droplet.This diagram can help guide future fabrications of micro-particles with desired morphologies.展开更多
Cellular collective motion in confluent epithelial monolayers is involved in many processes such as embryo development,carcinoma invasion,and wound healing.The development of new chemical strategies to achieve largesc...Cellular collective motion in confluent epithelial monolayers is involved in many processes such as embryo development,carcinoma invasion,and wound healing.The development of new chemical strategies to achieve largescale control of cells’collective motion is essential for biomedical applications.Here a series of DNA nanostructures with different dimensions were synthesized and their influences on cells’collective migration and packing behaviors in epithelial monolayers were investigated.We found that the framed DNA nanoassemblies effectively reduced the cells’speed by increasing the rigidity of cells,while the lipid-DNA micelles had a more pronounced effect on cells’projection area and shape factor.These DNA nanostructures all significantly enhanced the dependence of cells’speed on their shape factor.Our results indicate that cells’mobility in monolayers can be manipulated by chemical intercellular interactions without any genetic intervention.This may provide a new chemical strategy for tissue engineering and tumor therapy.展开更多
基金supports from Chinese Academy of Sciences(No.XDA17010504 and No.XDPB15)the National Natural Science Foundation of China(No.12047503)+1 种基金the support of the National Natural Science Foundation of China(Grant No.11774394)the Key Research Program of Frontier Sciences of Chinese Academy of Sciences(Grant No.QYZDB-SSW-SYS003)
文摘Micro-droplets of soft matter solutions have different morphologies upon drying,and can become wrinkled,buckled or cavitated particles.We investigate the morphology evolution of a drying soft matter droplet in this work:at the early stage of drying,wrinkling or cavitation instability can occur in the droplet,depending on the comparison between the critical wrinkling and cavitation pressure;at a later stage of drying,no wrinkles will appear if cavitation happens first,while cavitation can still occur if wrinkling happens first.A three-dimensional phase diagram in the space of elastic length,gel layer thickness and weight loss is provided to illustrate the drying pathways of a soft matter droplet.This diagram can help guide future fabrications of micro-particles with desired morphologies.
基金the National Key Research and Development Program of China(2020YFA0908200,2018YFA0902600,2020YFA0712102,and 2020YFA0712102)the National Natural Science Foundation of China(12074407,11774394,22125701,21834007,and 21907088)+1 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB33000000)the Youth Innovation Promotion Association of CAS(2020228,2021007).
文摘Cellular collective motion in confluent epithelial monolayers is involved in many processes such as embryo development,carcinoma invasion,and wound healing.The development of new chemical strategies to achieve largescale control of cells’collective motion is essential for biomedical applications.Here a series of DNA nanostructures with different dimensions were synthesized and their influences on cells’collective migration and packing behaviors in epithelial monolayers were investigated.We found that the framed DNA nanoassemblies effectively reduced the cells’speed by increasing the rigidity of cells,while the lipid-DNA micelles had a more pronounced effect on cells’projection area and shape factor.These DNA nanostructures all significantly enhanced the dependence of cells’speed on their shape factor.Our results indicate that cells’mobility in monolayers can be manipulated by chemical intercellular interactions without any genetic intervention.This may provide a new chemical strategy for tissue engineering and tumor therapy.
