Background:Tumor recurrence severely impacts the prognosis of hepatocellular carcinoma(HCC)patients undergoing liver transplantation(LT).We aimed to explore novel and robust biomarkers for precise prediction of tumor ...Background:Tumor recurrence severely impacts the prognosis of hepatocellular carcinoma(HCC)patients undergoing liver transplantation(LT).We aimed to explore novel and robust biomarkers for precise prediction of tumor recurrence and prognosis following LT.Methods:Cancerous tissues of 252 HCC patients who underwent LT across three centers were included in the study.Tissue microarrays and in situ hybridization were utilized to assess the circ0006646 level.Kaplan-Meier method along with the log-rank test was performed to analyze overall survival and recurrence-free survival.To identify prognostic factors,particularly related to tumor recurrence,we conducted univariate and multivariate Cox regression analyses.Nomogram was constructed to predict the risk of tumor recurrence after LT and subsequently the efficacy of the nomogram was validated.Results:Elevated circ0006646 levels in HCC were associated with reduced survival and increased recurrence rates following LT(5-year overall survival:29.2%vs.60.4%,P<0.01;5-year recurrence-free survival:42.3%vs.63.0%,P<0.001).High circ0006646 expression was significantly correlated with higher Child-Pugh grade(P=0.040),larger total tumor diameter(P=0.033),and beyond the Milan criteria(P=0.033).Cox regression analysis unveiled that circ0006646 expression score,preoperative transarterial chemoembolization(TACE),positive HBsAg status,poor tumor differentiation and beyond the Hangzhou criteria were independent risk factors for post-transplant tumor recurrence,leading to the development of a novel nomogram for precise prediction.The nomogram demonstrated a reasonable prognostic effectiveness(area under the receiver operating characteristic curve=0.7636,C-index=0.745)and outperformed conventional models like the Milan criteria.Besides,the inclusion of circ0006646 enhanced the precision of the Milan and Hangzhou criteria.Moreover,circ0006646 served as a potent biomarker in alpha-fetoprotein(AFP)-negative HCC undergoing LT.Conclusions:circ0006646 is a novel and robust prognostic biomarker for predicting post-transplant survival and tumor recurrence in HCC patients.A nomogram integrating circ0006646 stands as a valuable prognostic instrument in LT for HCC.展开更多
This paper studies the security of an image encryption scheme based on the Hill cipher (Ismail et al., 2006) and reports its following problems: (1) There is a simple necessary and sufficient condition that makes a nu...This paper studies the security of an image encryption scheme based on the Hill cipher (Ismail et al., 2006) and reports its following problems: (1) There is a simple necessary and sufficient condition that makes a number of secret keys invalid; (2) It is insensitive to the change of the secret key; (3) It is insensitive to the change of the plain-image; (4) It can be broken with only one known/chosen plaintext; (5) It has some other minor defects. The proposed cryptanalysis discourages any use of the scheme in practice.展开更多
We often need to identify the colors of such objects as buildings,clothing,photos,and traffic signs in everyday life.Some people cannot distinguish among such colors.This study proposes a method to help people,includi...We often need to identify the colors of such objects as buildings,clothing,photos,and traffic signs in everyday life.Some people cannot distinguish among such colors.This study proposes a method to help people,including colorblind people,identify colors.We establish a platform for color identification that is connected by the Internet of Things(IoT).The Espressif Systems 32(ESP32)single chip is connected to a Wi-Fi communication network to transmit data to the color identification platform.The system interface is displayed in the form of color code and color name display.The speech synthesis module Speech Synthesizer Node 6288(SYN6288)is used to broadcast color-related information.Since there are many color conversion technologies in modern times,or other color recognition methods are not applicable to the guide-blind function.Therefore,the authors use the method of reading out color-related information to directly enable colorblind people to conveniently identify the colors of objects.After experiments:the accuracy of various colors,the accuracy of environmental impact,the comparison of the original sensing experiment and the effect of adding interference light sources,the time required for color sensing to identify various colors,and the interference test results of any color light source,it is proved that the research mentioned in this research.The proposed method can not only improve the rate of recognition of the system in different environments,but can also accurately identify a variety of colors.The platform is integrated with the IoT to allow users to quickly monitor the displayed data.展开更多
基金supported by grants from Youth Fund of the National Natural Science Foundation of China(82303379)General Program of the National Natural Science Foundation of China(81970552)the Natural Science Foundation of Zhejiang Province(LQ23H160030)。
文摘Background:Tumor recurrence severely impacts the prognosis of hepatocellular carcinoma(HCC)patients undergoing liver transplantation(LT).We aimed to explore novel and robust biomarkers for precise prediction of tumor recurrence and prognosis following LT.Methods:Cancerous tissues of 252 HCC patients who underwent LT across three centers were included in the study.Tissue microarrays and in situ hybridization were utilized to assess the circ0006646 level.Kaplan-Meier method along with the log-rank test was performed to analyze overall survival and recurrence-free survival.To identify prognostic factors,particularly related to tumor recurrence,we conducted univariate and multivariate Cox regression analyses.Nomogram was constructed to predict the risk of tumor recurrence after LT and subsequently the efficacy of the nomogram was validated.Results:Elevated circ0006646 levels in HCC were associated with reduced survival and increased recurrence rates following LT(5-year overall survival:29.2%vs.60.4%,P<0.01;5-year recurrence-free survival:42.3%vs.63.0%,P<0.001).High circ0006646 expression was significantly correlated with higher Child-Pugh grade(P=0.040),larger total tumor diameter(P=0.033),and beyond the Milan criteria(P=0.033).Cox regression analysis unveiled that circ0006646 expression score,preoperative transarterial chemoembolization(TACE),positive HBsAg status,poor tumor differentiation and beyond the Hangzhou criteria were independent risk factors for post-transplant tumor recurrence,leading to the development of a novel nomogram for precise prediction.The nomogram demonstrated a reasonable prognostic effectiveness(area under the receiver operating characteristic curve=0.7636,C-index=0.745)and outperformed conventional models like the Milan criteria.Besides,the inclusion of circ0006646 enhanced the precision of the Milan and Hangzhou criteria.Moreover,circ0006646 served as a potent biomarker in alpha-fetoprotein(AFP)-negative HCC undergoing LT.Conclusions:circ0006646 is a novel and robust prognostic biomarker for predicting post-transplant survival and tumor recurrence in HCC patients.A nomogram integrating circ0006646 stands as a valuable prognostic instrument in LT for HCC.
基金the National Basic Research Program of China(No. 2006CB303104)the City University of Hong Kong under theSRG Project, China (No. 7002134)
文摘This paper studies the security of an image encryption scheme based on the Hill cipher (Ismail et al., 2006) and reports its following problems: (1) There is a simple necessary and sufficient condition that makes a number of secret keys invalid; (2) It is insensitive to the change of the secret key; (3) It is insensitive to the change of the plain-image; (4) It can be broken with only one known/chosen plaintext; (5) It has some other minor defects. The proposed cryptanalysis discourages any use of the scheme in practice.
文摘We often need to identify the colors of such objects as buildings,clothing,photos,and traffic signs in everyday life.Some people cannot distinguish among such colors.This study proposes a method to help people,including colorblind people,identify colors.We establish a platform for color identification that is connected by the Internet of Things(IoT).The Espressif Systems 32(ESP32)single chip is connected to a Wi-Fi communication network to transmit data to the color identification platform.The system interface is displayed in the form of color code and color name display.The speech synthesis module Speech Synthesizer Node 6288(SYN6288)is used to broadcast color-related information.Since there are many color conversion technologies in modern times,or other color recognition methods are not applicable to the guide-blind function.Therefore,the authors use the method of reading out color-related information to directly enable colorblind people to conveniently identify the colors of objects.After experiments:the accuracy of various colors,the accuracy of environmental impact,the comparison of the original sensing experiment and the effect of adding interference light sources,the time required for color sensing to identify various colors,and the interference test results of any color light source,it is proved that the research mentioned in this research.The proposed method can not only improve the rate of recognition of the system in different environments,but can also accurately identify a variety of colors.The platform is integrated with the IoT to allow users to quickly monitor the displayed data.
