AIM:To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F)uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS:Seventy-eight patients(44 females,me...AIM:To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F)uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS:Seventy-eight patients(44 females,mean age 63,range 44-83)underwent whole body 18F-Na F positron emission tomography/computed tomography.Cardiovascular risk(CVR)was used to divide these patients in three categories:Low(LR),medium(MR)and high risk(HR).18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium;average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR).Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta.RESULTS:A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84±0.76 vs 1.07±0.3,P<0.001),but also between MR and HR-LR(1.4±0.4,P<0.02 and P<0.01,respectively).Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P<0.01).Myocardial uptake provided an effective CVR classes stratification(P<0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R=0.67),but it peaked when correlating the descending thoracic segment(R=0.75),in comparison with the aortic arch and the ascending segment(R=0.55 and 0.53,respectively).CONCLUSION:Fluoride uptake within the thoracic aorta wall effectively depicts patients'risk class and correlates with cardiovascular risk.Descending aorta is the most effective in CVR determination.展开更多
文摘AIM:To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F)uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS:Seventy-eight patients(44 females,mean age 63,range 44-83)underwent whole body 18F-Na F positron emission tomography/computed tomography.Cardiovascular risk(CVR)was used to divide these patients in three categories:Low(LR),medium(MR)and high risk(HR).18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium;average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR).Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta.RESULTS:A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84±0.76 vs 1.07±0.3,P<0.001),but also between MR and HR-LR(1.4±0.4,P<0.02 and P<0.01,respectively).Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P<0.01).Myocardial uptake provided an effective CVR classes stratification(P<0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R=0.67),but it peaked when correlating the descending thoracic segment(R=0.75),in comparison with the aortic arch and the ascending segment(R=0.55 and 0.53,respectively).CONCLUSION:Fluoride uptake within the thoracic aorta wall effectively depicts patients'risk class and correlates with cardiovascular risk.Descending aorta is the most effective in CVR determination.
