Non-alcoholic fatty liver disease(NAFLD)is a global public health problem and is the most common cause of chronic liver disease worldwide.The prevalence of NAFLD is approximately 30%,irrespective of ethnicity,and para...Non-alcoholic fatty liver disease(NAFLD)is a global public health problem and is the most common cause of chronic liver disease worldwide.The prevalence of NAFLD is approximately 30%,irrespective of ethnicity,and parallels the exponential rise of the obesity and diabetes epidemics.The active inflammatory and cell injury component of NAFLD,known as non-alcoholic steatohepatitis(NASH),increases the risk of liver-related mortality by 5 to 10 times;but this is largely dependent on the extent of fibrosis(1,2).Despite this,cardiovascular disease(CVD)and extra-hepatic malignancy remain the commonest causes of death in these cohorts.Therefore,non-surprisingly the last decade has seen the clinical focus switch from NAFLD as a solitary organ entity to a multi-systemic disease.展开更多
文摘Non-alcoholic fatty liver disease(NAFLD)is a global public health problem and is the most common cause of chronic liver disease worldwide.The prevalence of NAFLD is approximately 30%,irrespective of ethnicity,and parallels the exponential rise of the obesity and diabetes epidemics.The active inflammatory and cell injury component of NAFLD,known as non-alcoholic steatohepatitis(NASH),increases the risk of liver-related mortality by 5 to 10 times;but this is largely dependent on the extent of fibrosis(1,2).Despite this,cardiovascular disease(CVD)and extra-hepatic malignancy remain the commonest causes of death in these cohorts.Therefore,non-surprisingly the last decade has seen the clinical focus switch from NAFLD as a solitary organ entity to a multi-systemic disease.
