Nucleosomes play a vital role in chromatin organization and gene regulation,acting as key hubs that inter-act with various chromatin-associated factors through diverse binding mechanisms.Recent research has highlighte...Nucleosomes play a vital role in chromatin organization and gene regulation,acting as key hubs that inter-act with various chromatin-associated factors through diverse binding mechanisms.Recent research has highlighted the prevalence of mutations in linker histones across different types of cancer,emphasizing their critical involvement in cancer progression.These cancer-associated mutations in linker histones have been shown to disrupt nucleosome stacking and the formation of higher-order chromatin structures,which in turn significantly affect epigenetic regulatory processes.In this review,we provide a comprehensive analysis of how cancer-associated linker histone mutations alter their physicochemical properties,influencing their binding to nucleosomes,and overall chromatin architecture.Additionally,we explore the significant impact of mutations near post-translational modification sites,which further modulate chromatin dynamics and regulatory functions,offering insights into their role in oncogenesis and potential therapeutic targets.展开更多
We consider large-time behaviors of weak solutions to the evolutionary p-Laplacian with logarithmic source of time-dependent coefficient.We find that the weak solutions may neither decay nor blow up,provided that the ...We consider large-time behaviors of weak solutions to the evolutionary p-Laplacian with logarithmic source of time-dependent coefficient.We find that the weak solutions may neither decay nor blow up,provided that the initial data u(·,t_(0))is on the Nehari manifold N:={v∈W_(0)^(1,p)(Ω):I(v,to)=0,||▽v||P^(P)≠0}.This is quite different from the known results that the weak solutions may blow up as,u(·,to)∈N^(+):={v∈W_(0)^(1,p)(Ω):I(v,t_(0))<0}and weak solutions may decay as u(·,t_(0))∈N^(+):={v∈W_(0)^(1,p)(Ω):I(v,t_(0))>0}.展开更多
An occasional presence of bivalent stimuli in a block of univalent trials can elicit a slowing of the response on all subsequent univalent trials.This type of modulation of cognitive control is termed the bivalency ef...An occasional presence of bivalent stimuli in a block of univalent trials can elicit a slowing of the response on all subsequent univalent trials.This type of modulation of cognitive control is termed the bivalency effect.To explore whether this modulation is task specific,this study used a triplet task switching paradigm,with three following tasks that were presented concussively:a shape color judgment(red vs.blue),a number parity judgment(odd vs.even),and a letter case judgment(lowercase vs.upper-case).The event-related potential(ERP)results showed that(1)the bivalency effect was reflected by the decreased amplitude of N2 and P3a over the frontal region for both the color and letter tasks;(2)the bivalency effect occurred earlier for the color task compared with that for the letter task;(3)for the number parity task,the bivalency effect was observed in the increased N1 and the decreased P2p over the parietal region.These findings indicate that the modulation of cognitive control is task-specific after the presentation of bivalent stimuli in task switching.展开更多
Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a...Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of asthma.Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung function.In this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial asthma.Furthermore,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma.展开更多
基金supported by the National Natural Science Foundation of China(No.12205112)financially supported by self-determined research funds of CCNU from the colleges’basic research and operation of MOE(CCNU24JC012)supported by Natural Science Foundation of Wuhan(No.2024040801020302).
文摘Nucleosomes play a vital role in chromatin organization and gene regulation,acting as key hubs that inter-act with various chromatin-associated factors through diverse binding mechanisms.Recent research has highlighted the prevalence of mutations in linker histones across different types of cancer,emphasizing their critical involvement in cancer progression.These cancer-associated mutations in linker histones have been shown to disrupt nucleosome stacking and the formation of higher-order chromatin structures,which in turn significantly affect epigenetic regulatory processes.In this review,we provide a comprehensive analysis of how cancer-associated linker histone mutations alter their physicochemical properties,influencing their binding to nucleosomes,and overall chromatin architecture.Additionally,we explore the significant impact of mutations near post-translational modification sites,which further modulate chromatin dynamics and regulatory functions,offering insights into their role in oncogenesis and potential therapeutic targets.
文摘We consider large-time behaviors of weak solutions to the evolutionary p-Laplacian with logarithmic source of time-dependent coefficient.We find that the weak solutions may neither decay nor blow up,provided that the initial data u(·,t_(0))is on the Nehari manifold N:={v∈W_(0)^(1,p)(Ω):I(v,to)=0,||▽v||P^(P)≠0}.This is quite different from the known results that the weak solutions may blow up as,u(·,to)∈N^(+):={v∈W_(0)^(1,p)(Ω):I(v,t_(0))<0}and weak solutions may decay as u(·,t_(0))∈N^(+):={v∈W_(0)^(1,p)(Ω):I(v,t_(0))>0}.
基金supported by the National Natural Science Foundation of China(Grant Nos.32360201,31860278 and 31760285).
文摘An occasional presence of bivalent stimuli in a block of univalent trials can elicit a slowing of the response on all subsequent univalent trials.This type of modulation of cognitive control is termed the bivalency effect.To explore whether this modulation is task specific,this study used a triplet task switching paradigm,with three following tasks that were presented concussively:a shape color judgment(red vs.blue),a number parity judgment(odd vs.even),and a letter case judgment(lowercase vs.upper-case).The event-related potential(ERP)results showed that(1)the bivalency effect was reflected by the decreased amplitude of N2 and P3a over the frontal region for both the color and letter tasks;(2)the bivalency effect occurred earlier for the color task compared with that for the letter task;(3)for the number parity task,the bivalency effect was observed in the increased N1 and the decreased P2p over the parietal region.These findings indicate that the modulation of cognitive control is task-specific after the presentation of bivalent stimuli in task switching.
基金supported by the National Science Foundation of Guangdong Province,China(No.2022A1515011731,2021A1515011062)Guangdong Provincial Administration of Traditional Chinese Medicine(China)(No.20221211)+1 种基金Project of Zhanjiang City,Guangdong,China(No.2020A01016,2020B01346,2021A05077,2016B01062)Affiliated Hospital of Guangdong Medical University(China)(No.4SG21231G,LCYJ2017A003,CLP202113001,CLP2021B001,LCYJ2020B008,BK201616).
文摘Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of asthma.Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung function.In this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial asthma.Furthermore,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma.
