BACKGROUND Ischemic bowel disease(IBD)is a critical condition caused by reduced blood flow to the intestines,leading to tissue damage and potentially severe complications.Early recognition and timely management are es...BACKGROUND Ischemic bowel disease(IBD)is a critical condition caused by reduced blood flow to the intestines,leading to tissue damage and potentially severe complications.Early recognition and timely management are essential for improving patient outcomes and reducing morbidity and mortality associated with IBD.AIM To evaluate the knowledge,attitude and practice(KAP)of healthcare professionals regarding IBD.METHODS This cross-sectional study was conducted among healthcare professionals in China from November 2023 to December 2023 using a self-designed questionnaire.RESULTS A total of 315 valid questionnaires were analyzed,with 215 participants(68.25%)being female.The mean KAP scores were 17.55±5.35(range:0-24),27.65±2.77(range:8-40),and 18.88±4.23(range:6-30),respectively.Multivariate linear regression analysis revealed the following factors to be independently associated with knowledge:Age 26-35 years(β=2.80,95%CI:0.31-5.30,P=0.028),professional title(β=2.66,95%CI:0.91-4.41,P=0.003),position(β=-3.78,95%CI:-5.45 to-2.11,P<0.001),participation in IBD-related training(β=3.45,95%CI:2.39-4.51,P<0.001),and admission of more than five IBD cases in the past month(β=3.25,95%CI:1.58-4.92,P<0.001).Attitude was independently associated with knowledge(β=0.20,95%CI:0.15-0.26,P<0.001)and being a nurse or nursing supervisor(β=-1.30,95%CI:-2.16 to-0.40,P=0.003).Practice was independently associated with knowledge(β=0.20,95%CI:0.10-0.30,P<0.001)and attitude(β=0.24,95%CI:0.06-0.42,P=0.007).Structural equation modeling demonstrated direct effects of knowledge on attitude(β=0.24,P<0.001)and practice(β=0.26,P<0.001),as well as of attitude on practice(β=0.22,P=0.012).CONCLUSION Healthcare professionals demonstrated adequate knowledge but moderate attitude and inactive practice regarding IBD.Addressing the gaps in attitude and practice through targeted training programs and interventions is essential for improving patient care and outcomes.展开更多
Loss-of-function variants in CSDE1 have been strongly linked to neuropsychiatric disorders,yet the precise role of CSDE1 in neurogenesis remains elusive.In this study,we demonstrate that knockout of Csde1 during corti...Loss-of-function variants in CSDE1 have been strongly linked to neuropsychiatric disorders,yet the precise role of CSDE1 in neurogenesis remains elusive.In this study,we demonstrate that knockout of Csde1 during cortical development in mice results in impaired neural progenitor proliferation,leading to abnormal cortical lamination and embryonic lethality.Transcriptomic analysis revealed that Csde1 upregulates the transcription of genes involved in the cell cycle network.Applying a dual thymidine-labelling approach,we further revealed prolonged cell cycle durations of neuronal progenitors in Csde1-knockout mice,with a notable extension of the G1 phase.Intersection with CLIP-seq data demonstrated that Csde1 binds to the 3′untranslated region(UTR)of mRNA transcripts encoding cell cycle genes.Particularly,we uncovered that Csde1 directly binds to the 3′UTR of mRNA transcripts encoding Cdk6,a pivotal gene in regulating the transition from the G1 to S phases of the cell cycle,thereby maintaining its stability.Collectively,this study elucidates Csde1 as a novel regulator of Cdk6,sheds new light on its critical roles in orchestrating brain development,and underscores how mutations in Csde1 may contribute to the pathogenesis of neuropsychiatric disorders.展开更多
Revealing the latent low-dimensional geometric structure of high-dimensional data is a crucial task in unsupervised representation learning.Traditional manifold learning,as a typical method for discovering latent geom...Revealing the latent low-dimensional geometric structure of high-dimensional data is a crucial task in unsupervised representation learning.Traditional manifold learning,as a typical method for discovering latent geometric structures,has provided important nonlinear insight for the theoretical development of unsupervised representation learning.However,due to the shallow learning mechanism of the existing methods,they can only exploit the simple geometric structure embedded in the initial data,such as the local linear structure.Traditional manifold learning methods are fairly limited in mining higher-order nonlinear geometric information,which is also crucial for the development of unsupervised representation learning.To address the abovementioned limitations,this paper proposes a novel dynamic geometric structure learning model(DGSL)to explore the true latent nonlinear geometric structure.Specifically,by mathematically analysing the reconstruction loss function of manifold learning,we first provide universal geometric relational function between the curvature and the non-Euclidean metric of the initial data.Then,we leverage geometric flow to design a deeply iterative learning model to optimize this relational function.Our method can be viewed as a general-purpose algorithm for mining latent geometric structures,which can enhance the performance of geometric representation methods.Experimentally,we perform a set of representation learning tasks on several datasets.The experimental results show that our proposed method is superior to traditional methods.展开更多
The regulation of the interfacial electric field plays a pivotal role in magnifying the electromagnetic en-ergy attenuation capability during the design and synthesis of efficient and tunable absorbers for elec-tromag...The regulation of the interfacial electric field plays a pivotal role in magnifying the electromagnetic en-ergy attenuation capability during the design and synthesis of efficient and tunable absorbers for elec-tromagnetic waves(EMW).Herein,a rational and universally applicable two-step hydrothermal method strategy was proposed to effectively control the electronic structure of Mott-Schottky EMW absorbing materials derived from Co-MOF.The as-synthesized Co_(3)S_(4)@MoS_(2)/NC ensures efficient electron transfer,while the change redistribution leads to the emergence of additional electric dipoles under an external EMM field.In addition,the hierarchical Co_(3)S_(4)@MoS_(2)/NC nano-architecture with a hierarchical arrange-ment in 2D and 3D offers more polarization sites,thereby extending the path for EMW transmission through multiple reflections and scattering.The potential to enhance the EMW absorption performance of Co_(3)S_(4)@MoS_(2)/NC lies in its unique microstructure and substantial surface area,which optimize impedance matching properties through a synergistic effect of dipole and interfacial polarization induced by Mott-Schottky heterointerfaces.As anticipated,the Co_(3)S_(4)@MoS_(2)/NC exhibits a maximum EMW absorption ca-pacity with an RLmin value of-41.97 dB and a broad EAB of 4.24 GHz at a thickness of 2.0 mm.This study provides insights for designing highly efficient Mott-Schottky EMW absorbing materials at the molecular level rationally.展开更多
Background:Elevated levels of serum C-reactive protein(CRP) have been reported to have prognostic significance in lung cancer patients.This study aimed to further identify CRP-bound components as prognostic markers fo...Background:Elevated levels of serum C-reactive protein(CRP) have been reported to have prognostic significance in lung cancer patients.This study aimed to further identify CRP-bound components as prognostic markers for lung cancer and validate their prognostic value.Methods:CRP-bound components obtained from the serum samples from lung cancer patients or healthy controls were analyzed by differential proteomics analysis.CRP-bound serum amyloid A(CRP-SAA) was evaluated by coimmunoprecipitation(IP).Serum samples from two independent cohorts with lung cancer(retrospective cohort,242patients;prospective cohort,222 patients) and healthy controls(159 subjects) were used to evaluate the prognostic value of CRP-SAA by enzyme-linked immunosorbent assay.Results:CRP-SAA was identified specifically in serum samples from lung cancer patients by proteomic analysis.CRP binding to SAA was confirmed by co-IP in serum samples from lung cancer patients and cell culture media.The level of CRP-SAA was significantly higher in patients than in healthy controls(0.37 ± 0.58 vs.0.03 ± 0.04,P < 0.001).Elevated CRP-SAA levels were significantly associated with severe clinical features of lung cancer.The elevation of CRPSAA was associated with lower survival rates for both the retrospective(hazard ration[HR]= 2.181,95%confidence interval[CI]= 1.641-2.897,P < 0.001) and the prospective cohorts(HR = 2.744,95%CI = 1.810-4.161,P < 0.001).Multivariate Cox analysis showed that CRP-SAA was an independent prognostic marker for lung cancer.Remarkably,in stages l-ll patients,only CRP-SAA,not total SAA or CRP,showed significant association with overall survival in two cohorts.Moreover,univariate and multivariate Cox analyses also showed that only CRP-SAA could be used as an independent prognostic marker for early-stage lung cancer patients.Conclusion:CRP-SAA could be a better prognostic marker for lung cancer than total SAA or CRP,especially in earlystage patients.展开更多
Since the impoundment of the Three Gorges Reservoir in 2003, algal blooms have frequently been observed in it. The chlorophyll a concentration is an important parameter for evaluating algal blooms. In this study, the ...Since the impoundment of the Three Gorges Reservoir in 2003, algal blooms have frequently been observed in it. The chlorophyll a concentration is an important parameter for evaluating algal blooms. In this study, the chlorophyll a concentration in Xiangxi Bay, in the Three Gorges Reservoir, was predicted using HJ-1 satellite imagery. Several models were established based on a correlation analysis between in situ measurements of the chlorophyll a concentration and the values obtained from satellite images of the study area from January 2010 to December 2011. Chlorophyll a concentrations in Xiangxi Bay were predicted based on the established models. The results show that the maximum correlation is between the reflectance of the band combination of B4/（B2＋B3） and in situ measurements of chlorophyll a concentration. The root mean square errors of the predicted values using the linear and quadratic models are 18.49 mg/m3 and 18.52 mg/m3, respectively, and the average relative errors are 37.79% and 36.79%, respectively. The results provide a reference for water bloom prediction in typical tributaries of the Three Gorges Reservoir and contribute to large-scale remote sensing monitoring and water quality management.展开更多
The effects of chloride salts(NaCl,MgCl2and NH4Cl)on the hydrolysis kinetics of MgH2prepared by hydridingcombustion synthesis and mechanical milling(HCS+MM)were discussed.X-ray diffraction(XRD)analyses show that high-...The effects of chloride salts(NaCl,MgCl2and NH4Cl)on the hydrolysis kinetics of MgH2prepared by hydridingcombustion synthesis and mechanical milling(HCS+MM)were discussed.X-ray diffraction(XRD)analyses show that high-purityMgH2was successfully prepared by HCS.Hydrolysis performance test results indicate that the chloride salt added during the millingprocess is favorable to the initial reaction rate and hydrogen generation yield within60min.A MgH2?10%NH4Cl composite exhibitsthe best performance with the hydrogen generation yield of1311mL/g and a conversion rate of85.69%in60min at roomtemperature.It is suggested that the chloride salts not only play as grinding aids in the milling process,but also create fresh surface ofreactive materials,favoring the hydrolysis reaction.展开更多
Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss,but the mechanisms and therapeutics remain incompletely elucidated.Here,we reveal an o...Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss,but the mechanisms and therapeutics remain incompletely elucidated.Here,we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenesis under sympatho-adrenergic activation with characterized micro RNA response and efficient therapeutics.We discovered that osteoclastic mi R-21 was tightly regulated by sympatho-adrenergic cues downstream theβ2-adrenergic receptor(β2AR)signaling,critically modulated osteoclastogenesis in vivo by inhibiting programmed cell death 4(Pdcd4),and mediated detrimental effects of both isoproterenol(ISO)and chronic variable stress(CVS)on bone.Intriguingly,without affecting osteoblastic bone formation,bone protection against ISO and CVS was sufficiently achieved by a(D-Asp8)-lipid nanoparticle-mediated targeted inhibition of osteoclastic mi R-21 or by clinically relevant drugs to suppress osteoclastogenesis.Collectively,these results unravel a previously underdetermined molecular and functional paradigm that osteoclastogenesis crucially contributes to sympatho-adrenergic regulation of bone and establish multiple targeted therapeutic strategies to counteract osteopenias under stresses.展开更多
This paper investigated the influence of geometric factors of vapor groove structures on the performance of flat evaporator of a loop heat pipe system. COMSOL multiphysics software was employed to simulate the heat tr...This paper investigated the influence of geometric factors of vapor groove structures on the performance of flat evaporator of a loop heat pipe system. COMSOL multiphysics software was employed to simulate the heat transfer in the evaporator with convex platforms of different shapes,sizes and area ratios(φ)between convex platforms and the heated surface. The maximum temperature and temperature distribution of each model were obtained. The results showed that the decrease of the size of platforms and the increase of φ can lower temperatures and improve temperature distribution homogeneity of the heated surface. Compared with circle and oval platforms,square platforms achieved lower temperature. The results also indicated that φ had the most significant impact on the performance of the evaporator.展开更多
As a type of bi-functional device,electrochromic supercapacitors(EC-SCs)have attracted extensive attention in diverse applications such as flexible electronics.However,despite recent encouraging progress,rational desi...As a type of bi-functional device,electrochromic supercapacitors(EC-SCs)have attracted extensive attention in diverse applications such as flexible electronics.However,despite recent encouraging progress,rational design and development of high-performance EC-SC materials with desirable stability remain challenging for practical applications.Here,we propose a fluorination strategy to develop high-performance EC-SC materials with tough hydrogen bonding cross-linked intermolecular polymer network by one-step electrosynthesis of 3-fluorothiophene.The electrosynthesized free-standing poly(3-fluorothiophene)(PFT)films simultaneously achieve high electrochromic performance(optical contrast 42%at 560 nm with reversible color changes between purple and blue),and good capacitance property(290 F·g^(-1),1 A·g^(-1)),as well as outstanding cyclic stability(<2%reduction after 20000 cycles).We further demonstrate the fabrication of PFT-based flexible electrochromic supercapacitor devices(FESDs),and the resultant devices can be used to visually monitor the energy storage state in real-time and maintain outstanding stability under mechanical distortion like bending.Such a tough fluorination hydrogen bonding cross-linking strategy may provide a new design concept for high-performance EC-SC materials and reliable FESDs toward practical applications.展开更多
Benchmark experiments are indispensable for the development of neutron nuclear data evaluation libraries.Given the lack of domestic benchmarking of nuclear data in the fission energy region,this study developed a neut...Benchmark experiments are indispensable for the development of neutron nuclear data evaluation libraries.Given the lack of domestic benchmarking of nuclear data in the fission energy region,this study developed a neutron leakage spectrum measurement system using a spherical sample based on the^(252)Cf spontaneous fission source.The EJ309 detector(for highenergy measurements)and CLYC detector(for low-energy measurements)were combined to measure the time-of-flight spectrum using theγtagging method.To assess the performance of the system,the time-of-flight spectrum without a sample was measured first.The experimental spectra were consistent with those simulated using the Monte Carlo method and the standard^(252)Cf spectrum from ISO:8529-1.This demonstrates that the system can effectively measure the neutron events in the 0.15-8.0 MeV range.Then,a spherical polyethylene sample was used as the standard to verify the accuracy of the system for the benchmark experiment.The simulation results were obtained using the Monte Carlo method with evaluated data from the ENDF/B-Ⅷ.0,CENDL-3.2,JEFF-3.3,and JENDL-5 libraries.The measured neutron leakage spectra were compared with the corresponding simulated results for the neutron spectrum shape and calculated C/E values.The results showed that the simulated spectra with different data libraries reproduced the experimental results well in the 0.15-8.0 MeV range.This study confirms that the leakage neutron spectrum measurement system based on the^(252)Cf source can perform benchmarking and provides a foundation for evaluating neutron nuclear data through benchmark experiments.展开更多
Objectives:Decades of clinical and fundamental research advancements in oncology have led to significant breakthroughs such as early screening,targeted therapies,and immunotherapy,contributing to reduced mortality rat...Objectives:Decades of clinical and fundamental research advancements in oncology have led to significant breakthroughs such as early screening,targeted therapies,and immunotherapy,contributing to reduced mortality rates in cancer patients.Despite these achievements,cancer continues to be a major public health challenge.This study employs bibliometric techniques to visually analyze the English literature on cancer prevention,screening,diagnosis,treatment,and rehabilitation.Methods:We systematically reviewed publications from 01 March 2014,to 01 March 2024,indexed in the Web of Science core collection.Tools such as VOSviewer Version 1.6.20 is characterized by its core idea of co-occurrence clustering.CiteSpace 6.3.R3 is distinguished by its powerful capabilities in bibliometric analysis,including co-citation analysis,co-occurrence analysis of keywords,author collaboration network analysis,and journal co-citation analysis,providing effective insights into research hotspots and detecting emerging trends.Bibliometrix version 3.0.3 offers rich visualization features,including collaboration network diagrams,citation distribution graphs,and keyword clouds.facilitated the analysis of the literature,helping to map out the current research landscape,identify pressing issues,and discern emerging trends,thus offering insights for future research directions.Results:The analysis revealed that major research hotspots include lung and breast cancer.Attention is predominantly concentrated on cancer treatment,subdivided into targeted therapy,immunotherapy,traditional Chinese medicine,and the development of new anticancer drugs.Significant terms identified in the study include immune checkpoint inhibitors,tumor microenvironment,and cancer stem cells.Conclusion:This bibliometric analysis highlights the evolving directions in oncology research,pinpointing nanotherapy,resistance to targeted therapies,and the integration of artificial intelligence as pivotal future research avenues in the prevention,screening,diagnosis,treatment,and rehabilitation of cancer.展开更多
Objective:Circadian rhythm disruption(CRD)is a risk factor that correlates with poor prognosis across multiple tumor types,including hepatocellular carcinoma(HCC).However,its mechanism remains unclear.This study aimed...Objective:Circadian rhythm disruption(CRD)is a risk factor that correlates with poor prognosis across multiple tumor types,including hepatocellular carcinoma(HCC).However,its mechanism remains unclear.This study aimed to define HCC subtypes based on CRD and explore their individual heterogeneity.Methods:To quantify CRD,the HCC CRD score(HCCcrds)was developed.Using machine learning algorithms,we identified CRD module genes and defined CRD-related HCC subtypes in The Cancer Genome Atlas liver HCC cohort(n=369),and the robustness of this method was validated.Furthermore,we used bioinformatics tools to investigate the cellular heterogeneity across these CRD subtypes.Results:We defined three distinct HCC subtypes that exhibit significant heterogeneity in prognosis.The CRD-related subtype with high HCCcrds was significantly correlated with worse prognosis,higher pathological grade,and advanced clinical stages,while the CRD-related subtype with low HCCcrds had better clinical outcomes.We also identified novel biomarkers for each subtype,such as nicotinamide nmethyltransferase and myristoylated alanine-rich protein kinase C substrate-like 1.Conclusion:We classify the HCC patients into three distinct groups based on circadian rhythm and identify their specific biomarkers.Within these groups greater HCCcrds was associated with worse prognosis.This approach has the potential to improve prediction of an individual’s prognosis,guide precision treatments,and assist clinical decision making for HCC patients.展开更多
This study presents a novel approach to enhance silicon anode performance through barium titanate(BTO)incorporation,with the establishment of a force-electric coupling model.By introducing piezoelectric BTO into silic...This study presents a novel approach to enhance silicon anode performance through barium titanate(BTO)incorporation,with the establishment of a force-electric coupling model.By introducing piezoelectric BTO into silicon matrices,we successfully improved both the mechanical stability and electrochemical kinetics of the anode.The developed force-electric coupling model explains how BTO mitigates stress accumulation during lithiation while optimizing the kinetics of Li^(+)and electron transfer.Experimental verification and multiphysical simulation indicate that Si@BTO effectively eliminates structural degradation during the cycling process and significantly reduces the charge transfer resistance.The force-electric coupling mechanism further facilitates stable solid electrolyte interphase(SEI)formation.When paired with LiFePO_(4)cathodes,Si@BTO maintains 76% capacity retention after 500 cycles at a 10 C rate.This work establishes a basic force-electric coupling model framework and offers insights into the development of advanced silicon anode batteries with exceptional performance.展开更多
Insufficient metallurgical compatibility between Zr and Ni can lead to the formation of brittle welds and introduce thermal stress-related challenges during the electron beam welding process.Through the implementation...Insufficient metallurgical compatibility between Zr and Ni can lead to the formation of brittle welds and introduce thermal stress-related challenges during the electron beam welding process.Through the implementation of beam deflection and vibration,a transformation was achieved in the primary Ni_(5)Zr dendrite structure,transitioning from a mass into a layered configuration,consequently resulting in the formation of an ultrafine-grained eutectic−dendrite complex structure.It is revealed that the enhanced strength−ductility synergy of this structure significantly contributes to the high tensile strength and improved plasticity observed in the welded joints.As a result,the welding cracks are effectively mitigated,and notable advancements are achieved in the mechanical properties of Zr/Ni joints,elevating the tensile strength of the joints from 36.4 to 189 MPa.This research not only highlights the potential of this technique in enhancing the strength and ductility of Zr/Ni welded joints but also serves as a valuable reference for future investigations involving welding applications of dissimilar metals.展开更多
Objective:To investigate the effect of the spinal cord extracts(SCE)after spinal cord injuries(SCIs)on the proliferation of rat embryonic neural stem cells(NSCs)and the expressions of mRNA of Notch1 as well as of Hes1...Objective:To investigate the effect of the spinal cord extracts(SCE)after spinal cord injuries(SCIs)on the proliferation of rat embryonic neural stem cells(NSCs)and the expressions of mRNA of Notch1 as well as of Hes1 in this process in vitro.Methods:The experiment was conducted in 4 different mediums:NSCs+PBS(Group A-blank control group),NSCs+SCE with healthy SD rats(Croup B-normal control group),NSCs+SCE with SD rats receiving sham-operation treatment(Croup C-sham-operation group)and NSCs+SCE with SCIs rats(Group D-paraplegic group).Proliferative abilities of 4 different groups were analyzed by MTT chromatometry after co-culture for 1,2,3,4 and 5 d,respectively.The expressions of Notch 1 and Hes1 mRNA were also detected with RT-PCR after co-culture for 24 and 48 h,respectively.Results:After co-culture for 1,2,3,4 and 5 d respectively,the MTT values of group D were significantly higher than those of group A,group B and group C(P<0.05).However,there were no significantly differences regarding MTT values between group A,group B and group C after co-culture for 1,2,3,4 and 5 d,respectively(P>0.05).Both the expressions of Notch1 and Hes1 mRNA of group D were significantly higher than those of other 3 groups after co-culture for 24 h and 48 h as well(P<0.05).But there was no difference oin expressions of Notch1 and Hes1 mRNA among group A,group B and group C after co-culture for 24 h and 48 h(P>0.05).There was no difference in expressions of Notch1and Hes1 mRNA between 24 h and 48 h treatment in group D.Conclusions:SCE could promote the proliferation of NSCs.It is demonstrated that the microenvironment of SCI may promote the proliferation of NSCs.Besides,SCE could increase the expression of Notch1 and Hes1 mRNA of NSC.It can be concluded that the Notch signaling pathway activation is one of the mechanisms that locally injured microenvironment contributes to the proliferation of ENSC after SCIs.This process may be performed by up-regulating the expressions of Notch1 and Hes1 gene.展开更多
In this paper,a novel Ce(Gd2 Y)Al5O12/Ce:Y3Al5O12(Ce:GYAG/Ce:YAG)composite scintillation ceramic was designed and fabricated by a solid-state reaction method.The phase,luminescence and scintillation properties were in...In this paper,a novel Ce(Gd2 Y)Al5O12/Ce:Y3Al5O12(Ce:GYAG/Ce:YAG)composite scintillation ceramic was designed and fabricated by a solid-state reaction method.The phase,luminescence and scintillation properties were investigated.The Ce:GYAG/Ce:YAG composite ceramic consisting of two-phase has a broad emission band ranging from 500 to 750 nm.The total mass attenuation coefficient of Ce:GYAG/Ce:YAG is 0.3864 cm^-1,in between those of Ce:YAG and Ce:GYAG ceramics.In addition,the composite ceramic had a high light yield of 20430 ph/MeV.By controlling the ratio of GYAG and YAG,the composite ceramic can realize a spectrum design and total mass attenuation coefficient control to meet the requirements for wide-X-ray-energy-range detectors.展开更多
文摘BACKGROUND Ischemic bowel disease(IBD)is a critical condition caused by reduced blood flow to the intestines,leading to tissue damage and potentially severe complications.Early recognition and timely management are essential for improving patient outcomes and reducing morbidity and mortality associated with IBD.AIM To evaluate the knowledge,attitude and practice(KAP)of healthcare professionals regarding IBD.METHODS This cross-sectional study was conducted among healthcare professionals in China from November 2023 to December 2023 using a self-designed questionnaire.RESULTS A total of 315 valid questionnaires were analyzed,with 215 participants(68.25%)being female.The mean KAP scores were 17.55±5.35(range:0-24),27.65±2.77(range:8-40),and 18.88±4.23(range:6-30),respectively.Multivariate linear regression analysis revealed the following factors to be independently associated with knowledge:Age 26-35 years(β=2.80,95%CI:0.31-5.30,P=0.028),professional title(β=2.66,95%CI:0.91-4.41,P=0.003),position(β=-3.78,95%CI:-5.45 to-2.11,P<0.001),participation in IBD-related training(β=3.45,95%CI:2.39-4.51,P<0.001),and admission of more than five IBD cases in the past month(β=3.25,95%CI:1.58-4.92,P<0.001).Attitude was independently associated with knowledge(β=0.20,95%CI:0.15-0.26,P<0.001)and being a nurse or nursing supervisor(β=-1.30,95%CI:-2.16 to-0.40,P=0.003).Practice was independently associated with knowledge(β=0.20,95%CI:0.10-0.30,P<0.001)and attitude(β=0.24,95%CI:0.06-0.42,P=0.007).Structural equation modeling demonstrated direct effects of knowledge on attitude(β=0.24,P<0.001)and practice(β=0.26,P<0.001),as well as of attitude on practice(β=0.22,P=0.012).CONCLUSION Healthcare professionals demonstrated adequate knowledge but moderate attitude and inactive practice regarding IBD.Addressing the gaps in attitude and practice through targeted training programs and interventions is essential for improving patient care and outcomes.
基金supported by STI 2030-Major Project(2021ZD0201704)the National Natural Science Foundation of China(32271141,82222025,82130043,82330035,82361138573,82160219,and 82401388)+3 种基金Hunan Provincial Grants(2023SK2084,2023RC1020,2023SK2114,2021SK1010,and 2024JJ6545)China Postdoctoral Science Foundation(2023M733969)Postdoctoral Fellowship Program of China Postdoctoral Science Foundation(GZB20230875)National Key Research and Development Program of China(2021YFA0805200)。
文摘Loss-of-function variants in CSDE1 have been strongly linked to neuropsychiatric disorders,yet the precise role of CSDE1 in neurogenesis remains elusive.In this study,we demonstrate that knockout of Csde1 during cortical development in mice results in impaired neural progenitor proliferation,leading to abnormal cortical lamination and embryonic lethality.Transcriptomic analysis revealed that Csde1 upregulates the transcription of genes involved in the cell cycle network.Applying a dual thymidine-labelling approach,we further revealed prolonged cell cycle durations of neuronal progenitors in Csde1-knockout mice,with a notable extension of the G1 phase.Intersection with CLIP-seq data demonstrated that Csde1 binds to the 3′untranslated region(UTR)of mRNA transcripts encoding cell cycle genes.Particularly,we uncovered that Csde1 directly binds to the 3′UTR of mRNA transcripts encoding Cdk6,a pivotal gene in regulating the transition from the G1 to S phases of the cell cycle,thereby maintaining its stability.Collectively,this study elucidates Csde1 as a novel regulator of Cdk6,sheds new light on its critical roles in orchestrating brain development,and underscores how mutations in Csde1 may contribute to the pathogenesis of neuropsychiatric disorders.
基金supported in part by the Young Elite Scientists Sponsorship Program by China Association for Science and Technology(2022QNRC001)the National Natural Science Foundation of China(62406315)+2 种基金China Postdoctoral Science Foundation(2025M771504)GuangDong Basic and Applied Basic Research Foundation(2024A1515110108)Shaanxi Provincial Key Research and Development Program(2025SF-YBXM-023).
文摘Revealing the latent low-dimensional geometric structure of high-dimensional data is a crucial task in unsupervised representation learning.Traditional manifold learning,as a typical method for discovering latent geometric structures,has provided important nonlinear insight for the theoretical development of unsupervised representation learning.However,due to the shallow learning mechanism of the existing methods,they can only exploit the simple geometric structure embedded in the initial data,such as the local linear structure.Traditional manifold learning methods are fairly limited in mining higher-order nonlinear geometric information,which is also crucial for the development of unsupervised representation learning.To address the abovementioned limitations,this paper proposes a novel dynamic geometric structure learning model(DGSL)to explore the true latent nonlinear geometric structure.Specifically,by mathematically analysing the reconstruction loss function of manifold learning,we first provide universal geometric relational function between the curvature and the non-Euclidean metric of the initial data.Then,we leverage geometric flow to design a deeply iterative learning model to optimize this relational function.Our method can be viewed as a general-purpose algorithm for mining latent geometric structures,which can enhance the performance of geometric representation methods.Experimentally,we perform a set of representation learning tasks on several datasets.The experimental results show that our proposed method is superior to traditional methods.
基金supported by the National Natural Science Foundation of China(Nos.22271178,22301239)Science and Technology New Star in Shaanxi Province(No.2023KJXX-045)+3 种基金the Youth Talent Promotion Project of Science and Technology Association of Universities of Shaanxi Province(No.20240601)Shaanxi Provincial Department of Education service local special project,industrialization cultivation project(No.23JC007)the Research Program of the Shaanxi Provincial Department of Education(Nos.23JK0596,23JP135)the Open Foundation of Xi’an Key Laboratory of Functional Supramolecular Structure and Materials(No.CFZKFKT23003).
文摘The regulation of the interfacial electric field plays a pivotal role in magnifying the electromagnetic en-ergy attenuation capability during the design and synthesis of efficient and tunable absorbers for elec-tromagnetic waves(EMW).Herein,a rational and universally applicable two-step hydrothermal method strategy was proposed to effectively control the electronic structure of Mott-Schottky EMW absorbing materials derived from Co-MOF.The as-synthesized Co_(3)S_(4)@MoS_(2)/NC ensures efficient electron transfer,while the change redistribution leads to the emergence of additional electric dipoles under an external EMM field.In addition,the hierarchical Co_(3)S_(4)@MoS_(2)/NC nano-architecture with a hierarchical arrange-ment in 2D and 3D offers more polarization sites,thereby extending the path for EMW transmission through multiple reflections and scattering.The potential to enhance the EMW absorption performance of Co_(3)S_(4)@MoS_(2)/NC lies in its unique microstructure and substantial surface area,which optimize impedance matching properties through a synergistic effect of dipole and interfacial polarization induced by Mott-Schottky heterointerfaces.As anticipated,the Co_(3)S_(4)@MoS_(2)/NC exhibits a maximum EMW absorption ca-pacity with an RLmin value of-41.97 dB and a broad EAB of 4.24 GHz at a thickness of 2.0 mm.This study provides insights for designing highly efficient Mott-Schottky EMW absorbing materials at the molecular level rationally.
基金supported by grants from the Ministry of Science and Technology of China(2011CB504304 and 2012CB967003)the National Natural Science Foundation of China(81271902 and 81230045)
文摘Background:Elevated levels of serum C-reactive protein(CRP) have been reported to have prognostic significance in lung cancer patients.This study aimed to further identify CRP-bound components as prognostic markers for lung cancer and validate their prognostic value.Methods:CRP-bound components obtained from the serum samples from lung cancer patients or healthy controls were analyzed by differential proteomics analysis.CRP-bound serum amyloid A(CRP-SAA) was evaluated by coimmunoprecipitation(IP).Serum samples from two independent cohorts with lung cancer(retrospective cohort,242patients;prospective cohort,222 patients) and healthy controls(159 subjects) were used to evaluate the prognostic value of CRP-SAA by enzyme-linked immunosorbent assay.Results:CRP-SAA was identified specifically in serum samples from lung cancer patients by proteomic analysis.CRP binding to SAA was confirmed by co-IP in serum samples from lung cancer patients and cell culture media.The level of CRP-SAA was significantly higher in patients than in healthy controls(0.37 ± 0.58 vs.0.03 ± 0.04,P < 0.001).Elevated CRP-SAA levels were significantly associated with severe clinical features of lung cancer.The elevation of CRPSAA was associated with lower survival rates for both the retrospective(hazard ration[HR]= 2.181,95%confidence interval[CI]= 1.641-2.897,P < 0.001) and the prospective cohorts(HR = 2.744,95%CI = 1.810-4.161,P < 0.001).Multivariate Cox analysis showed that CRP-SAA was an independent prognostic marker for lung cancer.Remarkably,in stages l-ll patients,only CRP-SAA,not total SAA or CRP,showed significant association with overall survival in two cohorts.Moreover,univariate and multivariate Cox analyses also showed that only CRP-SAA could be used as an independent prognostic marker for early-stage lung cancer patients.Conclusion:CRP-SAA could be a better prognostic marker for lung cancer than total SAA or CRP,especially in earlystage patients.
基金supported by the National Natural Science Foundation of China(Grants No.51009080 and 51179095)the Research Innovation Fund for Postgraduates in China Three Gorges University(Grant No.2012CX012)
文摘Since the impoundment of the Three Gorges Reservoir in 2003, algal blooms have frequently been observed in it. The chlorophyll a concentration is an important parameter for evaluating algal blooms. In this study, the chlorophyll a concentration in Xiangxi Bay, in the Three Gorges Reservoir, was predicted using HJ-1 satellite imagery. Several models were established based on a correlation analysis between in situ measurements of the chlorophyll a concentration and the values obtained from satellite images of the study area from January 2010 to December 2011. Chlorophyll a concentrations in Xiangxi Bay were predicted based on the established models. The results show that the maximum correlation is between the reflectance of the band combination of B4/（B2＋B3） and in situ measurements of chlorophyll a concentration. The root mean square errors of the predicted values using the linear and quadratic models are 18.49 mg/m3 and 18.52 mg/m3, respectively, and the average relative errors are 37.79% and 36.79%, respectively. The results provide a reference for water bloom prediction in typical tributaries of the Three Gorges Reservoir and contribute to large-scale remote sensing monitoring and water quality management.
基金Projects(51571112,51171079,51471087) supported by the National Natural Science Foundation of ChinaProject(13KJA430003) supported by Jiangsu Higher Education Institutions of China+1 种基金Project supported by Qing Lan Project,ChinaProject supported by the Priority Academic Program Development(PAPD) of Jiangsu Higher Education Institutions,China
文摘The effects of chloride salts(NaCl,MgCl2and NH4Cl)on the hydrolysis kinetics of MgH2prepared by hydridingcombustion synthesis and mechanical milling(HCS+MM)were discussed.X-ray diffraction(XRD)analyses show that high-purityMgH2was successfully prepared by HCS.Hydrolysis performance test results indicate that the chloride salt added during the millingprocess is favorable to the initial reaction rate and hydrogen generation yield within60min.A MgH2?10%NH4Cl composite exhibitsthe best performance with the hydrogen generation yield of1311mL/g and a conversion rate of85.69%in60min at roomtemperature.It is suggested that the chloride salts not only play as grinding aids in the milling process,but also create fresh surface ofreactive materials,favoring the hydrolysis reaction.
基金supported by grants from the National Natural Science Foundation of China(81870796,82170988,81930025 and 82100969)the General Research Funds from the Research Grants Council of Hong Kong SAR(12114416,12100918,12136616 and 12103519)the China Postdoctoral Science Foundation(2019M663986 and BX20190380)。
文摘Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss,but the mechanisms and therapeutics remain incompletely elucidated.Here,we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenesis under sympatho-adrenergic activation with characterized micro RNA response and efficient therapeutics.We discovered that osteoclastic mi R-21 was tightly regulated by sympatho-adrenergic cues downstream theβ2-adrenergic receptor(β2AR)signaling,critically modulated osteoclastogenesis in vivo by inhibiting programmed cell death 4(Pdcd4),and mediated detrimental effects of both isoproterenol(ISO)and chronic variable stress(CVS)on bone.Intriguingly,without affecting osteoblastic bone formation,bone protection against ISO and CVS was sufficiently achieved by a(D-Asp8)-lipid nanoparticle-mediated targeted inhibition of osteoclastic mi R-21 or by clinically relevant drugs to suppress osteoclastogenesis.Collectively,these results unravel a previously underdetermined molecular and functional paradigm that osteoclastogenesis crucially contributes to sympatho-adrenergic regulation of bone and establish multiple targeted therapeutic strategies to counteract osteopenias under stresses.
基金Sponsored by the National Natural Science Foundation of China(Grant No.51276012)
文摘This paper investigated the influence of geometric factors of vapor groove structures on the performance of flat evaporator of a loop heat pipe system. COMSOL multiphysics software was employed to simulate the heat transfer in the evaporator with convex platforms of different shapes,sizes and area ratios(φ)between convex platforms and the heated surface. The maximum temperature and temperature distribution of each model were obtained. The results showed that the decrease of the size of platforms and the increase of φ can lower temperatures and improve temperature distribution homogeneity of the heated surface. Compared with circle and oval platforms,square platforms achieved lower temperature. The results also indicated that φ had the most significant impact on the performance of the evaporator.
基金financially supported by the National Natural Science Foundation of China(Nos.52103214,52364039 and 51973102)Natural Science Foundation of Jiangxi Provincial(Nos.GJJ2201301 and 20232BAB202044)+4 种基金Natural Science Foundation of Shandong Province(Nos.ZR2022MB042 and ZR2019MB067)Innovation Ability Improvement Project ofScience and Technology Small and Medium-Size Enterprise in Shandong Province(No.2022TSGC1121)Qinghai Provincial Basic Research Program(No.2021-ZJ-710)Scientific Fund of Jiangxi Science&Technology Normal University(No.2022QNBJRC004)Talent Fund of QUST(2020)。
文摘As a type of bi-functional device,electrochromic supercapacitors(EC-SCs)have attracted extensive attention in diverse applications such as flexible electronics.However,despite recent encouraging progress,rational design and development of high-performance EC-SC materials with desirable stability remain challenging for practical applications.Here,we propose a fluorination strategy to develop high-performance EC-SC materials with tough hydrogen bonding cross-linked intermolecular polymer network by one-step electrosynthesis of 3-fluorothiophene.The electrosynthesized free-standing poly(3-fluorothiophene)(PFT)films simultaneously achieve high electrochromic performance(optical contrast 42%at 560 nm with reversible color changes between purple and blue),and good capacitance property(290 F·g^(-1),1 A·g^(-1)),as well as outstanding cyclic stability(<2%reduction after 20000 cycles).We further demonstrate the fabrication of PFT-based flexible electrochromic supercapacitor devices(FESDs),and the resultant devices can be used to visually monitor the energy storage state in real-time and maintain outstanding stability under mechanical distortion like bending.Such a tough fluorination hydrogen bonding cross-linking strategy may provide a new design concept for high-performance EC-SC materials and reliable FESDs toward practical applications.
基金supported by the National Natural Science Foundation of China(No.U2067205)。
文摘Benchmark experiments are indispensable for the development of neutron nuclear data evaluation libraries.Given the lack of domestic benchmarking of nuclear data in the fission energy region,this study developed a neutron leakage spectrum measurement system using a spherical sample based on the^(252)Cf spontaneous fission source.The EJ309 detector(for highenergy measurements)and CLYC detector(for low-energy measurements)were combined to measure the time-of-flight spectrum using theγtagging method.To assess the performance of the system,the time-of-flight spectrum without a sample was measured first.The experimental spectra were consistent with those simulated using the Monte Carlo method and the standard^(252)Cf spectrum from ISO:8529-1.This demonstrates that the system can effectively measure the neutron events in the 0.15-8.0 MeV range.Then,a spherical polyethylene sample was used as the standard to verify the accuracy of the system for the benchmark experiment.The simulation results were obtained using the Monte Carlo method with evaluated data from the ENDF/B-Ⅷ.0,CENDL-3.2,JEFF-3.3,and JENDL-5 libraries.The measured neutron leakage spectra were compared with the corresponding simulated results for the neutron spectrum shape and calculated C/E values.The results showed that the simulated spectra with different data libraries reproduced the experimental results well in the 0.15-8.0 MeV range.This study confirms that the leakage neutron spectrum measurement system based on the^(252)Cf source can perform benchmarking and provides a foundation for evaluating neutron nuclear data through benchmark experiments.
基金supported by the grants from the Scientific and Technological Innovation Project of Information Traditional Chinese Medicine,China Academy of Chinese Medical Sciences(No.CI2021 B002).
文摘Objectives:Decades of clinical and fundamental research advancements in oncology have led to significant breakthroughs such as early screening,targeted therapies,and immunotherapy,contributing to reduced mortality rates in cancer patients.Despite these achievements,cancer continues to be a major public health challenge.This study employs bibliometric techniques to visually analyze the English literature on cancer prevention,screening,diagnosis,treatment,and rehabilitation.Methods:We systematically reviewed publications from 01 March 2014,to 01 March 2024,indexed in the Web of Science core collection.Tools such as VOSviewer Version 1.6.20 is characterized by its core idea of co-occurrence clustering.CiteSpace 6.3.R3 is distinguished by its powerful capabilities in bibliometric analysis,including co-citation analysis,co-occurrence analysis of keywords,author collaboration network analysis,and journal co-citation analysis,providing effective insights into research hotspots and detecting emerging trends.Bibliometrix version 3.0.3 offers rich visualization features,including collaboration network diagrams,citation distribution graphs,and keyword clouds.facilitated the analysis of the literature,helping to map out the current research landscape,identify pressing issues,and discern emerging trends,thus offering insights for future research directions.Results:The analysis revealed that major research hotspots include lung and breast cancer.Attention is predominantly concentrated on cancer treatment,subdivided into targeted therapy,immunotherapy,traditional Chinese medicine,and the development of new anticancer drugs.Significant terms identified in the study include immune checkpoint inhibitors,tumor microenvironment,and cancer stem cells.Conclusion:This bibliometric analysis highlights the evolving directions in oncology research,pinpointing nanotherapy,resistance to targeted therapies,and the integration of artificial intelligence as pivotal future research avenues in the prevention,screening,diagnosis,treatment,and rehabilitation of cancer.
基金supported by Tianjian advanced biomedical laboratory key research and development projectHenan Province Natural Science Foundation(grant number:242300421283)+1 种基金Henan Province Science and Technology Research and Development(grant number:242102311176)Henan Province medical science and technology research project(grant number:SBGJ202403038)。
文摘Objective:Circadian rhythm disruption(CRD)is a risk factor that correlates with poor prognosis across multiple tumor types,including hepatocellular carcinoma(HCC).However,its mechanism remains unclear.This study aimed to define HCC subtypes based on CRD and explore their individual heterogeneity.Methods:To quantify CRD,the HCC CRD score(HCCcrds)was developed.Using machine learning algorithms,we identified CRD module genes and defined CRD-related HCC subtypes in The Cancer Genome Atlas liver HCC cohort(n=369),and the robustness of this method was validated.Furthermore,we used bioinformatics tools to investigate the cellular heterogeneity across these CRD subtypes.Results:We defined three distinct HCC subtypes that exhibit significant heterogeneity in prognosis.The CRD-related subtype with high HCCcrds was significantly correlated with worse prognosis,higher pathological grade,and advanced clinical stages,while the CRD-related subtype with low HCCcrds had better clinical outcomes.We also identified novel biomarkers for each subtype,such as nicotinamide nmethyltransferase and myristoylated alanine-rich protein kinase C substrate-like 1.Conclusion:We classify the HCC patients into three distinct groups based on circadian rhythm and identify their specific biomarkers.Within these groups greater HCCcrds was associated with worse prognosis.This approach has the potential to improve prediction of an individual’s prognosis,guide precision treatments,and assist clinical decision making for HCC patients.
基金the financial support of the National Natural Science Foundation of China(NSFC,No.12074093)。
文摘This study presents a novel approach to enhance silicon anode performance through barium titanate(BTO)incorporation,with the establishment of a force-electric coupling model.By introducing piezoelectric BTO into silicon matrices,we successfully improved both the mechanical stability and electrochemical kinetics of the anode.The developed force-electric coupling model explains how BTO mitigates stress accumulation during lithiation while optimizing the kinetics of Li^(+)and electron transfer.Experimental verification and multiphysical simulation indicate that Si@BTO effectively eliminates structural degradation during the cycling process and significantly reduces the charge transfer resistance.The force-electric coupling mechanism further facilitates stable solid electrolyte interphase(SEI)formation.When paired with LiFePO_(4)cathodes,Si@BTO maintains 76% capacity retention after 500 cycles at a 10 C rate.This work establishes a basic force-electric coupling model framework and offers insights into the development of advanced silicon anode batteries with exceptional performance.
基金supported by the National Natural Science Foundation of China(No.52375322).
文摘Insufficient metallurgical compatibility between Zr and Ni can lead to the formation of brittle welds and introduce thermal stress-related challenges during the electron beam welding process.Through the implementation of beam deflection and vibration,a transformation was achieved in the primary Ni_(5)Zr dendrite structure,transitioning from a mass into a layered configuration,consequently resulting in the formation of an ultrafine-grained eutectic−dendrite complex structure.It is revealed that the enhanced strength−ductility synergy of this structure significantly contributes to the high tensile strength and improved plasticity observed in the welded joints.As a result,the welding cracks are effectively mitigated,and notable advancements are achieved in the mechanical properties of Zr/Ni joints,elevating the tensile strength of the joints from 36.4 to 189 MPa.This research not only highlights the potential of this technique in enhancing the strength and ductility of Zr/Ni welded joints but also serves as a valuable reference for future investigations involving welding applications of dissimilar metals.
基金supported by Health Bureau of Luzhou No:2012-S-40(1/5)Health Department of Sichuan(120389)
文摘Objective:To investigate the effect of the spinal cord extracts(SCE)after spinal cord injuries(SCIs)on the proliferation of rat embryonic neural stem cells(NSCs)and the expressions of mRNA of Notch1 as well as of Hes1 in this process in vitro.Methods:The experiment was conducted in 4 different mediums:NSCs+PBS(Group A-blank control group),NSCs+SCE with healthy SD rats(Croup B-normal control group),NSCs+SCE with SD rats receiving sham-operation treatment(Croup C-sham-operation group)and NSCs+SCE with SCIs rats(Group D-paraplegic group).Proliferative abilities of 4 different groups were analyzed by MTT chromatometry after co-culture for 1,2,3,4 and 5 d,respectively.The expressions of Notch 1 and Hes1 mRNA were also detected with RT-PCR after co-culture for 24 and 48 h,respectively.Results:After co-culture for 1,2,3,4 and 5 d respectively,the MTT values of group D were significantly higher than those of group A,group B and group C(P<0.05).However,there were no significantly differences regarding MTT values between group A,group B and group C after co-culture for 1,2,3,4 and 5 d,respectively(P>0.05).Both the expressions of Notch1 and Hes1 mRNA of group D were significantly higher than those of other 3 groups after co-culture for 24 h and 48 h as well(P<0.05).But there was no difference oin expressions of Notch1 and Hes1 mRNA among group A,group B and group C after co-culture for 24 h and 48 h(P>0.05).There was no difference in expressions of Notch1and Hes1 mRNA between 24 h and 48 h treatment in group D.Conclusions:SCE could promote the proliferation of NSCs.It is demonstrated that the microenvironment of SCI may promote the proliferation of NSCs.Besides,SCE could increase the expression of Notch1 and Hes1 mRNA of NSC.It can be concluded that the Notch signaling pathway activation is one of the mechanisms that locally injured microenvironment contributes to the proliferation of ENSC after SCIs.This process may be performed by up-regulating the expressions of Notch1 and Hes1 gene.
基金financially supported by the National Natural Science Foundation of China(Nos.61378069,61405221,and 11535010)Youth Innovation Promotion Association of the Chinese Academy of Science(CAS)+2 种基金National Key Research and Development Program of China(SQ2017YFGX010025-03)Interdisciplinary Innovation Team of the CASGeneral Financial Grant from the China Postdoctoral Science Foundation(No.2016M601654)
文摘In this paper,a novel Ce(Gd2 Y)Al5O12/Ce:Y3Al5O12(Ce:GYAG/Ce:YAG)composite scintillation ceramic was designed and fabricated by a solid-state reaction method.The phase,luminescence and scintillation properties were investigated.The Ce:GYAG/Ce:YAG composite ceramic consisting of two-phase has a broad emission band ranging from 500 to 750 nm.The total mass attenuation coefficient of Ce:GYAG/Ce:YAG is 0.3864 cm^-1,in between those of Ce:YAG and Ce:GYAG ceramics.In addition,the composite ceramic had a high light yield of 20430 ph/MeV.By controlling the ratio of GYAG and YAG,the composite ceramic can realize a spectrum design and total mass attenuation coefficient control to meet the requirements for wide-X-ray-energy-range detectors.
