Background:Subarachnoid hemorrhage(SAH)is a subtype of hemorrhagic stroke characterized by high mortality and low rates of full recovery.This study aimed to investigate the epidemiological characteristics of SAH betwe...Background:Subarachnoid hemorrhage(SAH)is a subtype of hemorrhagic stroke characterized by high mortality and low rates of full recovery.This study aimed to investigate the epidemiological characteristics of SAH between 1990 and 2021.Methods:Data on SAH incidence,mortality,and disability-adjusted life-years(DALYs)from 1990 to 2021 were obtained from the Global Burden of Disease Study(GBD)2021.Estimated annual percentage changes(EAPCs)were calculated to evaluate changes in the age-standardized rate(ASR)of incidence and mortality,as well as trends in SAH burden.The relationship between disease burden and socio-demographic index(SDI)was also analyzed.Results:In 2021,the incidence of SAH was found to be 37.09%higher than that in 1990;however,the age-standardized incidence rates(ASIRs)showed a decreased[EAPC:-1.52;95%uncertainty interval(UI)-1.66 to-1.37].Furthermore,both the number and rates of deaths and DALYs decreased over time.It was observed that females had lower rates compared to males.Among all regions,the high-income Asia Pacific region exhibited the highest ASIR(14.09/100,000;95%UI 12.30/100,000-16.39/100,000)in 2021,with an EPAC for ASIR<0 indicating decreasing trend over time for SAH ASIR.Oceania recorded the highest age-standardized mortality rates(ASMRs)and age-standardized DALYs rates among all regions in 2021 at values of respectively 8.61(95%UI 6.03-11.95)and 285.62(95%UI 209.42-379.65).The burden associated with SAH primarily affected individuals aged between 50-69 years old.Metabolic risks particularly elevated systolic blood pressure were identified as the main risk factors contributing towards increased disease burden associated with SAH when compared against environmental or occupational behavioral risks evaluated within the GBD framework.Conclusions:The burden of SAH varies by gender,age group,and geographical region.Although the ASRs have shown a decline over time,the burden of SAH remains significant,especially in regions with middle and low-middle SDI levels.High systolic blood pressure stands out as a key risk factor for SAH.More specific supportive measures are necessary to alleviate the global burden of SAH.展开更多
Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existin...Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that micro RNAs（mi RNAs）, known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression,and growing numbers of novel mi RNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis,and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of mi RNAs in regulating bone remodeling as well as novel applications for mi RNAs in biomaterials for therapeutic purposes.展开更多
In recent years,LaBr_(3)(Ce)crystals and silicon photomultipliers(SiPMs)have been increasingly used in radiation imaging.This study involved the establishment of a detector model with a monolithic LaBr_(3)(Ce)crystal ...In recent years,LaBr_(3)(Ce)crystals and silicon photomultipliers(SiPMs)have been increasingly used in radiation imaging.This study involved the establishment of a detector model with a monolithic LaBr_(3)(Ce)crystal and SiPM array forγ-radiation imaging on the GEANT4 platform.The optical process included in the detector model was defined by key parameters,such as the emission spectrum,scintillation yield,and intrinsic resolution of the LaBr_(3):5%Ce crystal,as well as the detection efficiency of the SiPM array.The response of the detector model to^(57)Co flooded field irradiation was simulated and evaluated.The radiation images generated by the detector model exhibited a compression effect that was very close to that on images acquired by the physical detector.The spatial resolution of the simulated detector closely approximates that of the physical experiment.A detector model without the optical process was also established for comparison with a detector using the optical process.Both were used in a near-field modified uniform redundant array(MURA)imaging system to acquire images of a point source and a ring source of^(57)Co at the center of the field-of-view of the imaging system.The spatial resolution and signal-to-noise ratio of the images that were reconstructed using the two detector models were determined and compared.Compared with the detector model without optical processes,although the images from the proposed detector model have slightly inferior signal-to-noise ratios and more artifacts,they are more consistent with the reconstructed versions of images acquired in real physical experiments.The results confirm that the detector model can be used to design aγ-radiation imaging detector and to develop an imaging algorithm that can significantly shorten the development time and reduce the cost.展开更多
We theoretically explore the manipulation of a temporal electron-spin splitter by aδ-potential in an embedded magnetic-elec tric-barrier micro structure(EMEBM),which is constructed by patterning a ferromagnetic strip...We theoretically explore the manipulation of a temporal electron-spin splitter by aδ-potential in an embedded magnetic-elec tric-barrier micro structure(EMEBM),which is constructed by patterning a ferromagnetic stripe and a Schottky-metal stripe on the top and bottom of an InAs/Al_(x)In_(1-x)As heterostructure,respectively.Spin polarization of the dwell time remains,even though aδ-potential is inserted by atomic-layer doping.Both the magnitude and sign of the spinpolarized dwell time can be manipulated by changing the weight or position of the 6-potential.Thus,a structurally controllable temporal electron-spin splitter can be obtained for spintronics device applications.展开更多
Epoxy resin modified by nanometric γ-alumina or multi-walled carbon nanotubes (MCNTs) was prepared with solution mixingmethod, and the wear resistance of the composite was studied. The results show that when an optim...Epoxy resin modified by nanometric γ-alumina or multi-walled carbon nanotubes (MCNTs) was prepared with solution mixingmethod, and the wear resistance of the composite was studied. The results show that when an optimum amount of nanometricalumina or MCNTs is filled in epikote51 (E51), the wear resistance of the composite will increase. When 8 wt pct nanometricγ-alumina is filled in E51, the wear resistance of the composite increases to 230%. When 10% MCNTs is filled in E51, thewear resistance of the composite increases to 226%. When nanometric alumina is filled in, the wear resistance of modifiedepikote51 will increase as the cure temperature is heightened.展开更多
We theoretically investigate the wave-vector filtering(WVF)effect for electrons in an antiparallel asymmetric doubleδ-magnetic-barrier microstructure under a bias,which can be fabricated experimentally by patterning ...We theoretically investigate the wave-vector filtering(WVF)effect for electrons in an antiparallel asymmetric doubleδ-magnetic-barrier microstructure under a bias,which can be fabricated experimentally by patterning two asymmetric ferromagnetic(FM)stripes on the top and the bottom of GaAs/AlxGa1−xAs heterostructure,respectively.It is found that an appreciable WVF effect appears because of an essentially two-dimensional(2D)process for electrons across this microstructure.WVF effect is found to be sensitive to the applied bias.WVF efficiency can be tuned by changing bias,which may lead to an electrically-controllable momentum filter for nanoelectronics device applications.展开更多
Environment-friendly indium phosphide(InP)-based quantum dots(QDs)with efficient red-emitting properties are sufficiently needed to satisfy the requirement of burgeoning display and lighting technology.Currently,the s...Environment-friendly indium phosphide(InP)-based quantum dots(QDs)with efficient red-emitting properties are sufficiently needed to satisfy the requirement of burgeoning display and lighting technology.Currently,the syntheses of InP QDs using tris(trimethylsilyl)phosphine as the precursor are highly toxic and expensive.Herein,we successfully introduced gallium(Ga)ions into tris(dimethylamino)phosphine-based red InP cores through thermally-promoted cation exchange,and the obtained Ga-doped InP cores exhibited significantly increased photoluminescence quantum yields(PLQY)of up to 26%.The existence of Ga was directly confirmed by energy-dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy,and the functions of Ga were systematically studied.After subsequent coating of Ga-doped InP cores with ZnSeS and ZnS shells,the resulting Ga-InP/ZnSeS/ZnS QDs achieved a high PLQY of 62%with an emission maximum at 640 nm.In contrast,without Ga-doping,the PLQY only attained 36%using the same synthetic approach.This indicated an approximate 1.7-fold increase in PLQY.The enhancement of photoluminescence was related to the Ga^(3+),as it not only passivated surface defects of InP cores but also reduced core–shell interface stress.The Ga-InP/ZnSeS/ZnS QDs exhibited good stability towards heat treatment and ultraviolet(UV)irradiation.Moreover,the red light-emitting diode(LED)based on Ga-InP/ZnSeS/ZnS QDs performed well in a wide injected current range of 2 to 200 mA,with a maximum power efficiency of 0.68 lm/W.This work showcases Ga-doping through cation exchange as a promising strategy for enhancing the efficiency of InP-based red emitters.展开更多
文摘Background:Subarachnoid hemorrhage(SAH)is a subtype of hemorrhagic stroke characterized by high mortality and low rates of full recovery.This study aimed to investigate the epidemiological characteristics of SAH between 1990 and 2021.Methods:Data on SAH incidence,mortality,and disability-adjusted life-years(DALYs)from 1990 to 2021 were obtained from the Global Burden of Disease Study(GBD)2021.Estimated annual percentage changes(EAPCs)were calculated to evaluate changes in the age-standardized rate(ASR)of incidence and mortality,as well as trends in SAH burden.The relationship between disease burden and socio-demographic index(SDI)was also analyzed.Results:In 2021,the incidence of SAH was found to be 37.09%higher than that in 1990;however,the age-standardized incidence rates(ASIRs)showed a decreased[EAPC:-1.52;95%uncertainty interval(UI)-1.66 to-1.37].Furthermore,both the number and rates of deaths and DALYs decreased over time.It was observed that females had lower rates compared to males.Among all regions,the high-income Asia Pacific region exhibited the highest ASIR(14.09/100,000;95%UI 12.30/100,000-16.39/100,000)in 2021,with an EPAC for ASIR<0 indicating decreasing trend over time for SAH ASIR.Oceania recorded the highest age-standardized mortality rates(ASMRs)and age-standardized DALYs rates among all regions in 2021 at values of respectively 8.61(95%UI 6.03-11.95)and 285.62(95%UI 209.42-379.65).The burden associated with SAH primarily affected individuals aged between 50-69 years old.Metabolic risks particularly elevated systolic blood pressure were identified as the main risk factors contributing towards increased disease burden associated with SAH when compared against environmental or occupational behavioral risks evaluated within the GBD framework.Conclusions:The burden of SAH varies by gender,age group,and geographical region.Although the ASRs have shown a decline over time,the burden of SAH remains significant,especially in regions with middle and low-middle SDI levels.High systolic blood pressure stands out as a key risk factor for SAH.More specific supportive measures are necessary to alleviate the global burden of SAH.
基金supported by grants from the Science and Technology Fund of Sichuan Province (Grant No. 2011SZ0096)the National Natural Science Foundation of China (Grant No. 31470904)
文摘Bone remodeling is balanced by bone formation and bone resorption as well as by alterations in the quantities and functions of seed cells, leading to either the maintenance or deterioration of bone status. The existing evidence indicates that micro RNAs（mi RNAs）, known as a family of short non-coding RNAs, are the key post-transcriptional repressors of gene expression,and growing numbers of novel mi RNAs have been verified to play vital roles in the regulation of osteogenesis, osteoclastogenesis,and adipogenesis, revealing how they interact with signaling molecules to control these processes. This review summarizes the current knowledge of the roles of mi RNAs in regulating bone remodeling as well as novel applications for mi RNAs in biomaterials for therapeutic purposes.
基金supported by the National Natural Science Foundation of China (Nos. 41874121 and U19A2086)the major scientific instruments and equipment development project of the Ministry of Science and Technology,People’s Republic of China (No.2012YQ180118)+1 种基金the Sichuan Science and Technology Program (No.2018JY0181)Sichuan Science and Technology Miao-zi Project(Nos. 2021JDRC0107 and 2021JDRCO068)
文摘In recent years,LaBr_(3)(Ce)crystals and silicon photomultipliers(SiPMs)have been increasingly used in radiation imaging.This study involved the establishment of a detector model with a monolithic LaBr_(3)(Ce)crystal and SiPM array forγ-radiation imaging on the GEANT4 platform.The optical process included in the detector model was defined by key parameters,such as the emission spectrum,scintillation yield,and intrinsic resolution of the LaBr_(3):5%Ce crystal,as well as the detection efficiency of the SiPM array.The response of the detector model to^(57)Co flooded field irradiation was simulated and evaluated.The radiation images generated by the detector model exhibited a compression effect that was very close to that on images acquired by the physical detector.The spatial resolution of the simulated detector closely approximates that of the physical experiment.A detector model without the optical process was also established for comparison with a detector using the optical process.Both were used in a near-field modified uniform redundant array(MURA)imaging system to acquire images of a point source and a ring source of^(57)Co at the center of the field-of-view of the imaging system.The spatial resolution and signal-to-noise ratio of the images that were reconstructed using the two detector models were determined and compared.Compared with the detector model without optical processes,although the images from the proposed detector model have slightly inferior signal-to-noise ratios and more artifacts,they are more consistent with the reconstructed versions of images acquired in real physical experiments.The results confirm that the detector model can be used to design aγ-radiation imaging detector and to develop an imaging algorithm that can significantly shorten the development time and reduce the cost.
基金supported by the Science and Technology Innovation Plan Project of Hunan Province in China(S2019JJQNJJ2177)the National Natural Science Foundation of China(11864009)。
文摘We theoretically explore the manipulation of a temporal electron-spin splitter by aδ-potential in an embedded magnetic-elec tric-barrier micro structure(EMEBM),which is constructed by patterning a ferromagnetic stripe and a Schottky-metal stripe on the top and bottom of an InAs/Al_(x)In_(1-x)As heterostructure,respectively.Spin polarization of the dwell time remains,even though aδ-potential is inserted by atomic-layer doping.Both the magnitude and sign of the spinpolarized dwell time can be manipulated by changing the weight or position of the 6-potential.Thus,a structurally controllable temporal electron-spin splitter can be obtained for spintronics device applications.
文摘Epoxy resin modified by nanometric γ-alumina or multi-walled carbon nanotubes (MCNTs) was prepared with solution mixingmethod, and the wear resistance of the composite was studied. The results show that when an optimum amount of nanometricalumina or MCNTs is filled in epikote51 (E51), the wear resistance of the composite will increase. When 8 wt pct nanometricγ-alumina is filled in E51, the wear resistance of the composite increases to 230%. When 10% MCNTs is filled in E51, thewear resistance of the composite increases to 226%. When nanometric alumina is filled in, the wear resistance of modifiedepikote51 will increase as the cure temperature is heightened.
基金supported by the National Natural Science Foundation of China(Grant No.11864009).
文摘We theoretically investigate the wave-vector filtering(WVF)effect for electrons in an antiparallel asymmetric doubleδ-magnetic-barrier microstructure under a bias,which can be fabricated experimentally by patterning two asymmetric ferromagnetic(FM)stripes on the top and the bottom of GaAs/AlxGa1−xAs heterostructure,respectively.It is found that an appreciable WVF effect appears because of an essentially two-dimensional(2D)process for electrons across this microstructure.WVF effect is found to be sensitive to the applied bias.WVF efficiency can be tuned by changing bias,which may lead to an electrically-controllable momentum filter for nanoelectronics device applications.
基金the National Key R&D Program of China(No.2022YFA1504703)the National Natural Science Foundation of China(No.21973071).
文摘Environment-friendly indium phosphide(InP)-based quantum dots(QDs)with efficient red-emitting properties are sufficiently needed to satisfy the requirement of burgeoning display and lighting technology.Currently,the syntheses of InP QDs using tris(trimethylsilyl)phosphine as the precursor are highly toxic and expensive.Herein,we successfully introduced gallium(Ga)ions into tris(dimethylamino)phosphine-based red InP cores through thermally-promoted cation exchange,and the obtained Ga-doped InP cores exhibited significantly increased photoluminescence quantum yields(PLQY)of up to 26%.The existence of Ga was directly confirmed by energy-dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy,and the functions of Ga were systematically studied.After subsequent coating of Ga-doped InP cores with ZnSeS and ZnS shells,the resulting Ga-InP/ZnSeS/ZnS QDs achieved a high PLQY of 62%with an emission maximum at 640 nm.In contrast,without Ga-doping,the PLQY only attained 36%using the same synthetic approach.This indicated an approximate 1.7-fold increase in PLQY.The enhancement of photoluminescence was related to the Ga^(3+),as it not only passivated surface defects of InP cores but also reduced core–shell interface stress.The Ga-InP/ZnSeS/ZnS QDs exhibited good stability towards heat treatment and ultraviolet(UV)irradiation.Moreover,the red light-emitting diode(LED)based on Ga-InP/ZnSeS/ZnS QDs performed well in a wide injected current range of 2 to 200 mA,with a maximum power efficiency of 0.68 lm/W.This work showcases Ga-doping through cation exchange as a promising strategy for enhancing the efficiency of InP-based red emitters.
