Chronic hepatitis B(CHB)infection is characterized by ongoing viral replication in infected hepatocytes,leading to persistent production of viral nucleic acids and expression of viral antigens.Hepatitis B surface anti...Chronic hepatitis B(CHB)infection is characterized by ongoing viral replication in infected hepatocytes,leading to persistent production of viral nucleic acids and expression of viral antigens.Hepatitis B surface antigen(HBsAg)is one of the most important viral antigens,secreted at levels at least 1,000-fold higher than infectious virions in the bloodstream.1 HBsAg consists of three isoforms:large(LHBs),middle(MHBs),and small(SHBs)surface proteins,transcribed and translated from the open reading frame S of the HBV genome.展开更多
文摘Chronic hepatitis B(CHB)infection is characterized by ongoing viral replication in infected hepatocytes,leading to persistent production of viral nucleic acids and expression of viral antigens.Hepatitis B surface antigen(HBsAg)is one of the most important viral antigens,secreted at levels at least 1,000-fold higher than infectious virions in the bloodstream.1 HBsAg consists of three isoforms:large(LHBs),middle(MHBs),and small(SHBs)surface proteins,transcribed and translated from the open reading frame S of the HBV genome.
