Background:Vasomotor nephropathy is a common renal dysfunction in very preterm neonates.Objective:To determine whether theophylline could prevent vasomotor nephropathy in very preterm infants with respiratory distress...Background:Vasomotor nephropathy is a common renal dysfunction in very preterm neonates.Objective:To determine whether theophylline could prevent vasomotor nephropathy in very preterm infants with respiratory distress syndrome.Methods:A randomised,double blind,placebo controlled trial of 50 preterm infants of gestational age ≤32 weeks needing assisted ventilation.Infants received an intravenous dose of theophylline(1 mg/kg)or placebo for three days.The 24 hour urine volume was measured daily.On days 2,5,and 11,blood samples and 12 hour urine collections were analysed for electrolytes,creatinine,and urea.Results:On day 1,urine output was significantly higher in the theophylline(2.4(0.9)ml/kg/h)than the placebo(1.6(1.0)ml/kg/h;p = 0.023)-group(values are mean(SD)).The incidence of oligoanuria was significantly lower in the theophylline treated(5%)than the placebo(33%)group.Twenty four hours after the first administration of theophylline/placebo,serum creatinine concentration was significantly lower in the theophylline(0.76(0.23)mg/dl)-than the placebo(1.0(0.41)mg/dl;P = 0.025)group.On day 5 an increase in serum creatinine was observed in both groups.On day 11 a significant reduction in serum creatinine was observed,compared with day 5,with no difference between the two groups.Conclusion:The results suggest that,in very preterm infants with respiratory distress syndrome,early theophylline administration improves renal function during the first two days of life.展开更多
文摘Background:Vasomotor nephropathy is a common renal dysfunction in very preterm neonates.Objective:To determine whether theophylline could prevent vasomotor nephropathy in very preterm infants with respiratory distress syndrome.Methods:A randomised,double blind,placebo controlled trial of 50 preterm infants of gestational age ≤32 weeks needing assisted ventilation.Infants received an intravenous dose of theophylline(1 mg/kg)or placebo for three days.The 24 hour urine volume was measured daily.On days 2,5,and 11,blood samples and 12 hour urine collections were analysed for electrolytes,creatinine,and urea.Results:On day 1,urine output was significantly higher in the theophylline(2.4(0.9)ml/kg/h)than the placebo(1.6(1.0)ml/kg/h;p = 0.023)-group(values are mean(SD)).The incidence of oligoanuria was significantly lower in the theophylline treated(5%)than the placebo(33%)group.Twenty four hours after the first administration of theophylline/placebo,serum creatinine concentration was significantly lower in the theophylline(0.76(0.23)mg/dl)-than the placebo(1.0(0.41)mg/dl;P = 0.025)group.On day 5 an increase in serum creatinine was observed in both groups.On day 11 a significant reduction in serum creatinine was observed,compared with day 5,with no difference between the two groups.Conclusion:The results suggest that,in very preterm infants with respiratory distress syndrome,early theophylline administration improves renal function during the first two days of life.
