Aortic aneurysm is a chronic aortic disease affected by many factors.Although it is generally asymptomatic,it poses a significant threat to human life due to a high risk of rupture.Because of its strong concealment,it...Aortic aneurysm is a chronic aortic disease affected by many factors.Although it is generally asymptomatic,it poses a significant threat to human life due to a high risk of rupture.Because of its strong concealment,it is difficult to diagnose the disease in the early stage.At present,there are no effective drugs for the treatment of aneurysms.Surgical intervention and endovascular treatment are the only therapies.Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm,the specific mechanisms remain unclear.Researchers are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and treatment.To better understand aortic aneurysm,this review elaborates on the discovery history of aortic aneurysm,main classification and clinical manifestations,related molecular mechanisms,clinical cohort studies and animal models,with the ultimate goal of providing insights into the treatment of this devastating disease.The underlying problem with aneurysm disease is weakening of the aortic wall,leading to progressive dilation.If not treated in time,the aortic aneurysm eventually ruptures.An aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic wall.The disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.展开更多
Copper sulfide （Cu7S4） nanoparticles coated with an ultra-high payload （N5.0 ~ 107 fluorine atoms per particle） of fluorinated ligands （oleylamine functionalized 3,5-bis（trifluoromethyl）benzaldehyde, 19FOAm） e...Copper sulfide （Cu7S4） nanoparticles coated with an ultra-high payload （N5.0 ~ 107 fluorine atoms per particle） of fluorinated ligands （oleylamine functionalized 3,5-bis（trifluoromethyl）benzaldehyde, 19FOAm） exhibited a single intense 19F magnetic resonance （MR） signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong 19F MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous 19F MR imaging and photothermal therapy.展开更多
Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the com...Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the complementary modalities of I9F magnetic resonance imaging （19F MRI） and fluorescence imaging （FI） into a polymer nanoprobe composed of hydrophobic fluorescent organic core and hydrophilic fluorinated polymer shell. The alkyne-terminated fluorinated copolymer （Pn） of 2,2,2-trifluoroethyl acrylate （TFEA） and poly（ethylene glycol） methyl ether acrylate （PEGA） was first prepared vie atom transfer radical polymerization （ATRP）. The PEGA plays an important role in both improving ^19F signal and modulating the hydrophilicity of Pn. The alkynyl tail in Pn is readily conjugated with azide modified tetra-phenylethylene （TPE） through click chemistry to form azo polymer （TPE-azo-Pn）. The core-shell nanoprobes （TPE-P3N） with an average particle size of 57.2±8.8 nm are obtained via self-assembly with ultrasonication in aqueous solution. These nanoprobes demonstrate high water stability, good biocompatibility, strong fluorescence and good ^19F MRI performance, which present great potentials for simultaneous fluorescence imaging and ^19F-MR imaging.展开更多
Dear Editor,Aortic dissection(AD)is a fatal disease caused by dysfunction of elastin contractile units,which are composed of extracellular matrix(ECM)and aortic smooth muscle cells(AoSMCs),and eventual disruption of a...Dear Editor,Aortic dissection(AD)is a fatal disease caused by dysfunction of elastin contractile units,which are composed of extracellular matrix(ECM)and aortic smooth muscle cells(AoSMCs),and eventual disruption of aortic integrity[1].AoSMCs are the center of the elastin contractile unit,whose phenotype and functionality can be affected by factors that predispose patients to AD,including atherosclerosis,hypertension,smoking,hyperlipidemia,diabetes,and genetics.The intrinsic stiffness of AoSMCs,which is also impacted by these risk factors,plays an important role in regulating vascular tone and ECM remodeling.展开更多
基金This work was supported by the National Natural Science Foundation of China(81970425)by the National High Technology Research and Development Program of China(2020YFA0803700),and by Hangzhou Qianjiang Distinguished Expert Project(Prof.Lemin Zheng).
文摘Aortic aneurysm is a chronic aortic disease affected by many factors.Although it is generally asymptomatic,it poses a significant threat to human life due to a high risk of rupture.Because of its strong concealment,it is difficult to diagnose the disease in the early stage.At present,there are no effective drugs for the treatment of aneurysms.Surgical intervention and endovascular treatment are the only therapies.Although current studies have discovered that inflammatory responses as well as the production and activation of various proteases promote aortic aneurysm,the specific mechanisms remain unclear.Researchers are further exploring the pathogenesis of aneurysms to find new targets for diagnosis and treatment.To better understand aortic aneurysm,this review elaborates on the discovery history of aortic aneurysm,main classification and clinical manifestations,related molecular mechanisms,clinical cohort studies and animal models,with the ultimate goal of providing insights into the treatment of this devastating disease.The underlying problem with aneurysm disease is weakening of the aortic wall,leading to progressive dilation.If not treated in time,the aortic aneurysm eventually ruptures.An aortic aneurysm is a local enlargement of an artery caused by a weakening of the aortic wall.The disease is usually asymptomatic but leads to high mortality due to the risk of artery rupture.
文摘Copper sulfide （Cu7S4） nanoparticles coated with an ultra-high payload （N5.0 ~ 107 fluorine atoms per particle） of fluorinated ligands （oleylamine functionalized 3,5-bis（trifluoromethyl）benzaldehyde, 19FOAm） exhibited a single intense 19F magnetic resonance （MR） signal and efficient near infrared photothermal performance in water medium. In vivo assessment revealed strong 19F MR signals at cancerous lesions and effective inhibition of tumor growth after photothermal treatment, indicating the great potential of these fabricated nanoprobes for simultaneous 19F MR imaging and photothermal therapy.
基金This research was supported Science Foundation of China 21675009）, and the Fundamenta n part by the National Natural （Grant Nos. 21475007 and Research Funds for the Central Universities （buctrc201608 and buctrc201720）.
文摘Multimodal imaging techniques have been demonstrated to be greatly advantageous in achieving accurate diagnosis and gained increasing attention in recent decades. Herein, we present a new strategy to integrate the complementary modalities of I9F magnetic resonance imaging （19F MRI） and fluorescence imaging （FI） into a polymer nanoprobe composed of hydrophobic fluorescent organic core and hydrophilic fluorinated polymer shell. The alkyne-terminated fluorinated copolymer （Pn） of 2,2,2-trifluoroethyl acrylate （TFEA） and poly（ethylene glycol） methyl ether acrylate （PEGA） was first prepared vie atom transfer radical polymerization （ATRP）. The PEGA plays an important role in both improving ^19F signal and modulating the hydrophilicity of Pn. The alkynyl tail in Pn is readily conjugated with azide modified tetra-phenylethylene （TPE） through click chemistry to form azo polymer （TPE-azo-Pn）. The core-shell nanoprobes （TPE-P3N） with an average particle size of 57.2±8.8 nm are obtained via self-assembly with ultrasonication in aqueous solution. These nanoprobes demonstrate high water stability, good biocompatibility, strong fluorescence and good ^19F MRI performance, which present great potentials for simultaneous fluorescence imaging and ^19F-MR imaging.
基金supported by the National Natural Science Foundation of China(81970412,81772962,and 81970425)Xiamen Municipal Health Science and Technology Program Fund(3502Z20194034)+1 种基金the National High Technology Research and Development Program of China(2020YFA0803700)the Clinical Medicine Plus X-Young Scholars Project,Peking University,the Fundamental Research Funds for the Central Universities(PKU2023LCXQ015).
文摘Dear Editor,Aortic dissection(AD)is a fatal disease caused by dysfunction of elastin contractile units,which are composed of extracellular matrix(ECM)and aortic smooth muscle cells(AoSMCs),and eventual disruption of aortic integrity[1].AoSMCs are the center of the elastin contractile unit,whose phenotype and functionality can be affected by factors that predispose patients to AD,including atherosclerosis,hypertension,smoking,hyperlipidemia,diabetes,and genetics.The intrinsic stiffness of AoSMCs,which is also impacted by these risk factors,plays an important role in regulating vascular tone and ECM remodeling.
