Advances in wearable electronics and information technology drive sports data collection and analysis toward real-time visualization and precision. The growing pursuit of athleticism and healthy life makes it appealin...Advances in wearable electronics and information technology drive sports data collection and analysis toward real-time visualization and precision. The growing pursuit of athleticism and healthy life makes it appealing for individuals to track their real-time health and exercise data seamlessly. While numerous devices enable sports and health monitoring, maintaining comfort over long periods remains a considerable challenge, especially in high-intensity and sweaty sports scenarios. Textiles, with their breathability, deformability, and moisture-wicking abilities, ensure exceptional comfort during prolonged wear, making them ideal for wearable platforms. This review summarized the progress of research on textile-based sports monitoring devices. First, the design principles and fabrication methods of smart textiles were introduced systematically. Textiles undergo a distinctive fiber-yarn-fabric or fiber-fabric manufacturing process that allows for the regulation of performance and the integration of functional elements at every step. Then, the performance requirements for precise sports data collection of smart textiles, including main vital signs, joint movement, and data transmission, were discussed. Lastly, the applications of smart textiles in various sports scenarios are demonstrated. Additionally, the review provides an in-depth analysis of the emerging challenges, strategies, and opportunities for the research and development of sports-oriented smart textiles. Smart textiles not only maintain comfort and accuracy in sports, but also serve as inexpensive and efficient information-gathering terminals. Therefore, developing multifunctional, cost-effective textile-based systems for personalized sports and healthcare is a pressing need for the future of intelligent sports.展开更多
Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the...Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.展开更多
Colonic mucus and gut microbiota closely linked through mutual regulatory effect.While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are uncl...Colonic mucus and gut microbiota closely linked through mutual regulatory effect.While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear.Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus,gut microbiota,and their interaction with glutamine intervention.Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis.Further analysis revealed that goblet cells were under oxidative stress after sepsis,resulting in anterior gradient-2(AGR2),the key mucin-modifying enzyme,being dissynthesized,and inhibiting mucin 2(MUC2)maturation.Glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase(G6PD)glycosylation in the pentose phosphate pathway,increasing the reduced nicotinamide adenine dinucleotide phosphate(NADPH)synthesis,reducing endoplasmic reticulum stress,and accelerating AGR2 synthesis and MUC2 maturation.Additionally,glutamine aided in maintaining gut microbiota stability during sepsis,up-regulating mucin-associated bacteria such as Akkermansia and Alistipes.These bacteria,intimately linked to mucin synthesis and degradation,may impact intestinal mucus stability.In conclusion,glutamine can maintain goblet cell redox balance,promotes AGR2 synthesis and MUC2 maturation,shields the mucus barrier,and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus,thus alleviating sepsis-induced intestinal damage.展开更多
Layered double hydroxides(LDHs)are potential cathode materials for aqueous magnesium-ion batteries(AMIBs).However,the low capacity and sluggish kinetics significantly limit their electrochemical performance in AMIBs.H...Layered double hydroxides(LDHs)are potential cathode materials for aqueous magnesium-ion batteries(AMIBs).However,the low capacity and sluggish kinetics significantly limit their electrochemical performance in AMIBs.Herein,we find that oxygen vacancies can significantly boost the capacity,electrochemical kinetics,and structure stability of LDHs.The corresponding structure-performance relationship and energy storage mechanism are elaborated through exhaustive in/ex-situ experimental characterizations and density functional theory(DFT)calculations.Specially,in-situ Raman and DFT calculations reveal that oxygen vacancies elevate orbital energy of O 2p and electron density of O atoms,thereby enhancing the orbital hybridization of O 2p with Ni/Co 3d.This facilitates electron transfer between O and adjacent Ni/Co atoms and improves the covalency of Ni–O and Co–O bonds,which activates Ni/Co atoms to release more capacity and stabilizes the Ov-NiCo-LDH structure.Moreover,the distribution of relaxation times(DRT)and molecular dynamics(MD)simulations disclose that the enhanced d-p orbital hybridization optimizes the electronic structure of Ov-NiCo-LDH,which distinctly reduces the diffusion energy barriers of Mg^(2+)and improves the charge transfer kinetics of Ov-NiCo-LDH.Consequently,the assembled Ov-NiCo-LDH//active carbon(AC)and Ov-NiCo-LDH//perylenediimide(PTCDI)AMIBs can both deliver high specific discharge capacity(182.7 and 59.4 mAh g^(−1)at 0.5 A g^(−1),respectively)and long-term cycling stability(85.4%and 89.0%of capacity retentions after 2500 and 2400 cycles at 1.0 A g^(−1),respectively).In addition,the practical prospects for Ov-NiCo-LDH-based AMIBs have been demonstrated in different application scenarios.This work not only provides an effective strategy for obtaining high-performance cathodes of AMIBs,but also fundamentally elucidates the inherent mechanisms.展开更多
Ideal nanoscale phase-separated morphology is the primary condition to obtain high photovoltaic conversion efficiency(PCE)and high stability of organic solar cells(OSCs).However,the differences in solubility,miscibili...Ideal nanoscale phase-separated morphology is the primary condition to obtain high photovoltaic conversion efficiency(PCE)and high stability of organic solar cells(OSCs).However,the differences in solubility,miscibility and crystallinity between donors and acceptors make it difficult to achieve the optimal active layer morphology of OSCs.Herein,the volatile solid additive 3,5-dibromotoluene(DTL)with strong electronegativity and dipole moment has been developed for OSCs.DTL can interact with the acceptor,modulating its crystallization and stacking,enhancing donor/acceptor miscibility,reducing trap density,inhibiting carrier recombination,and balancing charge transport.Notably,the introduction of DTL finely tunes the energy level of the accepto r,which greatly enhances the open-circuit voltage(V_(OC))of the device compared to the conventional additive 1,8-diiodooctane(DIO).As a result,the DTL-treated PM6:L8-BObased OSCs obtained a high PCE of 18.87%and enhanced stability.Furthermore,the PM6:PM1:L8-BO+DTL-based OSCs achieved a champion PCE of 19.11%.This work deepens the working mechanism of additive strategy for regulating the morphology and improving performance,providing an effective method for achieving high-performance OSCs.展开更多
Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive and fatal malignancies,with a 5-year survival rate of<15%.Despite significant advancements in targeted therapies and immunotherapy,these approache...Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive and fatal malignancies,with a 5-year survival rate of<15%.Despite significant advancements in targeted therapies and immunotherapy,these approaches benefit only a limited subset of patients,leaving chemotherapy as the primary treatment modality for most patients.Chemotherapy is an essential adjunct to surgical resection,the only potentially curative option,playing a crucial role in reducing the tumor burden,delaying disease progression,and alleviating symptoms.However,its long-term efficacy is frequently undermined by the development of chemoresistance,wherein tumor cells adopt diverse strategies to evade or repair chemotherapy-induced damage.Addressing this critical barrier is imperative for improving the clinical outcomes of PDAC.This review comprehensively examines the multifaceted mechanisms of chemoresistance in PDAC and highlights innovative strategies designed to enhance chemosensitivity,thereby offering new hope for overcoming these challenges and improving patient survival.展开更多
Triphenylamine(TPA)is the most promising donor fragment for the construction of long-wavelength thermally activated delayed fluorescence(TADF)emitters owing to its suitable dihedral angle that could enhance radiative ...Triphenylamine(TPA)is the most promising donor fragment for the construction of long-wavelength thermally activated delayed fluorescence(TADF)emitters owing to its suitable dihedral angle that could enhance radiative decay to compete with the serious non-radiative decay.However,the moderate electron-donating capacity of TPA seriously limits the selection of acceptor for constructing longwavelength TADF emitters with narrow bandgaps.To address this issue,in this work,the peripheral benzene of TPA was replaced with 1,4-benzodioxane and anisole to obtain two new electrondonating units N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-phenyl-2,3-dihydrobenzo[b][1,4]dioxin-6-amine(TPADBO,−5.02 eV)and 4-methoxy-N-(4-methoxyphenyl)-N-phenylaniline(TPAMO,−5.00 eV),which possess much shallower highest occupied molecule orbital(HOMO)energy levels than the prototype TPA(−5.33 eV).Based on TPA and the modified TPA donor fragments,three TADF emitters were designed and synthesized,namely Py-TPA,Py-TPADBO and Py-TPAMO,with the same acceptor fragment 12-(2,6-diisopropylphenyl)pyrido[2′,3′:5,6]pyrazino[2,3-f][1,10]phenanthroline(Py).Among them,Py-TPAMO exhibits the highest photoluminescence quantum yield of 78.4%and the smallest singlet-triplet energy gap,which is because the introduction of anisole does not cause significant molecule deformation for the excited Py-TPAMO.And Py-TPAMO-based OLEDs successfully realize a maximum external quantum efficiency of 25.5%with the emission peak at 605 nm.This work provides a series of candidate of donor fragments for the development of efficient long-wavelength TADF emitters.展开更多
We obtain for the first time the analytic two-loop four-point MHV lightlike form factor of the stress-tensor supermultiplet in planar N 4=SYM where the momentum q carried by the operator is taken to be massless.Remark...We obtain for the first time the analytic two-loop four-point MHV lightlike form factor of the stress-tensor supermultiplet in planar N 4=SYM where the momentum q carried by the operator is taken to be massless.Remarkably,we find that the two-loop result can be constrained uniquely by the infrared divergences and the collinear limits using the master-bootstrap method.Moreover,the remainder function depends only on three dual conformal invariant variables,which can be understood from a hidden dual conformal symmetry of the form factor arising in the lightlike limit of q.The symbol alphabet of the remainder contains only nine letters,which are closed under the action of the dihedral group D_(4).Based on the dual description in terms of periodic Wilson lines(null-wrapped polygons),we also consider a new OPE picture for the lightlike form factors and introduce a new form factor transition that corresponds to the three-point lightlike form factor.With the form factor results up to two loops,we make some all-loop predictions using the OPE picture.展开更多
Objective: To investigate the therapeutic effect of Ginkgo biloba extract dropping pills combined with butylphthalide capsules on cognitive dysfunction in patients after acute ischemic stroke (AIS) and its impact on s...Objective: To investigate the therapeutic effect of Ginkgo biloba extract dropping pills combined with butylphthalide capsules on cognitive dysfunction in patients after acute ischemic stroke (AIS) and its impact on serum cytokines CRP, IL-6, and Hcy. Methods: This study selected 76 patients with cognitive dysfunction after ischemic stroke who were hospitalized at Zhuji People’s Hospital from January 2023 to January 2024. The patients were divided into two groups. The control group was treated with butylphthalide capsules, while the combination group received Ginkgo biloba extract dropping pills in addition to the treatment given to the control group. The neurological function, cognitive function, activities of daily living, and levels of serum cytokines CRP, IL-6, and Hcy were compared between the two groups after 1 month and 3 months of treatment. Results: The NIHSS scores, MMSE scores, ADL scores, and levels of CRP, IL-6, and Hcy in both groups showed statistically significant differences compared to before treatment (P Conclusion: The combination of Ginkgo biloba extract dropping pills and butylphthalide capsules has a better therapeutic effect on cognitive dysfunction in patients after ischemic stroke. It can improve the neurological function and cognitive function of patients, enhance their ability to perform daily activities, and reduce inflammatory responses.展开更多
We study the duality between color and kinematics for the Sudakov form factors of tr(F~2)in non-supersymmetric pure Yang-Mills theory.We construct the integrands that manifest the color-kinematics duality up to two lo...We study the duality between color and kinematics for the Sudakov form factors of tr(F~2)in non-supersymmetric pure Yang-Mills theory.We construct the integrands that manifest the color-kinematics duality up to two loops.The resulting numerators are given in terms of Lorentz products of momenta and polarization vectors,which have the same powers of loop momenta as that from the Feynman rules.The integrands are checked by d-dimensional unitarity cuts and are valid in any dimension.We find that massless-bubble and tadpole topologies are needed at two loops to realize the color-kinematics duality.Interestingly,the two-loop solution contains a large number of free parameters suggesting the duality may hold at higher loop orders.展开更多
To provide new insights into the development and utilization of Douchi artificial starters,three common strains(Aspergillus oryzae,Mucor racemosus,and Rhizopus oligosporus)were used to study their influence on the fer...To provide new insights into the development and utilization of Douchi artificial starters,three common strains(Aspergillus oryzae,Mucor racemosus,and Rhizopus oligosporus)were used to study their influence on the fermentation of Douchi.The results showed that the biogenic amine contents of the three types of Douchi were all within the safe range and far lower than those of traditional fermented Douchi.Aspergillus-type Douchi produced more free amino acids than the other two types of Douchi,and its umami taste was more prominent in sensory evaluation(P<0.01),while Mucor-type and Rhizopus-type Douchi produced more esters and pyrazines,making the aroma,sauce,and Douchi flavor more abundant.According to the Pearson and PLS analyses results,sweetness was significantly negatively correlated with phenylalanine,cysteine,and acetic acid(P<0.05),bitterness was significantly negatively correlated with malic acid(P<0.05),the sour taste was significantly positively correlated with citric acid and most free amino acids(P<0.05),while astringency was significantly negatively correlated with glucose(P<0.001).Thirteen volatile compounds such as furfuryl alcohol,phenethyl alcohol,and benzaldehyde caused the flavor difference of three types of Douchi.This study provides theoretical basis for the selection of starting strains for commercial Douchi production.展开更多
To achieve the resource utilization of solid waste phosphogypsum(PG)and tackle the problem of utilizing potassium feldspar(PF),a coupled synergistic process between PG and PF is proposed in this paper.The study invest...To achieve the resource utilization of solid waste phosphogypsum(PG)and tackle the problem of utilizing potassium feldspar(PF),a coupled synergistic process between PG and PF is proposed in this paper.The study investigates the features of P and F in PG,and explores the decomposition of PF using hydrofluoric acid(HF)in the sulfuric acid system for K leaching and leaching of P and F in PG.The impact factors such as sulfuric acid concentration,reaction temperature,reaction time,material ratio(PG/PF),liquid–solid ratio,PF particle size,and PF calcination temperature on the leaching of P and K is systematically investigated in this paper.The results show that under optimal conditions,the leaching rate of K and P reach more than 93%and 96%,respectively.Kinetics study using shrinking core model(SCM)indicates two significant stages with internal diffusion predominantly controlling the leaching of K.The apparent activation energies of these two stages are 11.92 kJ·mol^(-1)and 11.55 kJ·mol^(-1),respectively.展开更多
With the rapid development of information technology,Artificial Intelligence(AI)is gradually applied to a wide range of fields,especially the powerful ability of ChatGPT to bring infinite possibilities for education,b...With the rapid development of information technology,Artificial Intelligence(AI)is gradually applied to a wide range of fields,especially the powerful ability of ChatGPT to bring infinite possibilities for education,but teachers’attitudes toward using it are not yet clear.The study investigates the use of ChatGPT by kindergarten teachers to support instructional design using questionnaires and interviews to explore the attitudes and perceptions of kindergarten teachers toward its use.The results indicate that kindergarten teachers hold positive preferences for technology acceptance,perceived self-efficacy,and learning attitudes toward using ChatGPT for instructional design.Meanwhile,the study argues that more research is needed in the future to focus on how kindergarten teachers can aptly use ChatGPT to improve the quality of instruction in realistic instructionenvironments.展开更多
In soil-rice systems,microbial reduction of iron(Fe)has been recognized as a crucial biogeochemical process that regulates Fe and chromium(Cr)translocation;however,the underlying processes are unknown.To investigate t...In soil-rice systems,microbial reduction of iron(Fe)has been recognized as a crucial biogeochemical process that regulates Fe and chromium(Cr)translocation;however,the underlying processes are unknown.To investigate the impacts of biochar on the biochemical cycling of Fe and Cr and their toxicity to rice,maize straw biochar was applied at 1%(weight/weight)to a paddy soil spiked with 300 mg kg^(-1)Cr under two phosphorus(P)levels(0 or 90 mg kg^(-1))in a pot experiment.The key microbial groups affecting Fe dissimilatory reduction and their environmental drivers were explored.Biochar inhibited root Cr uptake by 36%,owing to the promoted iron plaque(IP)formation on the rice root surface.Correlation analysis showed that Fe concentration in pore water was strongly linked to the abundances of Geobacter(r=0.81-0.94,P<0.05)and Clostridium(r=0.83-0.95,P<0.05),indicating that Geobacter and Clostridium played essential roles in Fe reduction.Redundancy analysis showed that labile carbon and pore water P concentrations were the key determinants influencing Fe-reducing bacterial abundances,accounting for 42%and 32%of the variation in community composition,respectively.Besides,biochar increased Fe and P concentrations in root cell walls,which retained more Cr.Overall,Cr stress in rice under biochar treatment was relieved through increasing IP formation and altering subcellular distribution.These mechanistic insights had important implications for reducing Cr uptake by rice.展开更多
Multiple morphological abnormalities of the sperm flagella(MMAF)are characterized by bent,irregular,short,coiled,and absent flagella.MMAF is caused by a variety of genes,some of which have been identified.However,the ...Multiple morphological abnormalities of the sperm flagella(MMAF)are characterized by bent,irregular,short,coiled,and absent flagella.MMAF is caused by a variety of genes,some of which have been identified.However,the underlying genetic factors responsible for the majority of MMAF cases are still largely unknown.The glutamine-rich 2(QRICH2)gene plays an essential role in the development of sperm flagella by regulating the expression of essential sperm flagellar biogenesis-associated proteins,and genetic variants of QRICH2 have been identified as the primary cause of MMAF in humans and mice.Here,we recruited a Pakistani consanguineous family to identify the genetic variant causing infertility in patients with MMAF.Whole-exome sequencing and Sanger sequencing were conducted to identify potentially pathogenic variants causing MMAF in infertile patients.Hematoxylin and eosin(HE)staining was performed to analyze sperm morphology.Quantitative polymerase chain reaction,western blot,and immunofluorescence staining analyses were conducted to observe the expression of QRICH2 in spermatozoa.A novel homozygous missense variant(c.4618C>T)in QRICH2 was identified in the affected patients.Morphological analysis of spermatozoa revealed the MMAF phenotype in infertile patients.qPCR revealed a significant reduction in the level of sperm QRICH2 mRNA,and immunofluorescence staining revealed a lack of sperm QRICH2 expression.Additionally,patients harboring a homozygous QRICH2 mutation presented reduced expression of outer dense fiber 2(ODF2)in sperm,whereas sperm expression of A-kinase anchor protein 4(AKAP4)was normal.These findings expand our understanding of the genetic causes of MMAF-associated male infertility and emphasize the importance of genetic counseling.展开更多
Shear-thinning fluids have been widely used in microfluidic systems,but their internal flow mechanism is still unclear.Therefore,in this paper,molecular dynamics simulations are used to study the laminar flow of shear...Shear-thinning fluids have been widely used in microfluidic systems,but their internal flow mechanism is still unclear.Therefore,in this paper,molecular dynamics simulations are used to study the laminar flow of shear-thinning fluid in a microchannel.We validated the feasibility of our simulation method by evaluating the mean square displacement and Reynolds number of the solution layers.The results show that the change rule of the fluid system's velocity profile and interaction energy can reflect the shear-thinning characteristics of the fluids.The velocity profile resembles a top-hat shape,intensifying as the fluid's power law index decreases.The interaction energy between the wall and the fluid decreases gradually with increasing velocity,and a high concentration of non-Newtonian fluid reaches a plateau sooner.Moreover,the velocity profile of the fluid is related to the molecule number density distribution and their values are inversely proportional.By analyzing the radial distribution function,we found that the hydrogen bonds between solute and water molecules weaken with the increase in velocity.This observation offers an explanation for the shear-thinning phenomenon of the non-Newtonian flow from a micro perspective.展开更多
Erratumto:Journal of Bionic Engineering(2023)20:338-348 https:/doi.0rg/10.1007/s42235-022-00247-4 In Table 1,the value of Mesh's Feature dimensions(mm)"0.42"should have read"0.04".The original ...Erratumto:Journal of Bionic Engineering(2023)20:338-348 https:/doi.0rg/10.1007/s42235-022-00247-4 In Table 1,the value of Mesh's Feature dimensions(mm)"0.42"should have read"0.04".The original article has been corrected.展开更多
To address the problem of frequent battery replacement for wearable sensors applied to fall detection among the elderly,a portable and lowcost triboelectric nanogenerator(TENG)-based self-powered sensor for human gait...To address the problem of frequent battery replacement for wearable sensors applied to fall detection among the elderly,a portable and lowcost triboelectric nanogenerator(TENG)-based self-powered sensor for human gait monitoring is proposed.The main fabrication materials of the TENG are polytetrafluoroethylene(PTFE)film,aluminum(Al)foil,and polyimide(PI)film,where PTFE and Al are the friction layer materials and the PI film is used to improve the output performance.Exploiting the ability of TENGs to monitor changes in environmental conditions,a self-powered sensor based on the TENG is placed in an insole to collect gait information.Since a TENG does not require a power source to convert physical and mechanical signals into electrical signals,the electrical signals can be used as sensing signals to be analyzed by a computer to recognize daily human activities and fall status.Experimental results show that the accuracy of the TENG-based sensor for recognizing human gait is 97.2%,demonstrating superior sensing performance and providing valuable insights for future monitoring of fall events in the elderly population.展开更多
基金financially supported by the National Natural Science Foundation of China (52073051, 52373054)the Fundamental Research Funds for the Central Universities (2232022A-04, 24D110109/005, 2232024G-06-01)+1 种基金Natural Science Foundation of Shanghai (23ZR1400900)Shanghai Frontier Science Research Center for Modern Textiles。
文摘Advances in wearable electronics and information technology drive sports data collection and analysis toward real-time visualization and precision. The growing pursuit of athleticism and healthy life makes it appealing for individuals to track their real-time health and exercise data seamlessly. While numerous devices enable sports and health monitoring, maintaining comfort over long periods remains a considerable challenge, especially in high-intensity and sweaty sports scenarios. Textiles, with their breathability, deformability, and moisture-wicking abilities, ensure exceptional comfort during prolonged wear, making them ideal for wearable platforms. This review summarized the progress of research on textile-based sports monitoring devices. First, the design principles and fabrication methods of smart textiles were introduced systematically. Textiles undergo a distinctive fiber-yarn-fabric or fiber-fabric manufacturing process that allows for the regulation of performance and the integration of functional elements at every step. Then, the performance requirements for precise sports data collection of smart textiles, including main vital signs, joint movement, and data transmission, were discussed. Lastly, the applications of smart textiles in various sports scenarios are demonstrated. Additionally, the review provides an in-depth analysis of the emerging challenges, strategies, and opportunities for the research and development of sports-oriented smart textiles. Smart textiles not only maintain comfort and accuracy in sports, but also serve as inexpensive and efficient information-gathering terminals. Therefore, developing multifunctional, cost-effective textile-based systems for personalized sports and healthcare is a pressing need for the future of intelligent sports.
基金supported by the STI2030-Major Projects(2021ZD0204001)the National Natural Science Foundation of China(92049120,81870897,81271424,81671111,and 62475179)+8 种基金the Sino German Cooperation and Exchange Project(M-0679)the Guangdong Key Project in the Development of New Tools for the Diagnosis and Treatment of Autism(2018B030335001)the Natural Science Foundation of Jiangsu Province(BK20181436)the Priority Academic Program Development of Jiangsu Higher Education Institutions,the Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases(BM2013003)Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,Suzhou Science and Technology Plan Medical and Health Care Science and Technology Innovation Applied Basic Research(SKY2022161)the Research Project of Neurological Diseases in the Second Affiliated Hospital of Soochow University Research Center(ND2023A01)Boxi clinical research project of The First Affiliated Hospital of Soochow University(BXQN202204)Suzhou Science&Technology Projects for People's Livelihood(SKY2021065)Wuxi Municipal Health Commission(M202204).
文摘Oligodendrocyte lineage cells, including oligodendrocyte precursor cells (OPCs) and oligodendrocytes (OLs), are essential in establishing and maintaining brain circuits. Autophagy is a conserved process that keeps the quality of organelles and proteostasis. The role of autophagy in oligodendrocyte lineage cells remains unclear. The present study shows that autophagy is required to maintain the number of OPCs/OLs and myelin integrity during brain aging. Inactivation of autophagy in oligodendrocyte lineage cells increases the number of OPCs/OLs in the developing brain while exaggerating the loss of OPCs/OLs with brain aging. Inactivation of autophagy in oligodendrocyte lineage cells impairs the turnover of myelin basic protein (MBP). It causes MBP to accumulate in the cytoplasm as multimeric aggregates and fails to be incorporated into integral myelin, which is associated with attenuated endocytic recycling. Inactivation of autophagy in oligodendrocyte lineage cells impairs myelin integrity and causes demyelination. Thus, this study shows autophagy is required to maintain myelin quality during aging by controlling the turnover of myelin components.
基金supported by the National Natural Science Foundation of China(82172202)Innovative Leading Talents Project of Chongqing(cstc2022ycjh-bgzxm0148)+1 种基金the Project of NINGBO Leading Medical&Health Discipline(2022-F17)Ningbo Top Medical and Health Research Program(2023030615).
文摘Colonic mucus and gut microbiota closely linked through mutual regulatory effect.While their alterations during sepsis and whether glutamine can maintain the colonic mucus barrier and gut microbiota stability are unclear.Cecal ligation and puncture-induced sepsis in mice was utilized to observe changes in colonic mucus,gut microbiota,and their interaction with glutamine intervention.Our findings indicated that glutamine mitigated sepsis-induced intestinal damage and restores colonic mucus barrier function by augmenting mucin synthesis.Further analysis revealed that goblet cells were under oxidative stress after sepsis,resulting in anterior gradient-2(AGR2),the key mucin-modifying enzyme,being dissynthesized,and inhibiting mucin 2(MUC2)maturation.Glutamine could ameliorates this situation by promoting the key enzyme glucose-6-phosphate dehydrogenase(G6PD)glycosylation in the pentose phosphate pathway,increasing the reduced nicotinamide adenine dinucleotide phosphate(NADPH)synthesis,reducing endoplasmic reticulum stress,and accelerating AGR2 synthesis and MUC2 maturation.Additionally,glutamine aided in maintaining gut microbiota stability during sepsis,up-regulating mucin-associated bacteria such as Akkermansia and Alistipes.These bacteria,intimately linked to mucin synthesis and degradation,may impact intestinal mucus stability.In conclusion,glutamine can maintain goblet cell redox balance,promotes AGR2 synthesis and MUC2 maturation,shields the mucus barrier,and potentially maintains gut microbiota stability by regulating the interaction between bacteria and mucus,thus alleviating sepsis-induced intestinal damage.
基金financial support of the National Natural Science Foundation of China (22379063)
文摘Layered double hydroxides(LDHs)are potential cathode materials for aqueous magnesium-ion batteries(AMIBs).However,the low capacity and sluggish kinetics significantly limit their electrochemical performance in AMIBs.Herein,we find that oxygen vacancies can significantly boost the capacity,electrochemical kinetics,and structure stability of LDHs.The corresponding structure-performance relationship and energy storage mechanism are elaborated through exhaustive in/ex-situ experimental characterizations and density functional theory(DFT)calculations.Specially,in-situ Raman and DFT calculations reveal that oxygen vacancies elevate orbital energy of O 2p and electron density of O atoms,thereby enhancing the orbital hybridization of O 2p with Ni/Co 3d.This facilitates electron transfer between O and adjacent Ni/Co atoms and improves the covalency of Ni–O and Co–O bonds,which activates Ni/Co atoms to release more capacity and stabilizes the Ov-NiCo-LDH structure.Moreover,the distribution of relaxation times(DRT)and molecular dynamics(MD)simulations disclose that the enhanced d-p orbital hybridization optimizes the electronic structure of Ov-NiCo-LDH,which distinctly reduces the diffusion energy barriers of Mg^(2+)and improves the charge transfer kinetics of Ov-NiCo-LDH.Consequently,the assembled Ov-NiCo-LDH//active carbon(AC)and Ov-NiCo-LDH//perylenediimide(PTCDI)AMIBs can both deliver high specific discharge capacity(182.7 and 59.4 mAh g^(−1)at 0.5 A g^(−1),respectively)and long-term cycling stability(85.4%and 89.0%of capacity retentions after 2500 and 2400 cycles at 1.0 A g^(−1),respectively).In addition,the practical prospects for Ov-NiCo-LDH-based AMIBs have been demonstrated in different application scenarios.This work not only provides an effective strategy for obtaining high-performance cathodes of AMIBs,but also fundamentally elucidates the inherent mechanisms.
基金supported by the National Natural Science Foundation of China(NSFC Grant Nos.62075029,52130304,62105055,62222503,62474028 and 52073040)The Fundamental Research Funds for the Central Universities(Program No.ZYGX2021J017)+5 种基金Sichuan Provincial Regional Innovation Cooperation Project(Program No.2022YFQ0078)Creative Research Groups of the National Natural Science Foundation of Sichuan Province(2023NSFSC1973)The Sichuan Science and Technology Program(Grant No.2024NSFSC0012,2024NSFSC1447)The Sichuan Science and Technology Program(Grant Nos.2024NSFSC1446)National Key R and D Program of China(2023YFB2604101)The China Postdoctoral Science Foundation(Grant Nos.2023M740504,GZC20230380)。
文摘Ideal nanoscale phase-separated morphology is the primary condition to obtain high photovoltaic conversion efficiency(PCE)and high stability of organic solar cells(OSCs).However,the differences in solubility,miscibility and crystallinity between donors and acceptors make it difficult to achieve the optimal active layer morphology of OSCs.Herein,the volatile solid additive 3,5-dibromotoluene(DTL)with strong electronegativity and dipole moment has been developed for OSCs.DTL can interact with the acceptor,modulating its crystallization and stacking,enhancing donor/acceptor miscibility,reducing trap density,inhibiting carrier recombination,and balancing charge transport.Notably,the introduction of DTL finely tunes the energy level of the accepto r,which greatly enhances the open-circuit voltage(V_(OC))of the device compared to the conventional additive 1,8-diiodooctane(DIO).As a result,the DTL-treated PM6:L8-BObased OSCs obtained a high PCE of 18.87%and enhanced stability.Furthermore,the PM6:PM1:L8-BO+DTL-based OSCs achieved a champion PCE of 19.11%.This work deepens the working mechanism of additive strategy for regulating the morphology and improving performance,providing an effective method for achieving high-performance OSCs.
基金supported by grants from the CAMS Innovation Fund for Medical Sciences(No.2024-I2M-ZD-001)National Key R&D Program of China(No.2023YFC2413400)+5 种基金National Natural Science Foundation of China(No.82272917,No.62133006,No.82203158,No.82473086,No.82473096,and No.82403006)Beijing Natural Science Foundation(No.7242104,No.7244385,and No.L248053)Research and Translational Application of Clinical Characteristic Diagnosis and Treatment Techniques in the Capital(No.Z221100007422070)Beijing Science and Technology Plan(No.Z231100007223006)National High Level Hospital Clinical Research Funding(No.2022-PUMCH-B-004)the Postdoctoral Fellowship Program of CPSF(No.GZB20240074).
文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the most aggressive and fatal malignancies,with a 5-year survival rate of<15%.Despite significant advancements in targeted therapies and immunotherapy,these approaches benefit only a limited subset of patients,leaving chemotherapy as the primary treatment modality for most patients.Chemotherapy is an essential adjunct to surgical resection,the only potentially curative option,playing a crucial role in reducing the tumor burden,delaying disease progression,and alleviating symptoms.However,its long-term efficacy is frequently undermined by the development of chemoresistance,wherein tumor cells adopt diverse strategies to evade or repair chemotherapy-induced damage.Addressing this critical barrier is imperative for improving the clinical outcomes of PDAC.This review comprehensively examines the multifaceted mechanisms of chemoresistance in PDAC and highlights innovative strategies designed to enhance chemosensitivity,thereby offering new hope for overcoming these challenges and improving patient survival.
基金supported by the National Natural Science Foundation of China (Nos. 62222503, 52073040 and 52130304)the Sichuan Science and Technology Program (Nos. 2024NSFSC0012,2023NSFSC1973 and 2024NSFSC1446)+2 种基金the China Postdoctoral Science Foundation (Nos. 2023M740504 and GZC20230380)the Sichuan Provincial Human Resources and Social Security Department Programthe Collaborative Innovation Center of Suzhou Nano Science&Technology
文摘Triphenylamine(TPA)is the most promising donor fragment for the construction of long-wavelength thermally activated delayed fluorescence(TADF)emitters owing to its suitable dihedral angle that could enhance radiative decay to compete with the serious non-radiative decay.However,the moderate electron-donating capacity of TPA seriously limits the selection of acceptor for constructing longwavelength TADF emitters with narrow bandgaps.To address this issue,in this work,the peripheral benzene of TPA was replaced with 1,4-benzodioxane and anisole to obtain two new electrondonating units N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-N-phenyl-2,3-dihydrobenzo[b][1,4]dioxin-6-amine(TPADBO,−5.02 eV)and 4-methoxy-N-(4-methoxyphenyl)-N-phenylaniline(TPAMO,−5.00 eV),which possess much shallower highest occupied molecule orbital(HOMO)energy levels than the prototype TPA(−5.33 eV).Based on TPA and the modified TPA donor fragments,three TADF emitters were designed and synthesized,namely Py-TPA,Py-TPADBO and Py-TPAMO,with the same acceptor fragment 12-(2,6-diisopropylphenyl)pyrido[2′,3′:5,6]pyrazino[2,3-f][1,10]phenanthroline(Py).Among them,Py-TPAMO exhibits the highest photoluminescence quantum yield of 78.4%and the smallest singlet-triplet energy gap,which is because the introduction of anisole does not cause significant molecule deformation for the excited Py-TPAMO.And Py-TPAMO-based OLEDs successfully realize a maximum external quantum efficiency of 25.5%with the emission peak at 605 nm.This work provides a series of candidate of donor fragments for the development of efficient long-wavelength TADF emitters.
基金supported in part by the National Natural Science Foundation of China under Grant Nos. 12175291, 11935013, 12047503, 12247103by the CAS under Grant No. YSBR-101the HPC Cluster of ITP-CAS for the support
文摘We obtain for the first time the analytic two-loop four-point MHV lightlike form factor of the stress-tensor supermultiplet in planar N 4=SYM where the momentum q carried by the operator is taken to be massless.Remarkably,we find that the two-loop result can be constrained uniquely by the infrared divergences and the collinear limits using the master-bootstrap method.Moreover,the remainder function depends only on three dual conformal invariant variables,which can be understood from a hidden dual conformal symmetry of the form factor arising in the lightlike limit of q.The symbol alphabet of the remainder contains only nine letters,which are closed under the action of the dihedral group D_(4).Based on the dual description in terms of periodic Wilson lines(null-wrapped polygons),we also consider a new OPE picture for the lightlike form factors and introduce a new form factor transition that corresponds to the three-point lightlike form factor.With the form factor results up to two loops,we make some all-loop predictions using the OPE picture.
文摘Objective: To investigate the therapeutic effect of Ginkgo biloba extract dropping pills combined with butylphthalide capsules on cognitive dysfunction in patients after acute ischemic stroke (AIS) and its impact on serum cytokines CRP, IL-6, and Hcy. Methods: This study selected 76 patients with cognitive dysfunction after ischemic stroke who were hospitalized at Zhuji People’s Hospital from January 2023 to January 2024. The patients were divided into two groups. The control group was treated with butylphthalide capsules, while the combination group received Ginkgo biloba extract dropping pills in addition to the treatment given to the control group. The neurological function, cognitive function, activities of daily living, and levels of serum cytokines CRP, IL-6, and Hcy were compared between the two groups after 1 month and 3 months of treatment. Results: The NIHSS scores, MMSE scores, ADL scores, and levels of CRP, IL-6, and Hcy in both groups showed statistically significant differences compared to before treatment (P Conclusion: The combination of Ginkgo biloba extract dropping pills and butylphthalide capsules has a better therapeutic effect on cognitive dysfunction in patients after ischemic stroke. It can improve the neurological function and cognitive function of patients, enhance their ability to perform daily activities, and reduce inflammatory responses.
基金supported in part by the National Natural Science Foundation of China(Grants No.12175291,11935013,11822508,12047503)by the Key Research Program of the Chinese Academy of Sciences,Grant NO.XDPB15。
文摘We study the duality between color and kinematics for the Sudakov form factors of tr(F~2)in non-supersymmetric pure Yang-Mills theory.We construct the integrands that manifest the color-kinematics duality up to two loops.The resulting numerators are given in terms of Lorentz products of momenta and polarization vectors,which have the same powers of loop momenta as that from the Feynman rules.The integrands are checked by d-dimensional unitarity cuts and are valid in any dimension.We find that massless-bubble and tadpole topologies are needed at two loops to realize the color-kinematics duality.Interestingly,the two-loop solution contains a large number of free parameters suggesting the duality may hold at higher loop orders.
基金supported by Special key project of technological innovation and application development in Yongchuan District,Chongqing(2021yc-cxfz20002)the special funds of central government for guiding local science and technology developmentthe funds for the platform projects of professional technology innovation(CSTC2018ZYCXPT0006).
文摘To provide new insights into the development and utilization of Douchi artificial starters,three common strains(Aspergillus oryzae,Mucor racemosus,and Rhizopus oligosporus)were used to study their influence on the fermentation of Douchi.The results showed that the biogenic amine contents of the three types of Douchi were all within the safe range and far lower than those of traditional fermented Douchi.Aspergillus-type Douchi produced more free amino acids than the other two types of Douchi,and its umami taste was more prominent in sensory evaluation(P<0.01),while Mucor-type and Rhizopus-type Douchi produced more esters and pyrazines,making the aroma,sauce,and Douchi flavor more abundant.According to the Pearson and PLS analyses results,sweetness was significantly negatively correlated with phenylalanine,cysteine,and acetic acid(P<0.05),bitterness was significantly negatively correlated with malic acid(P<0.05),the sour taste was significantly positively correlated with citric acid and most free amino acids(P<0.05),while astringency was significantly negatively correlated with glucose(P<0.001).Thirteen volatile compounds such as furfuryl alcohol,phenethyl alcohol,and benzaldehyde caused the flavor difference of three types of Douchi.This study provides theoretical basis for the selection of starting strains for commercial Douchi production.
基金jointly supported by the National Key Research and Development Program of China (2019YFC1905800)the National Key Research & Development Program of China (2018YFC1903500)+4 种基金the commercial project by Beijing Zhong Dian Hua Yuan Environment Protection Technology Co., Ltd. (E01211200005)the Regional key projects of the science and technology service network program (STS program) of the Chinese Academy of Sciences (KFJ-STS-QYZD-153)the Ningbo Science and Technology Innovation Key Projects (2020Z099, 2022Z028)the Ningbo Municipal Commonweal Key Program (2019C10033)the support of Mineral Resources Analytical and Testing Center, Institute of Process Engineering, Chinese Academy of Science
文摘To achieve the resource utilization of solid waste phosphogypsum(PG)and tackle the problem of utilizing potassium feldspar(PF),a coupled synergistic process between PG and PF is proposed in this paper.The study investigates the features of P and F in PG,and explores the decomposition of PF using hydrofluoric acid(HF)in the sulfuric acid system for K leaching and leaching of P and F in PG.The impact factors such as sulfuric acid concentration,reaction temperature,reaction time,material ratio(PG/PF),liquid–solid ratio,PF particle size,and PF calcination temperature on the leaching of P and K is systematically investigated in this paper.The results show that under optimal conditions,the leaching rate of K and P reach more than 93%and 96%,respectively.Kinetics study using shrinking core model(SCM)indicates two significant stages with internal diffusion predominantly controlling the leaching of K.The apparent activation energies of these two stages are 11.92 kJ·mol^(-1)and 11.55 kJ·mol^(-1),respectively.
基金supported by Major Cultivating Projects of Leading Talents in Philosophy and Social Sciences of Zhejiang Province“Aiming for Common Prosperity:Improvement and Evaluation of Professional Competence of Teachers of Early Childhood Institutions Driven by Multimodal Data Fusion”(23YJRC13ZD-3YB).
文摘With the rapid development of information technology,Artificial Intelligence(AI)is gradually applied to a wide range of fields,especially the powerful ability of ChatGPT to bring infinite possibilities for education,but teachers’attitudes toward using it are not yet clear.The study investigates the use of ChatGPT by kindergarten teachers to support instructional design using questionnaires and interviews to explore the attitudes and perceptions of kindergarten teachers toward its use.The results indicate that kindergarten teachers hold positive preferences for technology acceptance,perceived self-efficacy,and learning attitudes toward using ChatGPT for instructional design.Meanwhile,the study argues that more research is needed in the future to focus on how kindergarten teachers can aptly use ChatGPT to improve the quality of instruction in realistic instructionenvironments.
基金supported by the National Natural Science Foundation of China(Nos.42107017 and 32172121)。
文摘In soil-rice systems,microbial reduction of iron(Fe)has been recognized as a crucial biogeochemical process that regulates Fe and chromium(Cr)translocation;however,the underlying processes are unknown.To investigate the impacts of biochar on the biochemical cycling of Fe and Cr and their toxicity to rice,maize straw biochar was applied at 1%(weight/weight)to a paddy soil spiked with 300 mg kg^(-1)Cr under two phosphorus(P)levels(0 or 90 mg kg^(-1))in a pot experiment.The key microbial groups affecting Fe dissimilatory reduction and their environmental drivers were explored.Biochar inhibited root Cr uptake by 36%,owing to the promoted iron plaque(IP)formation on the rice root surface.Correlation analysis showed that Fe concentration in pore water was strongly linked to the abundances of Geobacter(r=0.81-0.94,P<0.05)and Clostridium(r=0.83-0.95,P<0.05),indicating that Geobacter and Clostridium played essential roles in Fe reduction.Redundancy analysis showed that labile carbon and pore water P concentrations were the key determinants influencing Fe-reducing bacterial abundances,accounting for 42%and 32%of the variation in community composition,respectively.Besides,biochar increased Fe and P concentrations in root cell walls,which retained more Cr.Overall,Cr stress in rice under biochar treatment was relieved through increasing IP formation and altering subcellular distribution.These mechanistic insights had important implications for reducing Cr uptake by rice.
基金supported by the National Key Research and Development Program of China(2021YFC2700202,2022YFA0806303 and 2022YFC2702601)the Global Select Project of the Institute of Health and Medicine,Hefei Comprehensive National Science Center(DJK-LX-2022010)+1 种基金USTC Research Funds of the Double First-Class Initiative(the Joint Fund for New Medicine of USTC)(YD9100002034)the Fundamental Research Funds for the Central Universities(WK9100000004).
文摘Multiple morphological abnormalities of the sperm flagella(MMAF)are characterized by bent,irregular,short,coiled,and absent flagella.MMAF is caused by a variety of genes,some of which have been identified.However,the underlying genetic factors responsible for the majority of MMAF cases are still largely unknown.The glutamine-rich 2(QRICH2)gene plays an essential role in the development of sperm flagella by regulating the expression of essential sperm flagellar biogenesis-associated proteins,and genetic variants of QRICH2 have been identified as the primary cause of MMAF in humans and mice.Here,we recruited a Pakistani consanguineous family to identify the genetic variant causing infertility in patients with MMAF.Whole-exome sequencing and Sanger sequencing were conducted to identify potentially pathogenic variants causing MMAF in infertile patients.Hematoxylin and eosin(HE)staining was performed to analyze sperm morphology.Quantitative polymerase chain reaction,western blot,and immunofluorescence staining analyses were conducted to observe the expression of QRICH2 in spermatozoa.A novel homozygous missense variant(c.4618C>T)in QRICH2 was identified in the affected patients.Morphological analysis of spermatozoa revealed the MMAF phenotype in infertile patients.qPCR revealed a significant reduction in the level of sperm QRICH2 mRNA,and immunofluorescence staining revealed a lack of sperm QRICH2 expression.Additionally,patients harboring a homozygous QRICH2 mutation presented reduced expression of outer dense fiber 2(ODF2)in sperm,whereas sperm expression of A-kinase anchor protein 4(AKAP4)was normal.These findings expand our understanding of the genetic causes of MMAF-associated male infertility and emphasize the importance of genetic counseling.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.51775077 and 51909023)。
文摘Shear-thinning fluids have been widely used in microfluidic systems,but their internal flow mechanism is still unclear.Therefore,in this paper,molecular dynamics simulations are used to study the laminar flow of shear-thinning fluid in a microchannel.We validated the feasibility of our simulation method by evaluating the mean square displacement and Reynolds number of the solution layers.The results show that the change rule of the fluid system's velocity profile and interaction energy can reflect the shear-thinning characteristics of the fluids.The velocity profile resembles a top-hat shape,intensifying as the fluid's power law index decreases.The interaction energy between the wall and the fluid decreases gradually with increasing velocity,and a high concentration of non-Newtonian fluid reaches a plateau sooner.Moreover,the velocity profile of the fluid is related to the molecule number density distribution and their values are inversely proportional.By analyzing the radial distribution function,we found that the hydrogen bonds between solute and water molecules weaken with the increase in velocity.This observation offers an explanation for the shear-thinning phenomenon of the non-Newtonian flow from a micro perspective.
文摘Erratumto:Journal of Bionic Engineering(2023)20:338-348 https:/doi.0rg/10.1007/s42235-022-00247-4 In Table 1,the value of Mesh's Feature dimensions(mm)"0.42"should have read"0.04".The original article has been corrected.
基金supported by the Xi’an Science and Technology Plan Project (No.2020KJRC0108).
文摘To address the problem of frequent battery replacement for wearable sensors applied to fall detection among the elderly,a portable and lowcost triboelectric nanogenerator(TENG)-based self-powered sensor for human gait monitoring is proposed.The main fabrication materials of the TENG are polytetrafluoroethylene(PTFE)film,aluminum(Al)foil,and polyimide(PI)film,where PTFE and Al are the friction layer materials and the PI film is used to improve the output performance.Exploiting the ability of TENGs to monitor changes in environmental conditions,a self-powered sensor based on the TENG is placed in an insole to collect gait information.Since a TENG does not require a power source to convert physical and mechanical signals into electrical signals,the electrical signals can be used as sensing signals to be analyzed by a computer to recognize daily human activities and fall status.Experimental results show that the accuracy of the TENG-based sensor for recognizing human gait is 97.2%,demonstrating superior sensing performance and providing valuable insights for future monitoring of fall events in the elderly population.
