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Dynamic development of microglia and macrophages after spinal cord injury 被引量:1
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作者 Hu-Yao Zhou Xia Wang +5 位作者 Yi li Duan Wang Xuan-Zi Zhou Nong Xiao Guo-Xing li gang li 《Neural Regeneration Research》 2025年第12期3606-3619,共14页
Secondary injury following spinal cord injury is primarily characterized by a complex inflammatory response,with resident microglia and infiltrating macrophages playing pivotal roles.While previous studies have groupe... Secondary injury following spinal cord injury is primarily characterized by a complex inflammatory response,with resident microglia and infiltrating macrophages playing pivotal roles.While previous studies have grouped these two cell types together based on similarities in structure and function,an increasing number of studies have demonstrated that microglia and macrophages exhibit differences in structure and function and have different effects on disease processes.In this study,we used single-cell RNA sequencing and spatial transcriptomics to identify the distinct evolutionary paths of microglia and macrophages following spinal cord injury.Our results showed that microglia were activated to a pro-inflammatory phenotype immediately after spinal cord injury,gradually transforming to an anti-inflammatory steady state phenotype as the disease progressed.Regarding macrophages,our findings highlighted abundant communication with other cells,including fibroblasts and neurons.Both pro-inflammatory and neuroprotective effects of macrophages were also identified;the pro-inflammatory effect may be related to integrin β2(Itgb2) and the neuroprotective effect may be related to the oncostatin M pathway.These findings were validated by in vivo experiments.This research underscores differences in the cellular dynamics of microglia and macrophages following spinal cord injury,and may offer new perspectives on inflammatory mechanisms and potential therapeutic targets. 展开更多
关键词 acute inflammation bioinformatics analysis FIBROBLAST integrinβ2 ligand-receptor interaction NEUROINFLAMMATION oncostatin M single-cell RNA sequencing spatial transcriptomics spinal cord injury
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Continuous measurement of reactive ammonia in hydrogen fuel by online dilution module coupled with Fourier transform infrared spectrometer 被引量:1
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作者 Wenqing Deng Fanfeng Deng +5 位作者 Ting Zhang Junjie lin liang Zhao gang li Yi Pan Jiebin Yang 《Chinese Chemical Letters》 2025年第3期188-193,共6页
Fuel cell electric vehicles hold great promise for a diverse range of applications in reducing greenhouse gas emissions.In power fuel cell systems,hydrogen fuel serves as an energy vector.To ensure its suitability,it ... Fuel cell electric vehicles hold great promise for a diverse range of applications in reducing greenhouse gas emissions.In power fuel cell systems,hydrogen fuel serves as an energy vector.To ensure its suitability,it is necessary for the quality of hydrogen to adhere to the standards set by ISO 14687:2019,which sets maximum limits for 14 impurities in hydrogen,aiming to prevent any degradation of fuel cell performance.Ammonia(NH_(3))is a prominent pollutant in fuel cells,and accurate measurements of its concentration are crucial for hydrogen fuel cell quantity.In this study,a novel detection platform was developed for determining NH_(3)in real hydrogen samples.The online analysis platform integrates a self-developed online dilution module with a Fourier transform infrared spectrometer(ODM-FTIR).The ODM-FTIR can be operated fully automatically with remote operation.Under the optimum conditions,this method achieved a wide linear range between(50∼1000)nmol/mol.The limit of detection(LOD)was as low as 2 nmol/mol with a relative standard deviation(RSD,n=7)of 3.6%at a content of 50 nmol/mol.To ensure that the quality of the hydrogen products meets the requirement of proton exchange membrane fuel cell vehicles(PEMFCV),the developed ODM-FTIR system was applied to monitor the NH_(3)content in Chengdu Hydrogen Energy Co.,Ltd.for 21 days during Chengdu 2021 FISU World University Games.The proposed method retains several unique advantages,including a low detection limit,excellent repeatability,high accuracy,high speed,good stability,and calibration flexibility.It is an effective analytical method for accurately quantifying NH_(3)in hydrogen,especially suitable for online analysis.It also provides a new idea for the analysis of other impurity components in hydrogen. 展开更多
关键词 Fuel cell electric vehicles Hydrogen fuel ODM-FTIR NH_(3) IMPURITY Online analysis
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Advances in artificial blood vessels:Exploring materials,preparation,and functionality 被引量:1
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作者 Feng Wang Mengdi liang +5 位作者 Bei Zhang Weiqiang li Xianchen Huang Xicheng Zhang Kaili Chen gang li 《Journal of Materials Science & Technology》 2025年第16期225-256,共32页
Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery... Cardiovascular disease(CVD)is a major global health challenge,which causes significant illness and death worldwide.These include a range of conditions that affect the heart and blood vessels,including coro-nary artery disease,stroke,peripheral artery disease,and heart failure.Despite advances in medicine and healthcare delivery,CVD continues to have a serious impact on individuals,families,and the healthcare system.This review begins by delineating the merits and demerits of commonly employed synthetic and natural materials for artificial blood vessels.It delves into various techniques commonly employed in the fabrication of artificial blood vessels,encompassing advanced textile technologies,electrospinning,ther-mally induced phase separation,and 3D printing.The review critically analyzes the attributes of different preparation methodologies alongside the latest advancements in research.The review also outlines the requisite performance requirements for artificial blood vessels,which encompass robust mechanical prop-erties,appropriate porosity,exceptional compatibility,and antibacterial attributes.It provides a succinct overview of ongoing effort s in vascular functionalization,particularly emphasizing thrombus mitigation,promotion of endothelialization,and enhancement of nitric oxide production.The review finally encap-sulates the primary challenges confronting vascular grafts and prospective avenues for future research. 展开更多
关键词 Artificial blood vessels Materials choice Preparation techniques Performance requirements FUNCTIONALIZATION
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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury
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作者 Jiewen Chen Xiaolin Zeng +6 位作者 Le Wang Wenwu Zhang gang li Xing Cheng Peiqiang Su Yong Wan Xiang li 《Neural Regeneration Research》 SCIE CAS 2025年第2期557-573,共17页
Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord injury.Microglia and astrocytes play key roles in the spinal cord injury micro-e... Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord injury.Microglia and astrocytes play key roles in the spinal cord injury micro-environment and share a close interaction.However,the mechanisms involved remain unclear.In this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming phenotypes.The expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord injury.In vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between them.We further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling pathway.This,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling pathways.In vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function recovery.Overall,Gas6 may play a role in the treatment of spinal cord injury.It can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord. 展开更多
关键词 ASTROCYTES AXL cell polarization GAS6 Hippo signal inflammatory micro-environment intercellular interaction MICROGLIA single-cell sequencing spinal cord injury
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The relationship between meteorological factors and daily outpatient visits at rabies exposure treatment clinics in Jinan,China 被引量:1
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作者 Gui-Jie Luan Yuan-Yuan Wang +3 位作者 gang li liang Sun Wei-Yan Zhang Shao-Nan liu 《Infectious Diseases Research》 2025年第1期10-15,共6页
Background:This study investigated the relationship between meteorological factors and daily outpatient visits to rabies post-exposure prophylaxis clinics to inform animal injury prevention strategies.Methods:Daily ou... Background:This study investigated the relationship between meteorological factors and daily outpatient visits to rabies post-exposure prophylaxis clinics to inform animal injury prevention strategies.Methods:Daily outpatient visit data from rabies post-exposure prophylaxis clinics in Jinan and corresponding meteorological data were collected from January 1,2020,to December 31,2022.A generalized additive model was used to quantitatively assess the relationship between these factors.A total of 202,010 patients visited these clinics during this period.Results:Daily mean,maximum,and minimum temperatures,and relative humidity were positively associated with outpatient visits.A 1°C increase in mean,maximum,and minimum temperatures corresponded to increases in daily visits of 1.65%(95%Confidence Interval(CI):1.55–1.76),1.59%(95%CI:1.50–1.69),and 1.27%(95%CI:1.17–1.36)respectively.Each 1%increase in relative humidity was associated with a 0.18%(95%CI:0.15–0.20)increase in visits.Mean pressure was negatively associated with outpatient visits,the outpatient visits decreased by 0.91%(95%CI:−1.71 to−0.11)for every 1 kPa increased in mean pressure.Conclusion:The change of meteorological factors will lead to the increase of outpatient visits in rabies exposure treatment clinic. 展开更多
关键词 meteorological factors RABIES outpatient visits excess risk
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Spin-Polarized Two-Dimensional Electron Gas with Giant Rashba Splitting at the EuTiO_(3)/KTaO_(3)(111) Interface under Light Illumination
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作者 Yu-Chen Zhao Jian-Jie li +8 位作者 Zhen Wang Tian-lin Zhou Ming-Hang li Wen-Xiao Shi Feng-Xia Hu Ji-Rong Sun gang li Yun-Zhong Chen Bao-Gen Shen 《Chinese Physics Letters》 2025年第10期186-193,共8页
The two-dimensional electron gas(2DEG)formed at the interface between two oxide insulators provides new opportunities for electronics and spintronics.The broken inversion symmetry at the heterointerface results in a R... The two-dimensional electron gas(2DEG)formed at the interface between two oxide insulators provides new opportunities for electronics and spintronics.The broken inversion symmetry at the heterointerface results in a Rashba spin-orbit coupling(RSOC)effect that enables the conversion between spin and charge currents.However,conducting oxide interfaces that simultaneously exhibit strong RSOC and high carrier mobility-a combination query for achieving high spin-to-charge inter-conversion efficiencies-remain scarce.Herein,we report a correlated 2DEG with giant Rashba splitting and high electron mobility in(111)-oriented EuTiO_(3)/KTaO_(3)(ETO/KTO)heterostructures under light illumination.Upon light modulation,a unique carrier-dependent giant anomalous Hall effect,the signature of spin-polarized 2DEG,emerges with a sign crossover at a carrier density of approximately 5.0×10^(13)cm^(-2),highlighting dramatic changes in the band topology of KTO(111)interface.Furthermore,at 2 K,the carrier mobility is enhanced from 103 cm^(2)·V^(-1)·s^(-1)to 1800 cm^(2)·V^(-1)·s^(-1),a remarkable enhancement of approximately 20 times.Accompanying with a giant Rashba coefficient αR up to 360meV·˚A,this high mobility ferromagnetic 5d oxide 2DEG is predicted to achieve a giant spin-to-charge conversion efficiency ofλ~10 nm,showing great potential for designing low-power spin-orbitronic devices. 展开更多
关键词 spin polarized giant Rashba splitting broken inversion symmetry conversion spin charge currentshoweverconducting oxide interfaces eutio KTaO interface light illumination oxide insulators electronics spintronicsthe
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Light Hadronic Decays of Spin-0 Partner of X(3872)
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作者 Hong-Shuo Gao Zu-Xin Cai +1 位作者 gang li Shi-Dong liu 《Chinese Physics Letters》 2025年第10期28-35,共8页
The X(3872)is theoretically predicted to have a spin-0 partner state denoted as X_(0).Assuming the X_(0)as a molecular bound state,we calculate the decay widths of X_(0)→VV and X_(0)→PP(V and P stand for light vecto... The X(3872)is theoretically predicted to have a spin-0 partner state denoted as X_(0).Assuming the X_(0)as a molecular bound state,we calculate the decay widths of X_(0)→VV and X_(0)→PP(V and P stand for light vector and pseudoscalar mesons,respectively)via intermediate charmed meson loops.Three different configurations of the X_(0),i.e.,pure neutral components(θ=0),isospin singlet(θ=π/4),and pure charged components(θ=π/2),are investigated.Within a commonly accepted range of the model parameterα,the predicted decay widths of X_(0)→VV are on the order of a few hundred keV,while the decay widths of X_(0)→PP can reach several MeV.The X_(0)→ρρandππhave larger decay rates.The relative width ratios between the channels are nearly model-independent.Moreover,among those channels only with isovector or isoscalar mesons,the relevant ratios are also independent of the phase angle.The predicted ratios are helpful for searching the X_(0)in the future experiments at BESIII and Belle II. 展开更多
关键词 pseudoscalar mesonsrespectively via intermediate charmed meson loopsthree molecular bound statewe pure charged components X molecular bound state spin partner light hadronic decays
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Meta‑analysis of climate effects on radial growth of Qinghai spruce in northwestern China
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作者 Caihong Gao Bao Yang +5 位作者 Feng Wang gang li Fredrik Charpentier Ljungqvist Achim Bräuning liliana V.Belokopytova Eugene A.Vaganov 《Journal of Forestry Research》 2025年第6期95-106,共12页
Radial growth of trees is highly sensitive to environmental changes,but the effect of climate on tree rings in Qinghai spruce(Picea crassifolia),a widely distributed endemic conifer in western China,is more complex th... Radial growth of trees is highly sensitive to environmental changes,but the effect of climate on tree rings in Qinghai spruce(Picea crassifolia),a widely distributed endemic conifer in western China,is more complex than in many other conifers.A comprehensive understanding of the spatiotemporal climatic responses of its rings is needed to develop theoretical basis for designing strategies for its conservation and management.Here,our synthesis of the literature on responses of radial growth of Qinghai spruce to monthly climate variables in different environmental conditions by meta-analysis showed that precipitation and drought severity are the main limiting factors for Qinghai spruce radial growth in the semiarid region of northwestern China.In warmer and drier areas,radial growth of Qinghai spruce is mainly limited by drought.In the areas north of the 600-mm annual precipitation isoline,the tree-ring width(TRW)was significantly positively correlated with precipitation and significantly negatively correlated with temperature during the growing season(June-August).The limiting effect of drought on Qinghai spruce is also gradually increasing from southeast to northwest,to the west of 103°E and within 37°N-39°N. 展开更多
关键词 Qinghai spruce China Radial growth Temperature PRECIPITATION DROUGHT META-ANALYSIS
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Study on the correlation between insomnia degree and quality of life in psychiatric outpatients in Chifeng city
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作者 Meng-Ran Xie gang li +6 位作者 Yu-Ting Shi li Kang Na-Na Dou Bing liu Jia-li Cao Shi-Qi Fu Shi-Guang Hao 《World Journal of Psychiatry》 2025年第5期136-144,共9页
BACKGROUND Insomnia is a common sleep disorder that negatively impacts quality of life and is frequently comorbid with depression and anxiety.Chronic insomnia affects approximately 15%of the global population,with hig... BACKGROUND Insomnia is a common sleep disorder that negatively impacts quality of life and is frequently comorbid with depression and anxiety.Chronic insomnia affects approximately 15%of the global population,with higher prevalence among females and the elderly.While existing research suggests a bidirectional relationship between insomnia and emotional disorders,the specific impact of insomnia severity on depression,anxiety,and quality of life remains unclear.This study investigates the correlation between insomnia severity and these factors in psychiatric outpatients,hypothesizing that greater insomnia severity is associated with higher levels of depression and anxiety,as well as poorer quality of life.AIM To explore the correlation between insomnia severity and depression,anxiety,and quality of life in primary chronic insomnia patients.METHODS From June to December 2023,345 patients with primary insomnia in Chifeng city were recruited and divided into three groups based on Pittsburgh sleep quality index(PSQI)scores:Mild(n=137),moderate(n=162),and severe(n=46).Demographic data were collected via questionnaires.Self-rating depression scale(SDS),self-rating anxiety scale(SAS),PSQI,and short form 36(SF-36)scores were compared,and Pearson and partial correlation analyses were performed.RESULTS The greater the degree of insomnia,the greater the symptoms of depression and anxiety(P<0.001).The more severe the insomnia,the lower the SF-36 score(excluding body pain),and the difference between the three groups was statist ically significant(P<0.001).Pearson correlation analysis and partial correlation analysis depicted the SDS score and SAS score were apparently positively correlated with the severity of insomnia(P<0.001).Pearson correlation analysis and partial correlation analysis depicted the SF-36 scores were apparently positively correlated with the severity of insomnia(P<0.05).CONCLUSION Depression and anxiety are independent factors influencing insomnia severity in primary chronic insomnia patients.Higher depression/anxiety levels correlate with worse insomnia,impacting quality of life. 展开更多
关键词 Insomnia severity Life quality DEPRESSION ANXIETY Psychiatric outpatients Correlation analysis
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PDINN sandwiched silver nanowires for solution-processed semitransparent organic photovoltaics with over 4%light utilization efficiency and nearly 100%bifaciality factor
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作者 Junjie Wu Menghua Cao +4 位作者 Xin liu Rihong Zhu Jie Zhou Jiangsheng Yu gang li 《Journal of Energy Chemistry》 2025年第5期1-9,共9页
Semitransparent organic photovoltaics(ST-OPVs)for building integration represent a pivotal direction in the development of photovoltaic industry.Solution-processed silver nanowires(AgNWs)are considered promising candi... Semitransparent organic photovoltaics(ST-OPVs)for building integration represent a pivotal direction in the development of photovoltaic industry.Solution-processed silver nanowires(AgNWs)are considered promising candidates for transparent electrodes in semitransparent devices due to their high transparency-conductivity-efficiency merit,large-scale processability,and low cost.In this work,we develop two solution-processed organic–inorganic hybrid electrodes,named AgNWs-PD and AgNWsPC,utilizing AgNWs as the conductive framework and aliphatic amine-functionalized perylene-diimide(PDINN)as the sandwiched material,while AgNWs-PC exhibits significantly improved electrical conductivity and enhanced contact area with the underlying electron transport layer.The optimized device achieves a power conversion efficiency of 9.45%with an open circuit voltage of 0.846 V,a high filling factor of 75.4%,and an average visible transmittance(AVT)of 44.0%,delivering an outstanding light utilization efficiency(LUE)of 4.16%,which is the highest reported value for all solution-processed ST-OPVs.In addition,by coupling a 30-nm tellurium dioxide atop AgNWs-PC,the bifaciality factor of derivative devices improves from 73.7%to 99.4%,while maintaining a high bifacial LUE over 3.7%.Our results emphasize the superiority and effectiveness of PDINN-sandwiched AgNWs electrodes for highperformance and all solution-processed ST-OPVs. 展开更多
关键词 Semitransparent organic photovoltaics Solution-processed Silver nanowire electrode Conventional structure Light utilization efficiency Bifaciality factor
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Comparative studies of the NO_(x) impacts on the photooxidation mechanisms of isomeric monoterpenes ofβ-pinene and limonene
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作者 Yingqi Zhao Zhaoyan Zhang +8 位作者 Ya Zhao Chong Wang Hua Xie Jiayue Yang Weiqing Zhang Guorong Wu gang li ling Jiang Xueming Yang 《Journal of Environmental Sciences》 2025年第12期337-350,共14页
It is highly challenging to precisely compare the impacts of anthropogenic pollutants on the photooxidation of isomeric volatile organic compounds with respect to molecular compositions and particle number/mass concen... It is highly challenging to precisely compare the impacts of anthropogenic pollutants on the photooxidation of isomeric volatile organic compounds with respect to molecular compositions and particle number/mass concentrations of secondary organic aerosols(SOAs).In this study,we conducted a series of well-defined indoor chamber experiments to compare the effects of NO_(x)(NO and NO_(2))on the photooxidation of isomeric monoterpenes ofβ-pinene and limonene.For the photooxidation ofβ-pinene with NO_(x),the increase of the initial concentrations of NO([NO]_(0))shows a monotonous suppression of the particle mass concentration,whereas the increase of[NO_(2)]_(0) shows a monotonous enhancement of the particle mass concentration.For the photooxidation of limonene with NO_(x),the increase of[NO]_(0) exhibits a monotonous suppression of the particle mass concentration,whereas the increase of[NO_(2)]_(0) shows a parabolic trend of the particle mass concentration.Utilizing a newly developed vacuum ultraviolet free electron laser(VUV-FEL),the online threshold photoionization mass spectrometry reveals a series of novel compounds at molecular weight(MW)=232 and 306 for theβ-pinene+NO_(x) system and MW=187,261,280,and 306 for the limonene+NO_(x) system.The molecular structures and formation pathways of these species were inferred,which led to the prediction of the diversity and difference of SOA products(i.e.,ester and peroxide accretion products)formed from different monoterpene precursors.To improve the predictions of future air quality,it is recommended that climate models should incorporate the NO_(x)-driven diurnal photooxidation of monoterpenes for SOA formation mechanisms. 展开更多
关键词 Secondary organic aerosol Anthropogenic-biogenic interactions Photooxidation mechanism Β-PINENE LIMONENE
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Lightweight YOLOM-Net for Automatic Identification and Real-Time Detection of Fatigue Driving
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作者 Shanmeng Zhao Yaxue Peng +2 位作者 Yaqing Wang gang li Mohammed Al-Mahbashi 《Computers, Materials & Continua》 2025年第3期4995-5017,共23页
In recent years,the country has spent significant workforce and material resources to prevent traffic accidents,particularly those caused by fatigued driving.The current studies mainly concentrate on driver physiologi... In recent years,the country has spent significant workforce and material resources to prevent traffic accidents,particularly those caused by fatigued driving.The current studies mainly concentrate on driver physiological signals,driving behavior,and vehicle information.However,most of the approaches are computationally intensive and inconvenient for real-time detection.Therefore,this paper designs a network that combines precision,speed and lightweight and proposes an algorithm for facial fatigue detection based on multi-feature fusion.Specifically,the face detection model takes YOLOv8(You Only Look Once version 8)as the basic framework,and replaces its backbone network with MobileNetv3.To focus on the significant regions in the image,CPCA(Channel Prior Convolution Attention)is adopted to enhance the network’s capacity for feature extraction.Meanwhile,the network training phase employs the Focal-EIOU(Focal and Efficient Intersection Over Union)loss function,which makes the network lightweight and increases the accuracy of target detection.Ultimately,the Dlib toolkit was employed to annotate 68 facial feature points.This study established an evaluation metric for facial fatigue and developed a novel fatigue detection algorithm to assess the driver’s condition.A series of comparative experiments were carried out on the self-built dataset.The suggested method’s mAP(mean Average Precision)values for object detection and fatigue detection are 96.71%and 95.75%,respectively,as well as the detection speed is 47 FPS(Frames Per Second).This method can balance the contradiction between computational complexity and model accuracy.Furthermore,it can be transplanted to NVIDIA Jetson Orin NX and quickly detect the driver’s state while maintaining a high degree of accuracy.It contributes to the development of automobile safety systems and reduces the occurrence of traffic accidents. 展开更多
关键词 Fatigue driving facial feature lightweight network MobileNetv3-YOLOv8 dlib toolkit REAL-TIME
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Retraction:Line Trace Effective Comparison Algorithm Based on Wavelet Domain DTW
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作者 Nan Pan Yiliu +2 位作者 Dilin Pan Junbing Qian gang li 《Intelligent Automation & Soft Computing》 2025年第1期145-145,共1页
Intelligent Automation&Soft Computing has retracted the article titled“Line Trace Effective Comparison AlgorithmBased onWavelet Domain DTW”[1],Intell Automat Soft Comput.2019;25(2):359–366 at the request of the... Intelligent Automation&Soft Computing has retracted the article titled“Line Trace Effective Comparison AlgorithmBased onWavelet Domain DTW”[1],Intell Automat Soft Comput.2019;25(2):359–366 at the request of the authors.DOI:10.31209/2019.100000097 URL:https://www.techscience.com/iasc/v25n2/39663 The article duplicates significant parts of a paper published in Journal of Intelligent&Fuzzy Systems[2]. 展开更多
关键词 domain dtw intell trace effective comparison line trace comparison soft computing wavelet domain dtw intelligent automation
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丹参注射液联合生长抑素治疗对重症急性胰腺炎患者血清内脂素和Ghrelin水平的影响 被引量:7
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作者 张蕾 刚丽 张新莉 《广西医科大学学报》 CAS 2019年第10期1664-1667,共4页
目的:观察丹参注射液联合生长抑素治疗对重症急性胰腺炎患者血清内脂素(visfatin)和Ghrelin水平的影响。方法:选取2016年5月至2018年2月大连大学附属中山医院收治的86例重症急性胰腺炎患者,按随机数字表法分为研究组和对照组,每组43例... 目的:观察丹参注射液联合生长抑素治疗对重症急性胰腺炎患者血清内脂素(visfatin)和Ghrelin水平的影响。方法:选取2016年5月至2018年2月大连大学附属中山医院收治的86例重症急性胰腺炎患者,按随机数字表法分为研究组和对照组,每组43例。对照组采用静脉滴注生长抑素治疗,研究组在对照组治疗的基础上加用丹参注射液。比较两组临床疗效、重症缓解时间、治愈时间、死亡率、不良反应发生率及血清visfatin和Ghrelin水平。结果:研究组重症缓解时间和治愈时间明显短于对照组(P<0.05)。研究组治疗总有效率(93.0%)明显高于对照组(76.7%)(P<0.05)。治疗7 d后,研究组血清visfatin和Ghrelin水平显著低于对照组(P<0.05)。两组不良反应发生率和死亡率比较,差异均无统计学意义(均P>0.05)。结论:丹参注射液联合生长抑素治疗重症急性胰腺炎临床效果显著,能够降低患者血清visfatin和Ghrelin的水平。 展开更多
关键词 生长抑素 丹参注射液 重症急性胰腺炎 内脂素 GHRELIN
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Core-shell Bi@ mesoporous carbon nanospheres as high rate and long life anodes for sodium ion batteries
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作者 Wu YANG Zhe-wei YANG +5 位作者 Chao-hui WANG Hai-nan BIAN Yue-de PAN gang li Kai-ying WANG Jie-xi WANG 《Transactions of Nonferrous Metals Society of China》 2025年第6期1996-2007,共12页
In order to restrain the huge volume expansion of bismuth(Bi)anodes in sodium ion batteries(SIBs),the core-shell structure Bi@mesoporous carbon nanospheres(Bi@mC)composite was designed and prepared by sol-gel method c... In order to restrain the huge volume expansion of bismuth(Bi)anodes in sodium ion batteries(SIBs),the core-shell structure Bi@mesoporous carbon nanospheres(Bi@mC)composite was designed and prepared by sol-gel method coupled heat treatment.Structural characterization displays that the average diameter of the as-prepared Bi@mC composites is about 200 nm and thickness of the N-doped mesoporous carbon shells is 20-30 nm.Electrochemical test and kinetic analysis results show that the mesoporous carbon shell can not only effectively relieve the stress caused by volume expansion of Bi and protect active material from pulverization caused by the stress during charging/discharging process,but also facilitate quick diffusion of sodium ions,thus improving rate and cycling performance.Bi@mC delivers a high specific capacity of 279 mA·h/g and a capacity retention of 97.6%after 3500 cycles at a current density of 5 A/g.Even at a high current density of 20 A/g,Bi@mC can still maintain a high specific capacity of 266 mA·h/g.Additionally,the Bi@mC//NVP full button sodium-ion batteries(SIBs)assembled using Bi@mC anode and Na_(3)V_(2)(PO_(4))_(3)(NVP)cathode deliver an energy density of 182 W·h/kg. 展开更多
关键词 sodium ion battery BISMUTH core−shell structure sol−gel method kinetic analysis
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Characterization of gallbladder stones associated with occult pancreaticobiliary reflux using computed tomography
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作者 Chen Qiu Yu-Kai Xiang +6 位作者 Hai Hu Xuan-Bo Da gang li Yue-Yi Zhang Hong-Lei Zhang Cheng Zhang Yu-Long Yang 《World Journal of Gastroenterology》 2025年第12期49-61,共13页
BACKGROUND Occult pancreaticobiliary reflux(OPBR)is characterized by the absence of congenital anomalies at the pancreaticobiliary junction yet leads to altered bile composition and an increased incidence of gallbladd... BACKGROUND Occult pancreaticobiliary reflux(OPBR)is characterized by the absence of congenital anomalies at the pancreaticobiliary junction yet leads to altered bile composition and an increased incidence of gallbladder stones.AIM To explore the computed tomography(CT)imaging characteristics of gallbladder stones in patients diagnosed with OPBR.METHODS We analyzed 362 patients undergoing cholecystectomy(November 2020 to January 2022).Intraoperative bile samples were assayed for amylase(>110 U/L indicated OPBR).CT features,including stone density and visibility,were compared between 54 OPBR and 308 controls.Stone attenuation(HU)was measured under standardized conditions(uCT-780,120 kVp,160 mAs).Logistic regression and receiver operating characteristic curve analysis identified independent OPBR predictors,forming a validated nomogram.RESULTS OPBR patients exhibited significantly higher rates of CT-invisible stones(35.2%vs 12.3%)and uniform stones(87%vs 73.1%)along with lower overall stone density(P=0.01).Logistic regression identified stone visibility,uniformity,and density as independent predictors.A nomogram integrating these features with patient age achieved high diagnostic accuracy(area under the curve=0.71).CONCLUSION CT imaging distinctly identifies gallbladder stone density,indicating a heightened risk of OPBR in patients with uniform and CT-invisible stones.Such imaging is crucial for preoperative assessments to evaluate potential recurrent biliary pathologies post-cholecystectomy. 展开更多
关键词 Occult pancreaticobiliary reflux Pancreaticobiliary maljunction Pancreaticobiliary reflux Computed tomography Diagnostic model
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Ligand-mediated reactivity in CO oxidation of yttrium-nickel monoxide carbonyl complexes
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作者 Jumei Zhang Ziheng Zhang +3 位作者 gang li Hongjin Qiao Hua Xie ling Jiang 《Chinese Chemical Letters》 2025年第2期151-155,共5页
A series of heteronuclear yttrium-nickel monoxide carbonyl complexes YNiO(CO)_(n)^(-)(n=1-5)were generated in a pulsed-laser vaporization source and characterized by mass-selected photoelectron velocity-map spectrosco... A series of heteronuclear yttrium-nickel monoxide carbonyl complexes YNiO(CO)_(n)^(-)(n=1-5)were generated in a pulsed-laser vaporization source and characterized by mass-selected photoelectron velocity-map spectroscopy combined with theoretical calculations.CO ligand-mediated reactivity in CO oxidation of yttrium-nickel monoxide carbonyl complexes was experimentally and theoretically identified.During the consecutive CO adsorption,aμ^(2)-O linear structure was most favorable for YNiO(CO)_(n)^(-)(n=1,2),then a structure in which the terminal O was bonded to the Y atom became favored for YNiO(CO)_(3)^(-),and finally a structure bearing a CO_(2)moiety was most favorable for YNiO(CO)_(n)^(-)(n=4,5).Theoretical calculations indicated that the Ni atom acted as an electron acceptor and accumulated electron density at n≤3,and then served as an electron donor along with the Y atom to contribute electron density in the rearrangement that accompanied CO oxidation at n>3. 展开更多
关键词 Heteronuclear cluster CO oxidation Electron donor Quantum chemical calculation Photoelectron velocity-map imaging spectroscopy
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Double flipping behavior of domains under unidirectional electric field and giant electrostrain by defect regulation
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作者 Yuxin Jia Yongbo Fan +7 位作者 lin Lei gang li Yao Su Yuanbiao Gong Guangzhi Dong Weijia Wang Qiang li Huiqing Fan 《Journal of Materials Science & Technology》 2025年第12期15-21,共7页
Ferroelectric materials find extensive applications in brake systems due to their capability to convert electrical energy into mechanical energy.Recent research has focused on lead-free materials for their environment... Ferroelectric materials find extensive applications in brake systems due to their capability to convert electrical energy into mechanical energy.Recent research has focused on lead-free materials for their environmentally friendly characteristics.However,they exhibit several challenges such as significant negative strain,limited strain values,and large driving field.In this work,novel preparation techniques(electrospinning)were utilized for BaTiO_(3)to introduce oxygen vacancies and barium defects,facilitating the creation of oriented defect dipoles coupled with an intrinsic electric field(Ei)after poling and aging.Due to the existence of Ei,two minimum points in the strain hysteresis loop were shifted to the same quadrant in the Strain-Electric field space.Thus,when applying an electric field along the Ei direction,negative strain is eliminated.Additionally,the actual electric field is the sum of the applied electric field and Ei,thereby reducing the required driving field of the piezoelectric.The stretching of defect dipoles under the electric field further amplified the total strain.Through the proposed mechanisms,this work achieved a substantial unipolar electrostrain of 1.04%under a relatively low electric field(30 kV/cm)in BaTiO_(3).This work successfully addressed the challenges of high-driving electric fields,limited strain values,and negative strain,providing a comprehensive approach for improving field-induced strain performance through point defect engineering in ferroelectric materials. 展开更多
关键词 BaTiO_(3) Electrostrain Defect dipole Intrinsic electric field ELECTROSPINNING
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Implicit Feature Contrastive Learning for Few-Shot Object Detection
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作者 gang li Zheng Zhou +6 位作者 Yang Zhang Chuanyun Xu Zihan Ruan Pengfei Lv Ru Wang Xinyu Fan Wei Tan 《Computers, Materials & Continua》 2025年第7期1615-1632,共18页
Although conventional object detection methods achieve high accuracy through extensively annotated datasets,acquiring such large-scale labeled data remains challenging and cost-prohibitive in numerous real-world appli... Although conventional object detection methods achieve high accuracy through extensively annotated datasets,acquiring such large-scale labeled data remains challenging and cost-prohibitive in numerous real-world applications.Few-shot object detection presents a new research idea that aims to localize and classify objects in images using only limited annotated examples.However,the inherent challenge in few-shot object detection lies in the insufficient sample diversity to fully characterize the sample feature distribution,which consequently impacts model performance.Inspired by contrastive learning principles,we propose an Implicit Feature Contrastive Learning(IFCL)module to address this limitation and augment feature diversity for more robust representational learning.This module generates augmented support sample features in a mixed feature space and implicitly contrasts them with query Region of Interest(RoI)features.This approach facilitates more comprehensive learning of both intra-class feature similarity and inter-class feature diversity,thereby enhancing the model’s object classification and localization capabilities.Extensive experiments on PASCAL VOC show that our method achieves a respective improvement of 3.2%,1.8%,and 2.3%on 10-shot of three Novel Sets compared to the baseline model FPD. 展开更多
关键词 Few-shot learning object detection implicit contrastive learning feature mixing feature aggregation
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Exploration and Practice of Free Campus Network in Institutions of Higher Education:A Case Study of Dalian Jiaotong University
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作者 Guoli Zhang Hang Su gang li 《Journal of Contemporary Educational Research》 2025年第11期264-269,共6页
Against the backdrop of digital education,the campus network has become an indispensable infrastructure in universities,yet the limitations of traditional operation models have become increasingly prominent.This paper... Against the backdrop of digital education,the campus network has become an indispensable infrastructure in universities,yet the limitations of traditional operation models have become increasingly prominent.This paper systematically presents the entire process of the free campus network reform initiated by Dalian Jiaotong University,focusing on its background,implementation paths,existing challenges,and optimization strategies.It explores the construction of an on-demand service system for campus networks,and practical experience can provide some reference and guidance for sister universities. 展开更多
关键词 Digital education Campus network Free model CONSTRUCTION OPTIMIZATION
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