The Philippine Sea is the largest marginal sea in the Western Pacific Ocean and is divided into two parts by the Kyushu-Palau Ridge(KPR).The western part is the West Philippine Basin,and the eastern part consists of t...The Philippine Sea is the largest marginal sea in the Western Pacific Ocean and is divided into two parts by the Kyushu-Palau Ridge(KPR).The western part is the West Philippine Basin,and the eastern part consists of the Shikoku and Parece Vela basins.Based on surveyed data of massive high-resolution multibeam bathymetric data and sub-bottom profiles data collected from the southern section of the KPR from 2018 to 2021,this paper analyzes the topographic and geomorphological features,shallow sedimentary features,and tectonic genesis of the southern section of the KPR,obtaining the following conclusions.The southern section of the KPR has complex and rugged topography,with positive and negative topography alternatingly distributed and a maximum height difference of 4086 m.The slope of seamounts in this section generally exceeds 10°and is up to a maximum of 59°.All these contribute noticeably discontinuous topography.There are primarily nine geomorphological types in the southern section of the KPR,including seamounts,ridges,and intermontane valleys,etc.Among them,seven independent seamount groups are divided by five large troughs,forming an overall geomorphological pattern of seven abyssal seamount groups and five troughs.This reflects the geomorphological features of a deep oceanic ridge.Intramontane basins and intermontane valleys in the southern section of the KPR are covered by evenly thick sediments.In contrast,sediments in ridges and seamounts in this section are thin or even missing,with slumps developing locally.Therefore,the sediments are discontinuous and unevenly developed.The KPR formed under the control of tectonism such as volcanic activities and plate movements.In addition,exogenic forces such as underflow scouring and sedimentation also play a certain role in shaping seafloor landforms in the KPR.展开更多
In this paper,low-temperature dielectric-blocked discharge plasma(DBD)was employed for the first time to treat silica-doped H_(4)PMo_(11)VO_(40)(HPAV)catalysts(DBD(Ar/x)-MF-Catal)and apply them in the catalytic methac...In this paper,low-temperature dielectric-blocked discharge plasma(DBD)was employed for the first time to treat silica-doped H_(4)PMo_(11)VO_(40)(HPAV)catalysts(DBD(Ar/x)-MF-Catal)and apply them in the catalytic methacrolein(MAL)selective oxidation to produce methacrylic acid(MAA).This work investigates in detail the controllable regulation of the concentration of oxidation states on silica-doped HPAV catalysts by adjusting the DBD discharge with controlled changes in voltage,current,treatment time,and treatment medium.It reports the intrinsic correlation between oxidation states and MAL oxidation performance.The research results indicated that the catalytic performance was related to the presence of oxygen vacancies and oxygen species(VO^(2+)),and are the main reason for the selective oxidation of MAL to MAA.Besides,the generation of oxygen vacancies and VO^(2+)altered localized electrons,which resulted in the easier activation of O_(2).Theoretical calculations of DFT also proved the formation mechanism of oxygen vacancies and VO^(2+)and electron properties on high-performance polymers,which elucidated the intrinsic influence of catalyst components.The DBD(Ar/10)-MF-Catal catalysts with suitable VO^(2+)and oxygen vacancy concentrations exhibited the highest catalytic performance with 90%MAL conversion and 70%MAA selectivity and showed good stability(500 h).展开更多
BACKGROUND Endoscopy allows for the direct observation of primary tumor characteristics and responses after neoadjuvant treatment.However,reports on endoscopic evaluation following neoadjuvant immunotherapy remain lim...BACKGROUND Endoscopy allows for the direct observation of primary tumor characteristics and responses after neoadjuvant treatment.However,reports on endoscopic evaluation following neoadjuvant immunotherapy remain limited.AIM To examine the predictive value of endoscopic findings of primary tumors for responses to neoadjuvant immunotherapy.METHODS This retrospective study,conducted at a tertiary center in China,evaluated 74 patients with colorectal cancer,including 17 with deficient mismatch repair(dMMR)and 15 with proficient mismatch repair(pMMR)tumors.Patients underwent neoadjuvant immunotherapy followed by surgery.Endoscopic findings before and after neoadjuvant immunotherapy were reviewed and compared with the pathology of the resected specimens.RESULTS In the pMMR group(n=57 evaluable patients),endoscopy identified 11/17 patients who achieved a complete response(CR),while misidentifying 1/40 patients with residual disease as CR(64.7%vs 2.5%,P<0.01).Conversely,22/40 patients with residual disease were accurately identified as achieving a partial response(PR),with 1/17 patients who achieved CR misclassified as PR(55.0%vs 5.9%,P<0.01).The sensitivity,specificity,and accuracy of endoscopic diagnosis for pathological CR were 64.7%,97.5%,and 87.7%,respectively.In the dMMR cohort,endoscopy classified 9/17 patients as CR and 2 of the remaining patients with residual tumors as PR(64.3%vs 66.7%,P=0.73).The method demonstrated 100%sensitivity and 82.4%accuracy in diagnosing pathological CR.CONCLUSION Endoscopic evidence of CR or PR was well correlated with postoperative pathological outcomes in the pMMR cohort.Despite endoscopic indications of tumor residue,a complete pathological response post-surgery was possible in the dMMR cohort.展开更多
Feature selection(FS)is essential in machine learning(ML)and data mapping by its ability to preprocess high-dimensional data.By selecting a subset of relevant features,feature selection cuts down on the dimension of t...Feature selection(FS)is essential in machine learning(ML)and data mapping by its ability to preprocess high-dimensional data.By selecting a subset of relevant features,feature selection cuts down on the dimension of the data.It excludes irrelevant or surplus features,thus boosting the performance and efficiency of the model.Particle Swarm Optimization(PSO)boasts a streamlined algorithmic framework and exhibits rapid convergence traits.Compared with other algorithms,it incurs reduced computational expenses when tackling high-dimensional datasets.However,PSO faces challenges like inadequate convergence precision.Therefore,regarding FS problems,this paper presents a binary version enhanced PSO based on the Support Vector Machines(SVM)classifier.First,the Sand Cat Swarm Optimization(SCSO)is added to enhance the global search capability of PSO and improve the accuracy of the solution.Secondly,the Latin hypercube sampling strategy initializes populations more uniformly and helps to increase population diversity.The last is the roundup search strategy introducing the grey wolf hierarchy idea to help improve convergence speed.To verify the capability of Self-adaptive Cooperative Particle Swarm Optimization(SCPSO),the CEC2020 test suite and CEC2022 test suite are selected for experiments and applied to three engineering problems.Compared with the standard PSO algorithm,SCPSO converges faster,and the convergence accuracy is significantly improved.Moreover,SCPSO’s comprehensive performance far exceeds that of other algorithms.Six datasets from the University of California,Irvine(UCI)database were selected to evaluate SCPSO’s effectiveness in solving feature selection problems.The results indicate that SCPSO has significant potential for addressing these problems.展开更多
In this study,a catalyst was synthesized using a two-step in-situ molecular beam epitaxy method to grow H_(4)PMo_(11)VO_(40)(HPAV)on amination-treated SiO_(2) nanoparticles,which served as both dopant and host agents....In this study,a catalyst was synthesized using a two-step in-situ molecular beam epitaxy method to grow H_(4)PMo_(11)VO_(40)(HPAV)on amination-treated SiO_(2) nanoparticles,which served as both dopant and host agents.SiO_(2) dopant was modified with(3-aminopropyl)triethoxysilane(APTS),facilitating the formation of ammonium ions that enhanced the overall positive charge.This modification enabled the effective dispersion and exposure of HPAV's active species and induced a structural transformation of HPAV from a triclinic to a cubic crystal phase.The two-step hosting growth process optimized the proportions of Cs^(+),H^(+)and NH_(4)^(+)antinuclear ions,thereby fine-tuning the synergistic catalysis of oxidation and acidity,as well as the oxidative sensitivity at HPAV catalytic interface.The resultant 8(HPAV)&4(Cs_(3)PAV)-NH_(2)-SiO_(2) catalyst achieved a methacrolein(MAL)conversion rate of 84%and a methacrylic acid(MAA)selectivity of 71%.Even after 10.5 h of reaction time,the catalyst retained its high dispersion,cubic crystal structure,and Keggin configuration,demonstrating stable catalytic performance over a continuous 200-h reaction period.展开更多
BACKGROUND Diverting stoma(DS)is routinely proposed in intersphincteric resection for ultra-low rectal cancer,but it is associated with increased stoma-related complications and economic burden.Appropriate patient sel...BACKGROUND Diverting stoma(DS)is routinely proposed in intersphincteric resection for ultra-low rectal cancer,but it is associated with increased stoma-related complications and economic burden.Appropriate patient selection and operative strategies to avoid stoma formation need further elucidation.METHODS This study enrolled 505 consecutive patients,including 84 who underwent stoma-free(SF)intersphincteric resection.After matching,patients were divided into SF(n=78)and DS(n=78)groups.The primary endpoint was the anastomotic leakage(AL)rate within 6 months and its protective factors for both the total and SF cohorts.The secondary endpoints included overall survival and disease-free survival.RESULTS The AL rate was greater in the SF group than in the DS group(12.8%vs 2.6%,P=0.035).Male sex[(odds ratio(OR)=2.644,P=0.021],neoadjuvant chemoradiotherapy(nCRT)(OR=6.024,P<0.001),and tumor height from the anal verge≤4 cm(OR=4.160,P=0.007)were identified as independent risk factors.Preservation of the left colic artery(LCA)was protective in both the total cohort(OR=0.417,P=0.013)and the SF cohort(OR=0.312,P=0.027).The female patients who did not undergo nCRT and had preservation of the LCA experienced a significantly lower incidence of AL(2/97,2.1%).The 3-year overall survival or disease-free survival did not significantly differ be-tween the groups.CONCLUSION Female patients who do not receive nCRT may avoid the need for DS by preserving the LCA without increasing the risk of AL or compromising oncological outcomes.展开更多
With the advancement of information technology,the digital transformation of higher education has become a global trend in educational reform.Egypt has propelled the modernization of its higher education system throug...With the advancement of information technology,the digital transformation of higher education has become a global trend in educational reform.Egypt has propelled the modernization of its higher education system through digital means,focusing on enhancing teachers’digital teaching capabilities,improving course quality,and establishing a policy environment that supports digital instruction.The driving forces behind Egypt’s transformation include meeting the demand for skilled talent due to economic reforms,participating in internationalization processes,and the impetus provided by public diplomacy.By introducing high-quality international resources,deepening scientific research collaboration,and applying digital technologies,Egypt has effectively alleviated issues of resource insufficiency and uneven development,thereby enhancing its capacity for higher education quality assurance.Egypt’s practice demonstrates that digitalization is a key pathway for developing countries to improve the quality of higher education,providing valuable insights for constructing sustainable models of higher education development.展开更多
AIM: To investigate the effect of a fermented milk containing Bifidobacterium lactis DN-173010 and yogurt strains (BIO) on adult women with constipation in Beijing.METHODS: A total of 135 adult females with constipati...AIM: To investigate the effect of a fermented milk containing Bifidobacterium lactis DN-173010 and yogurt strains (BIO) on adult women with constipation in Beijing.METHODS: A total of 135 adult females with constipation were randomly allocated to consume for 2 wk either 100 g of the test fermented milk or 100 g of an acidified milk containing non-living bacteria (control).Stool frequency,defecation condition scores,stool consistency and food intake were recorded at baseline and after 1 and 2 wk in an intention-to-treat population of 126 subjects.In parallel,safety evaluation parameters were performed.RESULTS: At baseline,no differences were found between groups.Following consumption of test product,stool frequency was significantly increased after 1 wk (3.5 ± 1.5 vs 2.4 ± 0.6,P < 0.01) and 2 wk (4.1 ± 1.7 vs 2.4 ± 0.6,P < 0.01),vs baseline.Similarly,after 1 and 2 wk,of test product consumption,defecation condition (1.1 ± 0.9 vs 1.9 ± 1.2,P < 0.01 and 0.8 ± 1.0 vs 1.9 ± 1.2,P < 0.01,respectively) and stool consistency (1.0 ± 0.8 vs 1.5 ± 1.1,P < 0.01 and 0.6 ± 0.8 vs 1.5 ± 1.1,P < 0.01,respectively) were significantly improved.Compared with the control group,stool frequency was also significantly increased (3.5 ± 1.5 vs 2.5 ± 0.9,P < 0.01 and 4.1 ± 1.7 vs 2.6 ± 1.0,P < 0.01,respectively),and defecation condition (1.1 ± 0.9 vs 1.6 ± 1.1,P < 0.01 and 0.8 ± 1.0 vs 1.6 ± 1.1,P < 0.01,respectively) and stool consistency (1.0 ± 0.8 vs 1.4 ± 1.0,P < 0.05 and 0.6 ± 0.8 vs 1.3 ± 1.0,P < 0.01,respectively) significantly decreased after 1 and 2 wk of product consumption.During the same period,food intake did not change between the two groups,and safety parameters of the subjects were within normal ranges.CONCLUSION: This study suggests a beneficial effect of a fermented milk containing B.lactis DN-173010 on stool frequency,defecation condition and stool consistency in adult women with constipation constipated women after 1 and 2 wk of consumption.展开更多
The properties of woody debris(WD) vary across different forests under various soil conditions.Owing to the relatively shallow and low amounts of soils on karst terrains, it is necessary to determine the WD carbon inv...The properties of woody debris(WD) vary across different forests under various soil conditions.Owing to the relatively shallow and low amounts of soils on karst terrains, it is necessary to determine the WD carbon inventory of karst forests. In this study, we recorded WD with a basal diameter for standing snags and the largeend diameter for fallen logs of ≥ 1 cm. The carbon density of WD in a secondary karst mixed evergreen and deciduous broad-leaved forest that had been clear-cut 55 years ago in southwestern China were inventoried in a 2 ha plot. Woody debris carbon density calculated using specific gravity and carbon concentration was 4.07 Mg C ha^-1. Woody debris with diameters ≥ 10 cm(coarse WD) constituted 53.8% of total carbon storage whereas WD < 10 cm in diameters(fine WD) accounted for more pieces of WD(89.9%).Lithocarpus confinis contributed the most WD carbon(26.5%). Intermediate decayed WD was relatively more abundant, but WD with final decay contributed the least to the total pieces of WD(6.7%). The contribution of WD to carbon storage of karst forest was low compared to other forests worldwide. Significant positive correlations were found between WD carbon and biodiversity(R^2= 0.035,p < 0.01) and elevation(R^2= 0.047, p < 0.01) and negative correlations was found in outcrop coverage(R^2= 0.034, p <0.01). Further studies are needed to elucidate the ecological functions of WD to better understand their roles in maintaining biodiversity, enhancing productivity, and controlling vegetation degradation in karst forest ecosystems.展开更多
This paper presents an efficient enhanced snake optimizer termed BEESO for global optimization and engineering applications.As a newly mooted meta-heuristic algorithm,snake optimizer(SO)mathematically models the matin...This paper presents an efficient enhanced snake optimizer termed BEESO for global optimization and engineering applications.As a newly mooted meta-heuristic algorithm,snake optimizer(SO)mathematically models the mating characteristics of snakes to find the optimal solution.SO has a simple structure and offers a delicate balance between exploitation and exploration.However,it also has some shortcomings to be improved.The proposed BEESO consequently aims to lighten the issues of lack of population diversity,convergence slowness,and the tendency to be stuck in local optima in SO.The presentation of Bi-Directional Search(BDS)is to approach the global optimal value along the direction guided by the best and the worst individuals,which makes the convergence speed faster.The increase in population diversity in BEESO benefits from Modified Evolutionary Population Dynamics(MEPD),and the replacement of poorer quality individuals improves population quality.The Elite Opposition-Based Learning(EOBL)provides improved local exploitation ability of BEESO by utilizing solid solutions with good performance.The performance of BEESO is illustrated by comparing its experimental results with several algorithms on benchmark functions and engineering designs.Additionally,the results of the experiment are analyzed again from a statistical point of view using the Friedman and Wilcoxon rank sum tests.The findings show that these introduced strategies provide some improvements in the performance of SO,and the accuracy and stability of the optimization results provided by the proposed BEESO are competitive among all algorithms.To conclude,the proposed BEESO offers a good alternative to solving optimization issues.展开更多
Grafting is an ancient technique used for plant propagation and improvement in horticultural crops for at least 1,500 years.Citrus plants,with a seed-to-seed cycle of 5–15 years,are among the fruit crops that were pr...Grafting is an ancient technique used for plant propagation and improvement in horticultural crops for at least 1,500 years.Citrus plants,with a seed-to-seed cycle of 5–15 years,are among the fruit crops that were probably domesticated by grafting.Poncirus trifoliata,a widely used citrus rootstock,can promote early flowering,strengthen stress tolerance,and improve fruit quality via scion–rootstock interactions.Here,we report its genome assembly using PacBio sequencing.We obtained a final genome of 303 Mb with a contig N50 size of 1.17Mb and annotated 25,680 protein-coding genes.DNA methylome and transcriptome analyses indicated that the strong adaptability of P.trifoliata is likely attributable to its special epigenetic modification and expression pattern of resistance-related genes.Heterografting by using sweet orange as scion and P.trifoliata as rootstock and autografting using sweet orange as both scion and rootstock were performed to investigate the genetic effects of the rootstock.Single-base methylome analysis indicated that P.trifoliata as a rootstock caused DNA demethylation and a reduction in 24-nt small RNAs(sRNAs)in scions compared to the level observed with autografting,implying the involvement of sRNA-mediated graft-transmissible epigenetic modifications in citrus grafting.Taken together,the assembled genome for the citrus rootstock and the analysis of graft-induced epigenetic modifications provide global insights into the genetic effects of rootstock–scion interactions and grafting biology.展开更多
Bulked-segregant analysis is a time-and cost-saving strategy for identifying major quantitative trait loci(QTL) in a mapping population. Bulked-segregant analysis combined with whole-genome sequencing(BSA-seq) was per...Bulked-segregant analysis is a time-and cost-saving strategy for identifying major quantitative trait loci(QTL) in a mapping population. Bulked-segregant analysis combined with whole-genome sequencing(BSA-seq) was performed to rapidly identify QTL for heading date, plant height, and panicle length in a large F_(2) population derived from two landraces: Chuan 7(C7) and Haoboka(HBK). Twenty plants with extremely low or high phenotypic values for the target traits were selected from an F_(2) population of 940 plants to construct low-and high-value bulks. Three pairs of bulks for the three traits were constructed, resulting in six DNA pools. BSA-seq revealed nine QTL: four for heading date, three for plant height, and two for panicle length. These QTL were validated in a random F_(2) population or BC_(4)F_(2) populations. The major novel plant height QTL, qPH8, acting additively with an effect equivalent to that of semi-dwarf 1(sd1), is potentially valuable for hybrid rice breeding. qPH8 controls mainly the elongation of basal internodes. The C7 allele of qPH8 reduces plant height and increases lodging resistance without yield penalty, suggesting a potential role for qPH8 in improving rice plant architecture.展开更多
The intersection of the Kyushu-Palau Ridge(KPR)and the Central Basin Rift(CBR)of the West Philippine Basin(WPB)is a relic of a trench-trench-rift(TTR)type triple-junction,which preserves some pivotal information on th...The intersection of the Kyushu-Palau Ridge(KPR)and the Central Basin Rift(CBR)of the West Philippine Basin(WPB)is a relic of a trench-trench-rift(TTR)type triple-junction,which preserves some pivotal information on the cessation of the seafloor spreading of the WPB,the emplacement and disintegration of the proto-Izu-Bonin-Mariana(IBM)Arc,and the transition from initial rifting to steady-state spreading of the Parece Vela Basin(PVB).However,the structural characteristics of this triple-junction have not been thoroughly understood.In this paper,using the newly acquired multi-beam bathymetric,gravity,and magnetic data obtained by the Qingdao Institute of Marine Geology,China Geological Survey,the authors depict the topographic,gravity,and magnetic characteristics of the triple-junction and adjacent region.Calculations including the upward continuations and total horizontal derivatives of gravity anomaly are also performed to highlight the major structural features and discontinuities.Based on these works,the morphological and structural features and their formation mechanisms are analyzed.The results show that the last episode amagmatic extension along the CBR led to the formation of a deep rift valley,which extends eastward and incised the KPR.The morphological and structural fabrics of the KPR near and to the south of the triple-junction are consistent with those of the western PVB,manifesting as a series of NNE-SSW-and N-S-trending ridges and troughs,which were produced by the extensional faults associated with the initial rifting of the PVB.The superposition of the above two reasons induced the prominent discontinuity of the KPR in deep and shallow crustal structures between 15°N‒15°30′N and 13°30′N‒14°N.Combined with previous authors’results,we propose that the stress produced by the early spreading of the PVB transmitted westward and promoted the final stage amagmatic extension of the CBR.The eastward propagation of the CBR destroyed the KPR,of which the magmatism had decayed or ceased at that time.The destruction mechanism of the KPR associated with the rifting of the PVB varies along strike the KPR.Adjacent to the triple-junction,the KPR was destroyed mainly due to the oblique intersection of the PVB rifting center.Whereas south of the triple-junction,the KPR was destroyed by the E-W-directional extensional faulting on its whole width.展开更多
BACKGROUND As an emerging potential risk factor for gastric cancer,autoimmune gastritis(AIG)has garnered increasing attention from researchers.AIM To analyze the research overview and popular topics in the field of AI...BACKGROUND As an emerging potential risk factor for gastric cancer,autoimmune gastritis(AIG)has garnered increasing attention from researchers.AIM To analyze the research overview and popular topics in the field of AIG using bibliometrics.METHODS Relevant publications on AIG in the Web of Science Core Collection were collated,and data visualization and analysis of the number of publications,countries,institutions,journals,authors,keywords,and citations were performed using software such as VOSviewer,CiteSpace,and Scimago Graphic.RESULTS In total,316 relevant articles were included in the analysis.From 2015 to 2022,the number of publications increased annually.The countries,institutions,authors,and journals with the highest number of publications in this field were Italy,Monash University,Toh BH,and Internal Medicine.The main keywords used in this field of research were pathogenesis,Helicobacter pylori,autoantibody,parietal cell antibody,atrophic gastritis,classification,diagnosis,autoimmune disease,risk,cancer,gastric cancer,vitamin B12 deficiency,and pernicious anemia.The following directions may be popular for future research:(1)The role of Helicobacter pylori in the pathogenesis of AIG;(2)diagnostic criteria for AIG and reference values for serum antibodies;(3)comorbidity mechanisms between AIG and other autoimmune diseases;(4)specific risks of AIG complicating gastric and other cancers;and(5)the role of vitamin B12 supplementation in patients with early-stage AIG.CONCLUSION This bibliometric analysis reported on popular topics and emerging trends in AIG,with diagnosis and prognosis being research hotspots in this field.展开更多
Dear Editor,This letter presents a multi-automated guided vehicles(AGV) routing planning method based on deep reinforcement learning(DRL)and recurrent neural network(RNN), specifically utilizing proximal policy optimi...Dear Editor,This letter presents a multi-automated guided vehicles(AGV) routing planning method based on deep reinforcement learning(DRL)and recurrent neural network(RNN), specifically utilizing proximal policy optimization(PPO) and long short-term memory(LSTM).展开更多
Nowadays,massive amounts of data have been accumulated in various and wide fields,it has become today one of the central issues in interdisciplinary fields to analyze existing data and extract as much useful informati...Nowadays,massive amounts of data have been accumulated in various and wide fields,it has become today one of the central issues in interdisciplinary fields to analyze existing data and extract as much useful information as possible from data.It is often that the output data of systems are measurable while dynamic structures producing these data are hidden,and thus studies to reveal system structures by analyzing available data,i.e.,reconstructions of systems become one of the most important tasks of information extractions.In the past,most of the works in this respect were based on theoretical analyses and numerical verifications.Direct analyses of experimental data are very rare.In physical science,most of the analyses of experimental setups were based on the first principles of physics laws,i.e.,so-called top-down analyses.In this paper,we conducted an experiment of"Boer resonant instrument for forced vibration"(BRIFV)and inferred the dynamic structure of the experimental set purely from the analysis of the measurable experimental data,i.e.,by applying the bottom-up strategy.Dynamics of the experimental set is strongly nonlinear and chaotic,and it's subjects to inevitable noises.We proposed to use high-order correlation computations to treat nonlinear dynamics;use two-time correlations to treat noise effects.By applying these approaches,we have successfully reconstructed the structure of the experimental setup,and the dynamic system reconstructed with the measured data reproduces good experimental results in a wide range of parameters.展开更多
Golden eagle optimizer(GEO)is a recently introduced nature-inspired metaheuristic algorithm,which simulates the spiral hunting behavior of golden eagles in nature.Regrettably,the GEO suffers from the challenges of low...Golden eagle optimizer(GEO)is a recently introduced nature-inspired metaheuristic algorithm,which simulates the spiral hunting behavior of golden eagles in nature.Regrettably,the GEO suffers from the challenges of low diversity,slow iteration speed,and stagnation in local optimization when dealing with complicated optimization problems.To ameliorate these deficiencies,an improved hybrid GEO called IGEO,combined with Lévy flight,sine cosine algorithm and differential evolution(DE)strategy,is developed in this paper.The Lévy flight strategy is introduced into the initial stage to increase the diversity of the golden eagle population and make the initial population more abundant;meanwhile,the sine-cosine function can enhance the exploration ability of GEO and decrease the possibility of GEO falling into the local optima.Furthermore,the DE strategy is used in the exploration and exploitation stage to improve accuracy and convergence speed of GEO.Finally,the superiority of the presented IGEO are comprehensively verified by comparing GEO and several state-of-the-art algorithms using(1)the CEC 2017 and CEC 2019 benchmark functions and(2)5 real-world engineering problems respectively.The comparison results demonstrate that the proposed IGEO is a powerful and attractive alternative for solving engineering optimization problems.展开更多
As a late endosomal/lysosomal transport protein of the P5-type, ATP13A2 is capable of removing the abnormal accumulation of α-synuclein, which maintains the homeostasis of metal ions and polyamines in the central ner...As a late endosomal/lysosomal transport protein of the P5-type, ATP13A2 is capable of removing the abnormal accumulation of α-synuclein, which maintains the homeostasis of metal ions and polyamines in the central nervous system. Furthermore, ATP13A2 regulates the normal function of several organelles such as lysosomes, endoplasmic reticulum (ER) and mitochondria, and maintains the normal physiological activity of neural cells. Especially, ATP13A2 protects dopaminergic (DA) neurons against environmental or genetically induced Parkinson's disease (PD). As we all know, PD is a neurodegenerative disease characterized by the loss of DA neurons in the substantia nigra pars compacta. An increasing number of studies have reported that the loss-of- function of ATP13A2 affects normal physiological processes of various organelles, leading to abnormalities and the death of DA neurons. Previous studies in our laboratory have also shown that ATP13A2 deletion intensifies the neuroinflammatory response induced by astrocytes, thus inducing DA neuronal injury. In addition to elucidating the normal structure and function of ATP13A2, this review summarized the pathological mechanisms of ATP13A2 mutations leading to PD in existing literature studies, deepening the understanding of ATP13A2 in the pathological process of PD and other related neurodegenerative diseases. This review provides inspiration for investigators to explore the essential regulatory role of ATP13A2 in PD in the future.展开更多
基金This paper is funded by the National Special Program of China Geological Survey(DD20191002,DD20191003)。
文摘The Philippine Sea is the largest marginal sea in the Western Pacific Ocean and is divided into two parts by the Kyushu-Palau Ridge(KPR).The western part is the West Philippine Basin,and the eastern part consists of the Shikoku and Parece Vela basins.Based on surveyed data of massive high-resolution multibeam bathymetric data and sub-bottom profiles data collected from the southern section of the KPR from 2018 to 2021,this paper analyzes the topographic and geomorphological features,shallow sedimentary features,and tectonic genesis of the southern section of the KPR,obtaining the following conclusions.The southern section of the KPR has complex and rugged topography,with positive and negative topography alternatingly distributed and a maximum height difference of 4086 m.The slope of seamounts in this section generally exceeds 10°and is up to a maximum of 59°.All these contribute noticeably discontinuous topography.There are primarily nine geomorphological types in the southern section of the KPR,including seamounts,ridges,and intermontane valleys,etc.Among them,seven independent seamount groups are divided by five large troughs,forming an overall geomorphological pattern of seven abyssal seamount groups and five troughs.This reflects the geomorphological features of a deep oceanic ridge.Intramontane basins and intermontane valleys in the southern section of the KPR are covered by evenly thick sediments.In contrast,sediments in ridges and seamounts in this section are thin or even missing,with slumps developing locally.Therefore,the sediments are discontinuous and unevenly developed.The KPR formed under the control of tectonism such as volcanic activities and plate movements.In addition,exogenic forces such as underflow scouring and sedimentation also play a certain role in shaping seafloor landforms in the KPR.
基金financially supported by the Taishan Scholars Program of Shandong Province(No.tsqn202103051)the Science and Technology Project of Xinjiang Bingtuan Supported by the Central Government(No.2022BC001)the Project of Scientific Research in Shihezi University(No.CXFZ202205)。
文摘In this paper,low-temperature dielectric-blocked discharge plasma(DBD)was employed for the first time to treat silica-doped H_(4)PMo_(11)VO_(40)(HPAV)catalysts(DBD(Ar/x)-MF-Catal)and apply them in the catalytic methacrolein(MAL)selective oxidation to produce methacrylic acid(MAA).This work investigates in detail the controllable regulation of the concentration of oxidation states on silica-doped HPAV catalysts by adjusting the DBD discharge with controlled changes in voltage,current,treatment time,and treatment medium.It reports the intrinsic correlation between oxidation states and MAL oxidation performance.The research results indicated that the catalytic performance was related to the presence of oxygen vacancies and oxygen species(VO^(2+)),and are the main reason for the selective oxidation of MAL to MAA.Besides,the generation of oxygen vacancies and VO^(2+)altered localized electrons,which resulted in the easier activation of O_(2).Theoretical calculations of DFT also proved the formation mechanism of oxygen vacancies and VO^(2+)and electron properties on high-performance polymers,which elucidated the intrinsic influence of catalyst components.The DBD(Ar/10)-MF-Catal catalysts with suitable VO^(2+)and oxygen vacancy concentrations exhibited the highest catalytic performance with 90%MAL conversion and 70%MAA selectivity and showed good stability(500 h).
基金Supported by the National Natural Science Foundation of China,No.82072732.
文摘BACKGROUND Endoscopy allows for the direct observation of primary tumor characteristics and responses after neoadjuvant treatment.However,reports on endoscopic evaluation following neoadjuvant immunotherapy remain limited.AIM To examine the predictive value of endoscopic findings of primary tumors for responses to neoadjuvant immunotherapy.METHODS This retrospective study,conducted at a tertiary center in China,evaluated 74 patients with colorectal cancer,including 17 with deficient mismatch repair(dMMR)and 15 with proficient mismatch repair(pMMR)tumors.Patients underwent neoadjuvant immunotherapy followed by surgery.Endoscopic findings before and after neoadjuvant immunotherapy were reviewed and compared with the pathology of the resected specimens.RESULTS In the pMMR group(n=57 evaluable patients),endoscopy identified 11/17 patients who achieved a complete response(CR),while misidentifying 1/40 patients with residual disease as CR(64.7%vs 2.5%,P<0.01).Conversely,22/40 patients with residual disease were accurately identified as achieving a partial response(PR),with 1/17 patients who achieved CR misclassified as PR(55.0%vs 5.9%,P<0.01).The sensitivity,specificity,and accuracy of endoscopic diagnosis for pathological CR were 64.7%,97.5%,and 87.7%,respectively.In the dMMR cohort,endoscopy classified 9/17 patients as CR and 2 of the remaining patients with residual tumors as PR(64.3%vs 66.7%,P=0.73).The method demonstrated 100%sensitivity and 82.4%accuracy in diagnosing pathological CR.CONCLUSION Endoscopic evidence of CR or PR was well correlated with postoperative pathological outcomes in the pMMR cohort.Despite endoscopic indications of tumor residue,a complete pathological response post-surgery was possible in the dMMR cohort.
基金supported by the Fundamental Research Funds for the Central Universities of China(No.300102122105)the Natural Science Basic Research Plan in Shaanxi Province of China(2023-JC-YB-023).
文摘Feature selection(FS)is essential in machine learning(ML)and data mapping by its ability to preprocess high-dimensional data.By selecting a subset of relevant features,feature selection cuts down on the dimension of the data.It excludes irrelevant or surplus features,thus boosting the performance and efficiency of the model.Particle Swarm Optimization(PSO)boasts a streamlined algorithmic framework and exhibits rapid convergence traits.Compared with other algorithms,it incurs reduced computational expenses when tackling high-dimensional datasets.However,PSO faces challenges like inadequate convergence precision.Therefore,regarding FS problems,this paper presents a binary version enhanced PSO based on the Support Vector Machines(SVM)classifier.First,the Sand Cat Swarm Optimization(SCSO)is added to enhance the global search capability of PSO and improve the accuracy of the solution.Secondly,the Latin hypercube sampling strategy initializes populations more uniformly and helps to increase population diversity.The last is the roundup search strategy introducing the grey wolf hierarchy idea to help improve convergence speed.To verify the capability of Self-adaptive Cooperative Particle Swarm Optimization(SCPSO),the CEC2020 test suite and CEC2022 test suite are selected for experiments and applied to three engineering problems.Compared with the standard PSO algorithm,SCPSO converges faster,and the convergence accuracy is significantly improved.Moreover,SCPSO’s comprehensive performance far exceeds that of other algorithms.Six datasets from the University of California,Irvine(UCI)database were selected to evaluate SCPSO’s effectiveness in solving feature selection problems.The results indicate that SCPSO has significant potential for addressing these problems.
基金supported by the Taishan Scholars Program of Shandong Province(tsqn202103051)Tianshan Talents Training Program of Xinjiang(Science and Technology Innovation Team,2022TSYCTD0021)+2 种基金the Science and Technology Project of Xinjiang Bingtuan Supported by Central Government(2022BC001)the project of scientific research in Shihezi University(CXFZ202205)special funds for over provincial level leading talent of Yantai City.
文摘In this study,a catalyst was synthesized using a two-step in-situ molecular beam epitaxy method to grow H_(4)PMo_(11)VO_(40)(HPAV)on amination-treated SiO_(2) nanoparticles,which served as both dopant and host agents.SiO_(2) dopant was modified with(3-aminopropyl)triethoxysilane(APTS),facilitating the formation of ammonium ions that enhanced the overall positive charge.This modification enabled the effective dispersion and exposure of HPAV's active species and induced a structural transformation of HPAV from a triclinic to a cubic crystal phase.The two-step hosting growth process optimized the proportions of Cs^(+),H^(+)and NH_(4)^(+)antinuclear ions,thereby fine-tuning the synergistic catalysis of oxidation and acidity,as well as the oxidative sensitivity at HPAV catalytic interface.The resultant 8(HPAV)&4(Cs_(3)PAV)-NH_(2)-SiO_(2) catalyst achieved a methacrolein(MAL)conversion rate of 84%and a methacrylic acid(MAA)selectivity of 71%.Even after 10.5 h of reaction time,the catalyst retained its high dispersion,cubic crystal structure,and Keggin configuration,demonstrating stable catalytic performance over a continuous 200-h reaction period.
基金Supported by Beijing Natural Science Foundation,No.L222054 and No.4232058.
文摘BACKGROUND Diverting stoma(DS)is routinely proposed in intersphincteric resection for ultra-low rectal cancer,but it is associated with increased stoma-related complications and economic burden.Appropriate patient selection and operative strategies to avoid stoma formation need further elucidation.METHODS This study enrolled 505 consecutive patients,including 84 who underwent stoma-free(SF)intersphincteric resection.After matching,patients were divided into SF(n=78)and DS(n=78)groups.The primary endpoint was the anastomotic leakage(AL)rate within 6 months and its protective factors for both the total and SF cohorts.The secondary endpoints included overall survival and disease-free survival.RESULTS The AL rate was greater in the SF group than in the DS group(12.8%vs 2.6%,P=0.035).Male sex[(odds ratio(OR)=2.644,P=0.021],neoadjuvant chemoradiotherapy(nCRT)(OR=6.024,P<0.001),and tumor height from the anal verge≤4 cm(OR=4.160,P=0.007)were identified as independent risk factors.Preservation of the left colic artery(LCA)was protective in both the total cohort(OR=0.417,P=0.013)and the SF cohort(OR=0.312,P=0.027).The female patients who did not undergo nCRT and had preservation of the LCA experienced a significantly lower incidence of AL(2/97,2.1%).The 3-year overall survival or disease-free survival did not significantly differ be-tween the groups.CONCLUSION Female patients who do not receive nCRT may avoid the need for DS by preserving the LCA without increasing the risk of AL or compromising oncological outcomes.
基金The 2024 Northwest University Graduate Innovation Project“Research on the Public Diplomacy Policy of the United States towards North Africa in the Post 9/11 Era and Its Image Shaping of the United States”(2000 present)(CX2024078)。
文摘With the advancement of information technology,the digital transformation of higher education has become a global trend in educational reform.Egypt has propelled the modernization of its higher education system through digital means,focusing on enhancing teachers’digital teaching capabilities,improving course quality,and establishing a policy environment that supports digital instruction.The driving forces behind Egypt’s transformation include meeting the demand for skilled talent due to economic reforms,participating in internationalization processes,and the impetus provided by public diplomacy.By introducing high-quality international resources,deepening scientific research collaboration,and applying digital technologies,Egypt has effectively alleviated issues of resource insufficiency and uneven development,thereby enhancing its capacity for higher education quality assurance.Egypt’s practice demonstrates that digitalization is a key pathway for developing countries to improve the quality of higher education,providing valuable insights for constructing sustainable models of higher education development.
基金Danone (Shanghai) Consulting Co.Ltd115 national science and technology program
文摘AIM: To investigate the effect of a fermented milk containing Bifidobacterium lactis DN-173010 and yogurt strains (BIO) on adult women with constipation in Beijing.METHODS: A total of 135 adult females with constipation were randomly allocated to consume for 2 wk either 100 g of the test fermented milk or 100 g of an acidified milk containing non-living bacteria (control).Stool frequency,defecation condition scores,stool consistency and food intake were recorded at baseline and after 1 and 2 wk in an intention-to-treat population of 126 subjects.In parallel,safety evaluation parameters were performed.RESULTS: At baseline,no differences were found between groups.Following consumption of test product,stool frequency was significantly increased after 1 wk (3.5 ± 1.5 vs 2.4 ± 0.6,P < 0.01) and 2 wk (4.1 ± 1.7 vs 2.4 ± 0.6,P < 0.01),vs baseline.Similarly,after 1 and 2 wk,of test product consumption,defecation condition (1.1 ± 0.9 vs 1.9 ± 1.2,P < 0.01 and 0.8 ± 1.0 vs 1.9 ± 1.2,P < 0.01,respectively) and stool consistency (1.0 ± 0.8 vs 1.5 ± 1.1,P < 0.01 and 0.6 ± 0.8 vs 1.5 ± 1.1,P < 0.01,respectively) were significantly improved.Compared with the control group,stool frequency was also significantly increased (3.5 ± 1.5 vs 2.5 ± 0.9,P < 0.01 and 4.1 ± 1.7 vs 2.6 ± 1.0,P < 0.01,respectively),and defecation condition (1.1 ± 0.9 vs 1.6 ± 1.1,P < 0.01 and 0.8 ± 1.0 vs 1.6 ± 1.1,P < 0.01,respectively) and stool consistency (1.0 ± 0.8 vs 1.4 ± 1.0,P < 0.05 and 0.6 ± 0.8 vs 1.3 ± 1.0,P < 0.01,respectively) significantly decreased after 1 and 2 wk of product consumption.During the same period,food intake did not change between the two groups,and safety parameters of the subjects were within normal ranges.CONCLUSION: This study suggests a beneficial effect of a fermented milk containing B.lactis DN-173010 on stool frequency,defecation condition and stool consistency in adult women with constipation constipated women after 1 and 2 wk of consumption.
基金financially supported by National Natural Science Foundation of China (31870462)National Key Research & Development Program of China (2016YFC0502304 and 2016YFC0502101)
文摘The properties of woody debris(WD) vary across different forests under various soil conditions.Owing to the relatively shallow and low amounts of soils on karst terrains, it is necessary to determine the WD carbon inventory of karst forests. In this study, we recorded WD with a basal diameter for standing snags and the largeend diameter for fallen logs of ≥ 1 cm. The carbon density of WD in a secondary karst mixed evergreen and deciduous broad-leaved forest that had been clear-cut 55 years ago in southwestern China were inventoried in a 2 ha plot. Woody debris carbon density calculated using specific gravity and carbon concentration was 4.07 Mg C ha^-1. Woody debris with diameters ≥ 10 cm(coarse WD) constituted 53.8% of total carbon storage whereas WD < 10 cm in diameters(fine WD) accounted for more pieces of WD(89.9%).Lithocarpus confinis contributed the most WD carbon(26.5%). Intermediate decayed WD was relatively more abundant, but WD with final decay contributed the least to the total pieces of WD(6.7%). The contribution of WD to carbon storage of karst forest was low compared to other forests worldwide. Significant positive correlations were found between WD carbon and biodiversity(R^2= 0.035,p < 0.01) and elevation(R^2= 0.047, p < 0.01) and negative correlations was found in outcrop coverage(R^2= 0.034, p <0.01). Further studies are needed to elucidate the ecological functions of WD to better understand their roles in maintaining biodiversity, enhancing productivity, and controlling vegetation degradation in karst forest ecosystems.
基金supported by the National Natural Science Foundation of China (Grant No.51875454).
文摘This paper presents an efficient enhanced snake optimizer termed BEESO for global optimization and engineering applications.As a newly mooted meta-heuristic algorithm,snake optimizer(SO)mathematically models the mating characteristics of snakes to find the optimal solution.SO has a simple structure and offers a delicate balance between exploitation and exploration.However,it also has some shortcomings to be improved.The proposed BEESO consequently aims to lighten the issues of lack of population diversity,convergence slowness,and the tendency to be stuck in local optima in SO.The presentation of Bi-Directional Search(BDS)is to approach the global optimal value along the direction guided by the best and the worst individuals,which makes the convergence speed faster.The increase in population diversity in BEESO benefits from Modified Evolutionary Population Dynamics(MEPD),and the replacement of poorer quality individuals improves population quality.The Elite Opposition-Based Learning(EOBL)provides improved local exploitation ability of BEESO by utilizing solid solutions with good performance.The performance of BEESO is illustrated by comparing its experimental results with several algorithms on benchmark functions and engineering designs.Additionally,the results of the experiment are analyzed again from a statistical point of view using the Friedman and Wilcoxon rank sum tests.The findings show that these introduced strategies provide some improvements in the performance of SO,and the accuracy and stability of the optimization results provided by the proposed BEESO are competitive among all algorithms.To conclude,the proposed BEESO offers a good alternative to solving optimization issues.
基金the National Key Research and Development Program of China(2018YFD1000101)the National Natural Science Foundation of China(31925034 and 31872052)the National Postdoctoral Program for Innovative Talents(BX20200146)。
文摘Grafting is an ancient technique used for plant propagation and improvement in horticultural crops for at least 1,500 years.Citrus plants,with a seed-to-seed cycle of 5–15 years,are among the fruit crops that were probably domesticated by grafting.Poncirus trifoliata,a widely used citrus rootstock,can promote early flowering,strengthen stress tolerance,and improve fruit quality via scion–rootstock interactions.Here,we report its genome assembly using PacBio sequencing.We obtained a final genome of 303 Mb with a contig N50 size of 1.17Mb and annotated 25,680 protein-coding genes.DNA methylome and transcriptome analyses indicated that the strong adaptability of P.trifoliata is likely attributable to its special epigenetic modification and expression pattern of resistance-related genes.Heterografting by using sweet orange as scion and P.trifoliata as rootstock and autografting using sweet orange as both scion and rootstock were performed to investigate the genetic effects of the rootstock.Single-base methylome analysis indicated that P.trifoliata as a rootstock caused DNA demethylation and a reduction in 24-nt small RNAs(sRNAs)in scions compared to the level observed with autografting,implying the involvement of sRNA-mediated graft-transmissible epigenetic modifications in citrus grafting.Taken together,the assembled genome for the citrus rootstock and the analysis of graft-induced epigenetic modifications provide global insights into the genetic effects of rootstock–scion interactions and grafting biology.
基金partially supported by the National Natural Science Foundation of China(31701391)the National Key Laboratory of Crop Genetic Improvement Self-Research Program(ZW18B0101)。
文摘Bulked-segregant analysis is a time-and cost-saving strategy for identifying major quantitative trait loci(QTL) in a mapping population. Bulked-segregant analysis combined with whole-genome sequencing(BSA-seq) was performed to rapidly identify QTL for heading date, plant height, and panicle length in a large F_(2) population derived from two landraces: Chuan 7(C7) and Haoboka(HBK). Twenty plants with extremely low or high phenotypic values for the target traits were selected from an F_(2) population of 940 plants to construct low-and high-value bulks. Three pairs of bulks for the three traits were constructed, resulting in six DNA pools. BSA-seq revealed nine QTL: four for heading date, three for plant height, and two for panicle length. These QTL were validated in a random F_(2) population or BC_(4)F_(2) populations. The major novel plant height QTL, qPH8, acting additively with an effect equivalent to that of semi-dwarf 1(sd1), is potentially valuable for hybrid rice breeding. qPH8 controls mainly the elongation of basal internodes. The C7 allele of qPH8 reduces plant height and increases lodging resistance without yield penalty, suggesting a potential role for qPH8 in improving rice plant architecture.
基金This study was funded by the projects initiated by the China Geological Survey(DD20191003,DD20190236 and DD20190205).
文摘The intersection of the Kyushu-Palau Ridge(KPR)and the Central Basin Rift(CBR)of the West Philippine Basin(WPB)is a relic of a trench-trench-rift(TTR)type triple-junction,which preserves some pivotal information on the cessation of the seafloor spreading of the WPB,the emplacement and disintegration of the proto-Izu-Bonin-Mariana(IBM)Arc,and the transition from initial rifting to steady-state spreading of the Parece Vela Basin(PVB).However,the structural characteristics of this triple-junction have not been thoroughly understood.In this paper,using the newly acquired multi-beam bathymetric,gravity,and magnetic data obtained by the Qingdao Institute of Marine Geology,China Geological Survey,the authors depict the topographic,gravity,and magnetic characteristics of the triple-junction and adjacent region.Calculations including the upward continuations and total horizontal derivatives of gravity anomaly are also performed to highlight the major structural features and discontinuities.Based on these works,the morphological and structural features and their formation mechanisms are analyzed.The results show that the last episode amagmatic extension along the CBR led to the formation of a deep rift valley,which extends eastward and incised the KPR.The morphological and structural fabrics of the KPR near and to the south of the triple-junction are consistent with those of the western PVB,manifesting as a series of NNE-SSW-and N-S-trending ridges and troughs,which were produced by the extensional faults associated with the initial rifting of the PVB.The superposition of the above two reasons induced the prominent discontinuity of the KPR in deep and shallow crustal structures between 15°N‒15°30′N and 13°30′N‒14°N.Combined with previous authors’results,we propose that the stress produced by the early spreading of the PVB transmitted westward and promoted the final stage amagmatic extension of the CBR.The eastward propagation of the CBR destroyed the KPR,of which the magmatism had decayed or ceased at that time.The destruction mechanism of the KPR associated with the rifting of the PVB varies along strike the KPR.Adjacent to the triple-junction,the KPR was destroyed mainly due to the oblique intersection of the PVB rifting center.Whereas south of the triple-junction,the KPR was destroyed by the E-W-directional extensional faulting on its whole width.
基金Supported by National Natural Science Foundation of China,NO.U21A20411.
文摘BACKGROUND As an emerging potential risk factor for gastric cancer,autoimmune gastritis(AIG)has garnered increasing attention from researchers.AIM To analyze the research overview and popular topics in the field of AIG using bibliometrics.METHODS Relevant publications on AIG in the Web of Science Core Collection were collated,and data visualization and analysis of the number of publications,countries,institutions,journals,authors,keywords,and citations were performed using software such as VOSviewer,CiteSpace,and Scimago Graphic.RESULTS In total,316 relevant articles were included in the analysis.From 2015 to 2022,the number of publications increased annually.The countries,institutions,authors,and journals with the highest number of publications in this field were Italy,Monash University,Toh BH,and Internal Medicine.The main keywords used in this field of research were pathogenesis,Helicobacter pylori,autoantibody,parietal cell antibody,atrophic gastritis,classification,diagnosis,autoimmune disease,risk,cancer,gastric cancer,vitamin B12 deficiency,and pernicious anemia.The following directions may be popular for future research:(1)The role of Helicobacter pylori in the pathogenesis of AIG;(2)diagnostic criteria for AIG and reference values for serum antibodies;(3)comorbidity mechanisms between AIG and other autoimmune diseases;(4)specific risks of AIG complicating gastric and other cancers;and(5)the role of vitamin B12 supplementation in patients with early-stage AIG.CONCLUSION This bibliometric analysis reported on popular topics and emerging trends in AIG,with diagnosis and prognosis being research hotspots in this field.
基金supported by the National Natural Science Foundation of China (62202352,61902039,61972300)the Basic and Applied Basic Research Program of Guangdong Province (2021A1515110518)the Key Research and Development Program of Shaanxi Province (2020ZDLGY09-04)。
文摘Dear Editor,This letter presents a multi-automated guided vehicles(AGV) routing planning method based on deep reinforcement learning(DRL)and recurrent neural network(RNN), specifically utilizing proximal policy optimization(PPO) and long short-term memory(LSTM).
文摘Nowadays,massive amounts of data have been accumulated in various and wide fields,it has become today one of the central issues in interdisciplinary fields to analyze existing data and extract as much useful information as possible from data.It is often that the output data of systems are measurable while dynamic structures producing these data are hidden,and thus studies to reveal system structures by analyzing available data,i.e.,reconstructions of systems become one of the most important tasks of information extractions.In the past,most of the works in this respect were based on theoretical analyses and numerical verifications.Direct analyses of experimental data are very rare.In physical science,most of the analyses of experimental setups were based on the first principles of physics laws,i.e.,so-called top-down analyses.In this paper,we conducted an experiment of"Boer resonant instrument for forced vibration"(BRIFV)and inferred the dynamic structure of the experimental set purely from the analysis of the measurable experimental data,i.e.,by applying the bottom-up strategy.Dynamics of the experimental set is strongly nonlinear and chaotic,and it's subjects to inevitable noises.We proposed to use high-order correlation computations to treat nonlinear dynamics;use two-time correlations to treat noise effects.By applying these approaches,we have successfully reconstructed the structure of the experimental setup,and the dynamic system reconstructed with the measured data reproduces good experimental results in a wide range of parameters.
基金National Natural Science Foundation of China(Grant No.51875454).
文摘Golden eagle optimizer(GEO)is a recently introduced nature-inspired metaheuristic algorithm,which simulates the spiral hunting behavior of golden eagles in nature.Regrettably,the GEO suffers from the challenges of low diversity,slow iteration speed,and stagnation in local optimization when dealing with complicated optimization problems.To ameliorate these deficiencies,an improved hybrid GEO called IGEO,combined with Lévy flight,sine cosine algorithm and differential evolution(DE)strategy,is developed in this paper.The Lévy flight strategy is introduced into the initial stage to increase the diversity of the golden eagle population and make the initial population more abundant;meanwhile,the sine-cosine function can enhance the exploration ability of GEO and decrease the possibility of GEO falling into the local optima.Furthermore,the DE strategy is used in the exploration and exploitation stage to improve accuracy and convergence speed of GEO.Finally,the superiority of the presented IGEO are comprehensively verified by comparing GEO and several state-of-the-art algorithms using(1)the CEC 2017 and CEC 2019 benchmark functions and(2)5 real-world engineering problems respectively.The comparison results demonstrate that the proposed IGEO is a powerful and attractive alternative for solving engineering optimization problems.
基金The work reported herein was supported by the grants from the National Natural Science Foundation of China(Grant No.81803505)Jiangsu Research Hospital Association for Precision Medication(Grant No.JY202134).
文摘As a late endosomal/lysosomal transport protein of the P5-type, ATP13A2 is capable of removing the abnormal accumulation of α-synuclein, which maintains the homeostasis of metal ions and polyamines in the central nervous system. Furthermore, ATP13A2 regulates the normal function of several organelles such as lysosomes, endoplasmic reticulum (ER) and mitochondria, and maintains the normal physiological activity of neural cells. Especially, ATP13A2 protects dopaminergic (DA) neurons against environmental or genetically induced Parkinson's disease (PD). As we all know, PD is a neurodegenerative disease characterized by the loss of DA neurons in the substantia nigra pars compacta. An increasing number of studies have reported that the loss-of- function of ATP13A2 affects normal physiological processes of various organelles, leading to abnormalities and the death of DA neurons. Previous studies in our laboratory have also shown that ATP13A2 deletion intensifies the neuroinflammatory response induced by astrocytes, thus inducing DA neuronal injury. In addition to elucidating the normal structure and function of ATP13A2, this review summarized the pathological mechanisms of ATP13A2 mutations leading to PD in existing literature studies, deepening the understanding of ATP13A2 in the pathological process of PD and other related neurodegenerative diseases. This review provides inspiration for investigators to explore the essential regulatory role of ATP13A2 in PD in the future.
