This article investigated molybdenum recovery from oxygen pressure water leaching residue of Ni-Mo ore using alkaline leaching, followed by chemical treatment of leach liquor. Parameters affecting Mo leaching rate, su...This article investigated molybdenum recovery from oxygen pressure water leaching residue of Ni-Mo ore using alkaline leaching, followed by chemical treatment of leach liquor. Parameters affecting Mo leaching rate, such as sodium hydroxide concentration, reaction time, a liquid- to-solid ratio, and temperature for the preliminary alkaline leaching were experimentally determined. The results showed that more than 88 % of molybdenum was leached under the optimum conditions （2.5 ml.g-1 NaOH, 80 ℃, a liquid to solid ratio 3 ml.g-1, and reaction time 3 h）. After the purification of leach liquor, a CaMoO4 product of 99.2 % purity could be obtained by CaCla precipitation method. The whole Mo recovery reached about 82.7 %.展开更多
We present a faithful and efficient hyperentanglement purification protocol(hyper-EPP)for nonlocal two-photon systems in spatial-polarization-time-bin hyperentangled Bell states.As the single-photon detectors can dete...We present a faithful and efficient hyperentanglement purification protocol(hyper-EPP)for nonlocal two-photon systems in spatial-polarization-time-bin hyperentangled Bell states.As the single-photon detectors can detect and herald the undesirable properties caused by side leakage and finite coupling strength,the parity-check gates and swap gates of our hyper-EPP in the spatial,polarization and time-bin mode degrees of freedom(DoFs)work faithfully.The qubit-flip errors in photon systems in three DoFs can be corrected effectively with the faithful parity-check gates and the photon pairs can be reused to distill high-fidelity ones by introducing the faithful swap gates,which greatly increases the efficiency of our hyper-EPP.Further,the maximal hyperentanglement can be obtained in principle by operating multiple rounds of the hyper-EPP.展开更多
We present an error-detected hyperparallel Toffoli(hyper-Toffoli)gate for a three-photon system based on the interface between polarized photon and cavity-nitrogen-vacancy(NV)center system.This hyper-Toffoli gate can ...We present an error-detected hyperparallel Toffoli(hyper-Toffoli)gate for a three-photon system based on the interface between polarized photon and cavity-nitrogen-vacancy(NV)center system.This hyper-Toffoli gate can be used to perform double Toffoli gate operations simultaneously on both the polarization and spatial-mode degrees of freedom(DoFs)of a three-photon system with a low decoherence,shorten operation time,and less quantum resources required,in compared with those on two independent three-photon systems in one DoF only.As the imperfect cavity-NVcenter interactions are transformed into the detectable failures rather than infidelity based on the heralding mechanism of detectors,a near-unit fidelity of the quantum hyper-Toffoli gate can be implemented.By recycling the procedures,the efficiency of our protocol for the hyper-Toffoli gate is improved further.Meanwhile,the evaluation of gate performance with achieved experiment parameters shows that it is feasible with current experimental technology and provides a promising building block for quantum compute.展开更多
In recent years,RS and GIS technologies have played an increasingly important role in various aspects of rainfall induced landslide research.In order to systematically understand their application situation,this paper...In recent years,RS and GIS technologies have played an increasingly important role in various aspects of rainfall induced landslide research.In order to systematically understand their application situation,this paper extensively used various visualization analysis technologies for in-depth analysis of 1,161 documents collected by the WOS data platform in the past 27 years by combining quantitative and qualitative methods.Then,this article focuses on sub domain analysis from four aspects:landslide detection and monitoring,prediction models,sensitivity mapping,and risk assessment.The study found that the number of literature in thisfield has steadily increased and is expected to continue to rise.This literature review has attracted widespread attention from the academic community,but it challenging to meet research needs.Frequent and effective cooperationis between countries,institutions,and authors is very beneficial for promoting progress in thisfield.The future development direction is a new intelligent hybrid model that integrates multiple research methods.This study can provide researchers in thisfield with the core research force,hot topic evolution,and future development trends of future rainfall-induced landslides and contribute to landslide prevention and control decision-making and achieving the United Nations’sustainable development goals.展开更多
All-inorganic CsPbBr_(3)perovskite solar cells(PSCs)have attracted more attentions due to the excellent environmental stability,however,the wide bandgap and relatively poor crystallinity of CsPbBr_(3)have been the mai...All-inorganic CsPbBr_(3)perovskite solar cells(PSCs)have attracted more attentions due to the excellent environmental stability,however,the wide bandgap and relatively poor crystallinity of CsPbBr_(3)have been the main obstacle to improve their power conversion efficiency(PCE).Herein,we proposed an efficient and simple strategy of precursor additive in the two-step aqueous-solution method,the resulted CsPbBr_(3)film has achieved more uniform grain size,almost pure perovskite phase,smoother surface,less defects,enhanced light absorption and longer carrier lifetime.This is due to the rapid evaporation of additive(IPA and CH_(3)OH)in the CsBr/H_(2)O precursor leads to a relatively higher local CsBr concentration on the surface of PbBr_(2),which can provide more nucleation sites and accelerate the crystallization of perovskite.Further,when utilizing the optimal additive of 5%(in volume)IPA,the HTM-free carbonbased CsPbBr_(3)PSCs obtained a PCE improvement from 9.09%to 10.29%,and an ultrahigh fill factor(FF)of 85.21%.What is more,by adding 0.1 mol/L PbCl_(2)into the PbBr_(2)solution in the first step,the open circuit voltage of device has increased from 1.36 V to 1.48 V,the champion PCE reached 10.37%(steady output PCE of 10.17%),and the non-encapsulated device could maintain 85%of its initial efficiency after 50 d in the air.This work provides a cost-effective approach to grow CsPbBr_(3)film and boosts the efficiency benchmark of the CsPbBr_(3)PSCs to more than 10%,it is desirable that the highly efficient and stable CsPbBr_(3)PSCs can be developed in future.展开更多
Economists have put forward various proposals to deal with the growing risks of the global reserve currency system. In this paper we recommend that Asian economies hold each other＇s currencies as part of their foreig...Economists have put forward various proposals to deal with the growing risks of the global reserve currency system. In this paper we recommend that Asian economies hold each other＇s currencies as part of their foreign reserves. Different from crisis-fighting currency swap arrangements or crisis-rescuing fund mechanisms, this mechanism means that reserves wouM be held, with a regular arrangement in place and on an ongoing basis. We propose that the global reserve system shouM be pushed in the direction of diversification, which could be a transitional step toward a new single reserve system. This mechanism would not necessitate any currency being a globally accepted reserve currency but would mean that every currency carried some weight in the reserve system. Establishment of such a system would require significant development of regional bond markets and facilitation of macroeconomic surveillance among the economies.展开更多
In responding to a view that attributes sharp downturns in the Chinese economy in late 2008 and early 2009 to the ＂collapse of external demand,＂ the present paper scrutinizes three relevant issues： How have large C...In responding to a view that attributes sharp downturns in the Chinese economy in late 2008 and early 2009 to the ＂collapse of external demand,＂ the present paper scrutinizes three relevant issues： How have large Chinese importers behaved in a demand-price setting？ How have Chinese commodity imports and exports interacted in recent years？ Did the downturns in China＇s export growth come earlier and were they deeper than those in Chinese import growth？ All answers appear to suggest a conclusion contrary to the abovementioned view： sharp downturns in China＇s trade and economy during the reeent global financial crisis were, to a large extent, caused by certain domestic factors, or by factors that should not be regarded as entirely ＂external. ＂ Insomuch as globalization has advanced, a large economy like China＇s today faces new potential sources of macroeeonomic disturbances, from inside and outside.展开更多
Metabolic diseases have become a global health problem.In recent years,increasing attention has been paid to finding effective ways to prevent or improve metabolic diseases from functional foods.The fruit of Phyllanth...Metabolic diseases have become a global health problem.In recent years,increasing attention has been paid to finding effective ways to prevent or improve metabolic diseases from functional foods.The fruit of Phyllanthus emblica(FPE)has been consumed worldwide as a reliable food source,often in the form of sauces,beverages,nutraceuticals,or extracts.Gallic acid(GA)is reported to be the main functional compound of FPE.Currently,FPE and GA have been shown to have multiple health benefits.In this review,we offer a comprehensive summary of the use of FPE and its functional compound GA in improving three metabolic diseases,namely type 2 diabetes mellitus(T2DM),obesity,and nonalcoholic fatty liver disease(NAFLD).The evidence suggests that FPE and GA hold significant potential in managing these three metabolic diseases.They can maintain glucose homeostasis by regulating the PI3K/p-Akt pathway and improve insulin resistance by regulating the PPARγ/AMPK/NF-κB pathway.They inhibit adipogenesis by down-regulating the expression of PPARγ,C/EBPαand FABP4 proteins,and increase energy expenditure by up-regulating the expression of UCP1 and CPT-1A proteins.The information can be utilized to assess the effectiveness and feasibility of FPE and GA as strategies for managing metabolic diseases.It should be noted that human clinical trials of FPE and GA for the three metabolic diseases,especially obesity and NAFLD,are still scarce.More large-scale,long-term,well-designed clinical trials are needed to further confirm the functional benefits and safety of FPE and GA in preventing and improving T2DM,obesity,and NAFLD.展开更多
Orange essential oil(OEO)is an important citrus by-product that has been utilized as a nutritional modulator.In the study,we investigated the effects of limonene,linalool,and decanal(the major components of OEO)on hep...Orange essential oil(OEO)is an important citrus by-product that has been utilized as a nutritional modulator.In the study,we investigated the effects of limonene,linalool,and decanal(the major components of OEO)on hepatic lipid composition and metabolism in high-fat diet(HFD)mice.The results showed that limonene,linalool and decanal treatments alleviated weight gain and dyslipidemia induced by HFD.In addition,compared to the HFD group,hepatic lipids were significantly altered in the treated groups,PIs,PEs and PGs screened as marker metabolites.Furthermore,we found that limonene,linalool and decanal accelerated the oxidation of fatty acids by stimulating of PPAR-α and CPT-1 expression.Therefore,our study can provide theoretical support for aromatics as nutritional regulators.展开更多
Biotransformation of limonene is considered as a promising approach for the production of bioactive compounds.These compounds with excellent aroma characteristics and health benefits,such as perillyl alcohol,carvone,...Biotransformation of limonene is considered as a promising approach for the production of bioactive compounds.These compounds with excellent aroma characteristics and health benefits,such as perillyl alcohol,carvone,andα-terpineol,have great market potential in food,fragrance,cosmetics,pharmaceutical,and agricultural in-dustries.Here,we summarize the products and pathways of limonene biotransformation and highlight the biocatalysts involved in this bioprocess.Numerous microorganisms(e.g.,fungi,bacteria and microalgae),en-zymes isolated from these microorganisms(e.g.,cytochrome P450 enzyme,dehydrogenase,epoxide hydrolase,etc),as well as recombinant cells expressing these enzymes,can degrade and transform limonene into valuable products.Additionally,the extraction and purification of these products from fermentation broth,and their industrial applications are introduced.Finally,the future prospects of limonene biotransformation are discussed.展开更多
Metabolic abnormalities caused by an unbalanced diet(e.g.high fat)are risk factors for human health.Limonene(LIM)is a terpene compound in citrus peel,and there is increasing evidence to support its activity in regulat...Metabolic abnormalities caused by an unbalanced diet(e.g.high fat)are risk factors for human health.Limonene(LIM)is a terpene compound in citrus peel,and there is increasing evidence to support its activity in regulating lipid metabolism.Hence,this study aimed to investigate the effects of LIM(a food source nutrient regulator)on fatty acids(FAs)metabolism.The results showed that LIM alleviated lipid accumulation in serum and liver caused by high fat diet(HFD).Transcriptomic analysis predicted LIM-affected pathways including steroid biosynthesis,peroxisome,PPAR signaling,fatty acid degradation,and glutathione metabolism,which were all involved in FAs metabolism.Therefore,We quantified the genes expression involved in FA metabolism(uptake,synthesis,excretion and oxidation),and found that LIM up-regulatedthe the reduction in FAs uptake and excretion.In addition,LIM reduced de novo lipogenesis(DNL)in cytoplasm and stimulated FAs β-oxidation in mitochondria.Our findings suggested that LIM alleviated hepatic lipid accumulation by inhibiting DNL and stimulating beta-oxidation of FA.These findings showed that LIM has the potential to be a natural nutrient regulator(NR)and play an important role in MD induced by HFD.展开更多
基金supported by the National High Technology Research and Development Program of China(No.2009AA06Z106)Yunnan Provincial Science and Technology Department of China(No.2011GA004)
文摘This article investigated molybdenum recovery from oxygen pressure water leaching residue of Ni-Mo ore using alkaline leaching, followed by chemical treatment of leach liquor. Parameters affecting Mo leaching rate, such as sodium hydroxide concentration, reaction time, a liquid- to-solid ratio, and temperature for the preliminary alkaline leaching were experimentally determined. The results showed that more than 88 % of molybdenum was leached under the optimum conditions （2.5 ml.g-1 NaOH, 80 ℃, a liquid to solid ratio 3 ml.g-1, and reaction time 3 h）. After the purification of leach liquor, a CaMoO4 product of 99.2 % purity could be obtained by CaCla precipitation method. The whole Mo recovery reached about 82.7 %.
基金Project supported by the National Natural Science Foundation of China(Grant No.61901420 and 11604226)the Shanxi Province Science Foundation for Youths(Grant No.201901D211235)+1 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(Grant No.2019L0507)the Program of Beijing Municipal Commission of Education of China(Grant Nos.CIT&TCD201904080 and KM201810028005)。
文摘We present a faithful and efficient hyperentanglement purification protocol(hyper-EPP)for nonlocal two-photon systems in spatial-polarization-time-bin hyperentangled Bell states.As the single-photon detectors can detect and herald the undesirable properties caused by side leakage and finite coupling strength,the parity-check gates and swap gates of our hyper-EPP in the spatial,polarization and time-bin mode degrees of freedom(DoFs)work faithfully.The qubit-flip errors in photon systems in three DoFs can be corrected effectively with the faithful parity-check gates and the photon pairs can be reused to distill high-fidelity ones by introducing the faithful swap gates,which greatly increases the efficiency of our hyper-EPP.Further,the maximal hyperentanglement can be obtained in principle by operating multiple rounds of the hyper-EPP.
基金This work was supported in part by the National Natural Science Foundation of China under Contract 61901420the Shanxi Province Science Foundation for Youths under Contract 201901D211235+1 种基金the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi under Contract 2019L0507the Shanxi“1331 Project”Key Subjects Construction。
文摘We present an error-detected hyperparallel Toffoli(hyper-Toffoli)gate for a three-photon system based on the interface between polarized photon and cavity-nitrogen-vacancy(NV)center system.This hyper-Toffoli gate can be used to perform double Toffoli gate operations simultaneously on both the polarization and spatial-mode degrees of freedom(DoFs)of a three-photon system with a low decoherence,shorten operation time,and less quantum resources required,in compared with those on two independent three-photon systems in one DoF only.As the imperfect cavity-NVcenter interactions are transformed into the detectable failures rather than infidelity based on the heralding mechanism of detectors,a near-unit fidelity of the quantum hyper-Toffoli gate can be implemented.By recycling the procedures,the efficiency of our protocol for the hyper-Toffoli gate is improved further.Meanwhile,the evaluation of gate performance with achieved experiment parameters shows that it is feasible with current experimental technology and provides a promising building block for quantum compute.
基金supported by the National Key R&D Program of China(2019YFC1510700)the Sichuan Science and Technology Program(2023Y FS0380,2023YFS0377,2023NSFSC1989,2022YFS0539).
文摘In recent years,RS and GIS technologies have played an increasingly important role in various aspects of rainfall induced landslide research.In order to systematically understand their application situation,this paper extensively used various visualization analysis technologies for in-depth analysis of 1,161 documents collected by the WOS data platform in the past 27 years by combining quantitative and qualitative methods.Then,this article focuses on sub domain analysis from four aspects:landslide detection and monitoring,prediction models,sensitivity mapping,and risk assessment.The study found that the number of literature in thisfield has steadily increased and is expected to continue to rise.This literature review has attracted widespread attention from the academic community,but it challenging to meet research needs.Frequent and effective cooperationis between countries,institutions,and authors is very beneficial for promoting progress in thisfield.The future development direction is a new intelligent hybrid model that integrates multiple research methods.This study can provide researchers in thisfield with the core research force,hot topic evolution,and future development trends of future rainfall-induced landslides and contribute to landslide prevention and control decision-making and achieving the United Nations’sustainable development goals.
基金the National Natural Science Foundation of China under Grants 62004151,62274126 and 62204189the Special Financial Grant from the China Postdoctoral Science Foundation under Grant 2020T130490+1 种基金Young Talent Fund of Association for Science and Technology in Shaanxi under Grant 20220115Fundamental Research Funds for the National 111 Center.
文摘All-inorganic CsPbBr_(3)perovskite solar cells(PSCs)have attracted more attentions due to the excellent environmental stability,however,the wide bandgap and relatively poor crystallinity of CsPbBr_(3)have been the main obstacle to improve their power conversion efficiency(PCE).Herein,we proposed an efficient and simple strategy of precursor additive in the two-step aqueous-solution method,the resulted CsPbBr_(3)film has achieved more uniform grain size,almost pure perovskite phase,smoother surface,less defects,enhanced light absorption and longer carrier lifetime.This is due to the rapid evaporation of additive(IPA and CH_(3)OH)in the CsBr/H_(2)O precursor leads to a relatively higher local CsBr concentration on the surface of PbBr_(2),which can provide more nucleation sites and accelerate the crystallization of perovskite.Further,when utilizing the optimal additive of 5%(in volume)IPA,the HTM-free carbonbased CsPbBr_(3)PSCs obtained a PCE improvement from 9.09%to 10.29%,and an ultrahigh fill factor(FF)of 85.21%.What is more,by adding 0.1 mol/L PbCl_(2)into the PbBr_(2)solution in the first step,the open circuit voltage of device has increased from 1.36 V to 1.48 V,the champion PCE reached 10.37%(steady output PCE of 10.17%),and the non-encapsulated device could maintain 85%of its initial efficiency after 50 d in the air.This work provides a cost-effective approach to grow CsPbBr_(3)film and boosts the efficiency benchmark of the CsPbBr_(3)PSCs to more than 10%,it is desirable that the highly efficient and stable CsPbBr_(3)PSCs can be developed in future.
文摘Economists have put forward various proposals to deal with the growing risks of the global reserve currency system. In this paper we recommend that Asian economies hold each other＇s currencies as part of their foreign reserves. Different from crisis-fighting currency swap arrangements or crisis-rescuing fund mechanisms, this mechanism means that reserves wouM be held, with a regular arrangement in place and on an ongoing basis. We propose that the global reserve system shouM be pushed in the direction of diversification, which could be a transitional step toward a new single reserve system. This mechanism would not necessitate any currency being a globally accepted reserve currency but would mean that every currency carried some weight in the reserve system. Establishment of such a system would require significant development of regional bond markets and facilitation of macroeconomic surveillance among the economies.
文摘In responding to a view that attributes sharp downturns in the Chinese economy in late 2008 and early 2009 to the ＂collapse of external demand,＂ the present paper scrutinizes three relevant issues： How have large Chinese importers behaved in a demand-price setting？ How have Chinese commodity imports and exports interacted in recent years？ Did the downturns in China＇s export growth come earlier and were they deeper than those in Chinese import growth？ All answers appear to suggest a conclusion contrary to the abovementioned view： sharp downturns in China＇s trade and economy during the reeent global financial crisis were, to a large extent, caused by certain domestic factors, or by factors that should not be regarded as entirely ＂external. ＂ Insomuch as globalization has advanced, a large economy like China＇s today faces new potential sources of macroeeonomic disturbances, from inside and outside.
基金supported by the National Key Research and Development Program of China[grant number 2023YFC3504403]the Research Funding Project for Constructing and Training Doctoral Program of Traditional Chinese Medicine(Tibetan Medicine)in 2023[grant number BSDJS-23-11 and BSDJS-23-01].
文摘Metabolic diseases have become a global health problem.In recent years,increasing attention has been paid to finding effective ways to prevent or improve metabolic diseases from functional foods.The fruit of Phyllanthus emblica(FPE)has been consumed worldwide as a reliable food source,often in the form of sauces,beverages,nutraceuticals,or extracts.Gallic acid(GA)is reported to be the main functional compound of FPE.Currently,FPE and GA have been shown to have multiple health benefits.In this review,we offer a comprehensive summary of the use of FPE and its functional compound GA in improving three metabolic diseases,namely type 2 diabetes mellitus(T2DM),obesity,and nonalcoholic fatty liver disease(NAFLD).The evidence suggests that FPE and GA hold significant potential in managing these three metabolic diseases.They can maintain glucose homeostasis by regulating the PI3K/p-Akt pathway and improve insulin resistance by regulating the PPARγ/AMPK/NF-κB pathway.They inhibit adipogenesis by down-regulating the expression of PPARγ,C/EBPαand FABP4 proteins,and increase energy expenditure by up-regulating the expression of UCP1 and CPT-1A proteins.The information can be utilized to assess the effectiveness and feasibility of FPE and GA as strategies for managing metabolic diseases.It should be noted that human clinical trials of FPE and GA for the three metabolic diseases,especially obesity and NAFLD,are still scarce.More large-scale,long-term,well-designed clinical trials are needed to further confirm the functional benefits and safety of FPE and GA in preventing and improving T2DM,obesity,and NAFLD.
基金supported by the Fundamental Research Funds for the Central Universities(Program No.2662020SPPY002)the Key Research and Development Program in Hubei Province(2020BBA049)Hubei Science and Technology Innovation Talent Program(2023DJC116).
文摘Orange essential oil(OEO)is an important citrus by-product that has been utilized as a nutritional modulator.In the study,we investigated the effects of limonene,linalool,and decanal(the major components of OEO)on hepatic lipid composition and metabolism in high-fat diet(HFD)mice.The results showed that limonene,linalool and decanal treatments alleviated weight gain and dyslipidemia induced by HFD.In addition,compared to the HFD group,hepatic lipids were significantly altered in the treated groups,PIs,PEs and PGs screened as marker metabolites.Furthermore,we found that limonene,linalool and decanal accelerated the oxidation of fatty acids by stimulating of PPAR-α and CPT-1 expression.Therefore,our study can provide theoretical support for aromatics as nutritional regulators.
基金supported by the National Natural Science Founda-tion of China(grant number 32101868)the China Postdoctoral Science Foundation(grant number 2024M760795)+8 种基金the CNTC Research Program(grant number 110202403006)Joint Fund Project of Science and Technology R&D Plan of Henan Province(grant number 242103810080)the Food Engineering Technology Research Center/Key Laboratory of Henan Province,Henan University of Technology(grant number GO202420)Cultivation Programme for Young Backbone Teachers in Henan University of Technology(grant number 21421235)Natural Science Fund of Zhengzhou Science and Technology Bureau(grant number 22ZZRDZX26)Henan University of Technology Post-doctoral Scientific Research Fund(grant number 21450084)Henan Province Key R&D Special Project(grant number 231111111800,251111113400)Henan University of Technology Talent Introduction Fund(grant number 2021BS054)Cultivation Project of Tuoxin Team in Henan University of Technology(grant number 2024TXTD07).
文摘Biotransformation of limonene is considered as a promising approach for the production of bioactive compounds.These compounds with excellent aroma characteristics and health benefits,such as perillyl alcohol,carvone,andα-terpineol,have great market potential in food,fragrance,cosmetics,pharmaceutical,and agricultural in-dustries.Here,we summarize the products and pathways of limonene biotransformation and highlight the biocatalysts involved in this bioprocess.Numerous microorganisms(e.g.,fungi,bacteria and microalgae),en-zymes isolated from these microorganisms(e.g.,cytochrome P450 enzyme,dehydrogenase,epoxide hydrolase,etc),as well as recombinant cells expressing these enzymes,can degrade and transform limonene into valuable products.Additionally,the extraction and purification of these products from fermentation broth,and their industrial applications are introduced.Finally,the future prospects of limonene biotransformation are discussed.
基金supported by Science and Technology Project Plan of China Tobacco Henan Industrial Co.,Ltd.,(AW2024033)Yunnan Science and Technology Program(202304BT090030)+1 种基金Yinchuan Science and Technology Plan Project(YCHT2024103)Hubei Science and Technology Innovation Talent Program(2023DJC116,2024DJC029).
文摘Metabolic abnormalities caused by an unbalanced diet(e.g.high fat)are risk factors for human health.Limonene(LIM)is a terpene compound in citrus peel,and there is increasing evidence to support its activity in regulating lipid metabolism.Hence,this study aimed to investigate the effects of LIM(a food source nutrient regulator)on fatty acids(FAs)metabolism.The results showed that LIM alleviated lipid accumulation in serum and liver caused by high fat diet(HFD).Transcriptomic analysis predicted LIM-affected pathways including steroid biosynthesis,peroxisome,PPAR signaling,fatty acid degradation,and glutathione metabolism,which were all involved in FAs metabolism.Therefore,We quantified the genes expression involved in FA metabolism(uptake,synthesis,excretion and oxidation),and found that LIM up-regulatedthe the reduction in FAs uptake and excretion.In addition,LIM reduced de novo lipogenesis(DNL)in cytoplasm and stimulated FAs β-oxidation in mitochondria.Our findings suggested that LIM alleviated hepatic lipid accumulation by inhibiting DNL and stimulating beta-oxidation of FA.These findings showed that LIM has the potential to be a natural nutrient regulator(NR)and play an important role in MD induced by HFD.
