Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A t...Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A total of 27 patients with pancreatic cancer undergoing chemotherapy at two medical institutions were recruited between November 2023 and August 2024.Semi-structured interviews were conducted in person or over the phone.Data were analyzed using traditional content and thematic analyses.Results:Three themes were identified:symptom experience,self-coping patterns,and existing obstacles.During the early stages of chemotherapy,patients reported a higher frequency of unpleasant symptoms and recognized these symptoms earlier in the treatment course.Patients in the early stages primarily relied on external support to cope with symptoms,while those in the later stages adopted self-care strategies.Several challenges related to unpleasant symptoms were observed,which appeared to correlate with the self-coping patterns employed.Conclusion:Patients with pancreatic cancer undergoing chemotherapy experience a complex and diverse range of symptoms,with varying coping patterns at different stages of treatment.Symptom management during chemotherapy presents significant challenges.Healthcare providers should improve the ongoing monitoring of symptoms post-chemotherapy.By linking patients’symptom experiences and self-coping patterns at different stages of chemotherapy to their specific challenges,personalized symptom management strategies can be developed to enhance care quality.展开更多
Non-small cell lung cancer(NSCLC)accounts for the majority of lung cancer cases and remains the leading cause of cancer-related mortality worldwide.Firstly,this review explores the limitations of conventional therapie...Non-small cell lung cancer(NSCLC)accounts for the majority of lung cancer cases and remains the leading cause of cancer-related mortality worldwide.Firstly,this review explores the limitations of conventional therapies,chemotherapy,radiotherapy,and surgery,focusing on the development of drug resistance and significant toxicity that often hinder their efficacy.Thereafter,advancements in targeted therapies,such as immune checkpoint inhibitors(ICIs)and tyrosine kinase inhibitors(TKIs),are discussed,highlighting their impact on improving outcomes for patients with specific genetic mutations,including c-ros oncogene 1 receptor tyrosine kinase(ROS1),anaplastic lymphoma kinase(ALK),and epidermal growth factor receptor(EGFR).Additionally,the emergence of novel immunotherapies and phytochemicals is examined,emphasizing their potential to overcome therapeutic resistance,particularly in advanced-stage diseases.The review also delves into the role of next-generation sequencing(NGS)in enabling personalized treatment approaches and explores the clinical potential of innovative agents,such as bispecific T-cell engagers(BiTEs)and antibody-drug conjugates(ADCs).Finally,we address the socioeconomic barriers that limit the accessibility of these therapies in low-resource settings and propose future research directions aimed at improving the long-term efficacy and accessibility of these treatments.展开更多
The iron content is one of the most critical parameters affecting the microstructure and mechanical properties of recycled aluminum alloy.This study aimed to compare the microstructure and tensile properties of alloys...The iron content is one of the most critical parameters affecting the microstructure and mechanical properties of recycled aluminum alloy.This study aimed to compare the microstructure and tensile properties of alloys with varying iron content to ascertain the optimal iron content for formulating a recycled Al-Si-Mg aluminum alloy.Additionally,the effects of aging temperature and aging time on the microstructure and mechanical properties of recycled aluminum alloy were investigated.With increasing aging temperature and time,both tensile strength and yield strength are improved,while elongation is decreased.Specifically,when subject to a heat treatment consisting of a solution treatment at 535℃for 5 h followed by an aging treatment at 170℃for5.5 h,the newly designed recycled aluminum alloy achieves a tensile strength of 291 MPa and a yield strength of 238 MPa.These findings hold significant implications for the further development and broader application of recycled aluminum alloys.展开更多
The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,sp...The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.展开更多
Many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection preference.This study aims to determine whether grassland specimen collection...Many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection preference.This study aims to determine whether grassland specimen collection in China is preferred by species traits(i.e.,plant height,flowering and fruiting period),environmental range(i.e.,the temperature and precipitation range)and geographical range(i.e.,distribution range and altitudinal range).Ordinary least squares models and phylogenetic generalized linear mixed models were used to analyze the relationships between specimen number and the explanatory variables.Random Forest models were then used to find the most parsimonious multivariate model.The results showed that interannual variation in specimen number between 1900 and 2020 was considerable.Specimen number of these species in southeast China was notably lower than that in northwest China.Environmental range and geographical range of species had significant positive correlations with specimen number.In addition,there were relatively weak but significant associations between specimen number and species trait(i.e.,plant height and flowering and fruiting period).Random Forest models indicated that distribution range was the most important variable,followed by flowering and fruiting period,and altitudinal range.These findings suggest that future floristic surveys should pay more attention to species with small geographical range,narrow environmental range,short plant height,and short flowering and fruiting period.The correction of specimen collection preference will also make the results of species distribution model,species evolution and other works based on specimen data more accurate.展开更多
Wind power has been developing rapidly as a key measure to mitigate human-driven global warming.The under-standing of the development and impacts of wind farms on local climate and vegetation is of great importance fo...Wind power has been developing rapidly as a key measure to mitigate human-driven global warming.The under-standing of the development and impacts of wind farms on local climate and vegetation is of great importance for their rational use but is still limited.In this study,we combined remote sensing and on-site investigations to identify wind farm locations in Inner Mongolia and performed landscape pattern analyses using Fragstats.We explored the impacts of wind farms on land surface temperature(LST)and vegetation net primary productivity(NPP)between 1990 and 2020 by contrasting these metrics in wind farms with those in non-wind farm areas.The results showed that the area of wind farms increased rapidly from 1.2 km2 in 1990 to 10,755 km2 in 2020.Spatially,wind farms are mainly clustered in three aggregation areas in the center.Further,wind farms increased nighttime LST,with a mean value of 0.23℃,but had minor impacts on the daytime LST.Moreover,wind farms caused a decline in NPP,especially over forest areas,with an average reduction of 12.37 GC/m^(2).Given the impact of wind farms on LST and NPP,we suggest that the development of wind farms should fully consider their direct and potential impacts.This study provides scientific guidance on the spatial pattern of future wind farms.展开更多
This article investigates the problem of robust adaptive leaderless consensus for heterogeneous uncertain nonminimumphase linear multi-agent systems over directed communication graphs. Each agent is assumed tobe of un...This article investigates the problem of robust adaptive leaderless consensus for heterogeneous uncertain nonminimumphase linear multi-agent systems over directed communication graphs. Each agent is assumed tobe of unknown nominal dynamics and also subject to external disturbances and/or unmodeled dynamics. Anovel distributed robust adaptive control strategy is proposed. It is shown that the robust adaptive leaderlessconsensus problem is solved with the proposed control strategy under some sufficient conditions. Two examplesare provided to demonstrate the efficacy of the proposed control strategy.展开更多
Biological specimens are fundamental for taxonomy and flora/fauna research.More importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity re...Biological specimens are fundamental for taxonomy and flora/fauna research.More importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity research and conservation.However,there are few systematic studies on the patterns and drivers of bird specimen number at regional scales.This study is the first attempt to examine the relationships between bird specimen number and species traits as well as climate niche breadth in China,aiming to answer two questions:1)how do species’temperature niche breadth and precipitation niche breadth influence specimen number?2)which trait is most associated with bird specimen number?The associations between bird specimen number and explanatory variables were examined using ordinary least squares,generalized linear models,phylogenetic generalized linear mixed models,and multiple comparisons.The results showed that Muscicapidae was the family with the highest specimen number,and Passeriformes was the order with the highest specimen number.Bird specimen number significantly increased with larger temperature niche breadth and precipitation niche breadth.Specimen number was also positively associated with geographic range size,habitat specificity,hunting vulnerability and clutch size,but negatively associated with body size.These findings suggest that future bird specimen collection should pay more attention to birds with limited ecological niches,large body sizes,and small clutch sizes.This research enhances the use of bird specimen data to study and preserve biodiversity.展开更多
Formic acid(FA),which is obtainable through CO_(2)hydrogenation with green hydrogen or biomass conversion,has been used as a prospective liquid organic hydrogen carrier(LOHC)because of the abundant advantages of renew...Formic acid(FA),which is obtainable through CO_(2)hydrogenation with green hydrogen or biomass conversion,has been used as a prospective liquid organic hydrogen carrier(LOHC)because of the abundant advantages of renewability,wide availability,stability,and high volumetric capacity(53 g H_(2)/L).The development of highly efficient catalytic systems to achieve enhanced catalytic activity is attractive but still challenging.Herein,ultrafine and highly dispersed PdAu nanoclusters(NCs)anchored on amino-modified reduced graphene oxide(ArGO)were successfully synthesized via a facile impregnation-reduction method and applied as a catalyst toward formic acid dehydrogenation(FAD).Benefiting from the promoting effect of amino groups,the strain and ligand effect in the alloy,and the Mott–Schottky effect between PdAu NCs and ArGO,the resultant PdAu/ArGO affords an ultrahigh activity under visible light irradiation with an exceptional turnover frequency value of 10,699.5 h^(-1)at 298 K without any additives,more than 2.6times improvement than that under dark,which is the highest among all reported catalysts under the same conditions.This study provides a green and convenient strategy for developing more efficient and sustainable FAD catalysts and promotes the effective utilization of FA as a prospective renewable LOHC.展开更多
This paper addresses the problem of containment control for heterogeneous multi-agent systems subject to Markovian randomly switching topologies and unbounded communication delays.The objective is to design a distribu...This paper addresses the problem of containment control for heterogeneous multi-agent systems subject to Markovian randomly switching topologies and unbounded communication delays.The objective is to design a distributed control strategy that ensures the output of each follower converges to the convex hull formed by the outputs of a group of leaders in mean square sense.A novel distributed observer is proposed by tackling both Markovian randomly switching topologies and unbounded delays.Then,a distributed state feedback controller and a distributed output feedback controller are developed based on the distributed observer,respectively.Finally,simulation results are provided to demonstrate the effectiveness of the proposed controllers.展开更多
Water electrolysis via alkaline hydrogen evolution reaction(HER)is a promising approach for large-scale production of high-purity hydrogen at a low cost,utilizing renewable and clean energy.However,the sluggish kineti...Water electrolysis via alkaline hydrogen evolution reaction(HER)is a promising approach for large-scale production of high-purity hydrogen at a low cost,utilizing renewable and clean energy.However,the sluggish kinetics derived from the high energy barrier of water dissociation impedes seriously its practical application.Herein,a series of hybrid Pt nanoclusters/Ru nanowires(Pt/Ru NWs)catalysts are demonstrated to accelerate alkaline HER.And the optimized Pt/Ru NWs(10%wt Pt)exhibits exceptional performance with an ultralow overpotential(24 mV at 10 mA cm^(-2)),a small Tafel slope(26.3 mV dec^(-1)),and long-term stability,outperforming the benchmark commercial Pt/C-JM-20%wt catalyst.This amazing performance also occurred in the alkaline anion-exchange membrane water electrolysis devices,where it delivered a cell voltage of about 1.9 V at 1 A cm^(-2)and an outstanding stability(more than 100 h).The calculations have revealed such a superior performance exhibited by Pt/Ru NWs stems from the formed heterointerfaces,which significantly reduce the energy barrier of the decisive rate step of water dissociation via cooperative-action between Pt cluster and Ru substance.This work provides valuable perspectives for designing advanced materials toward alkaline HER and beyond.展开更多
Multi-agent systems(MASs)are typically composed of multiple smart entities with independent sensing,communication,computing,and decision-making capabilities.Nowadays,MASs have a wide range of applications in smart gri...Multi-agent systems(MASs)are typically composed of multiple smart entities with independent sensing,communication,computing,and decision-making capabilities.Nowadays,MASs have a wide range of applications in smart grids,smart manufacturing,sensor networks,and intelligent transportation systems.Control of the MASs are often coordinated through information interaction among agents,which is one of the most important factors affecting coordination and cooperation performance.However,unexpected physical faults and cyber attacks on a single agent may spread to other agents via information interaction very quickly,and thus could lead to severe degradation of the whole system performance and even destruction of MASs.This paper is concerned with the safety/security analysis and synthesis of MASs arising from physical faults and cyber attacks,and our goal is to present a comprehensive survey on recent results on fault estimation,detection,diagnosis and fault-tolerant control of MASs,and cyber attack detection and secure control of MASs subject to two typical cyber attacks.Finally,the paper concludes with some potential future research topics on the security issues of MASs.展开更多
Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have b...Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods: A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 ?g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. Results: After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63?1.26 to 2.03?1.46 (P<0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P<0.0001). Conclusion: The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life.展开更多
Objective： In our previous work, we prepared a type of chitosan hydrogel with excellent biocompatibility. In this study, tissue-engineered cartilage constructed with this chitosan hydrogel and costal chondrocytes was...Objective： In our previous work, we prepared a type of chitosan hydrogel with excellent biocompatibility. In this study, tissue-engineered cartilage constructed with this chitosan hydrogel and costal chondrocytes was used to repair the articular cartilage defects. Methods： Chitosan hydrogels were prepared with a crosslinker formed by combining 1,6-diisocyanatohexane and polyethylene glycol. Chitosan hydrogel scaffold was seeded with rabbit chondrocytes that had been cultured for one week in vitro to form the preliminary tissue-engineered cartilage. This preliminary tissue-engineered cartilage was then transplanted into the defective rabbit articular cartilage. There were three treatment groups： the experimental group received preliminary tissue-engineered cartilage; the blank group received pure chitosan hydrogels; and, the control group had received no implantation. The knee joints were harvested at predetermined time. The repaired cartilage was analyzed through gross morphology, histologically and immunohistochemically. The repairs were scored according to the international cartilage repair society （ICRS） standard. Results： The gross morphology results suggested that the defects were repaired completely in the experimental group after twelve weeks. The regenerated tissue connected closely with subchondral bone and the boundary with normal tissue was fuzzy. The cartilage lacuna in the regenerated tissue was similar to normal cartilage lacuna. The results of ICRS gross and histological grading showed that there were significant differences among the three groups （P〈0.05）. Conclusions： Chondrocytes implanted in the scaffold can adhere, proliferate, and secrete extracellular matrix. The novel tissue-engineered cartilage constructed in our research can completely repair the structure of damaged articular cartilage.展开更多
The catalytic performance is highly related to the catalyst structure.Herein,a series of Ni nanoparticles supported on Y_(2)O_(3) with different morphologies were successfully synthesized via hydrothermal process scre...The catalytic performance is highly related to the catalyst structure.Herein,a series of Ni nanoparticles supported on Y_(2)O_(3) with different morphologies were successfully synthesized via hydrothermal process screening different pH environments.These Ni/Y_(2)O_(3)catalysts were applied to efficiently produce CO_(x)-free H2through ammonia decomposition.We identify a significant impact of Y_(2)O_(3)supports on nickel nanoclusters sizes and dispersion.The experimental results show that Ni/Y11 catalyst achieves 100% ammonia decomposition conversion under a gas hour space velocity(GHSV) of 12,000 ml·h^(-1)·gcat^(-1) and temperature of 650℃.Such a high level of activity over Ni/Y11 catalyst was attributed to a large specific surface area,appropriate alkalinity,and small Ni nanoparticles diameter with high dispersion.展开更多
基金supported by the State Key Laboratory of Ultrasonic Medical Engineering/the Chongqing Science and Technology Bureau(Project No.2022KFKT7011)the Postdoctoral Fellowship Program of CPSF(GZC20233357)+1 种基金the Health Commission of Sichuan Province Medical Science and Technology Program(24QNMP007)the Medical Research Program of Health Commission of Chengdu(2023535).
文摘Objective:To explore symptom experiences and self-coping patterns during the early and late stages of chemotherapy in these patients to provide a basis for developing targeted symptom management strategies.Methods:A total of 27 patients with pancreatic cancer undergoing chemotherapy at two medical institutions were recruited between November 2023 and August 2024.Semi-structured interviews were conducted in person or over the phone.Data were analyzed using traditional content and thematic analyses.Results:Three themes were identified:symptom experience,self-coping patterns,and existing obstacles.During the early stages of chemotherapy,patients reported a higher frequency of unpleasant symptoms and recognized these symptoms earlier in the treatment course.Patients in the early stages primarily relied on external support to cope with symptoms,while those in the later stages adopted self-care strategies.Several challenges related to unpleasant symptoms were observed,which appeared to correlate with the self-coping patterns employed.Conclusion:Patients with pancreatic cancer undergoing chemotherapy experience a complex and diverse range of symptoms,with varying coping patterns at different stages of treatment.Symptom management during chemotherapy presents significant challenges.Healthcare providers should improve the ongoing monitoring of symptoms post-chemotherapy.By linking patients’symptom experiences and self-coping patterns at different stages of chemotherapy to their specific challenges,personalized symptom management strategies can be developed to enhance care quality.
文摘Non-small cell lung cancer(NSCLC)accounts for the majority of lung cancer cases and remains the leading cause of cancer-related mortality worldwide.Firstly,this review explores the limitations of conventional therapies,chemotherapy,radiotherapy,and surgery,focusing on the development of drug resistance and significant toxicity that often hinder their efficacy.Thereafter,advancements in targeted therapies,such as immune checkpoint inhibitors(ICIs)and tyrosine kinase inhibitors(TKIs),are discussed,highlighting their impact on improving outcomes for patients with specific genetic mutations,including c-ros oncogene 1 receptor tyrosine kinase(ROS1),anaplastic lymphoma kinase(ALK),and epidermal growth factor receptor(EGFR).Additionally,the emergence of novel immunotherapies and phytochemicals is examined,emphasizing their potential to overcome therapeutic resistance,particularly in advanced-stage diseases.The review also delves into the role of next-generation sequencing(NGS)in enabling personalized treatment approaches and explores the clinical potential of innovative agents,such as bispecific T-cell engagers(BiTEs)and antibody-drug conjugates(ADCs).Finally,we address the socioeconomic barriers that limit the accessibility of these therapies in low-resource settings and propose future research directions aimed at improving the long-term efficacy and accessibility of these treatments.
基金support from funded project:Key Industrial R&D Projects of Chongqing Technology Innovation and Application Demonstration (cstc2020jscx-dxwtBX0023)。
文摘The iron content is one of the most critical parameters affecting the microstructure and mechanical properties of recycled aluminum alloy.This study aimed to compare the microstructure and tensile properties of alloys with varying iron content to ascertain the optimal iron content for formulating a recycled Al-Si-Mg aluminum alloy.Additionally,the effects of aging temperature and aging time on the microstructure and mechanical properties of recycled aluminum alloy were investigated.With increasing aging temperature and time,both tensile strength and yield strength are improved,while elongation is decreased.Specifically,when subject to a heat treatment consisting of a solution treatment at 535℃for 5 h followed by an aging treatment at 170℃for5.5 h,the newly designed recycled aluminum alloy achieves a tensile strength of 291 MPa and a yield strength of 238 MPa.These findings hold significant implications for the further development and broader application of recycled aluminum alloys.
基金the Natural Science Foundation of China(Grant Nos.82072413,82101649)National Key Research and Development Program of China(Grant Nos.2021YFE0105400).
文摘The integrated repair of bone and cartilage boasts advantages for osteochondral restoration such as a long-term repair effect and less deterioration compared to repairing cartilage alone.Constructing multifactorial,spatially oriented scaffolds to stimulate osteochondral regeneration,has immense significance.Herein,targeted drugs,namely kartogenin@polydopamine(KGN@PDA)nanoparticles for cartilage repair and miRNA@calcium phosphate(miRNA@CaP)NPs for bone regeneration,were in situ deposited on a patterned supramolecular-assembled 2-ureido-4[lH]-pyrimidinone(UPy)modified gelation hydrogel film,facilitated by the dynamic and responsive coordination and complexation of metal ions and their ligands.This hydrogel film can be rolled into a cylindrical plug,mimicking the Haversian canal structure of natural bone.The resultant hydrogel demonstrates stable mechanical properties,a self-healing ability,a high capability for reactive oxygen species capture,and controlled release of KGN and miR-26a.In vitro,KGN@PDA and miRNA@CaP promote chondrogenic and osteogenic differentiation of mesenchymal stem cells via the JNK/RUNX1 and GSK-3β/β-catenin pathways,respectively.In vivo,the osteochondral plug exhibits optimal subchondral bone and cartilage regeneration,evidenced by a significant increase in glycosaminoglycan and collagen accumulation in specific zones,along with the successful integration of neocartilage with subchondral bone.This biomaterial delivery approach represents a significant toward improved osteochondral repair.
基金the Natural Science Foundation of Inner Mongolia,China(2023JQ01)the National Key R&D Program of China(2019YFA0607103)+2 种基金the Central Government Guides Local Science and Technology Development Fund Projects(2022ZY0224)the Open Project Program of Ministry of Education Key Laboratory of Ecology and Resources Use of the Mongolian Plateau,Hohhot,Inner Mongolia,China(KF2023003)Major Science and Technology Project of Inner Mongolia Autonomous Region:Monitoring,Assessment and Early Warning Technology Research of Biodiversity in Inner Mongolia(2021ZD0011)for financial support.
文摘Many different factors,such as species traits,socio-economic factors,geographical and environmental factors,can lead to specimen collection preference.This study aims to determine whether grassland specimen collection in China is preferred by species traits(i.e.,plant height,flowering and fruiting period),environmental range(i.e.,the temperature and precipitation range)and geographical range(i.e.,distribution range and altitudinal range).Ordinary least squares models and phylogenetic generalized linear mixed models were used to analyze the relationships between specimen number and the explanatory variables.Random Forest models were then used to find the most parsimonious multivariate model.The results showed that interannual variation in specimen number between 1900 and 2020 was considerable.Specimen number of these species in southeast China was notably lower than that in northwest China.Environmental range and geographical range of species had significant positive correlations with specimen number.In addition,there were relatively weak but significant associations between specimen number and species trait(i.e.,plant height and flowering and fruiting period).Random Forest models indicated that distribution range was the most important variable,followed by flowering and fruiting period,and altitudinal range.These findings suggest that future floristic surveys should pay more attention to species with small geographical range,narrow environmental range,short plant height,and short flowering and fruiting period.The correction of specimen collection preference will also make the results of species distribution model,species evolution and other works based on specimen data more accurate.
基金supported by the National Key Research and Develop-ment Program of China(Grant No.2021YFC3201201)the National Natural Science Foundation of China(Grant No.32071582)+2 种基金JCS consid-ers this work a contribution to Center for Ecological Dynamics in a Novel Biosphere(ECONOVO)funded by Danish National Research Founda-tion(Grant No.DNRF173 to JCS)his Investigator project“Biodi-versity Dynamics in a Changing World”,funded by VILLUM FONDEN(Grant No.16549).
文摘Wind power has been developing rapidly as a key measure to mitigate human-driven global warming.The under-standing of the development and impacts of wind farms on local climate and vegetation is of great importance for their rational use but is still limited.In this study,we combined remote sensing and on-site investigations to identify wind farm locations in Inner Mongolia and performed landscape pattern analyses using Fragstats.We explored the impacts of wind farms on land surface temperature(LST)and vegetation net primary productivity(NPP)between 1990 and 2020 by contrasting these metrics in wind farms with those in non-wind farm areas.The results showed that the area of wind farms increased rapidly from 1.2 km2 in 1990 to 10,755 km2 in 2020.Spatially,wind farms are mainly clustered in three aggregation areas in the center.Further,wind farms increased nighttime LST,with a mean value of 0.23℃,but had minor impacts on the daytime LST.Moreover,wind farms caused a decline in NPP,especially over forest areas,with an average reduction of 12.37 GC/m^(2).Given the impact of wind farms on LST and NPP,we suggest that the development of wind farms should fully consider their direct and potential impacts.This study provides scientific guidance on the spatial pattern of future wind farms.
基金Research Grants Council of Hong Kong under Grant CityU-11205221.
文摘This article investigates the problem of robust adaptive leaderless consensus for heterogeneous uncertain nonminimumphase linear multi-agent systems over directed communication graphs. Each agent is assumed tobe of unknown nominal dynamics and also subject to external disturbances and/or unmodeled dynamics. Anovel distributed robust adaptive control strategy is proposed. It is shown that the robust adaptive leaderlessconsensus problem is solved with the proposed control strategy under some sufficient conditions. Two examplesare provided to demonstrate the efficacy of the proposed control strategy.
基金supported by the Natural Science Foundation of Inner Mongolia,China(2023JQ01)the National Key R&D Program of China(2019YFA0607103)+2 种基金the Central Government Guides Local Science and Technology Development Fund Projects(2022ZY0224)the Open Project Program of’Ministry of Education Key Laboratory of Ecology and Resources Use of the Mongolian Plateau(KF2023003)’the Major Science and Technology Project of Inner Mongolia Autonomous Region:Monitoring,Assessment and Early Warning Technology Research of Biodiversity in Inner Mongolia(2021ZD0011)。
文摘Biological specimens are fundamental for taxonomy and flora/fauna research.More importantly,they also play crucial roles in recording environmental impacts on morphology and behavior,which is vital for biodiversity research and conservation.However,there are few systematic studies on the patterns and drivers of bird specimen number at regional scales.This study is the first attempt to examine the relationships between bird specimen number and species traits as well as climate niche breadth in China,aiming to answer two questions:1)how do species’temperature niche breadth and precipitation niche breadth influence specimen number?2)which trait is most associated with bird specimen number?The associations between bird specimen number and explanatory variables were examined using ordinary least squares,generalized linear models,phylogenetic generalized linear mixed models,and multiple comparisons.The results showed that Muscicapidae was the family with the highest specimen number,and Passeriformes was the order with the highest specimen number.Bird specimen number significantly increased with larger temperature niche breadth and precipitation niche breadth.Specimen number was also positively associated with geographic range size,habitat specificity,hunting vulnerability and clutch size,but negatively associated with body size.These findings suggest that future bird specimen collection should pay more attention to birds with limited ecological niches,large body sizes,and small clutch sizes.This research enhances the use of bird specimen data to study and preserve biodiversity.
基金financially supported by the National Natural Science Foundation of China(Nos.22162014 and 22162013)Department of Science and Technology of Jiangxi Province(Nos.20212ACB204009,20212BCJL23059 and 20232ACB214002)。
文摘Formic acid(FA),which is obtainable through CO_(2)hydrogenation with green hydrogen or biomass conversion,has been used as a prospective liquid organic hydrogen carrier(LOHC)because of the abundant advantages of renewability,wide availability,stability,and high volumetric capacity(53 g H_(2)/L).The development of highly efficient catalytic systems to achieve enhanced catalytic activity is attractive but still challenging.Herein,ultrafine and highly dispersed PdAu nanoclusters(NCs)anchored on amino-modified reduced graphene oxide(ArGO)were successfully synthesized via a facile impregnation-reduction method and applied as a catalyst toward formic acid dehydrogenation(FAD).Benefiting from the promoting effect of amino groups,the strain and ligand effect in the alloy,and the Mott–Schottky effect between PdAu NCs and ArGO,the resultant PdAu/ArGO affords an ultrahigh activity under visible light irradiation with an exceptional turnover frequency value of 10,699.5 h^(-1)at 298 K without any additives,more than 2.6times improvement than that under dark,which is the highest among all reported catalysts under the same conditions.This study provides a green and convenient strategy for developing more efficient and sustainable FAD catalysts and promotes the effective utilization of FA as a prospective renewable LOHC.
文摘This paper addresses the problem of containment control for heterogeneous multi-agent systems subject to Markovian randomly switching topologies and unbounded communication delays.The objective is to design a distributed control strategy that ensures the output of each follower converges to the convex hull formed by the outputs of a group of leaders in mean square sense.A novel distributed observer is proposed by tackling both Markovian randomly switching topologies and unbounded delays.Then,a distributed state feedback controller and a distributed output feedback controller are developed based on the distributed observer,respectively.Finally,simulation results are provided to demonstrate the effectiveness of the proposed controllers.
基金supported by the Shanxi Province Natural Science Foundation(20210302124446,202102070301018)the Basic Research Project from Institute of Coal Chemistry,CAS(SCJC-HN-2022-17)the Foundation of State Key Laboratory of Coal Conversion(Grant No.J23-24-909).
文摘Water electrolysis via alkaline hydrogen evolution reaction(HER)is a promising approach for large-scale production of high-purity hydrogen at a low cost,utilizing renewable and clean energy.However,the sluggish kinetics derived from the high energy barrier of water dissociation impedes seriously its practical application.Herein,a series of hybrid Pt nanoclusters/Ru nanowires(Pt/Ru NWs)catalysts are demonstrated to accelerate alkaline HER.And the optimized Pt/Ru NWs(10%wt Pt)exhibits exceptional performance with an ultralow overpotential(24 mV at 10 mA cm^(-2)),a small Tafel slope(26.3 mV dec^(-1)),and long-term stability,outperforming the benchmark commercial Pt/C-JM-20%wt catalyst.This amazing performance also occurred in the alkaline anion-exchange membrane water electrolysis devices,where it delivered a cell voltage of about 1.9 V at 1 A cm^(-2)and an outstanding stability(more than 100 h).The calculations have revealed such a superior performance exhibited by Pt/Ru NWs stems from the formed heterointerfaces,which significantly reduce the energy barrier of the decisive rate step of water dissociation via cooperative-action between Pt cluster and Ru substance.This work provides valuable perspectives for designing advanced materials toward alkaline HER and beyond.
基金partially supported by the National Natural Science Foundation of China(61873237)the Fundamental Research Funds for the Central Universities+2 种基金the Fundamental Research Funds for the Provincial Universities of Zhejiang(RF-A2019003)the Research Grants Council of the Hong Kong Special Administrative Region of China(City U/11204315)the Hong Kong Scholars Program(XJ2016030)。
文摘Multi-agent systems(MASs)are typically composed of multiple smart entities with independent sensing,communication,computing,and decision-making capabilities.Nowadays,MASs have a wide range of applications in smart grids,smart manufacturing,sensor networks,and intelligent transportation systems.Control of the MASs are often coordinated through information interaction among agents,which is one of the most important factors affecting coordination and cooperation performance.However,unexpected physical faults and cyber attacks on a single agent may spread to other agents via information interaction very quickly,and thus could lead to severe degradation of the whole system performance and even destruction of MASs.This paper is concerned with the safety/security analysis and synthesis of MASs arising from physical faults and cyber attacks,and our goal is to present a comprehensive survey on recent results on fault estimation,detection,diagnosis and fault-tolerant control of MASs,and cyber attack detection and secure control of MASs subject to two typical cyber attacks.Finally,the paper concludes with some potential future research topics on the security issues of MASs.
文摘Objective: Although a new matrix formulation fentanyl has been used throughout the world for cancer pain management, few data about its efficacy and clinical outcomes associated with its use in Chinese patients have been obtained. This study aimed to assess the efficacy and safety of the new system in Chinese patients with moderate to severe cancer pain. Methods: A total of 474 patients with moderate to severe cancer pain were enrolled in this study and were treated with the new transdermal fentanyl matrix patch (TDF) up to 2 weeks. All the patients were asked to record pain intensity, side effects, quality of life (QOL), adherence and global satisfaction. The initial dose of fentanyl was 25 ?g/h titrated with opioid or according to National Comprehensive Cancer Network (NCCN) guidelines. Transdermal fentanyl was changed every three days. Results: After 2 weeks. The mean pain intensity of the 459 evaluated patients decreased significantly from 5.63?1.26 to 2.03?1.46 (P<0.0001). The total remission rate was 91.29%, of which moderate remission rate 53.16%, obvious remission rate 25.49% and complete remission rate 12.64%. The rate of adverse events was 33.75%, 18.78% of which were moderate and 3.80% were severe. The most frequent adverse events were constipation and nausea. No fatal events were observed. The quality of life was remarkably improved after the treatment (P<0.0001). Conclusion: The new TDF is effective and safe in treating patients with moderate to severe cancer pain, and can significantly improve the quality of life.
基金supported by the National Natural Science Foundation of China(Nos.81171472,81201407,and 81071270)the Innovation Team Project of Sichuan Provincial Education Department(No.13TD0030)+1 种基金the Major Transformation Cultivation Project of Sichuan Provincial Education Department(No.15CZ0021)the Science and Technology Project of Nanchong City(No.14A0021),China
文摘Objective： In our previous work, we prepared a type of chitosan hydrogel with excellent biocompatibility. In this study, tissue-engineered cartilage constructed with this chitosan hydrogel and costal chondrocytes was used to repair the articular cartilage defects. Methods： Chitosan hydrogels were prepared with a crosslinker formed by combining 1,6-diisocyanatohexane and polyethylene glycol. Chitosan hydrogel scaffold was seeded with rabbit chondrocytes that had been cultured for one week in vitro to form the preliminary tissue-engineered cartilage. This preliminary tissue-engineered cartilage was then transplanted into the defective rabbit articular cartilage. There were three treatment groups： the experimental group received preliminary tissue-engineered cartilage; the blank group received pure chitosan hydrogels; and, the control group had received no implantation. The knee joints were harvested at predetermined time. The repaired cartilage was analyzed through gross morphology, histologically and immunohistochemically. The repairs were scored according to the international cartilage repair society （ICRS） standard. Results： The gross morphology results suggested that the defects were repaired completely in the experimental group after twelve weeks. The regenerated tissue connected closely with subchondral bone and the boundary with normal tissue was fuzzy. The cartilage lacuna in the regenerated tissue was similar to normal cartilage lacuna. The results of ICRS gross and histological grading showed that there were significant differences among the three groups （P〈0.05）. Conclusions： Chondrocytes implanted in the scaffold can adhere, proliferate, and secrete extracellular matrix. The novel tissue-engineered cartilage constructed in our research can completely repair the structure of damaged articular cartilage.
基金financially supported by the National Natural Science Foundation of China (Nos.21868016, 21763018,22005296 and 21875096)the Key Laboratory for Environment and Energy Catalysis of Jiangxi Province (No. 20181BCD40004)+1 种基金the Natural Science Foundation of Jiangxi Province (No.20181BAB203016)the Graduate Students Innovation Special Foundation of Jiangxi Province (No.YC2021-B014)。
文摘The catalytic performance is highly related to the catalyst structure.Herein,a series of Ni nanoparticles supported on Y_(2)O_(3) with different morphologies were successfully synthesized via hydrothermal process screening different pH environments.These Ni/Y_(2)O_(3)catalysts were applied to efficiently produce CO_(x)-free H2through ammonia decomposition.We identify a significant impact of Y_(2)O_(3)supports on nickel nanoclusters sizes and dispersion.The experimental results show that Ni/Y11 catalyst achieves 100% ammonia decomposition conversion under a gas hour space velocity(GHSV) of 12,000 ml·h^(-1)·gcat^(-1) and temperature of 650℃.Such a high level of activity over Ni/Y11 catalyst was attributed to a large specific surface area,appropriate alkalinity,and small Ni nanoparticles diameter with high dispersion.
