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大气压冷等离子体对大鼠凝血功能的影响
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作者 张克英 陈启亮 +6 位作者 芮刚 武霄铮 郭玲 张俊平 刘志强 李和平 丁桂荣 《中国医学物理学杂志》 CSCD 2019年第3期351-355,共5页
目的:筛选和探讨大气压冷等离子体(CAP)对血液凝固的影响并筛选其最佳参数,初步探讨其作用机制。方法:首先,利用不同作用距离(1、2、3cm),不同放电电压(3.33、6.73、8.03kV),不同作用时间(30、60、120s)的CAP处理大鼠血滴,观察不同参数... 目的:筛选和探讨大气压冷等离子体(CAP)对血液凝固的影响并筛选其最佳参数,初步探讨其作用机制。方法:首先,利用不同作用距离(1、2、3cm),不同放电电压(3.33、6.73、8.03kV),不同作用时间(30、60、120s)的CAP处理大鼠血滴,观察不同参数CAP对血滴凝固效果的影响,筛选CAP促进凝血的最佳参数。之后,将22只SD大鼠随机分为空白对照组(n=11)和CAP处理组(n=11),验证上述最佳CAP参数对SD大鼠出血模型的止血效果。最后,通过抗凝血滴实验探讨CAP促进血液凝固的机制。结果:体外血滴实验结果显示,与对照组相比,CAP组血滴凝固效果更明显,主要表现为血滴表面干燥和酒窝样凹陷增多,且血滴凝固效果与CAP处理时间和放电电压呈正相关,与CAP作用距离呈负相关。动物出血模型研究结果显示,放电电压8.03kV、作用时间120s、作用距离1cm的CAP处理出血部位可以显著缩短出血时间并降低出血量。抗凝血滴结果显示,CAP可以显著促进枸橼酸钠抗凝血滴的凝固。结论:CAP对血液凝固具有明显的时间促进作用,且与作用距离和放电电压密切相关。其机制可能与CAP促进纤维蛋白原向纤维蛋白转化有关。 展开更多
关键词 大气压冷等离子体 血滴凝固 出血模型 大鼠
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Analysis of Robot Accuracy Assessed via its Joint Clearance by Virtual Prototyping Method 被引量:1
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作者 guoling WANGLi-hong ZHANGYu-ru 《International Journal of Plant Engineering and Management》 2004年第1期25-34,共10页
This paper discusses how joint clearance influences robot end effectorpositioning accuracy and a robot accuracy analysis approach based on a virtual prototype isproposed. First, a 5-DOF(Degree of freedom) neurosurgery... This paper discusses how joint clearance influences robot end effectorpositioning accuracy and a robot accuracy analysis approach based on a virtual prototype isproposed. First, a 5-DOF(Degree of freedom) neurosurgery robot was introduced. Then we built itsvirtual prototype, made movement planning and measured the manipulator tip accuracy, through whichthis robot accuracy portrait was obtained. Finally, in order to validate the robot accuracyanalysis approach which is based on a virtual prototype, the result was compared with that from amodel built by robot forward kinematics and robot differential kinematics. The robot accuracyanalysis approach presented in this paper gives a new way to enhance robot design quality , and helpto optimize the control and programming of the robot. 展开更多
关键词 ROBOT joint clearance accuracy analysis virtual prototype
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Induction of Apoptosis by Superoxide Anion and the Protective Effects of Selenium and Vitamin E 被引量:1
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作者 guoling XUEAN-NA 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2001年第3期241-247,共7页
Objective\ The purpose of this study is to investigate the effect of superoxide anion on the apoptosis of cultured fibroblasts and the protective role of selenium and Vitamin E. Methods\ Cultured fibroblasts (NIH3T3)... Objective\ The purpose of this study is to investigate the effect of superoxide anion on the apoptosis of cultured fibroblasts and the protective role of selenium and Vitamin E. Methods\ Cultured fibroblasts (NIH3T3), with or without selenium or vitamin E in the medium, were treated by superoxide anion produced by xanthine/xanthine oxidase reaction system and changes in cell structure and DNA were observed microscopically and electrophoretically. Results\ Apoptosis was observed when superoxide anion at a concentration of 5 nmol/L or 10 nmol/L had acted on the fibroblasts for 5-10 h. Selenium and Vitamin E in the medium inhibited the apoptosis significantly when their concentrations reached 1.15 mol/L and 2.3 mol/L respectively. Conclusion Selenium and vitamin E have protective effect against the apoptosis induced by superoxide anion. The effect of selenium is more remarkable than that of vitamin E. 展开更多
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Synthesis and Crystal Structure of Pd(AETYF)Cl_2CH_2Cl_2 [AETYF = 4'5'Diaza-9' (4,5-bis(ethylthio)-1,3-dithiole-2-ylidene)-fluorene]
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作者 ZHUQin-Yu DAIJie +3 位作者 ZHANGYong JIADing-Xian ZHANGJia-Sheng guoling 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2004年第6期551-554,共4页
A stable Pd(II) compound Pd(AETYF)Cl2CH2Cl2 (AETYF = 4?5?diaza-9? (4,5-bis(ethylthio)-1,3-dithiole-2-ylidene)-fluorene) has been synthesized and its crystal structure was determined by X-ray crystallography. The cryst... A stable Pd(II) compound Pd(AETYF)Cl2CH2Cl2 (AETYF = 4?5?diaza-9? (4,5-bis(ethylthio)-1,3-dithiole-2-ylidene)-fluorene) has been synthesized and its crystal structure was determined by X-ray crystallography. The crystal is of monoclinic, space group P21/c with a = 15.249(6), b = 8.619(3), c = 19.078(7) ? b = 106.932(8), C19H18Cl4N2PdS4, Mr = 650.79, V = 2398.6(16) 3, Z = 4, Dc = 1.802 g/cm3, F(000) = 1296, m = 1.579 mm-1, Npar = 268, the final R = 0.0538 and wR = 0.1282 for 5068 observed reflections with I > 2s(I). The crystal structure determi- nation shows that the atoms of the molecule, except two ethyl-groups, are conjugated in a quasi- plane and these molecules are further stacked or contacted via plane to plane or edge to edge p-p interactions, forming parallel molecular chains along the b axis. 展开更多
关键词 diaza-fluorene palladium complex crystal structure intermolecular interaction
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