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Job Stress, Gene Polymorphism of β_2-AR, and Prevalence of Hypertension 被引量:9
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作者 SHAN-FA YU WEN-HUI ZHOU +2 位作者 KAI-YOU JIANG gui-zheng gu SHENG WANG 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2008年第3期239-246,共8页
Objective To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. Methods A cross-sectional epidemiological study was conducted in 452 workers from a thermal ... Objective To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. Methods A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. β2-AR genotypes and allele frequencies at amino acid positions 16 (β2-AR-16: Arg→Gly) and 27 (β2-AR-27: Gln→Glu) were identified by PCR-RFLE Results Job stress was related with the prevalence of hypertension in males (P〈0.05), whereas no significant relationship was found in females (P〉0.05). Differences in genotypes and allele frequencies of the β2-AR-16 were statistically significant between the hypertension and control groups (P〈0.05), whereas those of β2-AR-27 were not (P〉0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P〈0.01 or 0.05). Conclusion High job stress and polymorphism of β2-AR-16 have an interactive effect on the prevalence of hypertension in male workers. 展开更多
关键词 Job stress HYPERTENSION Β2-AR Gene polymorphism
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