3-Amino-2-methoxycarbonylthiophene used as the main raw material,an intermediate（thiofuran siamese） 2,4-dichloro-thieno[3,2-d]pyrimidine was synthesized.The prod-uct was characterized by nuclear magnetic resonance（...3-Amino-2-methoxycarbonylthiophene used as the main raw material,an intermediate（thiofuran siamese） 2,4-dichloro-thieno[3,2-d]pyrimidine was synthesized.The prod-uct was characterized by nuclear magnetic resonance（NMR）.The first step yield was 84%（190 ℃） and the second step yield was 81.4%（105 ℃,m（intermediate）：m（phosphorus oxychloride） = 1：6.4）.The raw product was refined with a unique refining process,which can enhance the purity up to 99.5% to meet the requirement of condi-tions for the development and research of thiofuran siamese as a new medicine of anticarcinogen.Contrasted with the traditional technique,this process featured with cheap raw materials,possible for solvent recovery and reuse,low comprehensive cost,and suit-able for production on certain scale.展开更多
基金Supported by the Innovation Fund for Technology Based Firms (10C26224212340)
文摘3-Amino-2-methoxycarbonylthiophene used as the main raw material,an intermediate（thiofuran siamese） 2,4-dichloro-thieno[3,2-d]pyrimidine was synthesized.The prod-uct was characterized by nuclear magnetic resonance（NMR）.The first step yield was 84%（190 ℃） and the second step yield was 81.4%（105 ℃,m（intermediate）：m（phosphorus oxychloride） = 1：6.4）.The raw product was refined with a unique refining process,which can enhance the purity up to 99.5% to meet the requirement of condi-tions for the development and research of thiofuran siamese as a new medicine of anticarcinogen.Contrasted with the traditional technique,this process featured with cheap raw materials,possible for solvent recovery and reuse,low comprehensive cost,and suit-able for production on certain scale.
