In multi-agent confrontation scenarios, a jammer is constrained by the single limited performance and inefficiency of practical application. To cope with these issues, this paper aims to investigate the multi-agent ja...In multi-agent confrontation scenarios, a jammer is constrained by the single limited performance and inefficiency of practical application. To cope with these issues, this paper aims to investigate the multi-agent jamming problem in a multi-user scenario, where the coordination between the jammers is considered. Firstly, a multi-agent Markov decision process (MDP) framework is used to model and analyze the multi-agent jamming problem. Secondly, a collaborative multi-agent jamming algorithm (CMJA) based on reinforcement learning is proposed. Finally, an actual intelligent jamming system is designed and built based on software-defined radio (SDR) platform for simulation and platform verification. The simulation and platform verification results show that the proposed CMJA algorithm outperforms the independent Q-learning method and provides a better jamming effect.展开更多
The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 w...The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.展开更多
目的观察重组全人源抗新型冠状病毒单克隆抗体(2B11)注射液对恒河猴2周重复给药的毒性反应,确定无毒性反应的安全剂量及给药剂量、给药时间与毒性之间的关系,为临床用药提供参考。方法30只健康恒河猴,随机分成3组,每组10只,雌雄各半。...目的观察重组全人源抗新型冠状病毒单克隆抗体(2B11)注射液对恒河猴2周重复给药的毒性反应,确定无毒性反应的安全剂量及给药剂量、给药时间与毒性之间的关系,为临床用药提供参考。方法30只健康恒河猴,随机分成3组,每组10只,雌雄各半。溶媒对照组给予0.9%氯化钠注射液,实验组分别给予2B11100和400 mg·kg^(-1)。每隔6 d iv给药1次,2周共给药3次,停药后恢复9周。实验期间进行一般症状观察、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、系统解剖、脏器系数、组织病理学和免疫学检测,同时进行抗药抗体(ADA)及血药浓度检测,并分析毒代动力学参数。结果实验期间2B112个剂量组恒河猴一般症状、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、脏器系数、组织病理学和免疫学检测等指标均未见与受试物有关的明显改变。2B112个剂量组均未检测到ADA,血浆药物浓度变化基本一致,且与给药剂量呈正比,峰浓度之比和暴露量之比也与给药剂量呈正比,2B11注射液在体内基本呈线性动力学特征。结论在本实验条件下,恒河猴2周重复iv给予2B113次是安全的,400 mg·kg^(-1)未观察到临床不良反应。展开更多
文摘目的 探讨miR-383在单钠尿酸盐(monosodium urate, MSU)诱导的非感染性类病原炎症反应中的调控作用,重点评估其在NLRP3炎性体活性调节及炎症自限性维持中的分子机制,为DAMPs介导的无菌性炎症调控提供理论基础。方法 构建miR-383基因敲除(miR-383-/-)及野生型(WT)小鼠的急性痛风性关节炎模型,分别于MSU注射后0、6、12、24、48 h测定足掌厚度。建立腹腔炎症模型并于刺激后6 h和12 h收集腹腔灌洗液,采用流式细胞术分析Ly6G+CD11b+中性粒细胞与F4/80+CD11b+巨噬细胞构成比,ELISA检测IL-1β与IL-6水平。另分离骨髓源性巨噬细胞(BMDMs),于MSU刺激(100μg/mL)后0、4、8 h收集RNA,利用RT-qPCR检测NLRP3、ASC、caspase-1与IL-1β mRNA表达水平。结果 miR-383-/-小鼠在MSU注射后6 h、12 h、24 h的足掌厚度较WT组显著增高(2.81±0.17 mm vs. 2.37±0.14 mm, 3.08±0.21 mm vs. 2.52±0.19 mm, 2.67±0.15 mm vs. 2.29±0.12 mm,均P<0.01)。12 h时腹腔中Ly6G+CD11b+中性粒细胞比例升高至72.34%±4.26%,显著高于WT组的60.91%±3.74%(P<0.01),F4/80+CD11b+巨噬细胞占比亦显著上升(18.46%±2.81%vs. 12.73%±2.57%,P<0.01)。ELISA结果显示miR-383-/-组IL-1β和IL-6峰值分别达641.5±43.6 pg/mL和984.2±51.8 pg/mL,均显著高于WT组(分别为438.7±39.4 pg/mL和732.4±44.9 pg/mL,均P<0.01)。BMDMs中,miR-383-/-组在刺激4 h时ASC mRNA表达为WT组的2.91倍(P<0.01),caspase-1和IL-1β表达分别升高至2.26倍(P<0.01)与3.42倍(P<0.01),NLRP3表达差异无统计学意义(P=0.117)。结论 miR-383通过负向调控ASC表达,从而限制NLRP3炎性体的激活及促炎因子的过度释放。其缺失导致炎症表型加重、免疫细胞过度募集及IL-1β、IL-6水平显著升高,提示miR-383在DAMPs介导的无菌性炎症应答中发挥关键负调控功能。miR-383-ASC信号轴的识别不仅丰富了炎性小体调控网络,也为痛风等炎症性疾病的分子干预提供潜在靶点。
基金supported by National Natural Science Foundation of China (No. 62071488 and No. 62061013)
文摘In multi-agent confrontation scenarios, a jammer is constrained by the single limited performance and inefficiency of practical application. To cope with these issues, this paper aims to investigate the multi-agent jamming problem in a multi-user scenario, where the coordination between the jammers is considered. Firstly, a multi-agent Markov decision process (MDP) framework is used to model and analyze the multi-agent jamming problem. Secondly, a collaborative multi-agent jamming algorithm (CMJA) based on reinforcement learning is proposed. Finally, an actual intelligent jamming system is designed and built based on software-defined radio (SDR) platform for simulation and platform verification. The simulation and platform verification results show that the proposed CMJA algorithm outperforms the independent Q-learning method and provides a better jamming effect.
基金supported by National Basic Research Program of China(2010CB834202)the National Natural Science Foundation of China(11305226,11175222)+1 种基金the Scientific Technology Research Projects of Lanzhou City(2015-3-75)the Western Talent Program of Chinese Academy of Sciences(Y460030XB0)
文摘The use of exogenous carbon monoxide releasing molecules（CORMs）provides promise for clinical application;however,the hazard potential of CORMs in vivo remains poorly understood.The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to400μmol/L during 4-144 h post fertilization.Toxicity endpoints of mortality,spontaneous movement,heart rate,hatching rate,malformation,body length,and larval behavior were measured.
文摘目的观察重组全人源抗新型冠状病毒单克隆抗体(2B11)注射液对恒河猴2周重复给药的毒性反应,确定无毒性反应的安全剂量及给药剂量、给药时间与毒性之间的关系,为临床用药提供参考。方法30只健康恒河猴,随机分成3组,每组10只,雌雄各半。溶媒对照组给予0.9%氯化钠注射液,实验组分别给予2B11100和400 mg·kg^(-1)。每隔6 d iv给药1次,2周共给药3次,停药后恢复9周。实验期间进行一般症状观察、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、系统解剖、脏器系数、组织病理学和免疫学检测,同时进行抗药抗体(ADA)及血药浓度检测,并分析毒代动力学参数。结果实验期间2B112个剂量组恒河猴一般症状、体重、摄食量、体温、眼科检查、血压、心电图、血常规、止凝血、血液生化及电解质、尿液、脏器系数、组织病理学和免疫学检测等指标均未见与受试物有关的明显改变。2B112个剂量组均未检测到ADA,血浆药物浓度变化基本一致,且与给药剂量呈正比,峰浓度之比和暴露量之比也与给药剂量呈正比,2B11注射液在体内基本呈线性动力学特征。结论在本实验条件下,恒河猴2周重复iv给予2B113次是安全的,400 mg·kg^(-1)未观察到临床不良反应。
