As an essential candidate for environment-friendly luminescent quantum dots(QDs),CuInS-based QDs have attracted more attention in recent years.However,several drawbacks still hamper their industrial applications,such ...As an essential candidate for environment-friendly luminescent quantum dots(QDs),CuInS-based QDs have attracted more attention in recent years.However,several drawbacks still hamper their industrial applications,such as lower photoluminescence quantum yield(PLQY),complex synthetic pathways,uncontrollable emission spectra,and insufficient photostability.In this study,CuInZnS@ZnS core/shell QDs was prepared via a one-pot/three-step synthetic scheme with accurate and tunable control of PL spectra.Then their ensemble spectroscopic properties during nucleation formation,alloying,and ZnS shell growth processes were systematically investigated.PL peaks of these QDs can be precisely manipulated from 530 to 850 nm by controlling the stoichiometric ratio of Cu/In,Zn^(2+)doping and ZnS shell growth.In particular,CuInZnS@ZnS QDs possess a significantly long emission lifetime(up to 750 ns),high PLQY(up to 85%),and excellent crystallinity.Their spectroscopic evolution is well validated by Cu-deficient related intragap emission model.By controlling the stoichiometric ratio of Cu/In,two distinct Cu-deficient related emission pathways are established based on the differing oxidation states of Cu defects.Therefore,this work provides deeper insights for fabricating high luminescent ternary or quaternary-alloyed QDs.展开更多
目的:探究雷珠单抗与阿柏西普玻璃体腔注射治疗渗出性年龄相关性黄斑变性的临床疗效与安全性。方法:选取2015年5月~2018年5月我院收治的渗出性年龄相关性黄斑变性患者98例(98眼),采用随机数字表法将患者分为两组,A组玻璃体腔内缓慢注射0...目的:探究雷珠单抗与阿柏西普玻璃体腔注射治疗渗出性年龄相关性黄斑变性的临床疗效与安全性。方法:选取2015年5月~2018年5月我院收治的渗出性年龄相关性黄斑变性患者98例(98眼),采用随机数字表法将患者分为两组,A组玻璃体腔内缓慢注射0.05 m L(0.5 mg)雷珠单抗注射液,B组玻璃体腔内缓慢注射0.05 m L(2 mg)阿柏西普注射液。比较两组患者的视力改善情况、眼动脉血流动力学、黄斑中心凹视网膜厚度及不良反应的发生情况。结果:治疗前两组患者的视力比较无统计学差异(P>0.05),治疗后,B组视力显著高于A组(P<0.05);。两组患者治疗前后眼动脉血流动力学相关指标比较均无统计学差异(P>0.05)。;两组患者治疗后的黄斑中心凹视网膜厚度均显著降低,且治疗3个月B组治疗3个月显著低于A组(P<0.05);B组患者注射药物后结膜下大出血发生率显著低于A组(P<0.05)。结论:阿柏西普可显著改善渗出性年龄相关性黄斑变性患者的视力,且安全性高,可能与其可显著改善患者的黄斑中心凹视网膜厚度有关,且不良反应发生率低,安全性好。展开更多
目的研究血清甲状腺激素水平与2型糖尿病小鼠视网膜病变的发生和进展的关系。方法选取健康C57BL小鼠作为对照(对照组),db/db小鼠为2型糖尿病模型(2型糖尿病组),db/db小鼠腹腔注射甲状腺素(T4)稀释液以建立2型糖尿病甲状腺功能亢进小鼠(...目的研究血清甲状腺激素水平与2型糖尿病小鼠视网膜病变的发生和进展的关系。方法选取健康C57BL小鼠作为对照(对照组),db/db小鼠为2型糖尿病模型(2型糖尿病组),db/db小鼠腹腔注射甲状腺素(T4)稀释液以建立2型糖尿病甲状腺功能亢进小鼠(2型糖尿病甲亢组),db/db小鼠以甲巯咪唑替代饮水建立2型糖尿病甲状腺功能减退小鼠(2型糖尿病甲减组)。2型糖尿病甲亢和2型糖尿病甲减模型建立6个月后,酶联免疫吸附试验(ELISA)法测定小鼠血清空腹血糖(FBG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、血清总三碘甲腺原氨酸(T3)、血清T4及促甲状腺激素(TSH)水平;电生理仪检测小鼠视觉电生理指标和TUNEL法检测小鼠视网膜神经节细胞(RGCs)凋亡率。结果与对照组相比,2型糖尿病组、2型糖尿病甲亢和2型糖尿病甲减组FBG、2 h PG和FINS均显著升高,差异均有统计学意义(P<0.05);但T2甲亢组或T2甲减组与2型糖尿病组相比差异均无统计学意义(P>0.05)。与2型糖尿病组相比,2型糖尿病甲亢组血清鼠T3、T4及视觉a波峰潜时均显著升高,血清TSH及a波峰振幅显著降低,差异均有统计学意义(P<0.05);与2型糖尿病组相比,2型糖尿病甲减组血清鼠T3、T4均显著降低,血清TSH显著升高,差异均有统计学意义(P<0.05),视觉a波峰潜时和a波峰振幅差异均无统计学意义(P>0.05)。2型糖尿病、2型糖尿病甲亢和2型糖尿病甲减组小鼠视网膜病变发生率和RGCs凋亡率均高于对照组,差异均有统计学意义(P<0.05),2型糖尿病甲亢组小鼠视网膜病变发生率和RGCs凋亡率均高于2型糖尿病组小鼠,差异均有统计学意义(P<0.05),2型糖尿病甲减组小鼠与2型糖尿病组小鼠视网膜病变发生率和RGCs凋亡率差异均无统计学意义(P>0.05)。结论血清甲状腺激素水平增加可引起2型糖尿病小鼠视网膜病变的发生,并且可导致其病变程度的进一步增加,而血清甲状腺激素水平降低则对2型糖尿病小鼠视网膜病变及进展无显著影响。展开更多
基金Fund Project for Transformation of Scientific and Technological Achievements of Jiangsu Province of China(BA2023020)。
文摘As an essential candidate for environment-friendly luminescent quantum dots(QDs),CuInS-based QDs have attracted more attention in recent years.However,several drawbacks still hamper their industrial applications,such as lower photoluminescence quantum yield(PLQY),complex synthetic pathways,uncontrollable emission spectra,and insufficient photostability.In this study,CuInZnS@ZnS core/shell QDs was prepared via a one-pot/three-step synthetic scheme with accurate and tunable control of PL spectra.Then their ensemble spectroscopic properties during nucleation formation,alloying,and ZnS shell growth processes were systematically investigated.PL peaks of these QDs can be precisely manipulated from 530 to 850 nm by controlling the stoichiometric ratio of Cu/In,Zn^(2+)doping and ZnS shell growth.In particular,CuInZnS@ZnS QDs possess a significantly long emission lifetime(up to 750 ns),high PLQY(up to 85%),and excellent crystallinity.Their spectroscopic evolution is well validated by Cu-deficient related intragap emission model.By controlling the stoichiometric ratio of Cu/In,two distinct Cu-deficient related emission pathways are established based on the differing oxidation states of Cu defects.Therefore,this work provides deeper insights for fabricating high luminescent ternary or quaternary-alloyed QDs.
文摘目的:探究雷珠单抗与阿柏西普玻璃体腔注射治疗渗出性年龄相关性黄斑变性的临床疗效与安全性。方法:选取2015年5月~2018年5月我院收治的渗出性年龄相关性黄斑变性患者98例(98眼),采用随机数字表法将患者分为两组,A组玻璃体腔内缓慢注射0.05 m L(0.5 mg)雷珠单抗注射液,B组玻璃体腔内缓慢注射0.05 m L(2 mg)阿柏西普注射液。比较两组患者的视力改善情况、眼动脉血流动力学、黄斑中心凹视网膜厚度及不良反应的发生情况。结果:治疗前两组患者的视力比较无统计学差异(P>0.05),治疗后,B组视力显著高于A组(P<0.05);。两组患者治疗前后眼动脉血流动力学相关指标比较均无统计学差异(P>0.05)。;两组患者治疗后的黄斑中心凹视网膜厚度均显著降低,且治疗3个月B组治疗3个月显著低于A组(P<0.05);B组患者注射药物后结膜下大出血发生率显著低于A组(P<0.05)。结论:阿柏西普可显著改善渗出性年龄相关性黄斑变性患者的视力,且安全性高,可能与其可显著改善患者的黄斑中心凹视网膜厚度有关,且不良反应发生率低,安全性好。
文摘目的研究血清甲状腺激素水平与2型糖尿病小鼠视网膜病变的发生和进展的关系。方法选取健康C57BL小鼠作为对照(对照组),db/db小鼠为2型糖尿病模型(2型糖尿病组),db/db小鼠腹腔注射甲状腺素(T4)稀释液以建立2型糖尿病甲状腺功能亢进小鼠(2型糖尿病甲亢组),db/db小鼠以甲巯咪唑替代饮水建立2型糖尿病甲状腺功能减退小鼠(2型糖尿病甲减组)。2型糖尿病甲亢和2型糖尿病甲减模型建立6个月后,酶联免疫吸附试验(ELISA)法测定小鼠血清空腹血糖(FBG)、餐后2 h血糖(2 h PG)、空腹胰岛素(FINS)、血清总三碘甲腺原氨酸(T3)、血清T4及促甲状腺激素(TSH)水平;电生理仪检测小鼠视觉电生理指标和TUNEL法检测小鼠视网膜神经节细胞(RGCs)凋亡率。结果与对照组相比,2型糖尿病组、2型糖尿病甲亢和2型糖尿病甲减组FBG、2 h PG和FINS均显著升高,差异均有统计学意义(P<0.05);但T2甲亢组或T2甲减组与2型糖尿病组相比差异均无统计学意义(P>0.05)。与2型糖尿病组相比,2型糖尿病甲亢组血清鼠T3、T4及视觉a波峰潜时均显著升高,血清TSH及a波峰振幅显著降低,差异均有统计学意义(P<0.05);与2型糖尿病组相比,2型糖尿病甲减组血清鼠T3、T4均显著降低,血清TSH显著升高,差异均有统计学意义(P<0.05),视觉a波峰潜时和a波峰振幅差异均无统计学意义(P>0.05)。2型糖尿病、2型糖尿病甲亢和2型糖尿病甲减组小鼠视网膜病变发生率和RGCs凋亡率均高于对照组,差异均有统计学意义(P<0.05),2型糖尿病甲亢组小鼠视网膜病变发生率和RGCs凋亡率均高于2型糖尿病组小鼠,差异均有统计学意义(P<0.05),2型糖尿病甲减组小鼠与2型糖尿病组小鼠视网膜病变发生率和RGCs凋亡率差异均无统计学意义(P>0.05)。结论血清甲状腺激素水平增加可引起2型糖尿病小鼠视网膜病变的发生,并且可导致其病变程度的进一步增加,而血清甲状腺激素水平降低则对2型糖尿病小鼠视网膜病变及进展无显著影响。
