Striving to peak carbon emissions and achieve carbon neutrality(known as the"Dual-Carbon"goal)is an inevitable requirement for elevating the environmental resource constraints and realizing harmonious coexis...Striving to peak carbon emissions and achieve carbon neutrality(known as the"Dual-Carbon"goal)is an inevitable requirement for elevating the environmental resource constraints and realizing harmonious coexistence between the mankind and the earth.In the energy system,nuclear energy offers various advantages,such as high energy density,low carbon emission,strong environmental adaptability and large potential for energy co-generation and co-supply.It is one of the supporting energy sources for the transformation and upgradation of the energy system to a clean,efficient and low-carbon way.In this paper,the opportunities and challenges for innovation-driven nuclear energy development in the fields of electricity generation,hydrogen production,heat supply and seawater desalination under the goal of"Dual-Carbon"are discussed and analyzed.Besides,the relevant research on improving the safety and economy of the pressurized water reactor(PWR)and sodium-cooled fast reactor(SFR)conducted by the Nuclear THermal-hydraulic research Lab(NuTHeL)of Xi’an Jiaotong University is briefly introduced.展开更多
Cordyceps militaris Link.(C.militaris)with strong anti-hyperuricemia effects could be detected in mice urine and serum after oral administration as we previously proved.In this study,the mechanism and molecular effect...Cordyceps militaris Link.(C.militaris)with strong anti-hyperuricemia effects could be detected in mice urine and serum after oral administration as we previously proved.In this study,the mechanism and molecular effects of anti-hyperuricemia by C.militaris in gouty nephropathy(GN)mice were firstly investigated,and its key active structure was further explored.The results showed C.militaris could significantly reduce the uric acid(UA)level and related inflammatory factors.Meanwhile,C.militaris maintain the normal dynamic balance of UA by inhibiting hepatic xanthine oxidase(XO)and regulating the expression of renal transport proteins ABCG2,GLUT9 and URAT1.Then we employed network pharmacology to theoretically determine two active components in C.militaris,cordycepin and ergosterol,that act on GN.Moreover,the molecular docking and molecular dynamic simulation results showed cordycepin and ergosterol could stably bind to XO and cyclooxygenase-2(COX-2)due to hydrogen bonding and hydrophobic interactions.This study could provide theoretical evidence for utilization of C.militaris in hyperuricemia-management functional foods.展开更多
文摘Striving to peak carbon emissions and achieve carbon neutrality(known as the"Dual-Carbon"goal)is an inevitable requirement for elevating the environmental resource constraints and realizing harmonious coexistence between the mankind and the earth.In the energy system,nuclear energy offers various advantages,such as high energy density,low carbon emission,strong environmental adaptability and large potential for energy co-generation and co-supply.It is one of the supporting energy sources for the transformation and upgradation of the energy system to a clean,efficient and low-carbon way.In this paper,the opportunities and challenges for innovation-driven nuclear energy development in the fields of electricity generation,hydrogen production,heat supply and seawater desalination under the goal of"Dual-Carbon"are discussed and analyzed.Besides,the relevant research on improving the safety and economy of the pressurized water reactor(PWR)and sodium-cooled fast reactor(SFR)conducted by the Nuclear THermal-hydraulic research Lab(NuTHeL)of Xi’an Jiaotong University is briefly introduced.
基金supported by the Fundamental Research Funds for the Central Universities of China(No.2662018PY022).
文摘Cordyceps militaris Link.(C.militaris)with strong anti-hyperuricemia effects could be detected in mice urine and serum after oral administration as we previously proved.In this study,the mechanism and molecular effects of anti-hyperuricemia by C.militaris in gouty nephropathy(GN)mice were firstly investigated,and its key active structure was further explored.The results showed C.militaris could significantly reduce the uric acid(UA)level and related inflammatory factors.Meanwhile,C.militaris maintain the normal dynamic balance of UA by inhibiting hepatic xanthine oxidase(XO)and regulating the expression of renal transport proteins ABCG2,GLUT9 and URAT1.Then we employed network pharmacology to theoretically determine two active components in C.militaris,cordycepin and ergosterol,that act on GN.Moreover,the molecular docking and molecular dynamic simulation results showed cordycepin and ergosterol could stably bind to XO and cyclooxygenase-2(COX-2)due to hydrogen bonding and hydrophobic interactions.This study could provide theoretical evidence for utilization of C.militaris in hyperuricemia-management functional foods.
