The authors regret Revised“E_(pa)”to“E_(p)”in Fig.3D(Page 7).Revised“I_(p)a”to“I_(p)”in Fig.3D(Page 7).Correct the range from“92.16%-107.27%”(7th line fromthe bottomof the right columnon page 8)to“95.45%-10...The authors regret Revised“E_(pa)”to“E_(p)”in Fig.3D(Page 7).Revised“I_(p)a”to“I_(p)”in Fig.3D(Page 7).Correct the range from“92.16%-107.27%”(7th line fromthe bottomof the right columnon page 8)to“95.45%-102.56%”.The authors would like to apologise for any inconvenience caused.展开更多
A handy and efficient emulsifying emulsion was developed based on self-assembled soy protein isolate(SPI)and high methoxy pectin(HMP)for entrapping and loading carotenoids.The complex,ca.195 nm,showed a sig-nificant i...A handy and efficient emulsifying emulsion was developed based on self-assembled soy protein isolate(SPI)and high methoxy pectin(HMP)for entrapping and loading carotenoids.The complex,ca.195 nm,showed a sig-nificant improvement in solubility,emulsification(32.42 m^(2)/g)and stability(83.86%).Moreover,the physical stability of torularhodin was remarkably improved after entrapping into the SPI-HMP complex.The retention rate for entrapped torularhodin could be up to 66.03%,95.14%and 84.31%under treatment with ultraviolet irradiation for 8 h,thermal stock at 25 and 50℃ for 28 days,respectively.Increase of two affinities,enhancement of intermolecular hydrogen bond and hydrophobic interaction and charge changes caused by the preparation process of the complex were the main reasons for improving the properties of emulsion.At the same time,composite lotion encapsulation significantly improves the bioavailability of torularhodin,including the absorption of carotenoids in the small intestine,the content in the systemic circulation and the storage capacity in the liver.Therefore,the preparation of low price,safer,green and efficient SPI-HMP complex emulsion has long-term application prospects on the development,transportation and application of antioxidants.展开更多
Oxidative stress,inflammatory,and excessive apoptosis are the crucial culprits of drug-induced liver injury(DILI).Torularhodin was judged to have good potential to intervene DILI due to its antioxidant and immunomodul...Oxidative stress,inflammatory,and excessive apoptosis are the crucial culprits of drug-induced liver injury(DILI).Torularhodin was judged to have good potential to intervene DILI due to its antioxidant and immunomodulation activity.The aim of this study was to clarify the preventive effect of torularhodin on hepatic injury caused by acetaminophen(APAP)and its mechanism in mice.The liver injury model of mice was established by injecting APAP into the tail’s veins to evaluate the intervention effect of torularhodin on liver injury.The mechanisms involved were investigated using Western blot and transcriptome analysis.The results reflected that torularhodin significantly increased antioxidant enzyme capacities(Compared with the group Dam,the activities of SOD and GSH-Px in the group TorH increased by2.47 and 3.79 times,and the content of MDA decreased by 58.78%,respectively p<0.05),alleviated inflammation(Compared with the group Dam,the contents of TNF-α,IL-1β and IL-6 in the group TorH increased by 61.98%,64.93%and 58.49,respectively,p<0.05)and improved the pathological condition of liver in mice.Transcriptomic result indicated that differential genes caused by the intervention of torularhodin were mainly involved in cell metabolism processes,immunomodulation and apoptosis.Western blot results confirmed that torularhodin could inhibit hepatocyte apoptosis by regulating signaling pathways including PI3K/Akt/mTOR and Nrf2/HO-1 to increase antioxidant enzyme activity,thus intervening in DILI.It suggested that torularhodin might provide a promising preventive strategy for DILI.展开更多
Salt plays a crucial role in food processing and consumption,and the rapid detection of chloride ions in food and feed has great significance for practical applications.In this work,Ag-based nanomaterials were deposit...Salt plays a crucial role in food processing and consumption,and the rapid detection of chloride ions in food and feed has great significance for practical applications.In this work,Ag-based nanomaterials were deposited on the surface of a flexible integrated electrochemical sensor for the detection of Cl-in food.In order to enhance the detection performance,a unique needle-tip structure was formed by manipulating the electro-engraving process during the electrodeposition growth.Theoretical calculations and electrochemical investigations have demonstrated that the dendrimer’s rich tip structure significantly enhanced its electrochemical performance.A sensitive and flexible integrated electrochemical sensor was creatively developed for the detection of Cl-using needletip effect-promoted Ag micro dendrimers.The sensor achieved quantitative detection of Cl-over a dynamic range of 10.0μM–100.0 mM,with a low limit of detection of 0.148μM.The flexible electrochemical sensor proposed in this work exhibited good repeatability,selectivity and recoveries in real food samples.展开更多
文摘The authors regret Revised“E_(pa)”to“E_(p)”in Fig.3D(Page 7).Revised“I_(p)a”to“I_(p)”in Fig.3D(Page 7).Correct the range from“92.16%-107.27%”(7th line fromthe bottomof the right columnon page 8)to“95.45%-102.56%”.The authors would like to apologise for any inconvenience caused.
基金supported by the Innovation and Entrepreneurship Projects and Six Talent Peaks Project of Jiangsu Province,China(No.SWYY-023)National Natural Science Foundation of China(No.21603087)High-level Overseas Talent Workstation of Shandong Yuwang Ecological Food Industry CO.,Ltd.of Shandong Province.
文摘A handy and efficient emulsifying emulsion was developed based on self-assembled soy protein isolate(SPI)and high methoxy pectin(HMP)for entrapping and loading carotenoids.The complex,ca.195 nm,showed a sig-nificant improvement in solubility,emulsification(32.42 m^(2)/g)and stability(83.86%).Moreover,the physical stability of torularhodin was remarkably improved after entrapping into the SPI-HMP complex.The retention rate for entrapped torularhodin could be up to 66.03%,95.14%and 84.31%under treatment with ultraviolet irradiation for 8 h,thermal stock at 25 and 50℃ for 28 days,respectively.Increase of two affinities,enhancement of intermolecular hydrogen bond and hydrophobic interaction and charge changes caused by the preparation process of the complex were the main reasons for improving the properties of emulsion.At the same time,composite lotion encapsulation significantly improves the bioavailability of torularhodin,including the absorption of carotenoids in the small intestine,the content in the systemic circulation and the storage capacity in the liver.Therefore,the preparation of low price,safer,green and efficient SPI-HMP complex emulsion has long-term application prospects on the development,transportation and application of antioxidants.
基金This work was supported by the Innovation and Entrepreneurship Projects and Six Talent Peaks Project of Jiangsu Province(No.SWYY-023)F.P.thanks for the support from National Natural Science Foundation of China(No.21603087)High-level Overseas Talent Workstation of Shandong Province.
文摘Oxidative stress,inflammatory,and excessive apoptosis are the crucial culprits of drug-induced liver injury(DILI).Torularhodin was judged to have good potential to intervene DILI due to its antioxidant and immunomodulation activity.The aim of this study was to clarify the preventive effect of torularhodin on hepatic injury caused by acetaminophen(APAP)and its mechanism in mice.The liver injury model of mice was established by injecting APAP into the tail’s veins to evaluate the intervention effect of torularhodin on liver injury.The mechanisms involved were investigated using Western blot and transcriptome analysis.The results reflected that torularhodin significantly increased antioxidant enzyme capacities(Compared with the group Dam,the activities of SOD and GSH-Px in the group TorH increased by2.47 and 3.79 times,and the content of MDA decreased by 58.78%,respectively p<0.05),alleviated inflammation(Compared with the group Dam,the contents of TNF-α,IL-1β and IL-6 in the group TorH increased by 61.98%,64.93%and 58.49,respectively,p<0.05)and improved the pathological condition of liver in mice.Transcriptomic result indicated that differential genes caused by the intervention of torularhodin were mainly involved in cell metabolism processes,immunomodulation and apoptosis.Western blot results confirmed that torularhodin could inhibit hepatocyte apoptosis by regulating signaling pathways including PI3K/Akt/mTOR and Nrf2/HO-1 to increase antioxidant enzyme activity,thus intervening in DILI.It suggested that torularhodin might provide a promising preventive strategy for DILI.
基金financially supported by Key Research and Development Program in Hubei Province(Grant No.2023BBB042)the Fundamental Research Funds for the Central Universities(Grant No.2662023GXQD001)Key Laboratory of on Site Processing Equipment for Agricultural Products,Ministry of Agriculture and Rural Affairs(Grant No.2016NYZD2202).
文摘Salt plays a crucial role in food processing and consumption,and the rapid detection of chloride ions in food and feed has great significance for practical applications.In this work,Ag-based nanomaterials were deposited on the surface of a flexible integrated electrochemical sensor for the detection of Cl-in food.In order to enhance the detection performance,a unique needle-tip structure was formed by manipulating the electro-engraving process during the electrodeposition growth.Theoretical calculations and electrochemical investigations have demonstrated that the dendrimer’s rich tip structure significantly enhanced its electrochemical performance.A sensitive and flexible integrated electrochemical sensor was creatively developed for the detection of Cl-using needletip effect-promoted Ag micro dendrimers.The sensor achieved quantitative detection of Cl-over a dynamic range of 10.0μM–100.0 mM,with a low limit of detection of 0.148μM.The flexible electrochemical sensor proposed in this work exhibited good repeatability,selectivity and recoveries in real food samples.
