A high specific Young’s modulus steel could be achieved by introducing a large fraction of kappa-carbides(κ-carbide),and its ductility was improved by efficiency divorced eutectoid transformation(DET)treatment.For t...A high specific Young’s modulus steel could be achieved by introducing a large fraction of kappa-carbides(κ-carbide),and its ductility was improved by efficiency divorced eutectoid transformation(DET)treatment.For this steel,carbon and aluminum contents affect not only the carbide fraction,but also the type and morphology of carbides,and consequently the mechanical properties.In this work,the alloy was designed by considering both the carbide morphology and Young’s modulus,and the carbides in the high specific Young’s modulus steels were adjusted by controlling carbon content in a suitable range for achieving a good combination of strength and ductility.The detailed microstructure evolution process during DET reaction was studied,and it was found that a higher austenitizing temperature and the cooling rate lower than 300℃h^(−1)are suitable.The blocky carbides could be avoided by designing the carbon content in a limited content range.The microstructure-property relationship of the experimental steels was also discussed for giving an impetus to the future development of high specific Young’s modulus steels.展开更多
Alzheimer's disease(AD)is a neurodegenerative disease and a major threat to human health worldwide.The association between aluminum exposure and AD has been widely reported.Owing to the ubiquitous presence of alum...Alzheimer's disease(AD)is a neurodegenerative disease and a major threat to human health worldwide.The association between aluminum exposure and AD has been widely reported.Owing to the ubiquitous presence of aluminum in daily life;aluminum exposure can easily occur whenever and wherever possible.Thus;a rapid and sensitive reagent for detecting aluminum and assist in AD daily prevention for potential AD patient population is extremely needed.However;existing aluminum detection methods rely on precise instruments;which are impractical for household use.Herein;a series of aggregation-induced emission-based covalent-organic framework(AIE-COF)fluorescent probes has been designed with progressively tuned sizes and screened for aluminum detection.Among them;COF-N2 was found to have the highest response towards aluminum specifically;with a fluorescence intensity change of 19.14 times before and after chelation;which could determine the aluminum concentration by naked eye.Then;the molecular mechanism of COF-N2 fluorescence changes was explained and COF-N2 was used for both diagnose the aluminum distribution in various organs of APP/PS1 transgenic mice and quickly determine the aluminum content in daily necessities.The use of AIE-COF probes for aluminum detection provides a promising avenue for developing aluminum related AD clinical diagnosis and daily prevention tools.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.51804072 and 52171108)the Fundamental Research Funds for the Central Universities(No.N2007012)+1 种基金the 111 Project(No.B16009)the Liaoning Revitalization Talents Program(No.xlyc1907128).
文摘A high specific Young’s modulus steel could be achieved by introducing a large fraction of kappa-carbides(κ-carbide),and its ductility was improved by efficiency divorced eutectoid transformation(DET)treatment.For this steel,carbon and aluminum contents affect not only the carbide fraction,but also the type and morphology of carbides,and consequently the mechanical properties.In this work,the alloy was designed by considering both the carbide morphology and Young’s modulus,and the carbides in the high specific Young’s modulus steels were adjusted by controlling carbon content in a suitable range for achieving a good combination of strength and ductility.The detailed microstructure evolution process during DET reaction was studied,and it was found that a higher austenitizing temperature and the cooling rate lower than 300℃h^(−1)are suitable.The blocky carbides could be avoided by designing the carbon content in a limited content range.The microstructure-property relationship of the experimental steels was also discussed for giving an impetus to the future development of high specific Young’s modulus steels.
基金supported by the National Key R&D Program of China(2022YFB3805902)the National Natural Science Foundation of China(22131004,U21A20330,21975039 and 22077118)+3 种基金the“111”project(B18012)the Fundamental Research Funds for the Central Universities,Excellent Youth Team Program(2412023YQ001)the Finance Special Project on Medical and Health Talents of the Finance Department of Jilin Province(JLSWSRCZX2023-52)WBE Liver Fibrosis Foundation(2020009).
文摘Alzheimer's disease(AD)is a neurodegenerative disease and a major threat to human health worldwide.The association between aluminum exposure and AD has been widely reported.Owing to the ubiquitous presence of aluminum in daily life;aluminum exposure can easily occur whenever and wherever possible.Thus;a rapid and sensitive reagent for detecting aluminum and assist in AD daily prevention for potential AD patient population is extremely needed.However;existing aluminum detection methods rely on precise instruments;which are impractical for household use.Herein;a series of aggregation-induced emission-based covalent-organic framework(AIE-COF)fluorescent probes has been designed with progressively tuned sizes and screened for aluminum detection.Among them;COF-N2 was found to have the highest response towards aluminum specifically;with a fluorescence intensity change of 19.14 times before and after chelation;which could determine the aluminum concentration by naked eye.Then;the molecular mechanism of COF-N2 fluorescence changes was explained and COF-N2 was used for both diagnose the aluminum distribution in various organs of APP/PS1 transgenic mice and quickly determine the aluminum content in daily necessities.The use of AIE-COF probes for aluminum detection provides a promising avenue for developing aluminum related AD clinical diagnosis and daily prevention tools.
