Magnesium （Mg） alloys are receiving increasing attention for body implants owing to their good bio- compatibility and biodegradability. However, they often suffer from bacterial infections on account of their insuff...Magnesium （Mg） alloys are receiving increasing attention for body implants owing to their good bio- compatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-xCu （x = O, 0.2, 0.4, 0.6 and 0.8 wt%） alloys were prepared by selective laser melting （SLM） with alloying copper （Cu） to enhance their antibacterial ability. Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure, denaturing enzymes and inhibiting deoxyribonucleic acid （DNA） replication. In addition, their compres- sive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be Dromising implants for biomedical anDlications.展开更多
Background Insomnia disorder(ID)is one of the most common mental disorders.Research on ID focuses on exploring its mechanism of disease,novel treatments and treatment outcome prediction.An emerging technique in this f...Background Insomnia disorder(ID)is one of the most common mental disorders.Research on ID focuses on exploring its mechanism of disease,novel treatments and treatment outcome prediction.An emerging technique in this field is the use of electroencephalography(EEG)microstates,which offer a new method of EEG feature extraction that incorporates information from both temporal and 6/spatial dimensions.Aims To explore the electrophysiological mechanisms of repetitive transcranial magnetic stimulation(rTMS)for ID treatment and use baseline microstate metrics for the prediction of its efficacy.Methods This study included 60 patients with ID and 40 age-matched and gender-matched good sleep controls(GSC).Their resting-state EEG microstates were analysed,and the Pittsburgh Sleep Quality Index(PSQI)and polysomnography(PSG)were collected to assess sleep quality.The 60 patients with ID were equally divided into active and sham groups to receive rTMS for 20 days to test whether rTMS had a moderating effect on abnormal microstates in patients with ID.Furthermore,in an independent group of 90 patients with ID who received rTMS treatment,patients were divided into optimal and suboptimal groups based on their median PSQI reduction rate.Baseline EEG microstates were used to build a machine-learning predictive model for the effects of rTMS treatment.Results The class D microstate was less frequent and contribute in patients with ID,and these abnormalities were associated with sleep onset latency as measured by PSG.Additinally,the abnormalities were partially reversed to the levels observed in the GSC group following rTMS treatment.The baseline microstate characteristics could predict the therapeutic effect of ID after 20 days of rTMS,with an accuracy of 80.13%.Conclusions Our study highlights the value of EEG microstates as functional biomarkers of ID and provides a new perspective for studying the neurophysiological mechanisms of ID.In addition,we predicted the therapeutic effect of rTMS on ID based on the baseline microstates of patients with ID.This finding carries great practical significance for the selection of therapeutic options for patients with ID.展开更多
Long-term air contamination and pollution challenges in particulate matter(PM) have raised fervent concerns for public health, e.g., the PM physical damage or the bacteria and virus carried by the PM. The desired air ...Long-term air contamination and pollution challenges in particulate matter(PM) have raised fervent concerns for public health, e.g., the PM physical damage or the bacteria and virus carried by the PM. The desired air filter, seeking both high filtration efficiency and low pressure drop remains challenging. Here, we report a bio-inspired spindle-knot halloysite nanotube microsphere-incorporated nanofiber(HNM-NF) filter with the assembly and shape structures of the spider silk. The resulting HNM-NFs exhibit integrated properties of high surface energy, hydrophilicity and strong PM capture. The spindle-knot structures could shrink the outer pore size on two-dimensional(2 D) surface and construct the fluffy 3 D reticular architecture, facilitating high-efficiency air pollutant capture(>85.0%) while maintaining low resistance to airflow(~39 Pa). The spindle-knot construction method was applicable to various materials(i.e.,Al_(2)O_(3), ZnO and TiO_(2)) and volume production of the microsphere-incorporated NF cartridge. The diversified spindleknot construction will be valuable for adapting to meet different filtration requirements.展开更多
基金supported financially by the National Natural Science Foundation of China(Nos.51575537,81572577 and51705540)the Hunan Provincial Natural Science Foundation of China(No.2016JJ1027)+5 种基金the Project of Innovation-driven Plan of Central South University(No.2016CX023)the Open-End Fund for the Valuable and Precision Instruments of Central South Universitythe Fund of the State Key Laboratory of Solidification Processing at NWPU(No.SKLSP201605)the Project of State Key Laboratoryof High Performance Complex Manufacturing,Central South Universitythe National Postdoctoral Program for Innovative Talents(No.BX201700291)the Project of Hunan Provincial Science and Technology Plan(No.2017RS3008)
文摘Magnesium （Mg） alloys are receiving increasing attention for body implants owing to their good bio- compatibility and biodegradability. However, they often suffer from bacterial infections on account of their insufficient antibacterial ability. In this study, ZK60-xCu （x = O, 0.2, 0.4, 0.6 and 0.8 wt%） alloys were prepared by selective laser melting （SLM） with alloying copper （Cu） to enhance their antibacterial ability. Results showed that ZK60-Cu alloys exhibited strong antibacterial ability due to combination of release of Cu ions and alkaline environment which could kill bacteria by destroying cellular membrane structure, denaturing enzymes and inhibiting deoxyribonucleic acid （DNA） replication. In addition, their compres- sive strength increased due to grain refinement and uniformly dispersing of short-bar shaped MgZnCu phases. Moreover, ZK60-Cu alloys also exhibited good cytocompatibility. In summary, ZK60-Cu alloys with antibacterial ability may be Dromising implants for biomedical anDlications.
基金supported by the National Natural Science Foundation of China(Grant Nos.82371500,82260359,U22A20303)Hebei Provincial Natural Science Foundation(H2020206625,H2020206263)+2 种基金STI2030:2022ZD0214500,National Key Research and Development Program of Hunan Province(2021SK2023)Natural Science Foundation of Inner Mongolia 2021MS08014,2023QN08007,Hunan Provincial Natural Science Foundation of China(Grant No.2023JJ30412)the Fundamental Research Funds for the Central Universities(Grant No.QTZX23094).
文摘Background Insomnia disorder(ID)is one of the most common mental disorders.Research on ID focuses on exploring its mechanism of disease,novel treatments and treatment outcome prediction.An emerging technique in this field is the use of electroencephalography(EEG)microstates,which offer a new method of EEG feature extraction that incorporates information from both temporal and 6/spatial dimensions.Aims To explore the electrophysiological mechanisms of repetitive transcranial magnetic stimulation(rTMS)for ID treatment and use baseline microstate metrics for the prediction of its efficacy.Methods This study included 60 patients with ID and 40 age-matched and gender-matched good sleep controls(GSC).Their resting-state EEG microstates were analysed,and the Pittsburgh Sleep Quality Index(PSQI)and polysomnography(PSG)were collected to assess sleep quality.The 60 patients with ID were equally divided into active and sham groups to receive rTMS for 20 days to test whether rTMS had a moderating effect on abnormal microstates in patients with ID.Furthermore,in an independent group of 90 patients with ID who received rTMS treatment,patients were divided into optimal and suboptimal groups based on their median PSQI reduction rate.Baseline EEG microstates were used to build a machine-learning predictive model for the effects of rTMS treatment.Results The class D microstate was less frequent and contribute in patients with ID,and these abnormalities were associated with sleep onset latency as measured by PSG.Additinally,the abnormalities were partially reversed to the levels observed in the GSC group following rTMS treatment.The baseline microstate characteristics could predict the therapeutic effect of ID after 20 days of rTMS,with an accuracy of 80.13%.Conclusions Our study highlights the value of EEG microstates as functional biomarkers of ID and provides a new perspective for studying the neurophysiological mechanisms of ID.In addition,we predicted the therapeutic effect of rTMS on ID based on the baseline microstates of patients with ID.This finding carries great practical significance for the selection of therapeutic options for patients with ID.
基金supported by the National Natural Science Foundation of China (21878341,51804343,41572036 and 51225403)the Natural Science Foundation of Hunan Province(2018JJ3670)the Key R&D Program of Hunan Province(2017GK2251)。
文摘Long-term air contamination and pollution challenges in particulate matter(PM) have raised fervent concerns for public health, e.g., the PM physical damage or the bacteria and virus carried by the PM. The desired air filter, seeking both high filtration efficiency and low pressure drop remains challenging. Here, we report a bio-inspired spindle-knot halloysite nanotube microsphere-incorporated nanofiber(HNM-NF) filter with the assembly and shape structures of the spider silk. The resulting HNM-NFs exhibit integrated properties of high surface energy, hydrophilicity and strong PM capture. The spindle-knot structures could shrink the outer pore size on two-dimensional(2 D) surface and construct the fluffy 3 D reticular architecture, facilitating high-efficiency air pollutant capture(>85.0%) while maintaining low resistance to airflow(~39 Pa). The spindle-knot construction method was applicable to various materials(i.e.,Al_(2)O_(3), ZnO and TiO_(2)) and volume production of the microsphere-incorporated NF cartridge. The diversified spindleknot construction will be valuable for adapting to meet different filtration requirements.
