Ischemic stroke is a major public health problem worldwide.Although the circadian clock is involved in the process of ischemic stroke,the exact mechanism of the circadian clock in regulating angiogenesis after cerebra...Ischemic stroke is a major public health problem worldwide.Although the circadian clock is involved in the process of ischemic stroke,the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains unclear.In the present study,we determined that environmental circadian disruption(ECD)increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model,by measuring the infarct volume,neurological tests,and angiogenesis-related protein.We further report that Bmal1 plays an irreplaceable role in angiogenesis.Overexpression of Bmal1 promoted tube-forming,migration,and wound healing,and upregulated the vascular endothelial growth factor(VEGF)and Notch pathway protein levels.This promoting effect was reversed by the Notch pathway inhibitor DAPT,according to the results of angiogenesis capacity and VEGF pathway protein level.In conclusion,our study reveals the intervention of ECD in angiogenesis in ischemic stroke and further identifies the exact mechanism by which Bmal1 regulates angiogenesis through the VEGF-Notch1 pathway.展开更多
Mimic active defense technology effectively disrupts attack routes and reduces the probability of successful attacks by using a dynamic heterogeneous redundancy(DHR)architecture.However,current approaches often overlo...Mimic active defense technology effectively disrupts attack routes and reduces the probability of successful attacks by using a dynamic heterogeneous redundancy(DHR)architecture.However,current approaches often overlook the adaptability of the adjudication mechanism in complex and variable network environments,focusing primarily on system security while neglecting performance considerations.To address these limitations,we propose an output difference feedback and system benefit control based DHR architecture.This architecture introduces an adjudication mechanism based on output difference feedback,which enhances adaptability by considering the impact of each executor's output deviation on the global decision.Additionally,the architecture incorporates a scheduling strategy based on system benefit,which models the quality of service and switching overhead as a bi-objective optimization problem,balancing security with reduced computational costs and system overhead.Simulation results demonstrate that our architecture improves adaptability towards different network environments and effectively reduces both the attack success rate and average failure rate.展开更多
基金This work was supported by the National Natural Science Foundation for Young Scholars of China(82004346 and 82104766)the Natural Science Foundation of Hunan Province(2021JJ30521 and 2021JJ40424)+2 种基金the Open Fund for the First-class Discipline of Integrated Traditional Chinese and Western Medicine of Hunan University of Chinese Medicine(2020ZXYJH38 and 2020ZXYJH39)Natural Science Foundation of Changsha(kq2208202)the University-level Fund Project of Hunan University of Chinese Medicine(2021XJJJ039).
文摘Ischemic stroke is a major public health problem worldwide.Although the circadian clock is involved in the process of ischemic stroke,the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains unclear.In the present study,we determined that environmental circadian disruption(ECD)increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model,by measuring the infarct volume,neurological tests,and angiogenesis-related protein.We further report that Bmal1 plays an irreplaceable role in angiogenesis.Overexpression of Bmal1 promoted tube-forming,migration,and wound healing,and upregulated the vascular endothelial growth factor(VEGF)and Notch pathway protein levels.This promoting effect was reversed by the Notch pathway inhibitor DAPT,according to the results of angiogenesis capacity and VEGF pathway protein level.In conclusion,our study reveals the intervention of ECD in angiogenesis in ischemic stroke and further identifies the exact mechanism by which Bmal1 regulates angiogenesis through the VEGF-Notch1 pathway.
基金supported by the National Key R&D Program of China(Nos.2023YFB2904004 and 2023YFB2904000)the JiangsuKey Development Planning Project(No.BE2023004-2)+1 种基金the Natural Science Foundation of Jiangsu Province(Higher Education Institutions)(No.20KJA520001)the Postgraduate Research Practice Innovation Program of Jiangsu Province(No.KYCX22_1021)。
文摘Mimic active defense technology effectively disrupts attack routes and reduces the probability of successful attacks by using a dynamic heterogeneous redundancy(DHR)architecture.However,current approaches often overlook the adaptability of the adjudication mechanism in complex and variable network environments,focusing primarily on system security while neglecting performance considerations.To address these limitations,we propose an output difference feedback and system benefit control based DHR architecture.This architecture introduces an adjudication mechanism based on output difference feedback,which enhances adaptability by considering the impact of each executor's output deviation on the global decision.Additionally,the architecture incorporates a scheduling strategy based on system benefit,which models the quality of service and switching overhead as a bi-objective optimization problem,balancing security with reduced computational costs and system overhead.Simulation results demonstrate that our architecture improves adaptability towards different network environments and effectively reduces both the attack success rate and average failure rate.
