Dear Editor,Gaucher disease(GD)is the most common lysosomal storage disease(LSD)caused by an insufficiency of the lysosomal enzyme glucocerebrosidase(GCase)[1].GCase insufficiency produces the excessive lysosomal accu...Dear Editor,Gaucher disease(GD)is the most common lysosomal storage disease(LSD)caused by an insufficiency of the lysosomal enzyme glucocerebrosidase(GCase)[1].GCase insufficiency produces the excessive lysosomal accumulation of unmetabolized glycolipid substrates including glucosylceramide(GlcCer),leading to the disruption of the structure and function of tissues and organs,includingthe blood system,viscera,brain,boncs,and cartilage.展开更多
Dear Editor,Diseases caused by ischemia,including coronary artery disease and stroke,are a leading cause of death worldwide[1].Restoration of the blood and oxygen supply after restriction also causes tissue damage by ...Dear Editor,Diseases caused by ischemia,including coronary artery disease and stroke,are a leading cause of death worldwide[1].Restoration of the blood and oxygen supply after restriction also causes tissue damage by activating a number of pathological pathways,such as inflammatory,oxidative stress,and cell death pathways that are mediated by microRNAs and hypoxia-inducible factors[1,2].展开更多
基金the National Natural Science Foundation of China(81771416,81650110527,and 8197100)Shanghai Municipal Commission of Health and Family Planning(201740153)Key Discipline of Chongming District,Shanghai,China,2018.
文摘Dear Editor,Gaucher disease(GD)is the most common lysosomal storage disease(LSD)caused by an insufficiency of the lysosomal enzyme glucocerebrosidase(GCase)[1].GCase insufficiency produces the excessive lysosomal accumulation of unmetabolized glycolipid substrates including glucosylceramide(GlcCer),leading to the disruption of the structure and function of tissues and organs,includingthe blood system,viscera,brain,boncs,and cartilage.
基金the National Natural Science Foundation of China(81771416,81650110527 and 8197100)Shanghai Municipal Commission of Health and Family Planning(201740153)Key Discipline of Chongming District,Shanghai,China,2018。
文摘Dear Editor,Diseases caused by ischemia,including coronary artery disease and stroke,are a leading cause of death worldwide[1].Restoration of the blood and oxygen supply after restriction also causes tissue damage by activating a number of pathological pathways,such as inflammatory,oxidative stress,and cell death pathways that are mediated by microRNAs and hypoxia-inducible factors[1,2].
