For some historic reasons, our new journal is named 'Genomics, Pro teomics & Bioinformatics', or as we have nicknamed it in short the Journal of GPB. A growing number of '-ome' and '-omics'...For some historic reasons, our new journal is named 'Genomics, Pro teomics & Bioinformatics', or as we have nicknamed it in short the Journal of GPB. A growing number of '-ome' and '-omics' have appeared in many diverse fields of biology, especially in the recent years under profound influences of the Human Genome Project and many other genome projects completed or in progress. We had almost attempted to re-name this journal 'Ever-more-omics' to include all the new comers. However, after a second thought, we have decided to entertain these 'Three Kingdoms' first while we are keeping an eye on others.展开更多
The name of SR proteins is derived from their typical RS domain that is rich in serine (Ser, S) and arginine (Arg, R). They are conserved in evolution. Up to now, 10 members of the SR protein family have been identifi...The name of SR proteins is derived from their typical RS domain that is rich in serine (Ser, S) and arginine (Arg, R). They are conserved in evolution. Up to now, 10 members of the SR protein family have been identified in humans. SR proteins contain one or two RNA binding motifs aside from the RS domain, and also possess special biochemical and immunological features. As to the functions of SR proteins, they facilitate the recruitment of the components of splicesome via protein-protein interaction to prompt the assembly of early splicesome; while in alternative splicing, tissue-specifically expressed SR protein along with the relative ratio of SR protein and heterogeneous nuclear ribonucleoprotein (hnRNP) is composed of two main regulative mechanisms for alternative splicing. Almost all of the biochemical functions are regulated by reversible phosphorylation.展开更多
文摘For some historic reasons, our new journal is named 'Genomics, Pro teomics & Bioinformatics', or as we have nicknamed it in short the Journal of GPB. A growing number of '-ome' and '-omics' have appeared in many diverse fields of biology, especially in the recent years under profound influences of the Human Genome Project and many other genome projects completed or in progress. We had almost attempted to re-name this journal 'Ever-more-omics' to include all the new comers. However, after a second thought, we have decided to entertain these 'Three Kingdoms' first while we are keeping an eye on others.
基金This work was supported by the National Natural Science Foundation of China (30070285).
文摘The name of SR proteins is derived from their typical RS domain that is rich in serine (Ser, S) and arginine (Arg, R). They are conserved in evolution. Up to now, 10 members of the SR protein family have been identified in humans. SR proteins contain one or two RNA binding motifs aside from the RS domain, and also possess special biochemical and immunological features. As to the functions of SR proteins, they facilitate the recruitment of the components of splicesome via protein-protein interaction to prompt the assembly of early splicesome; while in alternative splicing, tissue-specifically expressed SR protein along with the relative ratio of SR protein and heterogeneous nuclear ribonucleoprotein (hnRNP) is composed of two main regulative mechanisms for alternative splicing. Almost all of the biochemical functions are regulated by reversible phosphorylation.
