Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great pote...Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great potential for melanoma treatment.展开更多
Bio-based polyurethane foam has attracted increasing attentions due to eco-friendliness and fossil feedstock issues.However,the inherent flammability limits its application in different fields.Herein,we demonstrate a ...Bio-based polyurethane foam has attracted increasing attentions due to eco-friendliness and fossil feedstock issues.However,the inherent flammability limits its application in different fields.Herein,we demonstrate a green bio-based flame-retardant system to fabricate polyurethane foam composite with durable flame retardancy,smoke suppression,and thermal insulation property.In this system,the green bio-based polyol(VED)with good reactivity and compatibility plays a role of flame retardant and EG acts as a synergistic filler.As a result,the LOI value of foam composite increased to 30.5 vol.%and it achieved a V-0 rating in the UL-94 vertical burning test.Additionally,the peak heat release rate(pHRR)and the total smoke production(TSP)decreased by 66.1%and 63.4%,respectively.Furthermore,the foam composite maintained durable flame retardancy after accelerated thermal aging test,whose thermal-insulating property was maintained even after being treated in high-humidity environment with 85%R.H.for a week.This work provides a facile strategy for durable flame retardancy and long-term thermal insulation performance,and creates opportunities for the practical applications of bio-based foam composites.展开更多
Gastric cancer(GC)poses a serious threat worldwide with unfavorable prognosis mainly due to late diagnosis and limited therapies.Therefore,precise molecular classification and search for potential targets are required...Gastric cancer(GC)poses a serious threat worldwide with unfavorable prognosis mainly due to late diagnosis and limited therapies.Therefore,precise molecular classification and search for potential targets are required for diagnosis and treatment,as GC is complicated and heterogeneous in nature.Accumulating evidence indicates that epigenetics plays a vital role in gastric carcinogenesis and progression,including histone modifications,DNA methylation and non-coding RNAs.Epigenetic biomarkers and drugs are currently under intensive evaluations to ensure efficient clinical utility in GC.In this review,key epigenetic alterations and related functions and mechanisms are summarized in GC.We focus on integration of existing epigenetic findings in GC for the bench-to-bedside translation of some pivotal epigenetic alterations into clinical practice and also describe the vacant field waiting for investigation.展开更多
Gastrointestinal(GI)cancers,including colorectal cancer,pancreatic cancer,liver cancer and gastric cancer,are severe social burdens due to high incidence and mortality rates.Bromodomain and extra-terminal(BET)proteins...Gastrointestinal(GI)cancers,including colorectal cancer,pancreatic cancer,liver cancer and gastric cancer,are severe social burdens due to high incidence and mortality rates.Bromodomain and extra-terminal(BET)proteins are epigenetic readers consisting of four conserved members(BRD2,BRD3,BRD4 and BRDT).BET family perform pivotal roles in tumorigenesis through transcriptional regulation,thereby emerging as potential therapeutic targets.BET inhibitors,disrupting the interaction between BET proteins and acetylated lysines,have been reported to suppress tumor initiation and progression in most of GI cancers.In this review,we will demonstrate how BET proteins participate in the GI cancers progression and highlight the therapeutic potential of targeting BET proteins for GI cancers treatment.展开更多
基金This work was supported by grants from the National Natural Science Foundation of China(82103183,82102803,82272849)the Natural Science Foundation of Hunan Province(2022JJ40767,2021JJ40976)+1 种基金the Natural Science Fund for Outstanding Youths in Hunan Province(2023JJ20093)the National Key Research and Development Program(2022YFC2504700).
文摘Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great potential for melanoma treatment.
基金supported by the National Natural Science Foundation of China(Nos.22175123,52122302,and 51991351)the 111 Project(No.B20001)Fundamental Research Funds for the Central Universities,and Open and Innovative Fund of Hubei Three Gorges Laboratory(Nos.2022LF2021 and SC213011).
文摘Bio-based polyurethane foam has attracted increasing attentions due to eco-friendliness and fossil feedstock issues.However,the inherent flammability limits its application in different fields.Herein,we demonstrate a green bio-based flame-retardant system to fabricate polyurethane foam composite with durable flame retardancy,smoke suppression,and thermal insulation property.In this system,the green bio-based polyol(VED)with good reactivity and compatibility plays a role of flame retardant and EG acts as a synergistic filler.As a result,the LOI value of foam composite increased to 30.5 vol.%and it achieved a V-0 rating in the UL-94 vertical burning test.Additionally,the peak heat release rate(pHRR)and the total smoke production(TSP)decreased by 66.1%and 63.4%,respectively.Furthermore,the foam composite maintained durable flame retardancy after accelerated thermal aging test,whose thermal-insulating property was maintained even after being treated in high-humidity environment with 85%R.H.for a week.This work provides a facile strategy for durable flame retardancy and long-term thermal insulation performance,and creates opportunities for the practical applications of bio-based foam composites.
基金The fellowship of the China Postdoctoral Science Foundation,No.2020M682594.
文摘Gastric cancer(GC)poses a serious threat worldwide with unfavorable prognosis mainly due to late diagnosis and limited therapies.Therefore,precise molecular classification and search for potential targets are required for diagnosis and treatment,as GC is complicated and heterogeneous in nature.Accumulating evidence indicates that epigenetics plays a vital role in gastric carcinogenesis and progression,including histone modifications,DNA methylation and non-coding RNAs.Epigenetic biomarkers and drugs are currently under intensive evaluations to ensure efficient clinical utility in GC.In this review,key epigenetic alterations and related functions and mechanisms are summarized in GC.We focus on integration of existing epigenetic findings in GC for the bench-to-bedside translation of some pivotal epigenetic alterations into clinical practice and also describe the vacant field waiting for investigation.
基金Fellowship of the China Postdoctoral Science Foundation,No.2020M682594,and No.2021T140748.
文摘Gastrointestinal(GI)cancers,including colorectal cancer,pancreatic cancer,liver cancer and gastric cancer,are severe social burdens due to high incidence and mortality rates.Bromodomain and extra-terminal(BET)proteins are epigenetic readers consisting of four conserved members(BRD2,BRD3,BRD4 and BRDT).BET family perform pivotal roles in tumorigenesis through transcriptional regulation,thereby emerging as potential therapeutic targets.BET inhibitors,disrupting the interaction between BET proteins and acetylated lysines,have been reported to suppress tumor initiation and progression in most of GI cancers.In this review,we will demonstrate how BET proteins participate in the GI cancers progression and highlight the therapeutic potential of targeting BET proteins for GI cancers treatment.
