Aims: To improve visualisation of angiographic features in patients with age r elated macular degeneration associated with choroidal neovascularisation (CNV) a nd related complications. To evaluate if image averaging ...Aims: To improve visualisation of angiographic features in patients with age r elated macular degeneration associated with choroidal neovascularisation (CNV) a nd related complications. To evaluate if image averaging can achieve this goal. Methods: 27 eyes of 20 sequential patients with age related macular degeneration over a 3 month period were studied. Indocyanine green angiograms (ICGA), fluore scein angiograms (FA), and oral fluorescein angiograms were recorded with a conf ocal scanning laser ophthalmoscope. Software was used to average multiple images from a 10-20 image series (over 0.5-1.0 seconds). Image quality was assessed by two masked observers and graded on a scale of 0-3. A more quantifiable gradi ng method was devised by adding a variable amount of Gaussian noise to the impro ved image until the original and image averaged image appeared equal. Results: M asked review showed mild to strong improvement of visualisation of structures in cluding borders of CNV. Improvement varied depending on the type and phase of th e angiogram. Improvement was highest in late phase FA, mid and late phase ICGA, and all phases of oral FA. Conclusion: Image averaging using software based algo rithms improves the quality of angiographic images, particularly late ICGA image s and oral FAs. This method may assist in the visualisation of choroidal neovasc ularisation in age related macular degeneration.展开更多
Objective: To determine the sensitivity and specificity of scanning laser entoptic perimetry for detecting visual function damage due to age- related macular degeneration (ARMD)- . Methods: We measured the presence or...Objective: To determine the sensitivity and specificity of scanning laser entoptic perimetry for detecting visual function damage due to age- related macular degeneration (ARMD)- . Methods: We measured the presence or absence of visual field disturbances by entoptic perimetry and determined the severity of ARMD based on masked readings of fundus photographs. A prospective masked study comparing the findings of entoptic perimetry with fundus photographs was performed. We recruited 91 patients with ARMD and 24 patients without ARMD during ophthalmologic visits. An appropriate institutional review board approval was obtained for the project. The main outcome measure was the detection of visual scotomata. Results: Scanning laser entoptic perimetry had an over- all sensitivity of 82% and a specificity of 100% for the detection of ARMD. The sensitivity for early stages of the disease is greater than 70% , and increases to above 90% for moderate to late stages. Conclusion: Scanning laser entoptic perimetry is a specific and sensitive test for detecting ARMD, even at the earliest stages when patients are typically asymptomatic.展开更多
文摘Aims: To improve visualisation of angiographic features in patients with age r elated macular degeneration associated with choroidal neovascularisation (CNV) a nd related complications. To evaluate if image averaging can achieve this goal. Methods: 27 eyes of 20 sequential patients with age related macular degeneration over a 3 month period were studied. Indocyanine green angiograms (ICGA), fluore scein angiograms (FA), and oral fluorescein angiograms were recorded with a conf ocal scanning laser ophthalmoscope. Software was used to average multiple images from a 10-20 image series (over 0.5-1.0 seconds). Image quality was assessed by two masked observers and graded on a scale of 0-3. A more quantifiable gradi ng method was devised by adding a variable amount of Gaussian noise to the impro ved image until the original and image averaged image appeared equal. Results: M asked review showed mild to strong improvement of visualisation of structures in cluding borders of CNV. Improvement varied depending on the type and phase of th e angiogram. Improvement was highest in late phase FA, mid and late phase ICGA, and all phases of oral FA. Conclusion: Image averaging using software based algo rithms improves the quality of angiographic images, particularly late ICGA image s and oral FAs. This method may assist in the visualisation of choroidal neovasc ularisation in age related macular degeneration.
文摘Objective: To determine the sensitivity and specificity of scanning laser entoptic perimetry for detecting visual function damage due to age- related macular degeneration (ARMD)- . Methods: We measured the presence or absence of visual field disturbances by entoptic perimetry and determined the severity of ARMD based on masked readings of fundus photographs. A prospective masked study comparing the findings of entoptic perimetry with fundus photographs was performed. We recruited 91 patients with ARMD and 24 patients without ARMD during ophthalmologic visits. An appropriate institutional review board approval was obtained for the project. The main outcome measure was the detection of visual scotomata. Results: Scanning laser entoptic perimetry had an over- all sensitivity of 82% and a specificity of 100% for the detection of ARMD. The sensitivity for early stages of the disease is greater than 70% , and increases to above 90% for moderate to late stages. Conclusion: Scanning laser entoptic perimetry is a specific and sensitive test for detecting ARMD, even at the earliest stages when patients are typically asymptomatic.
