Gadolinium(III)complexes have been employed for more than 30 years as contrast agents in magnetic resonance imaging(MRI).In order to further improve the diagnostic accuracy of enhanced magnetic resonance images or to ...Gadolinium(III)complexes have been employed for more than 30 years as contrast agents in magnetic resonance imaging(MRI).In order to further improve the diagnostic accuracy of enhanced magnetic resonance images or to provide comparable enhancement at a reduced administered dose,current research is focusing on the development of Gd^(Ⅲ)-complexes characterized by higher relaxivity.In this study we describe the synthesis and the equilibrium,kinetic,relaxation and structural properties of two new Gd^(Ⅲ)-complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid(HP-DO3A)structure which,due to an intramolecular prototropic exchange,display more than two-fold higher relaxivity compared to currently available Gd^(Ⅲ)-based MRI contrast agents.展开更多
基金the Hungarian National Research,Development and Innovation Office-NKFIH under the Grant NKFI NN 128368.D.H.:University of Debrecen,Faculty of Science and Technology,Department of Physical Chemistry,Doctoral School of Chemistry.
文摘Gadolinium(III)complexes have been employed for more than 30 years as contrast agents in magnetic resonance imaging(MRI).In order to further improve the diagnostic accuracy of enhanced magnetic resonance images or to provide comparable enhancement at a reduced administered dose,current research is focusing on the development of Gd^(Ⅲ)-complexes characterized by higher relaxivity.In this study we describe the synthesis and the equilibrium,kinetic,relaxation and structural properties of two new Gd^(Ⅲ)-complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid(HP-DO3A)structure which,due to an intramolecular prototropic exchange,display more than two-fold higher relaxivity compared to currently available Gd^(Ⅲ)-based MRI contrast agents.
