Objective:Serum amyloid A(SAA)is a protein involved in the acute phase of inflammation.SAA expression is upregulated in humans during the acute phase of various viral infections;in addition,SAA can be a useful biomark...Objective:Serum amyloid A(SAA)is a protein involved in the acute phase of inflammation.SAA expression is upregulated in humans during the acute phase of various viral infections;in addition,SAA can be a useful biomarker to predict the severity and prognosis of COVID-19 patients.This study aimed to evaluate a new chemiluminescence test for SAA detection.Methods:All serum samples were measured for SAA on a Maglumi 800(Snibe,Shenzhen,China)and compared with a BN ProSpec(Siemens,Munich,Germany)in the routine of the clinical laboratory of the University Hospital of the Tor Vergata University of Rome(Rome,Italy).Analytical precision,the correlation coefficient,and linearity were assessed.Statistical analyses were performed.Results:The linearity test was performed via serial dilutions and revealed a correlation coefficient equivalent to 0.9998.The results of the Snibe SAA test correlated well with those obtained by the SAA Siemens test,with a correlation coefficient of 0.974(P<0.001).The intraand interrun precision,as well as carryover,were assessed.-Conclusions:The results obtained from this study demonstrated that the new Snibe SAA test has reliable analytical performance and good accuracy and could represent a valid tool for routine hospital laboratory analysis.展开更多
文摘Objective:Serum amyloid A(SAA)is a protein involved in the acute phase of inflammation.SAA expression is upregulated in humans during the acute phase of various viral infections;in addition,SAA can be a useful biomarker to predict the severity and prognosis of COVID-19 patients.This study aimed to evaluate a new chemiluminescence test for SAA detection.Methods:All serum samples were measured for SAA on a Maglumi 800(Snibe,Shenzhen,China)and compared with a BN ProSpec(Siemens,Munich,Germany)in the routine of the clinical laboratory of the University Hospital of the Tor Vergata University of Rome(Rome,Italy).Analytical precision,the correlation coefficient,and linearity were assessed.Statistical analyses were performed.Results:The linearity test was performed via serial dilutions and revealed a correlation coefficient equivalent to 0.9998.The results of the Snibe SAA test correlated well with those obtained by the SAA Siemens test,with a correlation coefficient of 0.974(P<0.001).The intraand interrun precision,as well as carryover,were assessed.-Conclusions:The results obtained from this study demonstrated that the new Snibe SAA test has reliable analytical performance and good accuracy and could represent a valid tool for routine hospital laboratory analysis.
