AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with ind...AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March 2012.Patients underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without contrast.Cisplatin was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days weekly.This retrospective analysis was approved by the review boards of the participating institutions.Patients gave their consent to treatment and to anonymous analysis of clinical data.RESULTS:Thirty-three patients were males and 7 were females.Median follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,respectively.Overall response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 patients.Grade 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 patients.Overall toxicity was manageable and it did not cause any significant treatment delay.In the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 patients.CONCLUSION:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced NPC.The role of adjuvant chemotherapy remains to be defined.展开更多
In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting wh...In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.展开更多
The freight logistics includes all the processes needed to supply industry,retailers and wholesalers and final customers with goods.Such processes generate a flow of goods that,in the global supply chain,mainly relies...The freight logistics includes all the processes needed to supply industry,retailers and wholesalers and final customers with goods.Such processes generate a flow of goods that,in the global supply chain,mainly relies on the activities carried out within worldwide container terminals.In this paper,the authors present a simulation model of a real container terminal.After some preliminary analyses,the simulation model is first used with Design of Experiments and Analysis of Variance to investigate the effects of different resources allocations(i.e.,number of forklifts and tractors)and some parameters(i.e.,inter-arrival times,container unloading time)on the container terminal performances in terms of total number of handled containers per day.Then,based on the results achieved through the Design of Experiments and Analysis of Variance,the simulation model is used with genetic algorithms to carry out a range allocation optimization on berth assignment to incoming ships and number of tractors serving each quay crane.The aim of the optimization is the minimization of the average time spent by each ship in the port area(decreasing,as consequence,costs and increasing service level provided to final customers).展开更多
The focus of the research work presented in this article is the design of an industrial plant devoted to produce different types of hazelnuts-based products.The industrial plant design is initially based on a traditio...The focus of the research work presented in this article is the design of an industrial plant devoted to produce different types of hazelnuts-based products.The industrial plant design is initially based on a traditional approach(production process flow charts analysis and plant layout study)and it is then supported by a simulation model mainly used to investigate the system behavior in different operative scenarios.The industrial plant simulation model(called HAZIMUT,HAZelnuts Industrial plant design and man-agement based on advanced simulation Models Utilization)recreates the entire hazelnuts production process(based on nine different production lines).The HAZIMUT simulation model is used to evaluate the effects—caused by multiple changes in the production lines capacities—on multiple performance measures based on machines levels utilization,work in process and production system productivity.The simulation results show how variations in production lines capacities generate an over-reaction of the system with major changes in some of the performance measures therefore stressing the importance to use the HAZIMUT simulator to tune the system correctly to improve the overall plant performances.展开更多
文摘AIM:To provide efficacy and safety data about the combined use of radiotherapy and chemo-radiotherapy in nasopharyngeal carcinoma(NPC).METHODS:We reviewed data of 40 patients with locally advanced NPC treated with induction chemotherapy followed by concomitant chemo-radiotherapy(CCRT)(22/40 patients)or CCRT alone(18/40)from March 2006 to March 2012.Patients underwent fiberoscopy with biopsy of the primitive tumor,and computed tomography scan of head,neck,chest and abdomen with and without contrast.Cisplatin was used both as induction and as concomitant chemotherapy,while 3D conformal radiation therapy was delivered to the nasopharynx and relevant anatomic regions(total dose,70 Gy).The treatment was performed using 6 MV photons of the linear accelerator administered in 2 Gy daily fraction for five days weekly.This retrospective analysis was approved by the review boards of the participating institutions.Patients gave their consent to treatment and to anonymous analysis of clinical data.RESULTS:Thirty-three patients were males and 7 were females.Median follow-up time was 58 mo(range,1-92 mo).In the sub-group of twenty patients with a follow-up time longer than 36 mo,the 3-year survival and disease free survival rates were 85%and 75%,respectively.Overall response rate both in patients treated with induction chemotherapy followed by CCRT and in those treated with CCRT alone was 100%.Grade 3 neutropenia was the most frequent acute side-effect and it occurred in 20 patients.Grade 2 mucositis was seen in 29 patients,while grade 2 xerostomia was seen in 30 patients.Overall toxicity was manageable and it did not cause any significant treatment delay.In the whole sample population,long term toxicity included grade 2 xerostomia in 22 patients,grade 1 dysgeusia in 17 patients and grade 1 subcutaneous fibrosis in 30 patients.CONCLUSION:Both CCRT and induction chemotherapy followed by CCRT showed excellent activity in locally advanced NPC.The role of adjuvant chemotherapy remains to be defined.
基金supported by the Royal Society,ERC Starting(Grant No.639217)he European Union Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie Global Fellowship(Grant No.703916)+10 种基金the National Natural Science Foundation of China(Grant Nos.11233001,11773014,11633007,11403074,11333005,11503008,and 11590781)the National Basic Research Program of China(Grant No.2015CB857100)NASA(Grant No.NNX13AD28A)an ARC Future Fellowship(Grant No.FT120100363)the National Science Foundation(Grant No.PHY-1430152)the Spanish MINECO(Grant No.AYA2016-76012-C3-1-P)the ICCUB(Unidad de Excelencia’Maria de Maeztu’)(Grant No.MDM-2014-0369)EU’s Horizon Programme through a Marie Sklodowska-Curie Fellowship(Grant No.702638)the Polish National Science Center(Grant Nos.2015/17/B/ST9/03422,2015/18/M/ST9/00541,2013/10/M/ST9/00729,and 2015/18/A/ST9/00746)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA15020100)the NWO Veni Fellowship(Grant No.639.041.647)
文摘In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.
文摘The freight logistics includes all the processes needed to supply industry,retailers and wholesalers and final customers with goods.Such processes generate a flow of goods that,in the global supply chain,mainly relies on the activities carried out within worldwide container terminals.In this paper,the authors present a simulation model of a real container terminal.After some preliminary analyses,the simulation model is first used with Design of Experiments and Analysis of Variance to investigate the effects of different resources allocations(i.e.,number of forklifts and tractors)and some parameters(i.e.,inter-arrival times,container unloading time)on the container terminal performances in terms of total number of handled containers per day.Then,based on the results achieved through the Design of Experiments and Analysis of Variance,the simulation model is used with genetic algorithms to carry out a range allocation optimization on berth assignment to incoming ships and number of tractors serving each quay crane.The aim of the optimization is the minimization of the average time spent by each ship in the port area(decreasing,as consequence,costs and increasing service level provided to final customers).
文摘The focus of the research work presented in this article is the design of an industrial plant devoted to produce different types of hazelnuts-based products.The industrial plant design is initially based on a traditional approach(production process flow charts analysis and plant layout study)and it is then supported by a simulation model mainly used to investigate the system behavior in different operative scenarios.The industrial plant simulation model(called HAZIMUT,HAZelnuts Industrial plant design and man-agement based on advanced simulation Models Utilization)recreates the entire hazelnuts production process(based on nine different production lines).The HAZIMUT simulation model is used to evaluate the effects—caused by multiple changes in the production lines capacities—on multiple performance measures based on machines levels utilization,work in process and production system productivity.The simulation results show how variations in production lines capacities generate an over-reaction of the system with major changes in some of the performance measures therefore stressing the importance to use the HAZIMUT simulator to tune the system correctly to improve the overall plant performances.
